3upf A 2.6 BS01 0BU A 1 W42 D65 Q66 P69 E168 V170 K171 K174 K180 R182 R245 R392 W41 D64 Q65 P68 E167 V169 K170 K173 K179 R181 R244 R389 2.7.7.48,3.4.22.66,3.6.1.15 0003723,0003968,0004386,0005524,0006351,0039694 -logKd/Ki=6.70, IC50=200nM Q80J95 22446684 600 LPRPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDERVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRAILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSCPCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLELDMVKYTMALRRYGLLPTRADKEEPLERRQTLQGISFLRRAIVGDQFGWYGRLDRASIDRQLLWTKGPNHQNPFETLPGHRPQLMALLGEAAMHGEKYYRTVASRVSKEAAVVPRHRSVLRWVRFG 3upf B 2.6 BS01 0BU B 1 W42 D65 K68 V170 K171 K174 K178 R245 R392 W41 D64 K67 V169 K170 K173 K177 R244 R390 2.7.7.48,3.4.22.66,3.6.1.15 0003723,0003968,0004386,0005524,0006351,0039694 Q80J95 22446684 600 LPRPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDERVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRAILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLELDMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGWYGRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHGEKYYRTVASRVSKEAAQSGVVPRHRSVLRWVRFG 3upf C 2.6 BS01 0BU C 1 W42 D65 Q66 P69 E168 V170 K171 K174 K178 K180 R182 R245 R392 W38 D61 Q62 P65 E164 V166 K167 K170 K174 K176 R178 R241 R386 2.7.7.48,3.4.22.66,3.6.1.15 0003723,0003968,0004386,0005524,0006351,0039694 Q80J95 22446684 600 PSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDERVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRAILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLELDMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGWYGRLDRASIDRQLLWTKGPNHQNPFETLPGQRPSQLMALLGEAAMHGEKYYRTVASRVSKEVPRHRSVLRWVRFG 4mtz A 2.1 BS02 0BU C 1 R62 C66 H67 S87 P88 N89 R42 C46 H47 S67 P68 N69 2.3.2.27 P98170 3102 EEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYL 4mtz B 2.1 BS02 0BU D 1 R1062 C1066 H1067 S1087 P1088 N1089 R41 C45 H46 S66 P67 N68 2.3.2.27 P98170 3102 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYL 4mtz C 2.1 BS02 0BU C 1 R3062 C3066 H3067 S3087 P3088 N3089 R41 C45 H46 S66 P67 N68 2.3.2.27 P98170 3102 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYL 4mtz D 2.1 BS02 0BU D 1 R3062 C3066 H3067 S3087 P3088 N3089 R41 C45 H46 S66 P67 N68 2.3.2.27 P98170 3102 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYL