4i9u A 2.5 BS01 1E7 A 1 V25 G26 D51 V52 A95 R111 I115 F118 I119 V25 G26 D51 V52 A95 R103 I107 F110 I111 D165 R168 H192 D157 R160 H184 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=137uM -logKd/Ki=3.86, Kd=137uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9u B 2.5 BS01 1E7 B 1 V25 G26 D51 V52 A95 R111 I115 F118 I119 V25 G26 D51 V52 A95 R111 I115 F118 I119 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=137uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9u C 2.5 BS01 1E7 C 1 G26 D51 V52 A95 G96 R111 I115 F118 I119 G26 D51 V52 A95 G96 R111 I115 F118 I119 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=137uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9u D 2.5 BS01 1E7 D 1 V25 G26 D51 V52 A95 R111 N114 I115 F118 I119 V25 G26 D51 V52 A95 R111 N114 I115 F118 I119 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=137uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9u E 2.5 BS01 1E7 E 1 G26 D51 V52 A95 R98 R111 I115 F118 I119 G26 D51 V52 A95 R98 R111 I115 F118 I119 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=137uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9u F 2.5 BS01 1E7 F 1 V25 G26 D51 V52 A95 R111 I115 F118 V23 G24 D49 V50 A93 R109 I113 F116 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=137uM P13491 23302067 401 AALKDQLIHNLLKEVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9u G 2.5 BS01 1E7 G 1 V25 G26 D51 V52 A95 G96 R111 I115 F118 I119 V25 G26 D51 V52 A95 G96 R106 I110 F113 I114 R105 D165 R168 H192 R100 D160 R163 H187 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=137uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGAESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9u H 2.5 BS01 1E7 H 1 G26 D51 V52 A95 R111 I115 F118 G26 D51 V52 A95 R106 I110 F113 R105 D165 R168 H192 R100 D160 R163 H187 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=137uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGAESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF