3kfr B 1.3 BS02 1F1 B 1 P44 K45 K55 V56 R57 P44 K45 K55 V56 R57 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P12499 20659109 201 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF 4ego A 1.76 BS02 1F1 A 1 S95 L98 F182 S244 S247 A248 F298 S79 L82 F166 S228 S231 A232 F282 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=44.4uM Q2IU02 23135838 502 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4ego A 1.76 BS03 1F1 A 2 E153 P176 G179 D251 R391 E137 P160 G163 D235 R375 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=44.4uM Q2IU02 23135838 503 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4ego A 1.76 BS04 1F1 A 3 P90 R92 P93 P74 R76 P77 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=44.4uM Q2IU02 23135838 504 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4ego B 1.76 BS02 1F1 B 1 S95 L98 F182 S244 S247 A248 F298 S79 L82 F166 S228 S231 A232 F282 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=44.4uM Q2IU02 23135838 502 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4ego B 1.76 BS03 1F1 B 2 L175 G179 D251 R391 L159 G163 D235 R375 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=44.4uM Q2IU02 23135838 503 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4ego C 1.76 BS02 1F1 C 1 S95 L98 F182 S244 S247 A248 F298 S79 L82 F166 S228 S231 A232 F282 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=44.4uM Q2IU02 23135838 502 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4ego C 1.76 BS03 1F1 C 2 D251 R391 D235 R375 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=44.4uM Q2IU02 23135838 503 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4ego D 1.76 BS02 1F1 D 1 S95 L98 F182 S244 S247 A248 F298 S79 L82 F166 S228 S231 A232 F282 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=44.4uM Q2IU02 23135838 503 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4ej8 A 2.347 BS01 1F1 A 1 W42 P44 K45 K55 W42 P44 K45 K55 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 Kd=4.1uM -logKd/Ki=5.39, Kd=4.1uM P12499 23540839 106 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMNLPGRWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF 4ejd A 1.103 BS02 1F1 A 1 P44 K45 K55 V56 R57 P44 K45 K55 V56 R57 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 Kd=14.5uM P12499 23540839 102 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF 5cc7 A 2.12 BS02 1F1 A 1 V118 S275 R339 M515 W541 M631 D633 V114 S271 R325 M496 W522 M612 D614 D271 E273 R339 E434 D462 D633 D267 E269 R325 E415 D443 D614 2.3.3.9 0000287,0001968,0003824,0004474,0005515,0005518,0005576,0005737,0005829,0005886,0006097,0006099,0009274,0009436,0009986,0015936,0016740,0042603,0042803,0043236,0044406,0046810,0046872,0120225 P9WK17 802 TDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQALLNARDELQAQIDKWHRRRPIDMDAYRQFLTEIGYLLPEPDDFTITTSGVDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKVRGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIEILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLAARVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVFEGIMDALFTGLIAIHGLKASDINSRTGSIYIVKPKMHGPAEVAFTCELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWTMTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDNNCQSILGYVVRWVDQGVGASKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVRASLERMAPLVDRQNAYRPMAPNFDDSIAFLAAQELILSGAQQPNGYTEPILHRRRREFKARAAE 5j4h A 1.374 BS01 1F1 A 1 I171 A201 A203 Q217 I64 A94 A96 Q110 ? 0003677,0003684,0005524,0006259,0006281,0006310,0008094,0016887,0140664 O74036 27725183 401 ATIGRISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQLAHTLAVMVQLPPEEGGLNGSAMYIDTENTFRPERLREIAQNRGLDPDEVLDNVAYARAFNSNHQMLLVQQAEDMIKELLNTDRPVKLLIVDSLTSHFRSEYIGRGALAERQQKLAKHLADLHRLANLYDIAVFVTNQVHILAHSATLRVYLRKGKGGKRIARLIDAPHLPEGEAVFSITEKGIED