1add A 2.4 BS02 1DA A 1 H17 D19 F61 F65 M155 G184 E217 D296 H14 D16 F58 F62 M152 G181 E214 D293 H15 H17 H214 E217 H238 D295 H12 H14 H211 E214 H235 D292 3.5.4.4 0000255,0001666,0001701,0001829,0001889,0001890,0002314,0002467,0002636,0002686,0002901,0002906,0004000,0005737,0005764,0005829,0005886,0006154,0006157,0006196,0006915,0006939,0007155,0008270,0009117,0009168,0009897,0009986,0010460,0014074,0016020,0016787,0019239,0019722,0030217,0030324,0030890,0031410,0032261,0032263,0032264,0033077,0033089,0033632,0042100,0042110,0043066,0043084,0043605,0044209,0045580,0045582,0045987,0046059,0046061,0046085,0046101,0046103,0046111,0046632,0046638,0046872,0046936,0048286,0048541,0048566,0050728,0050850,0050852,0050862,0050870,0050900,0060169,0060205,0060407,0070161,0070242,0070244,0070254,0070256,0140928 Ki=0.18uM -logKd/Ki=6.74, Ki=0.18uM P03958 8439534 353 TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 5lmz A 2.55 BS01 1DA A 1 F213 N215 F254 R277 A279 F196 N198 F237 R260 A262 2.5.1.63,2.5.1.94,3.13.2.3 0016740,0016787,0033846 W0W999 24449539 301 RPIIAFMSDLGTTDDSVAQCKGLMHSICPGVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIRQAAQWAGSGDGFERADGSYIYIAPNNGLLTTVLEEHGYIEAYEVTSTKVIPANPEPTFYSREMVAIPSAHLAAGFPLAEVGRRLDDSEIVRFHRPAVEALSGVVTAIDHPFGNIWTNIHRTDLEKAGIGQGKHLKIILDDVLPFEAPLTPTFADAGAIGNIAFYLNSRGYLSLARNAASLAYPYNLKAGLKVRVEA 5lmz B 2.55 BS01 1DA B 1 F213 N215 F254 R277 A279 F197 N199 F238 R261 A263 2.5.1.63,2.5.1.94,3.13.2.3 0016740,0016787,0033846 W0W999 24449539 301 RPIIAFMSDLGTTDDSVAQCKGLMHSICPGVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIRQAAQWAGSGDGFERADGSYIYIAPNNGLLTTVLEEHGYIEAYEVTSTKVIPANPEPTFYSREMVAIPSAHLAAGFPLAEVGRRLDDSEIVRFHRPAVEIALSGVVTAIDHPFGNIWTNIHRTDLEKAGIGQGKHLKIILDDVLPFEAPLTPTFADAGAIGNIAFYLNSRGYLSLARNAASLAYPYNLKAGLKVRVEA 7xto A 2.48 BS01 1DA A 1 D14 F48 Y73 Y75 T78 W132 G134 D10 F44 Y69 Y71 T74 W128 G130 ? A0A2T0T269 36081280 301 APRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRVARIDRAFGNVWTNIPSAALVTLDATVARWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPDAPVEVH 7xto A 2.48 BS02 1DA D 1 F187 N189 F228 F175 N177 F203 ? A0A2T0T269 36081280 301 APRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRVARIDRAFGNVWTNIPSAALVTLDATVARWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPDAPVEVH 7xto B 2.48 BS01 1DA B 1 D14 F48 Y73 Y75 T78 W132 G134 D10 F44 Y69 Y71 T74 W128 G130 ? A0A2T0T269 36081280 301 APRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRHLVGRVARIDRAFGNVWTNIPSAALGVTLDATVARWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPDAPVEVHL 7xto B 2.48 BS02 1DA F 1 F187 N189 F228 F180 N182 F209 ? A0A2T0T269 36081280 301 APRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRHLVGRVARIDRAFGNVWTNIPSAALGVTLDATVARWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPDAPVEVHL 7xto C 2.48 BS01 1DA A 1 F187 N189 F228 R252 F178 N180 F206 R230 ? A0A2T0T269 36081280 301 PRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRLVGRVARIDRAFGNVWTNIPSAALVTLDATVARWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPDAPVEVH 7xto C 2.48 BS02 1DA C 1 D14 F48 Y73 Y75 T78 W132 G134 D9 F43 Y68 Y70 T73 W127 G129 ? A0A2T0T269 36081280 301 PRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRLVGRVARIDRAFGNVWTNIPSAALVTLDATVARWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPDAPVEVH 7xto D 2.48 BS01 1DA C 1 F187 N189 F228 F180 N182 F206 ? A0A2T0T269 36081280 301 APRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRHLVGRVARIDRAFGNVWTNIPSAAVTLDATVRWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPDAVEVHL 7xto D 2.48 BS02 1DA D 1 D14 F48 Y73 Y75 T78 W132 G134 D10 F44 Y69 Y71 T74 W128 G130 ? A0A2T0T269 36081280 301 APRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRHLVGRVARIDRAFGNVWTNIPSAAVTLDATVRWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPDAVEVHL 7xto E 2.48 BS01 1DA B 1 F187 N189 F228 F178 N180 F206 ? A0A2T0T269 36081280 301 PRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRLVGRVARIDRAFGNVWTNIPSAALVTLDATVARWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPAPVEVH 7xto E 2.48 BS02 1DA E 1 D14 F48 Y73 Y75 T78 W132 G134 D9 F43 Y68 Y70 T73 W127 G129 ? A0A2T0T269 36081280 301 PRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTRLVGRVARIDRAFGNVWTNIPSAALVTLDATVARWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVAPAPVEVH 7xto F 2.48 BS01 1DA E 1 F187 N189 F228 R252 F178 N180 F204 R228 ? A0A2T0T269 36081280 301 APRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTLVGRVARIDRAFGNVWTNIPSAAVTLDATVRWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVPDAEVHL 7xto F 2.48 BS02 1DA F 1 D14 F48 Y73 Y75 T78 W132 G134 D10 F44 Y69 Y71 T74 W128 G130 ? A0A2T0T269 36081280 301 APRVVAFLSDVGTHDEATGLCKGLMSRICPGVTIIDITHQVPAFDVVEGALMLEDVPEFFPEHTVICAYVYPETGSGTPTVAVRNDKGQLLVAPDNGLLTRALDASGVAEARLVTNPAVMNHPPTPTWYGRDVVAACAAHLAAGTPLADVGPVVDDPVRLPDVPFTLVGRVARIDRAFGNVWTNIPSAAVTLDATVRWPWCTTFSQVATTGRLAYANSRGRLSFALNRGSLVAELGVPDAEVHL