3vc4 A 2.23 BS01 0FS A 1 L44 V52 K67 R122 L174 I185 D186 L12 V20 K35 R90 L142 I153 D154 D167 K169 N172 D186 L193 T204 D135 K137 N140 D154 L161 T172 2.7.11.1 0004672,0004674,0005515,0005524,0005634,0005654,0005730,0005737,0005829,0005886,0006338,0006468,0006915,0008134,0016310,0022898,0030145,0043024,0043066,0043433,0044024,0045824,0045893,0046777,0046872,0050821,0060045,0070561,0071346,0090336,0106310,1902033,1904263,1905062,1990748 ic50=24nM -logKd/Ki=7.62, IC50=24nM IC50=17nM P11309 22339127 1 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS