4hw3 A 2.4 BS01 19G A 1 F228 M250 V253 R263 T266 L267 F270 F58 M80 V83 R93 T96 L97 F100 ? 0042981 Ki=0.32uM -logKd/Ki=6.49, Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH 4hw3 B 2.4 BS01 19G B 1 F228 M231 M250 V253 F254 R263 T266 L267 F270 I294 F58 M61 M80 V83 F84 R93 T96 L97 F100 I124 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 4hw3 C 2.4 BS01 19G C 1 F228 M231 F254 R263 T266 L267 F270 I294 F58 M61 F84 R93 T96 L97 F100 I124 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH 4hw3 D 2.4 BS01 19G D 1 M231 L246 M250 R263 L267 F270 I294 M61 L76 M80 R93 L97 F100 I124 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED 4hw3 E 2.4 BS01 19G E 1 M231 L246 M250 F254 R263 T266 L267 F270 M61 L76 M80 F84 R93 T96 L97 F100 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 4hw3 F 2.4 BS01 19G F 1 F228 L246 M250 V253 F254 R263 T266 L267 F270 I294 F58 L76 M80 V83 F84 R93 T96 L97 F100 I124 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 4hw3 G 2.4 BS01 19G G 1 F228 M250 R263 T266 L267 F270 I294 F58 M80 R93 T96 L97 F100 I124 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 4hw3 H 2.4 BS01 19G H 1 F228 M231 M250 V253 R263 T266 L267 F270 G271 F58 M61 M80 V83 R93 T96 L97 F100 G101 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH 4hw3 I 2.4 BS01 19G I 1 M250 V253 F254 R263 T266 L267 F270 M77 V80 F81 R90 T93 L94 F97 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH 4hw3 J 2.4 BS01 19G J 1 F228 M231 L235 L246 V249 M250 V253 R263 T266 L267 F270 F57 M60 L64 L75 V78 M79 V82 R92 T95 L96 F99 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 4hw3 K 2.4 BS01 19G K 1 F228 L246 M250 F254 R263 T266 L267 F270 I294 F58 L76 M80 F84 R93 T96 L97 F100 I124 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 4hw3 L 2.4 BS01 19G L 1 L246 M250 V253 R263 T266 L267 F270 L72 M76 V79 R89 T92 L93 F96 ? 0042981 Ki=0.32uM IC50=400nM, Ki=320nM Q07820 23244564 400 GDELYRQSLEIISRYLREQATGKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED