4hhz A 2.7199 BS01 15S A 1 Y49 D105 L108 H201 G202 I218 A219 P220 Y228 Y235 F236 S243 Y246 Y49 D105 L108 H201 G202 I218 A219 P220 Y228 Y235 F236 S243 Y246 S243 Y246 E327 S243 Y246 E327 2.4.2.-,2.4.2.30 0003950 P09874 23473053 401 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 4hhz B 2.7199 BS01 15S B 1 L108 H201 G202 R217 I218 A219 P220 Y228 Y235 F236 S243 Y246 E327 L108 H201 G202 R217 I218 A219 P220 Y228 Y235 F236 S243 Y246 E327 S243 Y246 E327 S243 Y246 E327 2.4.2.-,2.4.2.30 0003950 P09874 23473053 401 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 4hhz C 2.7199 BS01 15S C 1 Y49 L108 H201 G202 R217 I218 A219 P220 Y228 Y235 F236 S243 Y246 E327 Y49 L108 H201 G202 R217 I218 A219 P220 Y228 Y235 F236 S243 Y246 E327 S243 Y246 E327 S243 Y246 E327 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=7.72, IC50=0.019uM P09874 23473053 401 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 4hhz D 2.7199 BS01 15S D 1 D105 L108 H201 G202 R217 I218 A219 P220 Y228 Y235 F236 A237 S243 Y246 D61 L64 H148 G149 R164 I165 A166 P167 Y175 Y182 F183 A184 S190 Y193 S243 Y246 E327 S190 Y193 E274 2.4.2.-,2.4.2.30 0003950 P09874 23473053 401 SKLPKPVQDLIKMIFDVESMKKAMVEYEIKLSKRQIQAASNRFYTLIPHDDSVQAKAEMLDNLLDIEVAYSLLRGIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK