4i42 A 1.848 BS01 1HA A 1 V44 R45 S84 G85 G86 D87 Q88 K89 Y97 V108 Y129 G133 T155 S161 V44 R45 S84 G85 G86 D87 Q88 K89 Y97 V108 Y129 G133 T155 S161 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 A 1.848 BS02 1HA F 1 T254 F270 K273 T254 F270 K273 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 B 1.848 BS01 1HA B 1 V44 R45 S84 G85 G86 D87 Q88 K89 Y97 V108 Y129 G133 T155 S161 V43 R44 S83 G84 G85 D86 Q87 K88 Y96 V107 Y128 G132 T154 S160 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G85 R90 Y96 H104 L108 G132 V135 G155 S160 D162 G163 A249 Y257 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 IYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 C 1.848 BS01 1HA C 1 V44 R45 A47 S84 G85 G86 D87 Q88 V108 L109 Y129 G133 T155 V159 S161 V41 R42 A44 S81 G82 G83 D84 Q85 V105 L106 Y126 G130 T152 V156 S158 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G83 R88 Y94 H102 L106 G130 V133 G153 S158 D160 G161 A247 Y255 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 PDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 C 1.848 BS02 1HA E 1 T254 F270 K273 T251 F267 K270 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G83 R88 Y94 H102 L106 G130 V133 G153 S158 D160 G161 A247 Y255 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 PDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 D 1.848 BS01 1HA B 1 T254 F270 K273 T237 F253 K256 G86 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G85 L92 G116 V119 G139 S144 D146 G147 A233 Y241 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 IYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 E 1.848 BS01 1HA C 1 T254 F270 K273 T254 F270 K273 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 E 1.848 BS02 1HA E 1 Q43 V44 R45 A47 S84 G85 G86 D87 Q88 K89 Y97 V108 Y129 G133 T155 V159 S161 F162 Q43 V44 R45 A47 S84 G85 G86 D87 Q88 K89 Y97 V108 Y129 G133 T155 V159 S161 F162 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 F 1.848 BS01 1HA A 1 T254 F270 T254 F270 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 F 1.848 BS02 1HA F 1 Q43 V44 R45 S84 G85 G86 D87 Q88 K89 Y97 V108 Y129 G133 T155 V159 S161 Q43 V44 R45 S84 G85 G86 D87 Q88 K89 Y97 V108 Y129 G133 T155 V159 S161 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 G 1.848 BS01 1HA G 1 Q43 V44 R45 A47 S84 G85 G86 D87 Q88 Y97 V108 L109 Y129 G133 T155 V159 S161 Q43 V44 R45 A47 S84 G85 G86 D87 Q88 Y97 V108 L109 Y129 G133 T155 V159 S161 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 G 1.848 BS02 1HA L 1 T254 F270 K273 T254 F270 K273 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 H 1.848 BS01 1HA H 1 V44 R45 S84 G85 G86 D87 Q88 K89 V108 L109 Y129 G133 T155 V159 S161 F162 V43 R44 S83 G84 G85 D86 Q87 K88 V107 L108 Y128 G132 T154 V158 S160 F161 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G85 R90 Y96 H104 L108 G132 V135 G155 S160 D162 G163 A249 Y257 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 IYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 H 1.848 BS02 1HA J 1 T254 F270 T253 F269 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G85 R90 Y96 H104 L108 G132 V135 G155 S160 D162 G163 A249 Y257 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 IYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 I 1.848 BS01 1HA I 1 V44 R45 S84 G85 G86 D87 Q88 K89 Y97 V108 L109 Y129 G133 T155 S161 V44 R45 S84 G85 G86 D87 Q88 K89 Y97 V108 L109 Y129 G133 T155 S161 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 I 1.848 BS03 1HA K 1 T254 F270 T254 F270 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 J 1.848 BS01 1HA H 1 T254 F270 K273 T254 F270 K273 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 J 1.848 BS02 1HA J 1 Q43 V44 R45 S84 G85 G86 D87 Q88 V108 Y129 G133 T155 S161 Q43 V44 R45 S84 G85 G86 D87 Q88 V108 Y129 G133 T155 S161 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 K 1.848 BS01 1HA I 1 T254 F270 K273 T254 F270 K273 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 K 1.848 BS02 1HA K 1 V44 R45 S84 G85 G86 D87 Q88 K89 Y97 V108 Y129 G133 T155 V159 S161 V44 R45 S84 G85 G86 D87 Q88 K89 Y97 V108 Y129 G133 T155 V159 S161 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 L 1.848 BS01 1HA G 1 T254 F270 K273 T254 F270 K273 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i42 L 1.848 BS02 1HA L 1 V44 R45 A47 S84 G85 G86 D87 Q88 Y97 V108 L109 Y129 G133 T155 S161 V44 R45 A47 S84 G85 G86 D87 Q88 Y97 V108 L109 Y129 G133 T155 S161 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 G86 R91 Y97 H105 L109 G133 V136 G156 S161 D163 G164 A250 Y258 4.1.3.36 0003824,0005515,0005829,0008935,0009234,0016829,0071890 P0ABU0 23658663 301 MIYPDEAMLYAPVEWHDCSEGFEDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP 4i52 A 2.35 BS01 1HA A 1 H29 K30 R31 A33 S75 G76 G77 D78 Q79 L96 V98 Y119 I121 G123 T145 V149 S151 F152 H29 K30 R31 A33 S75 G76 G77 D78 Q79 L96 V98 Y119 I121 G123 T145 V149 S151 F152 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 4.1.3.36 0003824,0005829,0008935,0009234,0016829,0042372 P73495 23658663 301 MDWHIAKHYDDILYYKAGGIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPHSDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGSEGKQAFLEKRPPDFSQYPWLP 4i52 B 2.35 BS01 1HA B 1 H29 K30 R31 S75 G76 G77 D78 Q79 Y87 V98 Y119 I121 G123 T145 V149 S151 F152 D153 H29 K30 R31 S75 G76 G77 D78 Q79 Y87 V98 Y119 I121 G123 T145 V149 S151 F152 D153 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 4.1.3.36 0003824,0005829,0008935,0009234,0016829,0042372 P73495 23658663 301 MDWHIAKHYDDILYYKAGGIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPHSDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGSEGKQAFLEKRPPDFSQYPWLP 4i52 C 2.35 BS01 1HA C 1 K30 R31 A33 S75 G76 G77 D78 Q79 V98 Y119 G123 T145 V149 S151 F152 K29 R30 A32 S74 G75 G76 D77 Q78 V97 Y118 G122 T144 V148 S150 F151 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 G76 R81 Y86 R94 L98 G122 V125 G145 S150 D152 G153 A239 Y247 4.1.3.36 0003824,0005829,0008935,0009234,0016829,0042372 P73495 23658663 301 DWHIAKHYDDILYYKAGGIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPHSDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGSEGKQAFLEKRPPDFSQYPWLP 4i52 D 2.35 BS01 1HA D 1 H29 K30 R31 A33 S75 G76 G77 D78 Q79 Y87 V98 Y119 I121 G123 T145 V149 S151 F152 H29 K30 R31 A33 S75 G76 G77 D78 Q79 Y87 V98 Y119 I121 G123 T145 V149 S151 F152 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 4.1.3.36 0003824,0005829,0008935,0009234,0016829,0042372 P73495 23658663 301 MDWHIAKHYDDILYYKAGGIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPHSDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGSEGKQAFLEKRPPDFSQYPWLP 4i52 E 2.35 BS01 1HA E 1 H29 K30 R31 S75 G76 G77 D78 Q79 V98 Y119 I121 G123 T145 V149 S151 F152 H28 K29 R30 S74 G75 G76 D77 Q78 V97 Y118 I120 G122 T144 V148 S150 F151 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 G76 R81 Y86 R94 L98 G122 V125 G145 S150 D152 G153 A239 Y247 4.1.3.36 0003824,0005829,0008935,0009234,0016829,0042372 P73495 23658663 301 DWHIAKHYDDILYYKAGGIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPHSDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGSEGKQAFLEKRPPDFSQYPWLP 4i52 F 2.35 BS01 1HA F 1 H29 K30 R31 A33 S75 G76 G77 D78 Q79 Y87 V98 Y119 I121 G123 T145 V149 S151 F152 H28 K29 R30 A32 S74 G75 G76 D77 Q78 Y86 V97 Y118 I120 G122 T144 V148 S150 F151 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 G76 R81 Y86 R94 L98 G122 V125 G145 S150 D152 G153 A239 Y247 4.1.3.36 0003824,0005829,0008935,0009234,0016829,0042372 P73495 23658663 301 DWHIAKHYDDILYYKAGGIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPHSDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGSEGKQAFLEKRPPDFSQYPWLP 4i52 G 2.35 BS01 1HA G 1 K30 R31 S75 G76 G77 D78 Q79 Y87 L96 V98 Y119 I121 G123 T145 V149 S151 F152 K30 R31 S75 G76 G77 D78 Q79 Y87 L96 V98 Y119 I121 G123 T145 V149 S151 F152 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 4.1.3.36 0003824,0005829,0008935,0009234,0016829,0042372 P73495 23658663 301 MDWHIAKHYDDILYYKAGGIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPHSDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGSEGKQAFLEKRPPDFSQYPWLP 4i52 H 2.35 BS01 1HA H 1 H29 K30 R31 A33 F34 S75 G76 G77 D78 Q79 L96 V98 Y119 I121 G123 T145 V149 S151 F152 H29 K30 R31 A33 F34 S75 G76 G77 D78 Q79 L96 V98 Y119 I121 G123 T145 V149 S151 F152 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 4.1.3.36 0003824,0005829,0008935,0009234,0016829,0042372 P73495 23658663 301 MDWHIAKHYDDILYYKAGGIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPHSDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGSEGKQAFLEKRPPDFSQYPWLP 4i52 I 2.35 BS01 1HA I 1 H29 K30 R31 A33 S75 G76 G77 D78 Q79 V98 Y119 I121 G123 T145 V149 S151 F152 H29 K30 R31 A33 S75 G76 G77 D78 Q79 V98 Y119 I121 G123 T145 V149 S151 F152 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 G77 R82 Y87 R95 L99 G123 V126 G146 S151 D153 G154 A240 Y248 4.1.3.36 0003824,0005829,0008935,0009234,0016829,0042372 P73495 23658663 301 MDWHIAKHYDDILYYKAGGIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPHSDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNAIFGQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNADCDGQAGLQELAGNATLLYYMTEEGSEGKQAFLEKRPPDFSQYPWLP 4qij A 2.2 BS01 1HA A 1 V57 R58 A60 F61 K95 S103 G104 G105 D106 Q107 Y115 L134 I136 W157 G161 T184 D185 S190 V44 R45 A47 F48 K82 S90 G91 G92 D93 Q94 Y102 L121 I123 W144 G148 T171 D172 S177 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM -logKd/Ki=5.54, Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij A 2.2 BS02 1HA F 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM -logKd/Ki=5.54, Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij B 2.2 BS01 1HA B 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G161 T184 D185 S190 V44 R45 A47 K82 S90 G91 G92 D93 Q94 Y102 I123 L124 W144 G148 T171 D172 S177 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij B 2.2 BS02 1HA E 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij C 2.2 BS01 1HA C 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 L134 I136 L137 W157 G161 T184 D185 S190 F191 V44 R45 A47 K82 S90 G91 G92 D93 Q94 Y102 L121 I123 L124 W144 G148 T171 D172 S177 F178 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij C 2.2 BS02 1HA D 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij D 2.2 BS01 1HA C 1 F299 K302 F282 K285 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G88 R93 Y98 R113 H118 G144 S147 D168 S173 D175 G176 A262 Y270 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij D 2.2 BS02 1HA D 1 V57 R58 K95 S103 G104 G105 D106 Q107 Y115 I136 W157 G161 T184 D185 S190 F191 D192 V40 R41 K78 S86 G87 G88 D89 Q90 Y98 I119 W140 G144 T167 D168 S173 F174 D175 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G88 R93 Y98 R113 H118 G144 S147 D168 S173 D175 G176 A262 Y270 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij E 2.2 BS01 1HA B 1 F299 K302 F283 K286 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij E 2.2 BS02 1HA E 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G160 G161 T184 D185 V188 S190 F191 D192 V41 R42 A44 K79 S87 G88 G89 D90 Q91 Y99 I120 L121 W141 G144 G145 T168 D169 V172 S174 F175 D176 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij F 2.2 BS01 1HA A 1 F299 K302 F283 K286 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM -logKd/Ki=5.54, Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij F 2.2 BS02 1HA F 1 E56 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G161 T184 D185 V188 S190 E40 V41 R42 A44 K79 S87 G88 G89 D90 Q91 Y99 I120 L121 W141 G145 T168 D169 V172 S174 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM -logKd/Ki=5.54, Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij G 2.2 BS01 1HA G 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 W157 G161 T184 D185 V188 S190 F191 V40 R41 A43 K78 S86 G87 G88 D89 Q90 Y98 I119 W140 G144 T167 D168 V171 S173 F174 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G88 R93 Y98 R113 H118 G144 S147 D168 S173 D175 G176 A262 Y270 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij G 2.2 BS02 1HA K 1 F299 K302 F282 K285 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G88 R93 Y98 R113 H118 G144 S147 D168 S173 D175 G176 A262 Y270 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij H 2.2 BS01 1HA H 1 E56 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 W157 G161 T184 D185 V188 S190 F191 D192 E40 V41 R42 A44 K79 S87 G88 G89 D90 Q91 Y99 I120 W141 G145 T168 D169 V172 S174 F175 D176 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij H 2.2 BS02 1HA J 1 F299 K302 F283 K286 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij I 2.2 BS01 1HA I 1 E56 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G160 G161 T184 D185 V188 S190 F191 E40 V41 R42 A44 K79 S87 G88 G89 D90 Q91 Y99 I120 L121 W141 G144 G145 T168 D169 V172 S174 F175 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij I 2.2 BS02 1HA L 1 F299 K302 F283 K286 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij J 2.2 BS01 1HA H 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij J 2.2 BS02 1HA J 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G161 T184 D185 V188 S190 F191 V44 R45 A47 K82 S90 G91 G92 D93 Q94 Y102 I123 L124 W144 G148 T171 D172 V175 S177 F178 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij K 2.2 BS01 1HA G 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij K 2.2 BS02 1HA K 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G161 T184 D185 V188 S190 F191 D192 V44 R45 A47 K82 S90 G91 G92 D93 Q94 Y102 I123 L124 W144 G148 T171 D172 V175 S177 F178 D179 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij L 2.2 BS01 1HA I 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij L 2.2 BS02 1HA L 1 V57 R58 A60 S103 G104 G105 D106 Q107 Y115 I136 W157 G161 T184 D185 V188 S190 F191 V44 R45 A47 S90 G91 G92 D93 Q94 Y102 I123 W144 G148 T171 D172 V175 S177 F178 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF