3f3v A 2.6 BS01 1BU A 1 L273 E310 M314 M341 L393 A403 D404 L17 E54 M58 M85 L137 A147 D148 D386 R388 A390 N391 D404 F424 D130 R132 A134 N135 D148 F152 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=7.14, Kd=73nM IC50=21nM, Kd=73nM P00523 19462975 1 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGCLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 3f3v B 2.6 BS01 1BU B 1 A293 E310 M314 M341 L393 A403 D404 F405 A38 E55 M59 M86 L138 A148 D149 F150 D386 R388 A390 N391 D404 F424 D131 R133 A135 N136 D149 F153 2.7.10.2 0004672,0004713,0005524,0006468 IC50=21nM, Kd=73nM P00523 19462975 1 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGCLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 3f3w A 2.6 BS01 1BU A 1 A293 E310 M314 M341 L393 A403 D404 F405 A37 E54 M58 M85 L137 A147 D148 F149 D386 R388 A390 N391 D404 F424 D130 R132 A134 N135 D148 F152 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=7.47, IC50=34nM IC50=21nM, Kd=73nM P00523 19462975 1 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVMEYMSKGCLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 3f3w B 2.6 BS01 1BU B 1 L273 A293 E310 M314 V323 Y340 M341 A403 D404 F405 L16 A36 E53 M57 V66 Y83 M84 A146 D147 F148 D386 R388 A390 N391 D404 F424 D129 R131 A133 N134 D147 F151 2.7.10.2 0004672,0004713,0005524,0006468 IC50=21nM, Kd=73nM P00523 19462975 1 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVMEYMSKGCLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 3gcq A 2.0 BS01 1BU A 1 V30 A51 R70 E71 M78 I84 T106 L108 M109 H148 L167 D168 V27 A45 R64 E65 M72 I78 T100 L102 M103 H142 L161 D162 D150 K152 N155 D168 T185 D144 K146 N149 D162 T167 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 Kd=342nM -logKd/Ki=6.47, Kd=342nM IC50=800nM Q16539 19572644 401 ERPTFYRQELNKTIWEVPERYQNLSPVGSGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKSQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSLESRDLLIDEWKSLTYDEVISFVPPPLDQ