1fh0 A 1.6 BS01 0IW A 1 Q19 G23 C25 Q63 N66 G67 G68 F69 A135 D162 H163 W189 Q19 G23 C25 Q63 N66 G67 G68 F69 A136 D163 H164 W190 Q19 C25 H163 N187 Q19 C25 H164 N188 3.4.22.43 0006508,0008234 O60911 11027133 1280 LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSDNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 1fh0 B 1.6 BS01 0IW B 1 Q2019 G2023 C2025 Q2063 G2067 G2068 F2069 A2135 D2162 H2163 W2189 Q19 G23 C25 Q63 G67 G68 F69 A136 D163 H164 W190 Q2019 C2025 H2163 N2187 Q19 C25 H164 N188 3.4.22.43 0006508,0008234 O60911 11027133 2280 LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSDNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 3s3r A 2.64 BS01 0IW A 1 Q94 G98 C100 W101 L139 E142 G143 G144 L146 G269 H270 Q25 G29 C31 W32 L70 E73 G74 G75 L77 G200 H201 Q94 C100 H270 N290 Q25 C31 H201 N221 3.4.22.1 0006508,0008234 -logKd/Ki=8.68, IC50=2.09nM Q8MNY2 21832058 324 VEIPSSFDSRKKWPRCKSIATIRDQSRCGSCWAFGAVEAMSDRSCIQSGGKQNVELSAVDLLSCCESCGLGCEGGILGPAWDYWVKEGIVTGSSKENHAGCEPYPFPKCEHHTKGKYPPCGSKIYKTPRCKQTCQKKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEAGFTVYEDFLNYKSGIYKHITGETLGGHAIRIIGWGVENKAPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVTAGRIN 3s3r A 2.64 BS02 0IW B 1 R79 P83 R10 P14 Q94 C100 H270 N290 Q25 C31 H201 N221 3.4.22.1 0006508,0008234 -logKd/Ki=8.68, IC50=2.09nM Q8MNY2 21832058 324 VEIPSSFDSRKKWPRCKSIATIRDQSRCGSCWAFGAVEAMSDRSCIQSGGKQNVELSAVDLLSCCESCGLGCEGGILGPAWDYWVKEGIVTGSSKENHAGCEPYPFPKCEHHTKGKYPPCGSKIYKTPRCKQTCQKKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEAGFTVYEDFLNYKSGIYKHITGETLGGHAIRIIGWGVENKAPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVTAGRIN 3s3r B 2.64 BS01 0IW B 1 Q94 C100 W101 L139 E142 G143 G144 G269 H270 W292 E316 Q25 C31 W32 L65 E68 G69 G70 G195 H196 W218 E242 Q94 C100 H270 N290 Q25 C31 H196 N216 3.4.22.1 0006508,0008234 Q8MNY2 21832058 324 VEIPSSFDSRKKWPRCKSIATIRDQSRCGSCWAFGAVEAMSDRSCIQSVELSAVDLLSCCESCGLGCEGGILGPAWDYWVKEGIVTGSSKENHAGCEPYPFPKCEHHTKGKYPPCGSKIYKTPRCKQTCQKKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEAGFTVYEDFLNYKSGIYKHITGETLGGHAIRIIGWGVENKAPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVTAGRIN 3s3r C 2.64 BS01 0IW A 1 R79 P83 R9 P13 Q94 C100 H270 N290 Q24 C30 H200 N220 3.4.22.1 0006508,0008234 Q8MNY2 21832058 324 EIPSSFDSRKKWPRCKSIATIRDQSRCGSCWAFGAVEAMSDRSCIQSGGKQNVELSAVDLLSCCESCGLGCEGGILGPAWDYWVKEGIVTGSSKENHAGCEPYPFPKCEHHTKGKYPPCGSKIYKTPRCKQTCQKKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEAGFTVYEDFLNYKSGIYKHITGETLGGHAIRIIGWGVENKAPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVTAGRIN 3s3r C 2.64 BS02 0IW C 1 Q94 G98 C100 G143 G144 L146 G269 H270 W292 Q24 G28 C30 G73 G74 L76 G199 H200 W222 Q94 C100 H270 N290 Q24 C30 H200 N220 3.4.22.1 0006508,0008234 Q8MNY2 21832058 324 EIPSSFDSRKKWPRCKSIATIRDQSRCGSCWAFGAVEAMSDRSCIQSGGKQNVELSAVDLLSCCESCGLGCEGGILGPAWDYWVKEGIVTGSSKENHAGCEPYPFPKCEHHTKGKYPPCGSKIYKTPRCKQTCQKKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEAGFTVYEDFLNYKSGIYKHITGETLGGHAIRIIGWGVENKAPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVTAGRIN 8he9 A 1.55 BS01 0IW A 1 G27 C29 W30 N72 G73 G74 Y75 V176 G198 H199 W221 G28 C30 W31 N73 G74 G75 Y76 V175 G197 H198 W220 3.4.22.1 0006508,0008234 P07858 37990007 301 KLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTD 8hfv A 2.1 BS04 0IW A 1 Q19 G23 C25 E63 N66 G67 G68 L69 A135 M161 D162 H163 W189 Q19 G23 C25 E63 N66 G67 G68 L69 A135 M161 D162 H163 W189 3.4.22.15 0006508,0008234 P07711 37990007 310 APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 8hfv B 2.1 BS04 0IW B 1 Q19 G23 C25 E63 N66 G67 G68 L69 A135 D162 H163 W189 Q19 G23 C25 E63 N66 G67 G68 L69 A135 D162 H163 W185 3.4.22.15 0006508,0008234 P07711 37990007 310 APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 8hfv C 2.1 BS05 0IW C 1 Q19 C25 E63 G67 G68 L69 A135 M161 D162 H163 W189 Q19 C25 E63 G67 G68 L69 A135 M161 D162 H163 W187 3.4.22.15 0006508,0008234 P07711 37990007 310 APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 8hfv D 2.1 BS05 0IW D 1 Q19 C25 E63 G67 G68 L69 A135 M161 D162 H163 W189 Q19 C25 E63 G67 G68 L69 A135 M161 D162 H163 W189 3.4.22.15 0006508,0008234 P07711 37990007 310 APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV