2g9q A 2.5 BS03 1AB A 1 H377 N484 E672 A673 S674 G675 H345 N452 E640 A641 S642 G643 H377 K568 R569 K574 T676 K680 H345 K536 R537 K542 T644 K648 2.4.1.1 0000166,0004645,0005737,0005975,0005977,0005980,0008184,0016757,0030170,0098723,0102250,0102499 ic50=0.84uM -logKd/Ki=6.40, Ki=0.4uM Ki=400nM P00489 16970395 998 QISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFGYIQAVLDRNLAENISRVLYPFEGKELRLKQEYFVVAATLQDIIRRFKSSTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPA 6lgd A 1.75 BS03 1AB A 1 D102 Y105 H145 F211 D247 H388 D389 R455 D66 Y69 H109 F175 D211 H352 D353 R419 D140 D247 E322 H388 D389 D104 D211 E286 H352 D353 3.2.1.20 0005975,0016787,0046872 A0A077JI83 32381508 705 PPPTEVIQLDWWKNCVLYQIYPRSFKDSDGDGIGDLKGIISELKHFVDAGVDAIWMSPIFESPMVDFGYDISNFYDIHYEYGTMEDFEELLDKAHELGLKVLLDFVPNHASNESEYFIKSEAREPGYENFFIWADPLPNPENPGVRLPPSNWVSQFGGSAWEWSEKRQQYYLHQFAIQQVDFDFRNPAVKQEMFNIMKFWLDKGADGFRLDALPYLIEADPADHEGRYPDDPLSGLTQFESHQLGYTIPLYTKDLIELYDVVYEWREFLDEYNKNHGGDTRVVFSEGYANVSMTMLYYGNEDGAIGAHFPFNFDFITDLSSKSNARDFVYIILRWLTYMPYGGIPNWVFGNHDNNRMPTRFRHDMVDGLNIINMLLPGVAVTYQGEEIGMRDGYVSWEDTVDIEACNRGDPDTYHLYSRDPARTPYHWDNSTSAGFSTSTNTWLPVAEDYQEINLAKQKETARSHFKNYQALTKLRKQATLSHGEYDIRALSDRTFYLVRSLPTHDTYVLLFNVSERRDTVDLGRVPHLTLPATVYVSSIHSARLAGHEITSSQLSLEAGEALVLKAQPI 6lgd B 1.75 BS03 1AB B 1 D102 Y105 H145 F211 D247 H388 D389 R455 D66 Y69 H109 F175 D211 H352 D353 R419 D140 D247 E322 H388 D389 D104 D211 E286 H352 D353 3.2.1.20 0005975,0016787,0046872 A0A077JI83 32381508 703 PPPTEVIQLDWWKNCVLYQIYPRSFKDSDGDGIGDLKGIISELKHFVDAGVDAIWMSPIFESPMVDFGYDISNFYDIHYEYGTMEDFEELLDKAHELGLKVLLDFVPNHASNESEYFIKSEAREPGYENFFIWADPLPNPENPGVRLPPSNWVSQFGGSAWEWSEKRQQYYLHQFAIQQVDFDFRNPAVKQEMFNIMKFWLDKGADGFRLDALPYLIEADPADHEGRYPDDPLSGLTQFESHQLGYTIPLYTKDLIELYDVVYEWREFLDEYNKNHGGDTRVVFSEGYANVSMTMLYYGNEDGAIGAHFPFNFDFITDLSSKSNARDFVYIILRWLTYMPYGGIPNWVFGNHDNNRMPTRFRHDMVDGLNIINMLLPGVAVTYQGEEIGMRDGYVSWEDTVDIEACNRGDPDTYHLYSRDPARTPYHWDNSTSAGFSTSTNTWLPVAEDYQEINLAKQKETARSHFKNYQALTKLRKQATLSHGEYDIRALSDRTFYLVRSLPTHDTYVLLFNVSERRDTVDLGRVPHLTLPATVYVSSIHSARLAGHEITSSQLSLEAGEALVLKAQPI