3hfg A 2.3 BS01 17R A 1 I121 L126 L171 A172 Y177 Y183 G216 A226 V227 I96 L101 L146 A147 Y152 Y158 G191 A201 V202 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=10nM IC50=26nM P28845 19673466 1 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTS 3hfg B 2.3 BS01 17R B 1 I121 S125 L126 A172 Y177 Y183 G216 T222 M233 I100 S104 L105 A151 Y156 Y162 G195 T201 M211 S170 Y183 K187 S149 Y162 K166 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=10nM IC50=26nM P28845 19673466 1 PLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYST 3hfg C 2.3 BS01 17R C 1 L126 L171 A172 Y177 Y183 G216 L217 T222 A226 L103 L148 A149 Y154 Y160 G193 L194 T199 A203 S170 Y183 K187 S147 Y160 K164 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=10nM IC50=26nM P28845 19673466 1 NEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3hfg D 2.3 BS01 17R D 1 L171 A172 Y177 P178 Y183 G216 L217 L147 A148 Y153 P154 Y159 G192 L193 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=10nM IC50=26nM P28845 19673466 1 EEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS