3unk A 2.1 BS01 0BY A 1 I10 V18 A31 K33 F80 F82 L83 H84 K89 N132 L134 D145 I10 V18 A31 K33 F77 F79 L80 H81 K86 N129 L131 D142 D127 K129 Q131 N132 D145 T158 T165 D124 K126 Q128 N129 D142 T155 T162 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 ic50=15uM -logKd/Ki=4.82, IC50=15uM P24941 22248356 299 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 3uo6 A 2.8002 BS01 0BY A 1 R137 L139 L194 Y212 A213 G216 T217 L263 V279 R12 L14 L69 Y87 A88 G91 T92 L138 V154 D256 K258 E260 N261 D274 T292 D131 K133 E135 N136 D149 T167 2.7.11.1 0000212,0000226,0000278,0004672,0005524,0006468,0007052,0007098,0007100,0051321 -logKd/Ki=7.82, Kd=15nM IC50=2.5nM, Kd=15nM O14965 22248356 1 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRDTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK 3uo6 B 2.8002 BS01 0BY B 1 R137 L139 L194 Y212 A213 G216 T217 L263 V279 R12 L14 L69 Y87 A88 G91 T92 L138 V154 D256 K258 E260 N261 D274 T292 D131 K133 E135 N136 D149 T167 2.7.11.1 0000212,0000226,0000278,0004672,0005524,0006468,0007052,0007098,0007100,0051321 IC50=2.5nM, Kd=15nM O14965 22248356 2 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRDTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK