1i1d A 1.8 BS01 16G A 1 T28 E98 D99 I100 D134 R158 T28 E95 D96 I97 D131 R155 2.3.1.4 0004343,0005634,0005737,0006048,0016746,0016747 P43577 11278591 905 MSLPDGFYIRRMEEGDLEQVTETLKVLTTVGTITPESFCKLIKYWNEATVWNDKKIMQYNPMVIVDKRTETVAATGNIIIERKIIHELGLCGHIEDIAVNSKYQGQGLGKLLIDQLVTIGFDYGCYKIILDCDEKNVKFYEKCGFSNAGVEMQIRK 1i1d A 1.8 BS03 16G D 1 K86 I88 H89 Y129 K130 K83 I85 H86 Y126 K127 2.3.1.4 0004343,0005634,0005737,0006048,0016746,0016747 P43577 11278591 908 MSLPDGFYIRRMEEGDLEQVTETLKVLTTVGTITPESFCKLIKYWNEATVWNDKKIMQYNPMVIVDKRTETVAATGNIIIERKIIHELGLCGHIEDIAVNSKYQGQGLGKLLIDQLVTIGFDYGCYKIILDCDEKNVKFYEKCGFSNAGVEMQIRK 1i1d B 1.8 BS01 16G B 1 L27 T28 E98 D99 I100 D134 Y143 R158 L25 T26 E93 D94 I95 D129 Y138 R153 2.3.1.4 0004343,0005634,0005737,0006048,0016746,0016747 P43577 11278591 906 LPDGFYIRRMEEGDLEQVTETLKVLTTVGTITPESFCKLIKYWNEATVWNDKKIMQYNPMVIVDKRTETVAATGNIIIERKIIHELGLCGHIEDIAVNSKYQGQGLGKLLIDQLVTIGFDYGCYKIILDCDEKNVKFYEKCGFSNAGVEMQIRK 1i1d C 1.8 BS01 16G B 1 I88 H89 Y129 K130 I84 H85 Y125 K126 2.3.1.4 0004343,0005634,0005737,0006048,0016746,0016747 P43577 11278591 906 SMSLPDGFYIRRMEEGDLEQVTETLKVLTTVGTITPESFCKLIKYWNEATVWNKIMQYNPMVIVDKRTETVAATGNIIIERKIIHELGLCGHIEDIAVNSKYQGQGLGKLLIDQLVTIGFDYGCYKIILDCDEKNVKFYEKCGFSNAGVEMQIRK 1i1d D 1.8 BS01 16G A 1 I88 H89 Y129 K130 I90 H91 Y131 K132 2.3.1.4 0004343,0005634,0005737,0006048,0016746,0016747 P43577 11278591 905 GSMSLPDGFYIRRMEEGDLEQVTETLKVLTTVGTITPESFCKLIKYWNEATVWNDNEDKKIMQYNPMVIVDKRTETVAATGNIIIERKIIHELGLCGHIEDIAVNSKYQGQGLGKLLIDQLVTIGFDYGCYKIILDCDEKNVKFYEKCGFSNAGVEMQIRK 1i1d D 1.8 BS02 16G D 1 T28 E98 D99 I100 D134 R158 T30 E100 D101 I102 D136 R160 2.3.1.4 0004343,0005634,0005737,0006048,0016746,0016747 P43577 11278591 908 GSMSLPDGFYIRRMEEGDLEQVTETLKVLTTVGTITPESFCKLIKYWNEATVWNDNEDKKIMQYNPMVIVDKRTETVAATGNIIIERKIIHELGLCGHIEDIAVNSKYQGQGLGKLLIDQLVTIGFDYGCYKIILDCDEKNVKFYEKCGFSNAGVEMQIRK 1ne7 A 1.75 BS02 16G A 1 S151 S152 R158 V159 K160 T161 S151 S152 R158 V159 K160 T161 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 4299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQ 1ne7 A 1.75 BS04 16G B 1 M1 K2 H262 M1 K2 H262 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 2299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQ 1ne7 B 1.75 BS02 16G B 1 S151 S152 R158 V159 K160 T161 S151 S152 R158 V159 K160 T161 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 2299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 1ne7 B 1.75 BS04 16G C 1 M1 H262 M1 H262 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 3299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 1ne7 C 1.75 BS02 16G A 1 M1 K2 H262 M1 K2 H262 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 4299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 1ne7 C 1.75 BS03 16G C 1 S151 S152 R158 V159 K160 T161 S151 S152 R158 V159 K160 T161 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 3299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 1ne7 D 1.75 BS01 16G D 1 S151 S152 R158 V159 K160 T161 S151 S152 R158 V159 K160 T161 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 7299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 1ne7 D 1.75 BS03 16G E 1 M1 H262 M1 H262 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 5299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 1ne7 E 1.75 BS02 16G E 1 S151 S152 R158 V159 K160 T161 S151 S152 R158 V159 K160 T161 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 5299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 1ne7 E 1.75 BS04 16G F 1 M1 K2 H262 M1 K2 H262 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 6299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 1ne7 F 1.75 BS02 16G D 1 M1 K2 H262 M1 K2 H262 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 7299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 1ne7 F 1.75 BS03 16G F 1 S151 S152 R158 V159 K160 T161 S151 S152 R158 V159 K160 T161 D72 D141 H143 E148 D72 D141 H143 E148 3.5.99.6 0004342,0005515,0005737,0005829,0005975,0006043,0006044,0006046,0006048,0006091,0007338,0016787,0016853,0019262,0042802,0070062 P46926 12965206 6299 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKE 2dkc A 2.2 BS01 16G A 1 T368 V370 E387 H391 R512 S514 G515 T516 R521 T360 V362 E379 H383 R504 S506 G507 T508 R513 S66 H67 K76 S66 H67 K76 5.4.2.3 0000287,0004610,0005975,0006031,0006048,0016853,0016868,0046872,0071555 Q9P4V2 16651269 701 MSIEQTLSQYLPSHPKPQGVTFTYGTAGFRMKADKLDYVTFTVGIIASLRSKYLQGKTVGVMITASHNPPEDNGVKVVDPLGSMLESSWEKYATDLANASPSPNSLVEVIKNLVSDLKIDLSIPANVVIARDSRESSPALSMATIDGFQSVPNTKYQDFGLFTTPELHYVTRTLNDPDFGKPTEDGYYSKLAKSFQEIYTICESNNEKIDITIDAANGVGAPKIQELLEKYLHKEISFTVVNGDYKQPNLLNFDCGADYVKTNQKLPKNVKPVNNKLYASFDGDADRLICYYQNNDNKFKLLDGDKLSTLFALFLQQLFKQIDPTKISLNIGVVQTAYANGSSTKYVEDVLKIPVRCTPTGVKHLHHEAENFDIGVYFEANGHGTVIFNPEAEKKIFDYKPNNDNEAKAIKVLQNFSQLINQTVGDAISDLLAVLIVVHYLKLSPSDWDNEYTDLPNKLVKVIVPDRSIFKTTNAERTLVEPKGMQDEIDKLVAQYPNGRSFVRASGTEDAVRVYAEADTQNNVEELSKAVSELVK 2dkc B 2.2 BS01 16G B 1 T26 T368 G369 V370 E387 H391 R512 S514 T516 R521 T26 T359 G360 V361 E378 H382 R503 S505 T507 R512 S66 H67 K76 S66 H67 K76 5.4.2.3 0000287,0004610,0005975,0006031,0006048,0016853,0016868,0046872,0071555 Q9P4V2 16651269 702 MSIEQTLSQYLPSHPKPQGVTFTYGTAGFRMKADKLDYVTFTVGIIASLRSKYLQGKTVGVMITASHNPPEDNGVKVVDPLGSMLESSWEKYATDLANASPSPKNSLVEVIKNLVSDLKIDLSIPANVVIARDSRESSPALSMATIDGFQSVPNTKYQDFGLFTTPELHYVTRTLNDPDFGKPTEDGYYSKLAKSFQEIYTICENEKIDITIDAANGVGAPKIQELLEKYLHKEISFTVVNGDYKQPNLLNFDCGADYVKTNQKLPKNVKPVNNKLYASFDGDADRLICYYQNNDNKFKLLDGDKLSTLFALFLQQLFKQIDPTKISLNIGVVQTAYANGSSTKYVEDVLKIPVRCTPTGVKHLHHEAENFDIGVYFEANGHGTVIFNPEAEKKIFDYKPNNDNEAKAIKVLQNFSQLINQTVGDAISDLLAVLIVVHYLKLSPSDWDNEYTDLPNKLVKVIVPDRSIFKTTNAERTLVEPKGMQDEIDKLVAQYPNGRSFVRASGTEDAVRVYAEADTQNNVEELSKAVSELVK 2o28 A 1.8 BS01 16G A 1 T61 E120 D121 V122 R181 T59 E118 D119 V120 R179 2.3.1.4 0000139,0004343,0005515,0005768,0005794,0005829,0006048,0010008,0016020,0016746,0016747,0042802 Q96EK6 501 PDETPMFDPSLLKEVDWSQNTATFSPAISPTHPGEGLVLRPLCTADLNRGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQNVGFYKKFGYTVSEENYMCRRFLK 2o28 B 1.8 BS01 16G A 1 H111 Y151 K152 E175 H109 Y149 K150 E173 2.3.1.4 0000139,0004343,0005515,0005768,0005794,0005829,0006048,0010008,0016020,0016746,0016747,0042802 Q96EK6 501 PDETPMFDPSLLKEVDWSQNTATFSPAISPTHPGEGLVLRPLCTADLNRGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQNVGFYKKFGYTVSEENYMCRRF 2vxk A 1.8 BS01 16G A 1 T70 E129 D130 I131 D165 Y174 T45 E104 D105 I106 D140 Y149 2.3.1.4 0004343,0006048,0016746,0016747 Q4WCU5 18601654 1191 ENTPLFSPSLISPDVLAVLPADYTIRPLCRSDYKRGYLDVLRVLTTVGDINEEQWNSRYEWIRARSDEYYLLVVCDGEGRIVGTGSLVVERKFIHSLGMVGHIEDIAVEKGQQGKKLGLRIIQALDYVAEKVGCYKTILDCSEANEGFYIKCGFKRAGLEMAHYY 3igs A 1.5 BS01 16G A 1 K74 R83 M154 Y157 S208 R212 K75 R84 M155 Y158 S209 R213 5.1.3.9 0005829,0005975,0006051,0006053,0009385,0016853,0016857,0019262,0047465 Q8ZLQ7 230 AMSLLEQLDKNIAASGGLIVSCQPVPGSPLDKPEIVAAMALAAEQAGAVAVRIEGIDNLRMTRSLVSVPIIGIIKRDLDESPVRITPFLDDVDALAQAGAAIIAVDGTARQRPVAVEALLARIHHHHLLTMADCSSVDDGLACQRLGADIIGTTMSGYTTPDTPEEPDLPLVKALHDAGCRVIAEGRYNSPALAAEAIRYGAWAVTVGSAITRLEHICGWYNDALKKAAS 4ag9 A 1.76 BS02 16G A 1 T44 E104 D105 V106 E140 T43 E103 D104 V105 E139 2.3.1.4 0004343,0006048,0016746,0016747 Q17427 22868768 1168 SHIFDASVLAPHIPSNLPDNFKVRPLAKDDFSKGYVDLLSQLTSVGNLDQEAFEKRFEAMRTSVPNYHIVVIEDSNSQKVVASASLVVEMKFIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGFQDDCNFMTQRF 4ag9 A 1.76 BS03 16G B 1 H95 K136 H94 K135 2.3.1.4 0004343,0006048,0016746,0016747 Q17427 22868768 1167 SHIFDASVLAPHIPSNLPDNFKVRPLAKDDFSKGYVDLLSQLTSVGNLDQEAFEKRFEAMRTSVPNYHIVVIEDSNSQKVVASASLVVEMKFIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGFQDDCNFMTQRF 4ag9 B 1.76 BS01 16G A 1 H95 K136 H94 K135 2.3.1.4 0004343,0006048,0016746,0016747 Q17427 22868768 1168 SHIFDASVLAPHIPSNLPDNFKVRPLAKDDFSKGYVDLLSQLTSVGNLDQEAFEKRFEAMRTSVPNYHIVVIEDSNSQKVVASASLVVEMKFIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGFQDDCNFMTQRF 4ag9 B 1.76 BS03 16G B 1 T44 E104 D105 V106 E140 R164 T43 E103 D104 V105 E139 R163 2.3.1.4 0004343,0006048,0016746,0016747 Q17427 22868768 1167 SHIFDASVLAPHIPSNLPDNFKVRPLAKDDFSKGYVDLLSQLTSVGNLDQEAFEKRFEAMRTSVPNYHIVVIEDSNSQKVVASASLVVEMKFIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGFQDDCNFMTQRF 4u0w A 2.001 BS01 16G A 1 S88 F89 T90 R133 R135 E145 S165 I166 Y167 Q183 I209 R211 E222 Y228 S89 F90 T91 R134 R136 E146 S166 I167 Y168 Q184 I210 R212 E223 Y229 ? 0003677,0003700,0006355,0045892 Kd=1mM -logKd/Ki=3.00, Kd=1mM O34817 25564531 301 HMNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQFGISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGSRLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNESHFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNGTAFEHAKSVYRGDRYTFVHYMDRL 4u0w B 2.001 BS01 16G B 1 S88 F89 T90 R133 R135 E145 S165 I166 Y167 I209 R211 E222 Y228 S89 F90 T91 R134 R136 E146 S166 I167 Y168 I210 R212 E223 Y229 ? 0003677,0003700,0006355,0045892 Kd=1mM -logKd/Ki=3.00, Kd=1mM O34817 25564531 301 HMNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQFGISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGSRLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNESHFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNGTAFEHAKSVYRGDRYTFVHYMDRL 4zsk A 1.85 BS01 16G A 1 S97 Y98 T99 R142 R144 E154 S175 L176 Y177 R221 E232 V234 S236 Y238 S11 Y12 T13 R56 R58 E68 S89 L90 Y91 R135 E146 V148 S150 Y152 ? 0003677,0006355 Q9K492 27337024 301 MKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSQDRTGQPVEWVRSVYRGDRYKFVARLKRP 5oaw A 2.34 BS02 16G A 1 T29 M87 T361 G362 V363 E380 R505 S507 G508 T509 R514 T26 M84 T355 G356 V357 E374 R498 S500 G501 T502 R507 0000287,0004610,0005975,0016868 29967067 602 ASPAVRKAISDAAQYAKPGKIFQYGTAGFRMKADLLNTVVYAVGLLATLRSKKLSGQWIGVMVTASHNPAEDNGVKLVDPMGEMLEAEWEAYATKLANAPLEDVYDELVKEIDVSMENPARVVFARDTRASGSRLIGVLSAALTATEAEFIDMKFMTTPQLHYVVRCKNTLGTQYEYGEPTEQGYYEKLAAAFKRVMRGVKVKGSLTVDCANGVGGPKLRELIKYLPEDTGLDIKIVNDDVINPDSLNFECGADYVKTKQRAPPSSKASILDRCASLDGDADRILYYFLDEGNVFRLLDGDRIATLAASFIGDLARSAGIAQKLKIGVVQTAYANGSSTEYIEKVLKLPSVCTNTGVKHLHHAAMRFDVGVYFEANGHGTITFSENALKTIKNTEPQSPQQRSLECLQALTDLINQAVGDAISDMLLVEAILAHKGWTPKEWLATYTDLPSRLVRVEVAERSIFKAYDAERKLESPPGLQAKIDSLQSRYNKGRSFARASGTEDAVRVYAEAASRSEADDLATRVANAVRDAGT 5oaw B 2.34 BS01 16G B 1 T361 G362 V363 E380 R505 S507 G508 T509 R514 T322 G323 V324 E341 R466 S468 G469 T470 R475 0000287,0004610,0005975,0016868 29967067 601 SPARKAISDAALQYLNTVVYAVGLLATLRSKKLSGQWIGVMVTANGVKLVDPMGEMLWEAYATKLANAPLEDVYDELVKEDVSMNPARVVFARDTRASGSRLIGVLSAALTATEAEFIDMKFMTTPQLHYVVRCKNTLGTQYEYGEPTEQGYYEKLAAAFKRVMRGVKVKGSLTVDCANGVGGPKLRELIKYLPEDTGLDIKIVNDDVINPDSLNFECGADYVKTKQRAPPSSKASILDRCASLDGDADRILYYFLDEGNVFRLLDGDRIATLAASFIGDLARSAGIAQKLKIGVVQTAYANGSSTEYIEKVLKLPSVCTNTGVKHLHHAAMRFDVGVYFEANGHGTITFSENALKTIKNTEPQSPAQQRSLECLQALTDLINQAVGDAISDMLLVEAILAHKGWTPKEWLATYTDLPSRLVRVEVAERSIFKAYDAERKLESPPGLQAKIDSLQSRYNKGRSFARASGTEDAVRVYAEAASRSEADDLATRVANAVRD 6fv4 A 1.974 BS02 16G A 1 G132 A133 H134 H188 N212 A213 H244 I301 A302 G303 G135 A136 H137 H191 N215 A216 H247 I304 A305 G306 3.5.1.25 0006040,0006044,0006046,0008448,0016787,0016810,0046872,0047419 -logKd/Ki=2.92, Kd=1.2mM A0QU89 29728457 402 GSHMLLTADTVLTGTELLRPGWLEIASDRVVAVGAGAPPAQADRNLGAATVVPGFVDTHLHGGGGGNFSAATDDETARAVALHRAHGSTTLVASLVTAGPEDLLRQVSGLARQVRAGLIDGIHLEGPWLSTLRCGAHQPVLMRDPDPGEIGRVLDAGEGTVRMVTIAPERDGALAAIAQLVNAGVVAAVGHTEATYDQTRAAIDAGATVGTHLFNAMRPIDRREPGPAVALTEDSRVTVEMIVDGVHVAPAIYRHITQTVGPERLSLITAAMAATGMSDGVYRLGPLDIDVVAGVARVAGTDTIAGSTATMEQVFRLAVAHCGLPRDDALSLAVRQACVNPARALGLPAAGLAAGARADLVVLDHDLAVTAVMRAGEWVVT 8eym A 2.311 BS01 16G A 1 R50 D54 A74 A75 P77 S78 R47 D51 A71 A72 P74 S75 2.6.1.16 0004360,0005737,0008483,0097367,1901135 Q12KP2 37145875 401 TNTIMEQEARTAPQKIAEQLLANDAITESLGSVLREFKPKFVMIVGRGSSDHAGVFAKYLFEIEASIPTFAAAPSVASVYGKTLKLAGGLVIVISQSGRSPDILAQARMAKNAGAFCVALVNDETAPIKDIVDVVIPLRAGEEKAVAATKSYLATLSALLQVAAKWTQNESLVEAVNSLPQALQAAVDAEPQLRAGSLTDVKNLVVLGRGFGYAVSKEIALKLKEVCAIHAEAFSSAEFLHGPVTLVEKKLSILDVCIRDESYGSHVEQIANVKQRGANLIHLHQTSADIHPRIAPLALLQRFYIDVAAVAIALGINPD 8eym A 2.311 BS03 16G B 1 Y62 R212 S238 E241 Y59 R209 S235 E238 2.6.1.16 0004360,0005737,0008483,0097367,1901135 Q12KP2 37145875 401 TNTIMEQEARTAPQKIAEQLLANDAITESLGSVLREFKPKFVMIVGRGSSDHAGVFAKYLFEIEASIPTFAAAPSVASVYGKTLKLAGGLVIVISQSGRSPDILAQARMAKNAGAFCVALVNDETAPIKDIVDVVIPLRAGEEKAVAATKSYLATLSALLQVAAKWTQNESLVEAVNSLPQALQAAVDAEPQLRAGSLTDVKNLVVLGRGFGYAVSKEIALKLKEVCAIHAEAFSSAEFLHGPVTLVEKKLSILDVCIRDESYGSHVEQIANVKQRGANLIHLHQTSADIHPRIAPLALLQRFYIDVAAVAIALGINPD 8eym B 2.311 BS01 16G A 1 Y62 R212 S238 E241 Y60 R210 S236 E239 2.6.1.16 0004360,0005737,0008483,0097367,1901135 Q12KP2 37145875 401 TTNTIMEQEARTAPQKIAEQLLANDAITESLGSVLREFKPKFVMIVGRGSSDHAGVFAKYLFEIEASIPTFAAAPSVASVYGKTLKLAGGLVIVISQSGRSPDILAQARMAKNAGAFCVALVNDETAPIKDIVDVVIPLRAGEEKAVAATKSYLATLSALLQVAAKWTQNESLVEAVNSLPQALQAAVDAEPQLRAGSLTDVKNLVVLGRGFGYAVSKEIALKLKEVCAIHAEAFSSAEFLHGPVTLVEKKLSILDVCIRDESYGSHVEQIANVKQRGANLIHLHQTSADIHPRIAPLALLQRFYIDVAAVAIALGINPDKPAGLKKVTQT 8eym B 2.311 BS02 16G B 1 R50 D54 A74 A75 P77 S78 R48 D52 A72 A73 P75 S76 2.6.1.16 0004360,0005737,0008483,0097367,1901135 Q12KP2 37145875 401 TTNTIMEQEARTAPQKIAEQLLANDAITESLGSVLREFKPKFVMIVGRGSSDHAGVFAKYLFEIEASIPTFAAAPSVASVYGKTLKLAGGLVIVISQSGRSPDILAQARMAKNAGAFCVALVNDETAPIKDIVDVVIPLRAGEEKAVAATKSYLATLSALLQVAAKWTQNESLVEAVNSLPQALQAAVDAEPQLRAGSLTDVKNLVVLGRGFGYAVSKEIALKLKEVCAIHAEAFSSAEFLHGPVTLVEKKLSILDVCIRDESYGSHVEQIANVKQRGANLIHLHQTSADIHPRIAPLALLQRFYIDVAAVAIALGINPDKPAGLKKVTQT