4hnf A 2.07 BS01 16W A 1 G16 S17 A36 K38 E52 M80 M82 L85 G14 S15 A34 K36 E47 M75 M77 L80 D128 K130 D123 K125 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=711nM -logKd/Ki=6.15, IC50=711nM IC50=711nM P48730 23106386 301 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK 4hnf B 2.07 BS01 16W B 1 I15 G16 I23 A36 K38 E52 M80 M82 L85 L135 I148 I11 G12 I19 A32 K34 E48 M76 M78 L81 L131 I144 D128 K130 D124 K126 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=711nM IC50=711nM P48730 23106386 301 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK 4hni A 2.74 BS01 16W A 1 I15 A36 K38 M80 M82 L84 L85 L135 F150 I13 A34 K36 M71 M73 L75 L76 L126 F141 D128 K130 D119 K121 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.49, IC50=32nM IC50=32nM P49674 23106386 301 LRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML 4hni B 2.74 BS01 16W B 1 A36 K38 M80 M82 L84 L85 L135 A36 K38 M71 M73 L75 L76 L126 D128 K130 D119 K121 2.7.11.1 0004672,0005524,0006468 IC50=32nM P49674 23106386 301 MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML