3ik3 A 1.9 BS01 0LI A 1 L248 Y253 A269 K271 E286 M290 I293 V299 I313 I315 F317 M318 I360 H361 L370 V379 A380 D381 F382 L21 Y26 A42 K44 E59 M63 I66 V72 I86 I88 F90 M91 I133 H134 L143 V152 A153 D154 F155 D363 A365 R367 N368 D381 P402 D136 A138 R140 N141 D154 P169 2.7.10.2 0004672,0004713,0005524,0006468 ic50=2nM -logKd/Ki=8.70, IC50=2.0nM P00520 19878872 1 GSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIIIEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKR 3ik3 B 1.9 BS01 0LI B 1 L248 Y253 A269 K271 E286 M290 I293 V299 I313 I315 F317 M318 I360 H361 L370 V379 A380 D381 F382 L21 Y26 A42 K44 E59 M63 I66 V72 I86 I88 F90 M91 I133 H134 L143 V152 A153 D154 F155 D363 A365 R367 N368 D381 P402 D136 A138 R140 N141 D154 P175 2.7.10.2 0004672,0004713,0005524,0006468 ic50=2nM P00520 19878872 2 GSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIIIEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKR 3oxz A 2.2 BS01 0LI A 1 L248 Y253 A269 K271 E286 M290 I293 L298 V299 T315 F317 M318 I360 H361 L370 V379 A380 D381 F382 L21 Y26 A42 K44 E53 M57 I60 L65 V66 T82 F84 M85 I127 H128 L137 V146 A147 D148 F149 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P159 2.7.10.2 0004672,0004713,0005524,0006468 ic50=8.6nM -logKd/Ki=8.07, IC50=8.6nM P00520 21118377 1 GSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSYTGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELG 3zos A 1.92 BS01 0LI A 1 A653 K655 E672 M676 T701 Y703 M704 V763 H764 R765 L773 I782 A783 D784 F785 A52 K54 E71 M75 T100 Y102 M103 V151 H152 R153 L161 I170 A171 D172 F173 D766 R770 N771 D784 A793 D154 R158 N159 D172 A181 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 -logKd/Ki=8.89, Kd=1.3nM Q08345 24768818 1000 RVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 3zos A 1.92 BS02 0LI A 2 V799 C814 I815 L816 G818 F861 V187 C202 I203 L204 G206 F249 D766 R770 N771 D784 A793 D154 R158 N159 D172 A181 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 -logKd/Ki=8.89, Kd=1.3nM Q08345 24768818 1004 RVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 3zos B 1.92 BS01 0LI A 2 L805 I815 G818 L195 I205 G208 D766 R770 N771 D784 A793 D156 R160 N161 D174 A183 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 Q08345 24768818 1004 SMPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 3zos B 1.92 BS02 0LI B 1 A653 K655 E672 M676 L679 I684 T701 Y703 M704 V763 H764 R765 L773 I782 A783 D784 F785 A55 K57 E74 M78 L81 I86 T103 Y105 M106 V153 H154 R155 L163 I172 A173 D174 F175 D766 R770 N771 D784 A793 D156 R160 N161 D174 A183 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 Q08345 24768818 1000 SMPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 4c8b A 2.75 BS01 0LI A 1 A45 K47 E66 L70 L79 I93 T95 M98 L143 H144 L153 I162 A163 D164 F165 A38 K40 E59 L63 L72 I86 T88 M91 L136 H137 L146 I155 A156 D157 F158 R22 D146 K148 Q150 N151 D164 T189 R15 D139 K141 Q143 N144 D157 T160 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=1.000000nM O43353 26320862 1000 SALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGTIIYMPPENYSIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQS 4c8b B 2.75 BS01 0LI B 1 A45 K47 E66 L79 T95 M98 L143 H144 I162 A163 D164 F165 A37 K39 E53 L66 T82 M85 L130 H131 I149 A150 D151 F152 R22 D146 K148 Q150 N151 D164 T189 R14 D133 K135 Q137 N138 D151 T154 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=1.000000nM O43353 26320862 1000 ALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQS 4qrc A 1.901 BS01 0LI A 1 L473 A501 K503 E520 M524 V550 C552 A553 L603 C608 I609 H610 R611 L619 A629 D630 F631 L633 L20 A48 K50 E67 M71 V97 C99 A100 L150 C155 I156 H157 R158 L166 A176 D177 F178 L180 D612 A614 R616 N617 D630 R650 D159 A161 R163 N164 D177 R197 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=6.34, IC50=452nM IC50=8.0nM P22455 25317566 802 LPLDPLWEFPRDRLVLGKPLGEGAFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDEVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 4tyj A 2.45 BS01 0LI A 1 A501 K503 E520 M524 V550 A553 I609 H610 L619 I628 A629 D630 F631 A56 K58 E75 M79 V105 A108 I149 H150 L159 I168 A169 D170 F171 D612 A614 R616 N617 D630 D152 A154 R156 N157 D170 2.7.10.1 0004672,0004713,0005524,0006468 IC50=8.0nM P22455 25219510 801 MGSAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE 4u0i A 2.0 BS01 0LI A 1 L595 A621 V622 K623 E640 T670 Y672 C673 I789 H790 R791 L799 C809 D810 F811 L31 A54 V55 K56 E73 T103 Y105 C106 I153 H154 R155 L163 C173 D174 F175 D792 R796 N797 D810 D156 R160 N161 D174 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169 ic50<11nM -logKd/Ki=8.22, IC50=6nM IC50=1.7nM P10721 25239608 1001 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSLALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTN 4uxq A 1.85 BS01 0LI A 1 L473 V481 A501 K503 E520 M524 I527 I534 V550 A553 I609 H610 R611 L619 I628 A629 D630 F631 L22 V30 A50 K52 E69 M73 I76 I83 V99 A102 I145 H146 R147 L155 I164 A165 D166 F167 D612 A614 R616 N617 D630 D641 R650 D148 A150 R152 N153 D166 D177 R186 2.7.10.1 0004672,0004713,0005524,0006468 Kd=16nM -logKd/Ki=7.80, Kd=16.0nM IC50=8.0nM P22455 25465127 1752 LDLPLDPLWEFPRDRLVLGKPLGEGAFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 4v01 A 2.33 BS01 0LI A 1 A512 K514 E531 M534 M535 I545 V561 Y563 A564 I620 H621 L630 I639 A640 D641 A42 K44 E61 M64 M65 I75 V91 Y93 A94 I136 H137 L146 I155 A156 D157 D623 A625 R627 N628 D641 D139 A141 R143 N144 D157 2.7.10.1 0004672,0004713,0005007,0005524,0006468 -logKd/Ki=8.11, Kd=7.7nM P11362 25465127 1776 LPEDPRWELPRDRLVLGKPLGGQVVLAEAIGLDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 4v01 B 2.33 BS01 0LI B 1 A512 K514 E531 M534 V561 Y563 A564 I620 H621 L630 I639 A640 D641 F642 A47 K49 E66 M69 V96 Y98 A99 I140 H141 L150 I159 A160 D161 F162 D623 A625 R627 N628 D641 D143 A145 R147 N148 D161 2.7.10.1 0004672,0004713,0005007,0005524,0006468 P11362 25465127 1770 SEYELPEDPRWELPRDRLVLGKPLGEGGQVVLAEAIGLDPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN 4v04 A 2.12 BS01 0LI A 1 V492 A512 K514 E531 M534 V561 Y563 A564 L614 C619 I620 H621 R622 L630 I639 A640 D641 G643 L644 V27 A47 K49 E66 M69 V96 Y98 A99 L147 C152 I153 H154 R155 L163 I172 A173 D174 G176 L177 D623 A625 R627 N628 D641 D156 A158 R160 N161 D174 0004672,0004713,0005007,0005524,0006468 Kd=7.7nM -logKd/Ki=8.11, Kd=7.7nM 25465127 1772 YELPEDPRWELPRDRLVLGKPLGEGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 4v04 B 2.12 BS01 0LI B 1 A512 K514 E531 M534 V561 Y563 A564 L614 C619 I620 H621 R622 L630 I639 A640 D641 G643 L644 A55 K57 E74 M77 V104 Y106 A107 L144 C149 I150 H151 R152 L160 I169 A170 D171 G173 L174 D623 A625 R627 N628 D641 D153 A155 R157 N158 D171 0004672,0004713,0005007,0005524,0006468 Kd=7.7nM 25465127 1771 AGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 6eg9 A 2.414 BS01 0LI A 1 A211 E233 M237 Y262 Y264 M265 I308 H309 L318 S328 D329 F330 A48 E67 M71 Y96 Y98 M99 I142 H143 L152 S162 D163 F164 D311 K313 A315 N316 D329 T351 D145 K147 A149 N150 D163 T168 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=66.9nM Q9NWZ3 30679311 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 6eg9 B 2.414 BS01 0LI B 1 M192 A211 K213 E233 M237 V246 Y262 Y264 M265 I308 H309 L318 S328 D329 F330 M28 A47 K49 E66 M70 V79 Y95 Y97 M98 I141 H142 L151 S161 D162 F163 D311 K313 A315 N316 D329 T351 D144 K146 A148 N149 D162 T166 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=66.9nM Q9NWZ3 30679311 501 FHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 6p3d A 2.11 BS01 0LI A 1 A481 K483 E501 L514 I527 T529 W531 C532 I573 H574 F583 G593 D594 F595 A36 K38 E56 L69 I82 T84 W86 C87 I128 H129 F138 G148 D149 F150 D576 K578 N580 N581 D594 S616 D131 K133 N135 N136 D149 S158 2.7.11.1 0004672,0005524,0006468 ic50=14nM P15056 32873792 1001 KMDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATESGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELS 6tu9 A 1.94 BS01 0LI A 1 A504 E523 M527 F552 Y554 I555 V612 H613 L622 S632 D633 A45 E64 M68 F93 Y95 I96 V134 H135 L144 S154 D155 D615 R619 N620 D633 D137 R141 N142 D155 ? 0004672,0005524,0006468 Q01973 32619402 801 KPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWMEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSW 6tu9 B 1.94 BS01 0LI B 1 L479 A504 E523 M527 F552 Y554 I555 V612 H613 L622 S632 D633 L15 A36 E54 M58 F83 Y85 I86 V124 H125 L134 S144 D145 D615 R619 N620 D633 D127 R131 N132 D145 ? 0004672,0005524,0006468 Q01973 32619402 801 AKELPLSAVRFMEELGECAFGKIYKGHLYLHAQLVAIKTLKYNNPQQWMEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWE 7ote A 2.49 BS01 0LI A 1 A296 I297 K298 E313 M317 L325 T341 M344 G347 V386 H387 L396 V405 D407 A36 I37 K38 E53 M57 L65 T81 M84 G87 V126 H127 L136 V145 D147 2.7.10.2 0004672,0004713,0005524,0006468 P12931 37848415 601 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 7ote B 2.49 BS01 0LI B 1 L276 A296 K298 V316 M317 T341 Y343 M344 V386 H387 L396 V405 A406 D407 F408 L16 A36 K38 V56 M57 T81 Y83 M84 V126 H127 L136 V145 A146 D147 F148 2.7.10.2 0004672,0004713,0005524,0006468 P12931 37848415 601 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 7wf5 A 1.798 BS01 0LI A 1 L273 A293 K295 E310 M314 V323 T338 Y340 M341 V383 H384 L393 V402 A403 D404 F405 L17 A37 K39 E54 M58 V67 T82 Y84 M85 V127 H128 L137 V146 A147 D148 F149 2.7.10.2 0004672,0004713,0005524,0006468 P00523 35151199 601 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 7wf5 B 1.798 BS01 0LI B 1 A293 K295 E310 M314 V323 I336 T338 M341 V383 H384 L393 V402 A403 D404 F405 A40 K42 E57 M61 V70 I83 T85 M88 V130 H131 L140 V149 A150 D151 F152 2.7.10.2 0004672,0004713,0005524,0006468 P00523 35151199 601 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 8u8a B 3.4 BS01 0LI B 1 F1890 A1904 K1906 E1920 M1947 L1949 A1950 I1991 Y1992 L2001 A2016 D2017 F1130 A1144 K1146 E1160 M1187 L1189 A1190 I1231 Y1232 L1241 A1256 D1257 2.7.11.1,3.6.5.- 0000139,0000149,0000165,0000287,0001934,0003779,0003924,0004672,0004674,0004706,0004709,0005096,0005515,0005524,0005525,0005615,0005737,0005739,0005741,0005743,0005759,0005764,0005768,0005783,0005789,0005794,0005798,0005802,0005829,0005856,0005886,0005902,0006338,0006468,0006606,0006897,0006914,0006979,0007005,0007029,0007030,0007040,0007154,0007165,0007254,0007266,0007283,0007528,0008017,0008021,0008104,0008340,0009267,0009966,0010468,0010506,0010508,0010955,0010977,0014041,0015631,0016242,0016301,0016310,0016787,0017075,0018105,0018107,0019722,0021756,0021772,0022028,0030154,0030159,0030182,0030276,0030424,0030425,0030426,0030672,0031267,0031398,0031410,0031647,0031966,0032091,0032092,0032436,0032473,0032760,0032839,0034211,0034260,0034599,0034614,0035556,0035564,0035640,0035641,0035751,0036479,0039706,0040012,0042391,0042802,0042803,0042995,0043005,0043025,0043068,0043195,0043204,0043231,0043406,0044024,0044325,0044753,0044754,0045121,0045202,0045335,0045746,0045860,0046039,0046777,0048312,0048812,0051018,0051646,0051770,0051900,0051966,0060070,0060079,0060159,0060161,0060628,0060828,0061001,0070062,0070585,0070971,0070973,0071287,0071407,0090140,0090263,0090394,0097487,0098794,0098978,0099400,0099523,0106310,0140058,0141161,1900242,1900244,1902236,1902499,1902692,1902803,1902823,1902902,1903125,1903215,1903217,1903351,1903980,1904713,1904887,1905279,1905289,1990904,1990909,2000172,2000300,2000377 Q5S007 38263358 2601 GIQKCGLKVISSIVHFPDALGAMDSVLHTLQMYPDDQEIQCLGLSLIGYTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQASSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVPKNYMTQYFKLLEKFQIALVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSV 8u8a C 3.4 BS01 0LI C 1 F1890 A1904 K1906 E1920 M1947 L1949 A1950 I1991 Y1992 L2001 A2016 D2017 F1130 A1144 K1146 E1160 M1187 L1189 A1190 I1231 Y1232 L1241 A1256 D1257 2.7.11.1,3.6.5.- 0000139,0000149,0000165,0000287,0001934,0003779,0003924,0004672,0004674,0004706,0004709,0005096,0005515,0005524,0005525,0005615,0005737,0005739,0005741,0005743,0005759,0005764,0005768,0005783,0005789,0005794,0005798,0005802,0005829,0005856,0005886,0005902,0006338,0006468,0006606,0006897,0006914,0006979,0007005,0007029,0007030,0007040,0007154,0007165,0007254,0007266,0007283,0007528,0008017,0008021,0008104,0008340,0009267,0009966,0010468,0010506,0010508,0010955,0010977,0014041,0015631,0016242,0016301,0016310,0016787,0017075,0018105,0018107,0019722,0021756,0021772,0022028,0030154,0030159,0030182,0030276,0030424,0030425,0030426,0030672,0031267,0031398,0031410,0031647,0031966,0032091,0032092,0032436,0032473,0032760,0032839,0034211,0034260,0034599,0034614,0035556,0035564,0035640,0035641,0035751,0036479,0039706,0040012,0042391,0042802,0042803,0042995,0043005,0043025,0043068,0043195,0043204,0043231,0043406,0044024,0044325,0044753,0044754,0045121,0045202,0045335,0045746,0045860,0046039,0046777,0048312,0048812,0051018,0051646,0051770,0051900,0051966,0060070,0060079,0060159,0060161,0060628,0060828,0061001,0070062,0070585,0070971,0070973,0071287,0071407,0090140,0090263,0090394,0097487,0098794,0098978,0099400,0099523,0106310,0140058,0141161,1900242,1900244,1902236,1902499,1902692,1902803,1902823,1902902,1903125,1903215,1903217,1903351,1903980,1904713,1904887,1905279,1905289,1990904,1990909,2000172,2000300,2000377 Q5S007 38263358 2601 GIQKCGLKVISSIVHFPDALGAMDSVLHTLQMYPDDQEIQCLGLSLIGYTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQASSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVPKNYMTQYFKLLEKFQIALVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSV