4eg5 B 3.1 BS01 0OU B 1 Y250 D287 H289 G290 L456 Y472 V473 W474 I519 F522 Y19 D56 H58 G59 L195 Y211 V212 W213 I258 F261 H256 H259 S364 D367 K554 H25 H28 S133 D136 K293 6.1.1.10 0000166,0004812,0004825,0005524,0006418,0006431 Q38C91 22902861 810 GPGSMKVEKVFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVFALTGTDEHGQKVAEAAKQKQVSPYDFTTAVAGEFKKCFEQMDYSIDYFIRTTNEQHKAVVKELWTKLEQKGDIYLGRYEGWYSISDEWVSEENYMFRLSAFRERLLEWYHANPGCIVPEFRRREVIRAVEKGLPDLSVSRARATLHNWAIPVPGNPDHCVYVWLDALTNYLTGSRLRVDESGKEVSLVDDFNELERFPADVHVIGKDILKFHAIYWPAFLLSAGLPLPKKIVAHGWWTKDRKKIGNVFDPVEKAEEFGYDALKYFLLRESGFSDDGDYSDKNMIARLNGELADTLGNLVMRCTSAKINVNGEWPSPAAYTEEDESLIQLIKDLPGTADHYYLIPDIQKAIIAVFDVLRAINAYVTDMAPWKLVKTDPERLRTVLYITLEGVRVTTLLLSPILPRKSVVIFDMLGVPEVHRKGIENFEFGAVPPGTRLGPAVEGEVLFSKRS 5k0s A 2.45 BS01 0OU A 1 A11 I12 Y14 D51 H53 G54 F213 M227 Y228 V229 D232 A233 H269 A9 I10 Y12 D49 H51 G52 F211 M225 Y226 V227 D230 A231 H267 I12 H20 H23 D51 S128 D131 G150 W230 I265 I10 H18 H21 D49 S126 D129 G148 W228 I263 6.1.1.10 0000166,0004812,0004825,0005524,0005737,0006412,0006418,0006431 ic50=0.006uM -logKd/Ki=8.22, IC50=0.006uM P59078 27500735 601 REKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSVRDEAYYGEEETEVRADGVRYGPQGTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFNRIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRYV 5k0s B 2.45 BS01 0OU B 1 A11 I12 Y14 D51 H53 G54 F213 M227 Y228 V229 D232 A233 F268 H269 A9 I10 Y12 D49 H51 G52 F201 M215 Y216 V217 D220 A221 F256 H257 I12 H20 H23 D51 S128 D131 G150 W230 I265 I10 H18 H21 D49 S126 D129 G140 W218 I253 6.1.1.10 0000166,0004812,0004825,0005524,0005737,0006412,0006418,0006431 ic50=0.006uM P59078 27500735 601 REKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSVRDEAYYGEEERYGPTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRYVE 5k0s C 2.45 BS01 0OU C 1 A11 I12 Y14 D51 H53 G54 Y228 V229 W230 D232 A233 Y237 F268 H269 A9 I10 Y12 D49 H51 G52 Y226 V227 W228 D230 A231 Y235 F266 H267 I12 H20 H23 D51 S128 D131 G150 W230 I265 I10 H18 H21 D49 S126 D129 G148 W228 I263 6.1.1.10 0000166,0004812,0004825,0005524,0005737,0006412,0006418,0006431 ic50=0.006uM P59078 27500735 601 REKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSVRDEAYYGEEETEVRADGVRYGPQGTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFNRIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRYVE