4ifg A 2.11 BS01 1E8 A 1 L57 G58 V65 A78 K80 M112 L114 Y131 E135 L181 I194 D195 L198 L14 G15 V22 A35 K37 M69 L71 Y88 E92 L138 I151 D152 L155 D174 K176 E178 N179 D195 T214 D131 K133 E135 N136 D152 T171 2.7.11.17 0004672,0004674,0004683,0005509,0005516,0005524,0005634,0005737,0006468,0009931,0016020,0016310,0018105,0035556,0046777,0046872 Q9BJF5 601 TAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLKLCGN 4rz7 A 2.351 BS01 1E8 A 1 A561 T586 F609 T611 L613 V614 A551 T572 F595 T597 L599 V600 D657 K659 N662 D675 T692 D643 K645 N648 D661 T678 2.7.11.12 0004672,0004674,0004691,0004692,0005524,0005737,0005783,0005789,0005952,0006468,0007165,0016020,0016310,0018105,0030553,0046872 A5K0N4 901 GMRCNERNKKKAIFGEDTLMEDHLQLREKLSEDIEMIKASLKNNLVCSTLNDNEILTLSNYMQFFVFKGGDLVIKQGEKGSYFFIINSGKFDVYVNKVKSMGKGSSFGEAALIHNTQRSATIMAETDTLWGVQRSTFRATLKQLSNRNFNENRSFIDSVSVFDMLTEAQKNMITNACVIQMFKPGETIVKQGDYGDVLFILKEGKATVFINDKEIRVLNKGSYFGERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFRQFSAEQLNDLADTAIVRDYPANYHILHKDKVKSVKYLIVLEGKVELFLDDESIGILTRGKSFGDQYVLNQKQKFRHTVKSLDVCKIALITESCLADCLGDNNIDASIDHNNKKSIIKKMYIFRYLSEQQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEVTKNGKRLRTLGKNDYFGERALLYDEPRTASIISKATSVECWFVDKSVFLQIIQGPMLTHLEERIKMQDTKVEMHELETERIIGRGGTVKLVHHKPTQIRYALKCVSKRSIIQNNIKLEREITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETY 5p9i A 1.11 BS01 1E8 A 1 L408 V416 A428 K430 M449 T474 Y476 M477 G480 C481 N484 L528 S538 D539 F540 L20 V28 A40 K42 M61 T86 Y88 M89 G92 C93 N96 L140 S150 D151 F152 D521 A523 R525 N526 D539 F559 D133 A135 R137 N138 D151 F171 2.7.10.2 0004672,0004713,0005524,0006468 IC50=14nM, Kd=1.9nM, Ki=4.8nM Q06187 28062735 701 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES 5yu9 A 1.95 BS01 1E8 A 1 L718 G719 A743 K745 M766 M790 M793 C797 R841 L844 T854 D855 F856 L19 G20 A44 K46 M63 M87 M90 C94 R138 L141 T151 D152 F153 D837 A839 R841 N842 D855 D134 A136 R138 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=6.74, Kd=0.18uM IC50=0.5nM, Kd=6.9nM P00533 27626175 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYL 5yu9 B 1.95 BS01 1E8 B 1 L718 A743 K745 M790 M793 C797 R841 L844 T854 D855 L20 A45 K47 M87 M90 C94 R138 L141 T151 D152 D837 A839 R841 N842 D855 D134 A136 R138 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 IC50=0.5nM, Kd=6.9nM P00533 27626175 1101 PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVV 5yu9 C 1.95 BS01 1E8 C 1 V726 A743 M790 M793 G796 C797 D800 T854 D855 F856 V30 A47 M90 M93 G96 C97 D100 T154 D155 F156 D837 A839 R841 N842 D855 D137 A139 R141 N142 D155 2.7.10.1 0004672,0004713,0005524,0006468 IC50=0.5nM, Kd=6.9nM P00533 27626175 1101 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMVDADEYLIPQQ 5yu9 D 1.95 BS01 1E8 D 1 V726 A743 K745 M790 M793 G796 C797 D800 T854 D855 V27 A44 K46 M91 M94 G97 C98 D101 T155 D156 D837 A839 R841 N842 D855 D138 A140 R142 N143 D156 2.7.10.1 0004672,0004713,0005524,0006468 IC50=0.5nM, Kd=6.9nM P00533 27626175 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVD 6l8l A 2.888 BS01 1E8 A 1 V281 K295 I336 T338 M341 G344 S345 D348 L393 A403 D404 F405 V21 K35 I75 T77 M80 G83 S84 D87 L132 A142 D143 F144 D386 R388 A390 N391 D404 D125 R127 A129 N130 D143 2.7.10.2 0004672,0004713,0005524,0006468 P00523 33359446 600 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 6l8l B 2.888 BS01 1E8 B 1 V281 K295 V323 T338 G344 S345 D348 L393 A403 D404 F405 V19 K33 V61 T76 G82 S83 D86 L131 A141 D142 F143 D386 R388 A390 N391 D404 D124 R126 A128 N129 D142 2.7.10.2 0004672,0004713,0005524,0006468 P00523 33359446 600 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 6l8l C 2.888 BS01 1E8 C 1 L273 G274 A293 I336 T338 S345 L393 D404 F405 L13 G14 A33 I76 T78 S85 L133 D144 F145 D386 R388 A390 N391 D404 D126 R128 A130 N131 D144 2.7.10.2 0004672,0004713,0005524,0006468 P00523 33359446 600 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 6l8l D 2.888 BS01 1E8 D 1 V281 A293 K295 I336 T338 M341 G344 S345 D348 L393 A403 D404 V20 A32 K34 I74 T76 M79 G82 S83 D86 L131 A141 D142 D386 R388 A390 N391 D404 D124 R126 A128 N129 D142 2.7.10.2 0004672,0004713,0005524,0006468 P00523 33359446 600 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 6yg2 A 2.0 BS01 1E8 A 1 Y121 L122 I133 L136 W151 M153 G200 T201 F202 F209 A211 Y4 L5 I16 L19 W34 M36 G83 T84 F85 F92 A94 D259 K261 N264 D277 C296 D142 K144 N147 D160 C166 2.7.12.2 0004672,0005524,0006468 O14733 32783966 513 QTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESP 6yz4 A 1.7 BS01 1E8 A 1 Y121 L122 I133 W151 M153 G200 T201 F202 F209 Y5 L6 I17 W31 M33 G80 T81 F82 F89 D259 K261 N264 D277 C296 D139 K141 N144 D157 C166 2.7.12.2 0004672,0005524,0006468 O14733 32783966 514 KQTGYLTIGGQRYQAEINDLENLGEMGGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESP