4hgs A 2.4 BS01 15G A 1 L57 A70 K72 P100 L116 L119 G120 P121 L169 I184 D185 P331 T332 P333 L25 A38 K40 P68 L84 L87 G88 P89 L137 I152 D153 P299 T300 P301 D162 K164 T212 D130 K132 T180 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=8.30, IC50=5nM Q9Y6M4 401 GSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPV 4hgt A 1.8 BS01 15G A 1 I15 G18 I23 A36 K38 M82 L85 L135 I148 D149 I7 G10 I15 A28 K30 M71 L74 L124 I137 D138 D128 K130 D117 K119 2.7.11.1,2.7.11.26 0004672,0005524,0006468 -logKd/Ki=7.40, IC50=0.04uM IC50=40nM P48730 24900428 301 YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK 4hgt B 1.8 BS01 15G A 1 E2 R10 E1 R9 D128 K130 D116 K118 2.7.11.1,2.7.11.26 0004672,0005524,0006468 IC50=40nM P48730 24900428 301 ELRVGNRYRLGRKIDIYLGTDIAAGEEVAIKLECVQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNM 4hgt B 1.8 BS02 15G B 1 R13 I15 I23 A36 K38 P66 M82 L84 L85 L135 I148 D149 R12 I14 I16 A29 K31 P54 M70 L72 L73 L123 I136 D137 D128 K130 D116 K118 2.7.11.1,2.7.11.26 0004672,0005524,0006468 IC50=40nM P48730 24900428 301 ELRVGNRYRLGRKIDIYLGTDIAAGEEVAIKLECVQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNM