1o6i A 1.7 BS01 0HZ A 1 Y10 G96 W97 D142 E144 M212 Y214 W403 Y8 G94 W95 D140 E142 M210 Y212 W401 D140 D142 E144 Y214 D138 D140 E142 Y212 3.2.1.14 0004553,0005576,0005975,0008061,0030246 Ki=0.65mM -logKd/Ki=3.19, Ki=0.65mM P11797 12323074 1516 TRKAVIGYYFIPTNQINNYTETDTSVVPFPVSNITPAKAKQLTHINFSFLDINSNLECAWDPATNDAKARDVVNRLTALKAHNPSLRIMFSIGGWYYSNDLGVSHANYVNAVKTPASRAKFAQSCVRIMKDYGFDGVDIDWEYPQAAEVDGFIAALQEIRTLLNQQTITDGRQALPYQLTIAGAGGAFFLSRYYSKLAQIVAPLDYINLMTYDLAGPWEKVTNHQAALFGDAAGPTFYNALREANLGWSWEELTRAFPSPFSLTVDAAVQQHLMMEGVPSAKIVMGVPFYGRAFKGVSGGNGGQYSSHSTPGEDPYPSTDYWLVGCEECVRDKDPRIASYRQLEQMLQGNYGYQRLWNDKTKTPYLYHAQNGLFVTYDDAESFKYKAKYIKQQQLGGVMFWHLGQDNRNGDLLAALDRYFNAADYDDSQLDMGTGLRYTGVGPGNLPIMTAPAYVPGTTYAQGALVSYQGYVWQTKWGYITSAPGSDSAWLKVGRV 1o6i B 1.7 BS01 0HZ B 1 Y10 G96 W97 D142 E144 M212 Y214 W403 Y8 G94 W95 D140 E142 M210 Y212 W401 D140 D142 E144 Y214 D138 D140 E142 Y212 3.2.1.14 0004553,0005576,0005975,0008061,0030246 Ki=0.65mM P11797 12323074 1519 TRKAVIGYYFIPTNQINNYTETDTSVVPFPVSNITPAKAKQLTHINFSFLDINSNLECAWDPATNDAKARDVVNRLTALKAHNPSLRIMFSIGGWYYSNDLGVSHANYVNAVKTPASRAKFAQSCVRIMKDYGFDGVDIDWEYPQAAEVDGFIAALQEIRTLLNQQTITDGRQALPYQLTIAGAGGAFFLSRYYSKLAQIVAPLDYINLMTYDLAGPWEKVTNHQAALFGDAAGPTFYNALREANLGWSWEELTRAFPSPFSLTVDAAVQQHLMMEGVPSAKIVMGVPFYGRAFKGVSGGNGGQYSSHSTPGEDPYPSTDYWLVGCEECVRDKDPRIASYRQLEQMLQGNYGYQRLWNDKTKTPYLYHAQNGLFVTYDDAESFKYKAKYIKQQQLGGVMFWHLGQDNRNGDLLAALDRYFNAADYDDSQLDMGTGLRYTGVGPGNLPIMTAPAYVPGTTYAQGALVSYQGYVWQTKWGYITSAPGSDSAWLKVGRVA 5yvk A 1.292 BS01 0HZ A 1 Y49 T72 W73 N76 Y101 Y103 D214 Y22 T45 W46 N49 Y74 Y76 D187 ? 0046872 V5TER4 30222239 301 AVSIPINNAGFENPFMDVVDDYTIDTPPGWTTYDPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLSQNPGSGVAGFEQILDATLEPDTKYTLTVDVGNLAGTFKGLSFAGFPGYRVELLAGDTVLAADHNNLFIKEGEFKTSTVTYTSTAKDLHLGQKLGIRLVNLLQDKFSGLDFDNVRLTTEPT 5z53 A 1.86 BS03 0HZ A 1 D47 Y49 F88 F142 F147 D214 D21 Y23 F62 F116 F121 D188 ? A0A1P8VSI6 30222239 303 SVVSIPINNAGFEDPFIEVVDDYTVDTPPGWTTYNPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLAQKPGSGVAGFEQILDATLEPDTNYTLKVDVGNLAGTFKGLSFAGFPGYRVELLAGDTVLAADHNNLFIKEGEFKTSTVTYTSTAKDLHLGQKLGIRLVNLLQDKFSGLDFDNVRLTAEPT 5z53 B 1.86 BS03 0HZ B 1 Y49 T72 W73 N76 Y101 Y103 L138 D214 Y23 T46 W47 N50 Y75 Y77 L112 D188 ? A0A1P8VSI6 30222239 303 SVVSIPINNAGFEDPFIEVVDDYTVDTPPGWTTYNPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLAQKPGSGVAGFEQILDATLEPDTNYTLKVDVGNLAGTFKGLSFAGFPGYRVELLAGDTVLAADHNNLFIKEGEFKTSTVTYTSTAKDLHLGQKLGIRLVNLLQDKFSGLDFDNVRLTAEPT 5z53 C 1.86 BS03 0HZ C 1 Y49 T72 W73 I99 Y101 Y103 L138 D214 Y23 T46 W47 I73 Y75 Y77 L112 D188 ? A0A1P8VSI6 30222239 303 SVVSIPINNAGFEDPFIEVVDDYTVDTPPGWTTYNPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLAQKPGSGVAGFEQILDATLEPDTNYTLKVDVGNLAGTFKGLSFAGFPGYRVELLAGDTVLAADHNNLFIKEGEFKTSTVTYTSTAKDLHLGQKLGIRLVNLLQDKFSGLDFDNVRLTAEPT 5z53 D 1.86 BS03 0HZ D 1 Y49 W73 Y101 Y103 L138 D214 Y23 W47 Y75 Y77 L112 D188 ? A0A1P8VSI6 30222239 303 SVVSIPINNAGFEDPFIEVVDDYTVDTPPGWTTYNPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLAQKPGSGVAGFEQILDATLEPDTNYTLKVDVGNLAGTFKGLSFAGFPGYRVELLAGDTVLAADHNNLFIKEGEFKTSTVTYTSTAKDLHLGQKLGIRLVNLLQDKFSGLDFDNVRLTAEPTE 5z54 A 2.16 BS03 0HZ A 1 Y49 N76 F88 Y101 Y103 F138 F210 D214 Y23 N50 F62 Y75 Y77 F112 F184 D188 ? A0A076NBW8 30222239 303 SVVSIPINNAGFEDPFIEVVDDYTVDTPPGWTTYNPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLAQKPGSGVAGFEQILDATLEPDTKYTLKVDVGNFGGEFQKISLAGFPGYRVELLAGDTVLAADHNNLYIKDGEFKTSTVTFTATPDNPYLDQKLGIRLINLLQGTFSGLDFDNVRLTVEPA 5z54 B 2.16 BS03 0HZ B 1 Y49 T72 N76 Y101 F138 D214 Y23 T46 N50 Y75 F112 D188 ? A0A076NBW8 30222239 303 SVVSIPINNAGFEDPFIEVVDDYTVDTPPGWTTYNPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLAQKPGSGVAGFEQILDATLEPDTKYTLKVDVGNFGGEFQKISLAGFPGYRVELLAGDTVLAADHNNLYIKDGEFKTSTVTFTATPDNPYLDQKLGIRLINLLQGTFSGLDFDNVRLTVEPA 5z54 C 2.16 BS03 0HZ C 1 Y49 T72 W73 Y101 F138 F210 D214 Y22 T45 W46 Y74 F111 F183 D187 ? A0A076NBW8 30222239 303 VVSIPINNAGFEDPFIEVVDDYTVDTPPGWTTYNPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLAQKPGSGVAGFEQILDATLEPDTKYTLKVDVGNFGGEFQKISLAGFPGYRVELLAGDTVLAADHNNLYIKDGEFKTSTVTFTATPDNPYLDQKLGIRLINLLQGTFSGLDFDNVRLTVEPA 5z54 D 2.16 BS03 0HZ D 1 Y49 T72 W73 Y101 F138 F142 F210 D214 Y22 T45 W46 Y74 F111 F115 F183 D187 ? A0A076NBW8 30222239 303 VVSIPINNAGFEDPFIEVVDDYTVDTPPGWTTYNPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLAQKPGSGVAGFEQILDATLEPDTKYTLKVDVGNFGGEFQKISLAGFPGYRVELLAGDTVLAADHNNLYIKDGEFKTSTVTFTATPDNPYLDQKLGIRLINLLQGTFSGLDFDNVRLTVEPA 6j03 A 1.48 BS01 0HZ A 1 Y49 T72 W73 N76 G80 Y89 Y101 Y103 Y23 T46 W47 N50 G54 Y63 Y75 Y77 ? 0046872 V5TER4 301 SAVSIPINNAGFENPFMDVVDDYTIDTPPGWTTYDPNNLVPEKRTTWTSNNGVGYVGPGTQFYNQLAPEGRNIGYIYLSQNPGSGVAGFEQCLDATLEPDTKYTLTVDVGALAGTFKGLSFAGFPGYRVELLAGDTVLAADHNNLFIKEGEFKTSTVTYTSTAKDLHLGQKLGIRLVNLLQDKFSGLDFDNVRLTTEPTE