2bxe A 2.95 BS01 1FL A 1 N391 R410 Y411 K414 L430 G434 L453 S489 N378 R397 Y398 K401 L417 G421 L440 S476 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 Kd=1230nM, Ki=58884365535559nM P02768 16169013 2001 SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVAADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA 2bxe A 2.95 BS02 1FL A 2 F206 A213 L347 S480 L481 V482 F193 A200 L334 S467 L468 V469 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 Kd=1230nM, Ki=58884365535559nM P02768 16169013 2002 SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVAADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA 2bxe A 2.95 BS03 1FL A 3 Y150 L219 R222 L238 R257 L260 I290 A291 Y137 L206 R209 L225 R244 L247 I277 A278 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 Kd=1230nM, Ki=58884365535559nM P02768 16169013 2003 SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVAADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA 2bxe B 2.95 BS01 1FL B 1 N391 F403 R410 Y411 G434 L453 S489 N375 F387 R394 Y395 G418 L437 S473 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 Kd=1230nM, Ki=58884365535559nM P02768 16169013 2001 SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA 2bxe B 2.95 BS02 1FL B 2 F206 R209 L347 A350 K351 S480 L481 V482 F190 R193 L331 A334 K335 S464 L465 V466 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 Kd=1230nM, Ki=58884365535559nM P02768 16169013 2002 SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA 2bxe B 2.95 BS03 1FL B 3 Y150 L219 R222 L238 R257 Y134 L203 R206 L222 R241 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 Kd=1230nM, Ki=58884365535559nM P02768 16169013 2003 SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA 3d2t A 1.85 BS01 1FL A 1 K15 A108 L110 T119 K6 A99 L101 T110 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 Kd=75nM -logKd/Ki=7.12, Kd=75nM IC50=12000nM, Kd=407nM, EC50=5600nM P02766 14711308 502 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 3d2t B 1.85 BS01 1FL B 1 A108 L110 T119 A94 L96 T105 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 Kd=75nM -logKd/Ki=7.12, Kd=75nM IC50=12000nM, Kd=407nM, EC50=5600nM P02766 14711308 500 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANRYTIAALLSPYSYSTTAVVT 4i89 A 1.69 BS01 1FL A 1 K15 L17 A108 L110 S117 T118 T119 K6 L8 A99 L101 S108 T109 T110 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 IC50=12000nM, Kd=407nM, EC50=5600nM P02766 23792159 201 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGSSPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNP 4i89 B 1.69 BS01 1FL B 1 A108 S117 T118 T119 A99 S108 T109 T110 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 IC50=12000nM, Kd=407nM, EC50=5600nM P02766 23792159 201 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGSSPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 5g48 A 2.28 BS01 1FL A 1 T173 T175 K176 R177 L178 I248 L368 M369 M370 T173 T175 K176 R177 L178 I248 L364 M365 M366 ? 0003677,0003887,0005515,0005737,0006260,0006271,0008408,0009360,0071897 O25242 28656718 1375 MKISVSKNDLENALRYLQAFLDKKDASSIASHIHLEVIKEKLFLKASDSDIGLKSYIFTQSSDKEGVGTINGKKFLDIISCLKDSNIILETKDDSLAIKQNKSSFKLPMFDADEFPEFPVIDPKVSIEVNAPFLVDAFKKIAPVIEQTSHKRELAGILMQFDQKHQTLSVVGTDTKRLSYTQLEKISIHSTEEDISCILPKRALLEILKLFYENFSFKSDGMLAVIENEMHTFFTKLIDGNYPDYQKILPKEYISSFTLGKEEFKESIKLCSSLSSTIKLTLEKNNALFESLDSEHSETAKTSVEIEKGLDIEKAFHLGVNAKFFLEALNALGTTQFVLRCNEPSSPFLIQESLDHLNAKISTLMMPITL 5g48 B 2.28 BS01 1FL B 1 T175 K176 R177 L178 I248 P347 L368 M369 M370 T175 K176 R177 L178 I248 P347 L368 M369 M370 ? 0003677,0003887,0005515,0005737,0006260,0006271,0008408,0009360,0071897 O25242 28656718 1375 MKISVSKNDLENALRYLQAFLDKKDASSIASHIHLEVIKEKLFLKASDSDIGLKSYIFTQSSDKEGVGTINGKKFLDIISCLKDSNIILETKDDSLAIKQNKSSFKLPMFDADEFPEFPVIDPKVSIEVNAPFLVDAFKKIAPVIEQTSHKRELAGILMQFDQKHQTLSVVGTDTKRLSYTQLEKISIHSTEEDISCILPKRALLEILKLFYENFSFKSDGMLAVIENEMHTFFTKLIDGNYPDYQKILPKEYISSFTLGKEEFKESIKLCSSLSSTIKLTLEKNNALFESLDSEHSETAKTSVEIEKGLDIEKAFHLGVNAKFFLEALNALGTTQFVLRCNEPSSPFLIQESLDEKQSHLNAKISTLMMPITL 6e70 A 1.992 BS01 1FL A 1 K15 A108 A109 L110 S117 T118 T119 K6 A99 A100 L101 S108 T109 T110 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 IC50=12000nM, Kd=407nM, EC50=5600nM P02766 201 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 6e70 B 1.992 BS01 1FL B 1 K15 L17 A108 A109 L110 S117 T118 K6 L8 A99 A100 L101 S108 T109 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 IC50=12000nM, Kd=407nM, EC50=5600nM P02766 201 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 6e73 A 1.797 BS01 1FL A 1 K15 L17 A108 K6 L8 A99 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 IC50=12000nM, Kd=407nM, EC50=5600nM P02766 201 CPLMVKVLDAVRGSPAINVAMHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 6e73 B 1.797 BS01 1FL B 1 K15 L17 K6 L8 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 IC50=12000nM, Kd=407nM, EC50=5600nM P02766 201 CPLMVKVLDAVRGSPAINVAMHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 6e78 A 1.499 BS01 1FL A 1 L17 A108 L110 S117 L8 A99 L101 S108 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 IC50=12000nM, Kd=407nM, EC50=5600nM P02766 201 CPLMVKVLDAVRGSPAINVAVHVFRKAAADTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 6e78 B 1.499 BS01 1FL B 1 K15 L17 A108 L110 K6 L8 A99 L101 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 IC50=12000nM, Kd=407nM, EC50=5600nM P02766 201 CPLMVKVLDAVRGSPAINVAVHVFRKAAADTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 7k12 A 2.17 BS02 1FL A 1 F50 R51 V82 M191 F297 P298 L299 F48 R49 V80 M189 F295 P296 L297 4.-.-.- 0005737,0005829,0016787,0016829,0016831,0019748,0046872 Q83V25 33369426 402 KPRIDMHSHFFPRISEQEAAKFDANHAPWLQVSAKGDTGSIMMGKNNFRPVYQALWDPAFRIEEMDAQGVDVQVTCATPVMFGYTWEANKAAQWAERMNDFALEFAAHNPQRIKVLAQVPLQDLDLACKEASRAVAAGHLGIQIGNHLGDKDLDDATLEAFLTHCANEDIPILVHPWDMMGGQRMKKWMLPWLVAMPAETQLAILSLILSGAFERIPKSLKICFGHGGGSFAFLLGRVDNAWRHRDIVREDCPRPPSEYVDRFFVDSAVFNPGALELLVSVMGEDRVMLGSDYPFPLGEQKIGGLVLSSNLGESAKDKIISGNASKFFNIN 7ycq A 1.99 BS01 1FL A 1 A108 T119 A95 T106 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 P02766 36851846 201 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTSNRRYTIAALLSPYSYSTTAVVTN 7ycq B 1.99 BS01 1FL B 1 K15 L17 A108 L110 K6 L8 A99 L101 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 P02766 36851846 201 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTSNDSGPRRYTIAALLSPYSYSTTAVVTN