4kcx A 2.0 BS01 1QK A 1 W50 P51 F52 L61 D114 I115 M118 W22 P23 F24 L33 D86 I87 M90 ? Kd=37uM -logKd/Ki=4.43, Kd=37uM Q58F21 24007471 201 TNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMP 4kcx B 2.0 BS01 1QK B 1 W50 P51 F52 V56 L61 D114 I115 W22 P23 F24 V28 L33 D86 I87 ? Kd=37uM Q58F21 24007471 201 TNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMP 4kd1 A 1.7 BS01 1QK A 1 I10 A31 K33 F80 F82 L83 H84 Q85 D86 K89 Q131 L134 I10 A31 K33 F80 F82 L83 H84 Q85 D86 K89 Q131 L134 D127 K129 Q131 N132 D145 T158 T165 D127 K129 Q131 N132 D145 T158 T165 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 P24941 24007471 302 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 4o70 A 1.55 BS01 1QK A 1 W81 F83 N140 D144 D145 I146 W40 F42 N99 D103 D104 I105 ? ic50=19uM -logKd/Ki=4.72, IC50=19uM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o70 A 1.55 BS02 1QK A 2 K91 N93 K50 N52 ? ic50=19uM -logKd/Ki=4.72, IC50=19uM O60885 24568369 202 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o70 B 1.55 BS01 1QK A 1 H77 Q78 H36 Q37 ? ic50=19uM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o70 B 1.55 BS02 1QK B 1 W81 F83 L92 N140 D145 I146 W40 F42 L51 N99 D104 I105 ? ic50=19uM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 5l2w A 2.8 BS01 1QK A 1 I10 A31 F80 F82 L83 Q85 L134 A144 I11 A32 F81 F83 L84 Q86 L135 A145 D127 K129 Q131 N132 D145 T158 T165 D128 K130 Q132 N133 D146 T159 T166 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 -logKd/Ki=6.68, Kd=210nM P24941 27496135 900 SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 6gu6 A 2.33 BS01 1QK A 1 G11 E12 A31 K33 F80 L83 S84 M85 D86 Q132 L135 G11 E12 A31 K33 F80 L83 S84 M85 D86 Q132 L135 D128 K130 Q132 N133 D146 T166 D128 K130 Q132 N133 D146 T163 2.7.11.22,2.7.11.23 0000082,0000086,0000226,0000307,0000781,0001618,0003682,0004672,0004674,0004693,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005789,0005813,0005819,0005829,0005856,0005876,0006260,0006281,0006338,0006357,0006468,0006915,0006974,0007077,0007095,0007098,0007344,0008353,0009410,0009636,0010628,0010629,0010971,0014038,0014070,0014075,0014823,0016020,0016301,0016310,0016477,0016579,0018105,0018107,0030261,0030332,0030496,0030544,0030855,0031100,0034501,0035173,0042307,0042542,0042752,0043066,0044772,0045471,0045740,0045931,0045995,0046686,0046688,0046718,0048144,0048511,0048678,0051301,0055015,0060045,0062033,0065003,0070062,0070301,0070371,0071407,0072686,0090166,0097121,0097122,0097125,0097472,0106310,1900182,1902423,1902850,1905448 Kd=1810nM -logKd/Ki=5.74, Kd=1810nM P06493 30472117 301 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPITHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 8fow A 1.6 BS01 1QK A 1 I10 G11 E12 V18 A31 K33 F80 F82 L83 H84 Q85 L134 I8 G9 E10 V16 A29 K31 F66 F68 L69 H70 Q71 L120 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 P24941 37270540 303 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRTAIREISLLKELNHPNIVKLLDVIHTKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 8h4r A 2.75 BS01 1QK A 1 I10 A31 F80 L83 S84 Q85 D86 L134 I9 A30 F79 L82 S83 Q84 D85 L133 2.5.1.18,2.7.11.22 0000082,0000307,0004364,0004672,0004674,0004693,0005515,0005524,0005634,0005737,0006468,0006749,0006974,0007165,0008283,0010389,0010468,0016310,0016740,0030332,0045023,0045746,0051301,0106310 P08515,Q00526 401 DMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS 8p78 J 1.9 BS01 1QK J 1 L18 A39 F93 M94 E95 T96 D97 L9 A24 F69 M70 E71 T72 D73 2.7.11.22,2.7.11.23 0000307,0000439,0001650,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005654,0005675,0005737,0005829,0005886,0006281,0006366,0006367,0006468,0008094,0008353,0016301,0016310,0042795,0045944,0048471,0050821,0051301,0051726,0070516,0070985,0106310,2000045 P50613 38480681 401 KRYEKLDFLGEGQFATVYKARIVAIKKKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRP