4iti A 2.86 BS01 1HW A 1 A64 M67 V76 L78 L90 M92 H136 I154 A155 D156 L157 S161 F162 A57 M60 V69 L71 L83 M85 H129 I147 A148 D149 L150 S154 F155 D138 K140 E142 N143 D156 T189 D131 K133 E135 N136 D149 T172 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=6.36, IC50=439.5nM Q13546 23473668 301 NVIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE 4iti B 2.86 BS01 1HW B 1 A64 M67 N68 V75 V76 L78 L90 M92 H136 D156 S161 F162 W165 A51 M54 N55 V62 V63 L65 L77 M79 H123 D143 S148 F149 W152 D138 K140 E142 N143 D156 T189 D125 K127 E129 N130 D143 T165 2.7.11.1 0004672,0005524,0006468 Q13546 23473668 301 LNVIKMKSSDFLESAEKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE