3uyt A 2.0 BS01 0CK A 1 I15 I23 A36 M80 M82 L85 L135 I148 I11 I19 A32 M73 M75 L78 L128 I141 D128 K130 D121 K123 2.7.11.1,2.7.11.26 0004672,0005524,0006468 -logKd/Ki=7.85, IC50~14nM IC50=13nM P48730 22168824 295 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK 3uyt B 2.0 BS01 0CK B 1 I15 I23 A36 Y56 M80 M82 L84 L85 L135 I148 I11 I19 A32 Y49 M73 M75 L77 L78 L128 I141 D128 K130 D121 K123 2.7.11.1,2.7.11.26 0004672,0005524,0006468 IC50=13nM P48730 22168824 295 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML 3uyt C 2.0 BS01 0CK C 1 I23 A36 M80 M82 L85 I20 A33 M77 M79 L82 D128 K130 D125 K127 2.7.11.1,2.7.11.26 0004672,0005524,0006468 IC50=13nM P48730 22168824 295 RVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK 3uyt D 2.0 BS01 0CK D 1 I23 A36 K38 M80 M82 L84 L85 L135 I148 I20 A33 K35 M77 M79 L81 L82 L132 I145 D128 K130 D125 K127 2.7.11.1,2.7.11.26 0004672,0005524,0006468 IC50=13nM P48730 22168824 295 RVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK 3uzp A 1.94 BS01 0CK A 1 I23 A36 K38 M80 M82 L85 L135 I148 I21 A34 K36 M78 M80 L83 L133 I146 D128 K130 D126 K128 2.7.11.1,2.7.11.26 0004672,0005524,0006468 -logKd/Ki=7.89, IC50=13nM IC50=13nM P48730 22168824 295 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK 3uzp B 1.94 BS01 0CK B 1 I23 A36 K38 M80 M82 L85 L135 I148 I18 A31 K33 M70 M72 L75 L125 I138 D128 K130 D118 K120 2.7.11.1,2.7.11.26 0004672,0005524,0006468 IC50=13nM P48730 22168824 295 LRVGNRYRLGRKIGSGDIYLGTDIAAGEEVAIKLECVKTHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK