3v1x A 1.955 BS02 0FV A 1 E193 R300 N304 F305 C308 N345 S349 K352 E353 R433 Y434 E72 R171 N175 F176 C179 N216 S220 K223 E224 R304 Y305 4.2.3.118 0010333,0016829,0042214,0046872 Q9F1Y6 22455514 503 GRAVPGLYHHPVPEPDPVRVEEVSRRIKRWAEDEVQLYPFDGFSVGRYMVGCHPDAPTVDHLMLATRLMVAENAVDDSPVGLGGRLLLAHTAIDHFHSTAEYTPTWQASLAADAPRRAYDSAMGYFVRAATPSQSDRYRHDMARLHLGYLAEGAWAQTGHVPEVWEYLAMRQFNNFRPCPTITDTVGGYELPADLHARPDMQRVIALAGNATTIVNDLYSYTKELNSPGRHLNLPVVIAEREQLCERDAYLKAVEVHNELQHSFEAAAADLAEACPLPPVLRFLRGVAAWVDGNHDWHRTNTYRYSLPDFW 5nx5 A 1.82 BS01 0FV A 1 F76 D79 N218 K225 F64 D67 N202 K209 T75 F76 D79 D83 R157 R172 N218 S222 K225 D226 Q229 W302 G303 T63 F64 D67 D71 R141 R156 N202 S206 K209 D210 Q213 W285 G286 4.2.3.26 0000287,0016829,0033383,0034008,0045338,0046872 D5SL78 28966840 402 RVSPDLARARARHLDWVHAMDLVRGEEARRRYEFSCVADIGAYGYPHATGADLDLCVDVLGWTFLFDDQFDRERDALAVCAELTDLLWKGTAATAASPPIVVAFSDCWERMRAGMSDAWRRRTVHEWVDYLAGWPTKLADRAHGAVLDPAAHLRARHRTICCRPLFALAERVGGYEVPRRAWHSSRLDGMRFTTSDAVIGMNELHSFEKDRAQHANLVLSLVHHGGLTGPEAVTRVCDLVQGSIESFLRLRSGLPELGRALGVEGAVLDRYADALSAFCRGYHDWGR 5nx7 A 1.51 BS01 0FV A 1 F77 R174 L183 I216 N220 S224 K227 E228 W308 R314 Y315 F74 R161 L170 I203 N207 S211 K214 E215 W295 R301 Y302 F77 F78 D81 D85 R159 R174 G178 N220 S224 K227 E228 H231 W308 C309 R314 F74 F75 D78 D82 R148 R161 G165 N207 S211 K214 E215 H218 W295 C296 R301 4.2.3.108 0000287,0016829,0033383,0046872,0102313 B5GMG2 28966840 400 GHEEFDIPFPSRVNPFHARAEDRHVAWMRAMGLITGDAAEATYRRWSPAKVGARWFYLAQGEDLDLGCDIFGWFFAYDDHFDGTAAFVNRTVAMLDPRADPTGEHPLNIAFHDLWQRESAPMSPLWQRRAVDHWTQYLTAHITEATNRTRSPTIADYLELRHRTGFMPPLLDLIERVWRAEIPAPVYTTPEVQTLLHTTNQNINIVNDVLSLEKEEAHGDPHNLVLVIQHERQSTRQQALATARRMIDEWTDTFIRTEPRLPALCGRLGIPLADRTSLYTAVEGMRAAIRGNYDWCAETNRYVHRTPW 5nx7 B 1.51 BS01 0FV B 1 F77 R174 I216 N220 S224 K227 E228 R314 Y315 F74 R159 I201 N205 S209 K212 E213 R299 Y300 F77 F78 D81 D85 R159 R174 G178 N220 S224 K227 E228 H231 W308 C309 R314 F74 F75 D78 D82 R148 R159 G163 N205 S209 K212 E213 H216 W293 C294 R299 4.2.3.108 0000287,0016829,0033383,0046872,0102313 B5GMG2 28966840 400 GHEEFDIPFPSRVNPFHARAEDRHVAWMRAMGLITGDAAEATYRRWSPAKVGARWFYLAQGEDLDLGCDIFGWFFAYDDHFDGTAAFVNRTVAMLDPRADPTGEHPLNIAFHDLWQRESAPMSPLWQRRAVDHWTQYLTAHITEATNRTPTIADYLELRHRTGFMPPLLDLIERVWRAEIPAPVYTTPEVQTLLHTTNQNINIVNDVLSLEKEEAHGDPHNLVLVIQHERQSTRQQALATARRMIDEWTDTFIRTEPRLPALCGRLGIPLADRTSLYTAVEGMRAAIRGNYDWCAETNRYVHRPTPW 5uv1 A 2.4 BS03 0FV A 1 W315 I336 D343 T446 F484 R485 D488 W248 I269 D276 T379 F417 R418 D421 R306 W315 I336 D343 D347 S444 I445 T446 R485 D488 T492 Y565 R239 W248 I269 D276 D280 S377 I378 T379 R418 D421 T425 Y492 4.2.3.20 0000287,0009507,0010333,0016102,0016829,0034002,0046872 Ki=2.4uM -logKd/Ki=5.62, Ki=2.4uM A0A1C9J6A7 28272876 704 SIWDHDFLQSLNSNYTDETYKRRAEELKGKVKTAIKDVTEPLDQLELIDNLQRLGLAYHFEPEIRNILRNIHNHNKDYNWRKENLYATSLEFRLLRQHGYPVSQEVFSGFKDDKVGFICDDFKGILSLHEASYYSLEGESIMEEAWQFTSKHLKEMMIDVFVAEQAKRALELPLHWKAPMLEARWFIHVYEKREDKNHLLLELAKLEFNTLQAIYQEELKDISGWWKDTGLGEKLSFARNRLVASFLWSMGIAFEPQFAYCRRVLTISIALITVIDDIYDVYGTLDELEIFTDAVARWDINYALKHLPGYMKMCFLALYNFVNEFAYYVLKQQDFDMLLSIKHAWLGLIQAYLVEAKWYHSKYTPKLEEYLENGLVSITGPLIITISYLSGTNPIIKKELEFLESNPDIVHWSSKIFRLQDDLGTSSDVPKSIQCYMHETGASEEVAREHIKDMMRQMWKKVNAYTADKDSPLTRTTAEFLLNLVRMSHFMYLHGDVGFTLLFQPIPL