4ji9 A 2.4 BS01 1M3 A 1 L855 G856 G858 A880 M929 Y931 L932 G935 N981 L983 L13 G14 G16 A38 M83 Y85 L86 G89 N135 L137 D976 A978 R980 N981 D994 S1016 D130 A132 R134 N135 D148 S170 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 23870430 1201 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 4ji9 B 2.4 BS01 1M3 B 1 L855 A880 M929 Y931 L932 G935 N981 L983 D994 L17 A42 M87 Y89 L90 G93 N139 L141 D152 D976 A978 R980 N981 D994 S1016 D134 A136 R138 N139 D152 S174 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 23870430 1201 RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 4o76 A 1.7 BS01 1M3 A 1 W81 P82 F83 L92 L94 N140 W40 P41 F42 L51 L53 N99 ? ic50=0.13uM -logKd/Ki=6.89, IC50=0.13uM IC50=130nM, Kd=123nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o76 A 1.7 BS02 1M3 B 1 F79 W81 D145 M149 F38 W40 D104 M108 ? ic50=0.13uM -logKd/Ki=6.89, IC50=0.13uM IC50=130nM, Kd=123nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o76 B 1.7 BS01 1M3 B 1 P82 F83 L92 N140 P41 F42 L51 N99 ? ic50=0.13uM IC50=130nM, Kd=123nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o76 C 1.7 BS01 1M3 C 1 W81 P82 F83 V87 L92 L94 N140 W40 P41 F42 V46 L51 L53 N99 ? ic50=0.13uM IC50=130nM, Kd=123nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o76 C 1.7 BS02 1M3 D 1 F79 W81 D145 F38 W40 D104 ? ic50=0.13uM IC50=130nM, Kd=123nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o76 D 1.7 BS01 1M3 C 1 D145 L148 D104 L107 ? ic50=0.13uM IC50=130nM, Kd=123nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o76 D 1.7 BS02 1M3 D 1 W81 P82 F83 L92 L94 N140 W40 P41 F42 L51 L53 N99 ? ic50=0.13uM IC50=130nM, Kd=123nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 5hez A 2.66 BS02 1M3 A 1 F1019 W1020 Y1021 P1023 L1026 W1038 L1081 G1086 F176 W177 Y178 P180 L183 W195 L238 G243 D976 A978 R980 N981 D994 S1016 D133 A135 R137 N138 D151 S173 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1203 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSARNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez A 2.66 BS03 1M3 A 2 L855 G856 V863 A880 M929 L932 G935 L983 D994 L14 G15 V22 A39 M86 L89 G92 L140 D151 D976 A978 R980 N981 D994 S1016 D133 A135 R137 N138 D151 S173 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1204 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSARNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez A 2.66 BS04 1M3 C 2 I1079 L1082 I236 L239 D976 A978 R980 N981 D994 S1016 D133 A135 R137 N138 D151 S173 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1202 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSARNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez B 2.66 BS01 1M3 B 1 F1019 W1020 Y1021 L1026 W1038 L1078 L1081 F178 W179 Y180 L185 W197 L237 L240 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1202 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez B 2.66 BS02 1M3 B 2 L855 G856 V863 A880 L932 G935 L983 D994 L14 G15 V22 A39 L91 G94 L142 D153 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1203 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez B 2.66 BS04 1M3 D 1 L1082 K1083 L241 K242 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1202 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez C 2.66 BS01 1M3 A 1 L1082 K1083 L241 K242 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1203 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez C 2.66 BS03 1M3 C 1 L855 G856 G858 V863 A880 M929 Y931 L932 G935 L983 D994 L14 G15 G17 V22 A39 M88 Y90 L91 G94 L142 D153 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1201 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez C 2.66 BS04 1M3 C 2 F1019 W1020 Y1021 L1026 W1038 L1078 L1081 G1086 F178 W179 Y180 L185 W197 L237 L240 G245 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1202 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez D 2.66 BS01 1M3 B 1 L1082 K1083 L241 K242 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1202 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez D 2.66 BS02 1M3 D 1 F1019 W1020 Y1021 P1023 L1026 W1038 L1078 L1081 G1086 F178 W179 Y180 P182 L185 W197 L237 L240 G245 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1202 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 5hez D 2.66 BS03 1M3 D 2 L855 G856 V863 A880 M929 Y931 L932 G935 N981 L983 D994 L14 G15 V22 A39 M88 Y90 L91 G94 N140 L142 D153 D976 A978 R980 N981 D994 S1016 D135 A137 R139 N140 D153 S175 2.7.10.2 0004672,0004713,0005524,0006468 IC50=6.0nM O60674 27807284 1203 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSAPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG