4i9h A 2.17 BS01 1E4 A 1 G26 G28 V30 D51 V52 T94 A95 G96 R111 N114 I115 F118 V135 S136 N137 R168 A237 T247 G26 G28 V30 D51 V52 T94 A95 G96 R105 N108 I109 F112 V129 S130 N131 R162 A231 T241 D165 R168 H192 D159 R162 H186 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=0.068uM -logKd/Ki=7.17, Kd=0.068uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9h B 2.17 BS01 1E4 B 1 G26 V30 D51 V52 T94 A95 G96 R111 I115 F118 I119 V135 S136 N137 R168 A237 T247 G26 V30 D51 V52 T94 A95 G96 R107 I111 F114 I115 V131 S132 N133 R164 A233 T243 L105 D165 R168 H192 L102 D161 R164 H188 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=0.068uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQSRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9h C 2.17 BS01 1E4 C 1 G26 G28 V30 D51 V52 T94 A95 G96 R111 I115 F118 V135 S136 N137 R168 A237 T247 G26 G28 V30 D51 V52 T94 A95 G96 R108 I112 F115 V132 S133 N134 R165 A234 T244 R105 D165 R168 H192 R102 D162 R165 H189 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=0.068uM -logKd/Ki=7.17, Kd=0.068uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9h D 2.17 BS01 1E4 D 1 G26 G28 V30 D51 V52 T94 A95 G96 R111 N114 I115 F118 V135 S136 N137 R168 A237 T247 G26 G28 V30 D51 V52 T94 A95 G96 R111 N114 I115 F118 V135 S136 N137 R168 A237 T247 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=0.068uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9h E 2.17 BS01 1E4 E 1 G26 V30 D51 V52 T94 A95 G96 R111 N114 I115 F118 I119 V135 S136 N137 R168 A237 T247 G26 V30 D51 V52 T94 A95 G96 R111 N114 I115 F118 I119 V135 S136 N137 R168 A237 T247 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=0.068uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9h F 2.17 BS01 1E4 F 1 G26 G28 V30 D51 V52 T94 A95 G96 R111 N114 I115 F118 V135 S136 N137 R168 A237 T247 G24 G26 V28 D49 V50 T92 A93 G94 R109 N112 I113 F116 V133 S134 N135 R166 A235 T245 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=0.068uM P13491 23302067 401 AALKDQLIHNLLKEVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9h G 2.17 BS01 1E4 G 1 G26 G28 V30 D51 V52 T94 A95 G96 R111 N114 I115 F118 V135 S136 N137 R168 A237 T247 G26 G28 V30 D51 V52 T94 A95 G96 R104 N107 I108 F111 V128 S129 N130 R161 A230 T240 R105 D165 R168 H192 R98 D158 R161 H185 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=0.068uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9h H 2.17 BS01 1E4 H 1 G26 G28 V30 D51 V52 T94 A95 G96 R111 N114 I115 F118 V135 S136 N137 R168 A237 T247 G26 G28 V30 D51 V52 T94 A95 G96 R109 N112 I113 F116 V133 S134 N135 R166 A235 T245 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=0.068uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF