4edv A 2.01 BS01 0O2 A 1 R146 R222 E228 P229 K230 Y231 A314 R39 R115 E121 P122 K123 Y124 A207 2.7.7.101 0003896,0006269 O05338 22795082 502 SNADDLQMIEMHELIQEFYYYALTKTVEGEQALTYLQERGFTDALIKERGIGFAPDSSHFCHDFLQKKGYDIELAYEAGLLSRNEENFSYYDRFRNRIMFPLKNAQGRIVGYSGRTYTGQEPKYLNSPETPIFQKRKLLYNLDKARKSIRKLDEIVLLEGFMDVIKSDTAGLKNVVATMGTQLSDEHITFIRKLTSNITLMFDGDFAGSEATLKTGQHLLQQGLNVFVIQLPSGMDPDEYIGKYGNDAFTTFVKNDKKSFAHYKVSILKDEIAHNDLSYERYLKELSHDISLMKSSILQQKAINDVAPFFNVSPEQLANEI 4jk2 D 4.201 BS03 0O2 D 1 R362 K615 I619 D622 R345 K598 I602 D605 2.7.7.6 0000287,0000345,0000428,0003677,0003899,0005515,0005737,0005829,0006351,0006352,0006879,0008023,0008270,0009408,0016020,0016779,0031564,0032784,0034062,0036460,0042128,0044780,0046677,0046872,0048870,0071973,0090605,2000142 P0A8T7 23620295 1503 LKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERLYRSGLASLHARVKVRITEYEKDANGELVAKTSLKDTTVGRAILWMIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEKQVSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHEGIMMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADILVPRNTLLHEQWCDLLEENSVDAVKVRSVVSCDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRDITGGLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKRRLVITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVISDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANRELEANGKVGATYSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAG 4jk2 E 4.201 BS01 0O2 D 1 A2 R3 R52 A1 R2 R51 2.7.7.6 0000345,0000428,0001000,0003677,0003899,0005829,0006351,0006352,0006879,0008023,0009408,0016779,0030880,0031564,0032784,0034062,0036460,0042128,0044780,0048870,0065003,0071973,0090605,2000142 P0A800 23620295 1503 ARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGRR 4qrh B 1.65 BS01 0O2 B 1 G16 V17 G18 K19 S39 R43 Y55 E74 Y78 Y83 G84 E103 I104 E105 G15 V16 G17 K18 S38 R42 Y54 E73 Y77 Y82 G83 E102 I103 E104 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Ki=7uM -logKd/Ki=5.15, Ki=7.0uM A0A0J9X1Z9 25661490 303 DNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLEHLNEARKEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAK 4qrh C 1.65 BS01 0O2 C 1 G16 V17 G18 K19 S39 R43 Y55 E74 Y78 Y83 G84 E103 I104 E105 G14 V15 G16 K17 S37 R41 Y53 E72 Y76 Y81 G82 E101 I102 E103 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Ki=7uM A0A0J9X1Z9 25661490 304 NEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLEHLINEARKEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEA 4qrh D 1.65 BS01 0O2 D 1 G16 G18 K19 S39 R43 Y55 E74 Y78 Y83 G84 E103 I104 E105 G14 G16 K17 S37 R41 Y53 E72 Y76 Y81 G82 E101 I102 E103 2.7.4.8 0004385,0005524,0005737,0005829,0006163,0016301,0016310,0046037,0046710 Ki=7uM A0A0J9X1Z9 25661490 306 NEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLEHLIQSRINEARKEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRK 5ded A 2.942 BS01 0O2 A 1 K48 K56 R59 K60 R105 Y107 K112 S114 Y116 H120 E139 Q141 A151 E154 H155 K46 K54 R57 K58 R103 Y105 K110 S112 Y114 H118 E137 Q139 A149 E152 H153 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 301 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAA 5ded A 2.942 BS02 0O2 A 2 K21 K25 E41 F42 K19 K23 E39 F40 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 302 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAA 5ded B 2.942 BS01 0O2 D 2 K21 K25 R28 F42 T44 K19 K23 R26 F40 T42 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 302 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKSGNEKVKLRLQRASEAASRLDEEMSEIRGEVAA 5ded B 2.942 BS02 0O2 B 1 R46 K48 K56 R59 K60 R105 Y107 K112 S114 Y116 H120 E139 Q141 A151 E154 H155 R44 K46 K54 R57 K58 R103 Y105 K110 S112 Y114 H118 E137 Q139 A149 E152 H153 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 301 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKSGNEKVKLRLQRASEAASRLDEEMSEIRGEVAA 5ded C 2.942 BS01 0O2 A 2 K21 K25 R28 F42 T44 K19 K23 R26 F40 T42 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 302 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQE 5ded C 2.942 BS02 0O2 C 1 R46 R105 Y107 K112 S114 Y116 H120 E139 Q141 A151 E154 H155 R44 R103 Y105 K110 S112 Y114 H118 E137 Q139 A149 E152 H153 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 301 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQE 5ded D 2.942 BS01 0O2 D 1 R46 K48 R105 Y107 K112 S114 Y116 H120 E139 Q141 A151 E154 H155 R44 K46 R103 Y105 K110 S112 Y114 H118 E137 Q139 A149 E152 H153 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 301 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLYKPEKVKLRLQRASEAASRLDEEMSEIRGVQEA 5ded D 2.942 BS02 0O2 D 2 K21 K25 E41 F42 K19 K23 E39 F40 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 302 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLYKPEKVKLRLQRASEAASRLDEEMSEIRGVQEA 5ded E 2.942 BS01 0O2 E 1 R105 Y107 K112 S114 Y116 H120 E139 Q141 E154 H155 R103 Y105 K110 S112 Y114 H118 E137 Q139 E152 H153 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 301 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKIPEKVKLRLQRASEAASRLDEEMSEIRGEVQE 5ded E 2.942 BS02 0O2 H 2 K21 K25 F42 T44 K19 K23 F40 T42 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 302 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKIPEKVKLRLQRASEAASRLDEEMSEIRGEVQE 5ded F 2.942 BS01 0O2 F 1 K48 R59 R105 Y107 K112 S114 Y116 H120 E139 Q141 A151 E154 H155 K46 R57 R103 Y105 K110 S112 Y114 H118 E137 Q139 A149 E152 H153 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 301 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQ 5ded F 2.942 BS02 0O2 G 2 K21 K25 R28 F42 T44 K19 K23 R26 F40 T42 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 302 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQ 5ded G 2.942 BS01 0O2 G 1 R46 K48 K56 R105 Y107 K112 S114 Y116 H120 E139 Q141 A151 E154 H155 R44 K46 K54 R103 Y105 K110 S112 Y114 H118 E137 Q139 A149 E152 H153 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 301 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLYKIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEA 5ded G 2.942 BS02 0O2 G 2 K25 R28 E41 F42 K23 R26 E39 F40 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 302 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLYKIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEA 5ded H 2.942 BS01 0O2 H 1 K56 R59 K60 R105 Y107 K112 S114 Y116 H120 E139 Q141 A151 E154 H155 K54 R57 K58 R103 Y105 K110 S112 Y114 H118 E137 Q139 A149 E152 H153 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 301 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVAA 5ded H 2.942 BS02 0O2 H 2 K21 K25 F42 K19 K23 F40 2.7.6.5 0005524,0005525,0008728,0015969,0015970,0016301,0016310,0046872 O31611 26460002 302 DKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVAA 6ex0 A 2.78 BS01 0O2 A 1 R112 K147 N149 Y151 H155 Q176 A186 E189 H190 R193 R82 K117 N119 Y121 H125 Q146 A156 E159 H160 R163 2.7.6.5 0008728,0015969,0015970,0016301,0016310 W8U368 29326162 301 AFDTLLGFVELDHIYSSALKEISTKLSILDDNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDDIYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTIGMDMWASLEHKIRYEKYRDLLKECATEITEVEDKLQQIHSEITE 6ex0 B 2.78 BS01 0O2 B 1 R78 K80 K88 D107 R112 K147 N149 Y151 H155 Q176 A186 E189 H190 R47 K49 K57 D76 R81 K116 N118 Y120 H124 Q145 A155 E158 H159 2.7.6.5 0008728,0015969,0015970,0016301,0016310 W8U368 29326162 301 FDTLLGFVELDHIYSSALKEISTKLSILDDNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDDIYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTIGMDMWASLEHKIRYNAETEKYRDLLKECATEITEVEDKLQQIHSEITE 6g15 A 1.65 BS01 0O2 A 1 N58 K59 D61 M62 D86 K88 P129 N130 G132 K133 S134 T135 N57 K58 D60 M61 D85 K87 P126 N127 G129 K130 S131 T132 ? 0003924,0005525,0005737,0006412,0042254 A0A0H2XK72 30366986 301 VIQWYPGHMAKAKREVSEQLKKVDVVFELVDARIPYSSRNPMIDEVINQKPRVVILNKKDMSNLNEMSKWEQFFIDKGYYPVSVDAKHGLKKVEAAAIKATAEKFEREKAKGLKPRAIRAMIVGIPNVGKSTLINKLAKRSIGNKPGVTKQQQWIKVGNALQLLDTPGILWPKFEDEEVGKKLSLTGAIKDSIVHLDEVAIYGLNFLIQNDLARLKSHYNIEVPEDAEIIAWFDAIGKKRGLIRRGNEIDYEAVIELIIYDIRNAKIGNYCFDIFKDMTEELANDAN 6g15 B 1.65 BS01 0O2 B 1 N58 K59 D61 D86 K88 P129 N130 G132 K133 S134 T135 N57 K58 D60 D85 K87 P128 N129 G131 K132 S133 T134 ? 0003924,0005525,0005737,0006412,0042254 A0A0H2XK72 30366986 301 VIQWYPGHMAKAKREVSEQLKKVDVVFELVDARIPYSSRNPMIDEVINQKPRVVILNKKDMSNLNEMSKWEQFFIDKGYYPVSVDAKHGKNLKKVEAAAIKATAEKFEREKAKGLKPRAIRAMIVGIPNVGKSTLINKLAKRSIGNKPGVTKQQQWIKVGNALQLLDTPGILWPKFEDEEVGKKLSLTGAIKDSIVHLDEVAIYGLNFLIQNDLARLKSHYNIEVPEDAEIIAWFDAIGKKRGLIRRGNEIDYEAVIELIIYDIRNAKIGNYCFDIFKDMTEELANDAN 6gfm A 2.77 BS01 0O2 A 1 R340 G343 D344 A345 Y346 R343 G346 D347 A348 Y349 3.2.2.-,3.2.2.10,3.2.2.4 0005829,0008714,0016787,0032991,0042802,0047405,0047723,0051289,0097216 P0ADR8 31023582 501 LRAITHISPLGSMDMLSQLEVDMLKRTASSDLYQLFRNCSLAVLNSGSLTDNSKELLSRFENFDINVLRRERGVKLELINPPEEAFVDGRIIRALQANLFAVLRDILFVYGQIHNTVRFPNLNLDNSVHITNLVFSILRNARALHVGEAPNMVVCWGGHSINENEYLYARRVGNQLGLRELNICTGCGPGAMEAPMKGAAVGHAQQRYKDSRFIGMTEPSIIAAEPPNPLVNELIIMPDIEKRLEAFVRIAHGIIIFPGGVGTAEELLYLLGILMNPANKDQVLPLILTGPKESADYFRVLDEFVVHTLGENARRHYRIIIDDAAEVARQMKKSMPLVKENRRDTGDAYSFNWSMRIAPDLQMPFEPSHENMANLKLYPDQPVEVLAADLRRAFSGIVAGNVKEVGIRAIEEFGPYKINGDKEIMRRMDDLLQGFVAQHR 6vcl B 2.06 BS03 0O2 B 1 R8 R27 S32 Q37 Y77 Q95 V137 K140 R9 R28 S33 Q38 Y78 Q96 V138 K141 3.6.1.- 0000287,0005515,0005737,0006402,0008033,0016462,0016787,0016818,0034353,0050779,0110153,0110154,0110155 ic50=54.4uM P0A776 31960065 209 SMIDDDGYRPNVGIVICNRQGQVMWARRFGQHSWQFPQGGINPGESAEQAMYRELFEEVGLSRKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLVSGDAEINMQTSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFASVVMSLA 7o9h A 2.4 BS01 0O2 A 1 N302 G303 G305 K306 T307 T308 K447 D449 G472 G474 N109 G110 G112 K113 T114 T115 K254 D256 G279 G281 3.6.5.4 0005525,0006614,0016887 P10121 35217658 601 GFFARLKRSLLKTKENLGSGFISLFRGKKIDDDLFEELEEQLLIADVGVETTRKIITNLTEGASRKQLRDAEALYGLLKEEMGEILAKVDEPLNVEGKTPFVILMVGVNGVGKTTTIGKLARQFEQQGKSVMLAAGDTFRAAAVEQLQVWGQRNNIPVIAQHTGADSASVIFDAIQAAKARNIDVLIADTAGRLQNKSHLMEELKKIVRVMKKLDVEAPHEVMLTIDASTGQNAVSQAKLFHEAVGLTGITLTKLDGTAKGGVIFSVADQFGIPIRYIGVGERIEDLRPFKADDFIEALFAR 7o9h B 2.4 BS01 0O2 B 1 N302 G303 G305 K306 T307 T308 R333 K447 D449 G472 G474 N109 G110 G112 K113 T114 T115 R140 K254 D256 G279 G281 3.6.5.4 0005525,0006614,0016887 P10121 35217658 601 GFFARLKRSLLKTKENLGSGFISLFRGKKIDDDLFEELEEQLLIADVGVETTRKIITNLTEGASRKQLRDAEALYGLLKEEMGEILAKVDEPLNVEGKTPFVILMVGVNGVGKTTTIGKLARQFEQQGKSVMLAAGDTFRAAAVEQLQVWGQRNNIPVIAQHTGADSASVIFDAIQAAKARNIDVLIADTAGRLQNKSHLMEELKKIVRVMKKLDVEAPHEVMLTIDASTGQNAVSQAKLFHEAVGLTGITLTKLDGTAKGGVIFSVADQFGIPIRYIGVGERIEDLRPFKADDFIEALFARE 7o9i A 2.49 BS01 0O2 A 1 G110 G112 K113 T114 T115 Q147 D190 K249 D251 G274 G276 E277 G102 G104 K105 T106 T107 Q139 D182 K241 D243 G266 G268 E269 3.6.5.4 0003924,0005525,0006614,0016887,0048500 P0AGD7 35217658 401 LSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFINRVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAEQVGVDFFPSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMDEIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRI 7oiw A 2.63 BS01 0O2 A 1 R51 K52 N53 K148 D151 R152 N155 T158 M162 R169 R40 K41 N42 K123 D126 R127 N130 T133 M137 R144 2.7.6.5 0015969 Q931Q4 501 YPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAPLAHHLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWA 7oiw A 2.63 BS02 0O2 A 2 N188 K250 H251 S254 K258 R302 K304 K311 N313 Y315 Q333 A343 N163 K225 H226 S229 K233 R277 K279 K286 N288 Y290 Q308 A318 2.7.6.5 0015969 Q931Q4 502 YPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAPLAHHLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWA 7oiw B 2.63 BS01 0O2 B 1 R51 K52 N53 K148 D151 R152 N155 T158 M162 K166 R39 K40 N41 K124 D127 R128 N131 T134 M138 K142 2.7.6.5 0015969 Q931Q4 501 PYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAPLAHHLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHW 7oiw B 2.63 BS02 0O2 B 2 N188 R248 K250 H251 S254 K258 R302 K304 K311 N313 Y315 H319 Q333 A343 N164 R224 K226 H227 S230 K234 R278 K280 K287 N289 Y291 H295 Q309 A319 2.7.6.5 0015969 Q931Q4 502 PYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAPLAHHLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHW 8q3o A 3.0 BS01 0O2 B 1 R366 K367 E368 E369 W381 R366 K367 E368 E369 W381 3.6.4.- 0003676,0003723,0004386,0005515,0005524,0005829,0006353,0008186,0016020,0016787,0016887,0042802 P0AG30 37645988 501 MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKR 8q3o B 3.0 BS01 0O2 B 1 P180 K181 G183 K184 T185 M186 R212 F355 P180 K181 G183 K184 T185 M186 R212 F355 3.6.4.- 0003676,0003723,0004386,0005515,0005524,0005829,0006353,0008186,0016020,0016787,0016887,0042802 P0AG30 37645988 501 MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKR 8q3o B 3.0 BS02 0O2 C 1 R366 K367 E368 E369 R366 K367 E368 E369 3.6.4.- 0003676,0003723,0004386,0005515,0005524,0005829,0006353,0008186,0016020,0016787,0016887,0042802 P0AG30 37645988 501 MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKR 8q3o C 3.0 BS01 0O2 C 1 P180 K181 G183 K184 T185 M186 F355 P180 K181 G183 K184 T185 M186 F355 3.6.4.- 0003676,0003723,0004386,0005515,0005524,0005829,0006353,0008186,0016020,0016787,0016887,0042802 P0AG30 37645988 501 MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKR 8q3o C 3.0 BS02 0O2 D 1 R366 K367 R366 K367 3.6.4.- 0003676,0003723,0004386,0005515,0005524,0005829,0006353,0008186,0016020,0016787,0016887,0042802 P0AG30 37645988 501 MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKR 8q3o D 3.0 BS01 0O2 D 1 K181 G183 K184 T185 M186 F355 K181 G183 K184 T185 M186 F355 3.6.4.- 0003676,0003723,0004386,0005515,0005524,0005829,0006353,0008186,0016020,0016787,0016887,0042802 P0AG30 37645988 501 MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKR 8q3o E 3.0 BS01 0O2 E 1 K181 G183 K184 T185 M186 R212 F355 K181 G183 K184 T185 M186 R212 F355 3.6.4.- 0003676,0003723,0004386,0005515,0005524,0005829,0006353,0008186,0016020,0016787,0016887,0042802 P0AG30 37645988 501 MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKR