4fs3 A 1.8 BS02 0WE A 1 F96 A97 M99 L102 Y147 N156 Y157 S197 V201 F96 A97 M99 L102 Y147 N156 Y157 S197 V201 Y147 Y157 M160 K164 K199 Y147 Y157 M160 K164 K199 1.3.1.39 0000166,0004318,0006633,0016491,0030497,0042802,0050661,0141148 Ki=12.8nM -logKd/Ki=7.85, IC50=14nM Q6GI75 22948878 302 MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIKERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4jqc A 2.8 BS02 0WE A 1 F94 A95 L100 Y146 N155 Y156 A196 S198 I200 F94 A95 L100 Y146 N155 Y156 A196 S198 I200 A27 R30 A33 E49 A52 A53 D118 Y146 Y156 K163 A27 R30 A33 E49 A52 A53 D118 Y146 Y156 K163 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 P0AEK4 302 MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 4jqc B 2.8 BS02 0WE B 1 F94 A95 L100 Y146 N155 Y156 F93 A94 L99 Y145 N154 Y155 A27 R30 A33 E49 A52 A53 D118 Y146 Y156 K163 A26 R29 A32 E48 A51 A52 D117 Y145 Y155 K162 1.3.1.9 0004318,0005515,0005829,0006633,0008610,0009102,0016020,0016491,0030497,0032991,0042802,0046677,0051289,0070404,1902494 P0AEK4 302 GFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNE 4q9n A 1.795 BS02 0WE A 1 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 0004318,0006633 ic50=0.95uM 24958721 302 MLKIDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNASRELSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHIDILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFISLLSHFGPIMNAGASTISLTYLASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAGPLASRAGKAIGFIERMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHGANVMGIGPEMF 4q9n B 1.795 BS02 0WE B 1 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 0004318,0006633 ic50=0.95uM 24958721 302 MLKIDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNASRELSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHIDILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFISLLSHFGPIMNAGASTISLTYLASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAGPLASRAGKAIGFIERMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHGANVMGIGPEMF 4q9n C 1.795 BS02 0WE C 1 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 M240 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 M240 0004318,0006633 ic50=0.95uM 24958721 302 MLKIDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNASRELSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHIDILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFISLLSHFGPIMNAGASTISLTYLASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAGPLASRAGKAIGFIERMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHGANVMGIGPEMF 4q9n D 1.795 BS02 0WE D 1 N129 S130 I133 Y178 G187 Y188 A230 A233 F236 N129 S130 I133 Y178 G187 Y188 A230 A233 F236 0004318,0006633 ic50=0.95uM 24958721 302 MLKIDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNASRELSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHIDILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFISLLSHFGPIMNAGASTISLTYLASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAGPLASRAGKAIGFIERMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHGANVMGIGPEMF 4q9n E 1.795 BS02 0WE E 1 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 0004318,0006633 ic50=0.95uM 24958721 302 MLKIDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNASRELSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHIDILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFISLLSHFGPIMNAGASTISLTYLASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAGPLASRAGKAIGFIERMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHGANVMGIGPEMF 4q9n F 1.795 BS02 0WE F 1 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 0004318,0006633 ic50=0.95uM 24958721 302 MLKIDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNASRELSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHIDILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFISLLSHFGPIMNAGASTISLTYLASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAGPLASRAGKAIGFIERMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHGANVMGIGPEMF 4q9n G 1.795 BS02 0WE G 1 N129 S130 I133 Y178 G187 Y188 A230 A233 F236 M240 N129 S130 I133 Y178 G187 Y188 A230 A233 F236 M240 0004318,0006633 ic50=0.95uM 24958721 302 MLKIDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNASRELSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHIDILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFISLLSHFGPIMNAGASTISLTYLASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAGPLASRAGKAIGFIERMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHGANVMGIGPEMF 4q9n H 1.795 BS02 0WE H 1 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 M240 N129 S130 I133 Y178 G187 Y188 A230 A233 I234 F236 M240 0004318,0006633 ic50=0.95uM 24958721 302 MLKIDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNASRELSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHIDILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFISLLSHFGPIMNAGASTISLTYLASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAGPLASRAGKAIGFIERMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHGANVMGIGPEMF 4rlh A 2.26 BS01 0WE A 1 F94 A95 R97 I100 Y146 N155 Y156 M159 F203 F94 A95 R97 I100 Y146 N155 Y156 M159 F198 Y156 K163 Y156 K163 1.3.1.9 0004318,0006633,0016491 Q63SW7 500 MGFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPISGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVGGM 4rlh B 2.26 BS01 0WE B 1 F94 A95 Y146 N155 Y156 M159 F203 F94 A95 Y146 N155 Y156 M159 F203 Y156 K163 Y156 K163 1.3.1.9 0004318,0006633,0016491 Q63SW7 500 MGFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVGGM 4rlh C 2.26 BS01 0WE C 1 F94 A95 R97 I100 Y146 N155 Y156 I200 F94 A95 R97 I100 Y146 N155 Y156 I200 Y156 K163 Y156 K163 1.3.1.9 0004318,0006633,0016491 Q63SW7 500 MGFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVGGM 4rlh D 2.26 BS01 0WE D 1 F94 A95 R97 I100 Y146 N155 Y156 F203 F94 A95 R97 I100 Y146 N155 Y156 F198 Y156 K163 Y156 K163 1.3.1.9 0004318,0006633,0016491 Q63SW7 500 MGFLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFPCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGAKGVRVNAISAGPISGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASGVTAEVMHVDSGFNAVVGGM 6ahe A 2.29 BS02 0WE A 1 F96 A97 L102 Y149 N158 Y159 A199 F206 F94 A95 L100 Y147 N156 Y157 A197 F204 1.3.1.9 0000166,0004318,0006633,0016491 D0CAD5 32227402 301 QGLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEFAEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDGDFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGSERVMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASGIKSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDAGFNTVGMSQS 6ahe B 2.29 BS02 0WE B 1 F96 A97 L102 Y149 N158 Y159 A199 S201 I203 F206 F94 A95 L100 Y147 N156 Y157 A197 S199 I201 F204 1.3.1.9 0000166,0004318,0006633,0016491 D0CAD5 32227402 301 QGLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEFAEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDGDFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGSERVMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASGIKSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDAGFNTVGMSQS 6ahe C 2.29 BS02 0WE C 1 F96 A97 L102 Y149 Y159 A199 F206 M209 F94 A95 L100 Y147 Y157 A197 F204 M207 1.3.1.9 0000166,0004318,0006633,0016491 D0CAD5 32227402 301 QGLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEFAEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDGDFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGSERVMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASGIKSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDAGFNTVGMSQS 6ahe D 2.29 BS02 0WE D 1 F96 A97 L102 Y149 N158 Y159 A199 S201 I203 F206 F94 A95 L100 Y147 N156 Y157 A197 S199 I201 F204 1.3.1.9 0000166,0004318,0006633,0016491 D0CAD5 32227402 301 QGLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEFAEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDGDFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGSERVMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASGIKSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDAGFNTVGMSQS