4jg8 A 3.1002 BS01 1LE A 1 I428 C436 A449 K451 M493 L495 M496 D561 I14 C22 A35 K37 M79 L81 M82 D147 D539 K541 N544 D561 T581 D125 K127 N130 D147 T167 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.60, IC50<2.5nM P51812 23540679 801 SIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVMELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ 7up7 A 2.8 BS01 1LE A 1 L432 G433 E434 C440 A453 K455 L501 L551 D565 L18 G19 E20 C26 A39 K41 L87 L137 D147 2.7.11.1 0004672,0005524,0006468 O75582 35859861 900 KDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDLEIKIIDFGFARLKPYDESCDLWSLGVILYTMLSGQVPFQLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKY 7up7 B 2.8 BS01 1LE B 1 L432 S438 C440 A453 K455 M498 L501 L551 I564 D565 L17 S23 C25 A38 K40 M83 L86 L136 I146 D147 2.7.11.1 0004672,0005524,0006468 O75582 35859861 900 DSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDELEIKIIDFGFARLKPDESCDLWSLGVILYTMLSGQVPFQSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKRE