3v5l A 1.86 BS01 0G1 A 1 I369 V377 A389 F435 F437 M438 H440 G441 C442 L489 I15 V21 A33 F75 F77 M78 H80 G81 C82 L129 D482 A484 R486 N487 D500 P521 D122 A124 R126 N127 D140 P145 2.7.10.2 0004672,0004713,0004715,0005524,0006468 ic50=7nM -logKd/Ki=8.15, IC50=7.0nM IC50=7nM Q08881 22464456 701 GSVIDPSELTFVQEIGSGGLVHLGYWLNKDKVAIKTIMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIA 3v5l B 1.86 BS01 0G1 B 1 I369 V377 A389 F435 F437 M438 H440 G441 L489 I15 V19 A31 F73 F75 M76 H78 G79 L127 D482 A484 R486 N487 D500 P521 D120 A122 R124 N125 D138 P143 2.7.10.2 0004672,0004713,0004715,0005524,0006468 ic50=7nM IC50=7nM Q08881 22464456 701 GSVIDPSELTFVQEIGSLVHLGYWLNKDKVAIKTIRSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESG 3v5l C 1.86 BS01 0G1 C 1 I369 V377 A389 F435 F437 M438 H440 G441 L489 I15 V20 A32 F78 F80 M81 H83 G84 L132 D482 A484 R486 N487 D500 P521 D125 A127 R129 N130 D143 P149 2.7.10.2 0004672,0004713,0004715,0005524,0006468 ic50=7nM IC50=7nM Q08881 22464456 701 GSVIDPSELTFVQEIGSGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIA 3v5l D 1.86 BS01 0G1 D 1 I369 V377 A389 F435 F437 M438 G441 C442 L489 I15 V22 A34 F78 F80 M81 G84 C85 L132 D482 A484 R486 N487 D500 P521 D125 A127 R129 N130 D143 P148 2.7.10.2 0004672,0004713,0004715,0005524,0006468 ic50=7nM IC50=7nM Q08881 22464456 701 GSVIDPSELTFVQEIGSGQGLVHLGYWLNKDKVAIKTIRAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESG