3uic A 2.5 BS02 09T A 1 Y146 Y156 A196 I200 F203 M206 Y145 Y155 A195 I199 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL 3uic B 2.5 BS02 09T B 1 Y146 Y156 A196 I200 F203 M206 Y145 Y155 A195 I199 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGN 3uic C 2.5 BS02 09T C 1 A92 F93 Y146 Y156 A196 I200 F203 A91 F92 Y145 Y155 A195 I199 F202 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL 3uic D 2.5 BS02 09T D 1 F93 Y146 Y156 M159 A196 F203 M206 F92 Y145 Y155 M158 A195 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMG 3uic E 2.5 BS02 09T E 1 L99 Y146 S155 Y156 A196 I200 F203 M206 L98 Y145 S154 Y155 A195 I199 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNV 3uic F 2.5 BS02 09T F 1 Y146 Y156 M159 A196 I200 F203 M206 Y145 Y155 M158 A195 I199 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL 3uic G 2.5 BS02 09T G 1 Y146 S155 Y156 M159 I200 F203 M206 Y145 S154 Y155 M158 I199 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGN 3uic H 2.5 BS02 09T H 1 Y146 Y156 A196 F203 M206 Y145 Y155 A195 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL 3uic I 2.5 BS02 09T I 1 F93 Y146 Y156 A196 F203 F92 Y145 Y155 A195 F202 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL 3uic J 2.5 BS02 09T J 1 F93 Y146 Y156 M159 A196 F203 M206 F92 Y145 Y155 M158 A195 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGN 3uic K 2.5 BS02 09T K 1 Y146 Y156 A196 I200 F203 M206 Y145 Y155 A195 I199 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL 3uic L 2.5 BS02 09T L 1 Y146 Y156 A196 I200 F203 M206 Y145 Y155 A195 I199 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGN 3uic M 2.5 BS02 09T M 1 F93 Y146 S155 Y156 M159 F203 F92 Y145 S154 Y155 M158 F202 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGN 3uic N 2.5 BS02 09T N 1 Y146 Y156 A196 I200 F203 M206 Y145 Y155 A195 I199 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL 3uic O 2.5 BS02 09T O 1 L99 Y146 S155 Y156 A196 I200 F203 M206 L98 Y145 S154 Y155 A195 I199 F202 M205 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMG 3uic P 2.5 BS02 09T P 1 Y146 Y156 M159 A196 I200 F203 Y145 Y155 M158 A195 I199 F202 M28 A33 C51 N55 P56 A57 D117 T145 Y156 M159 K163 T194 M27 A32 C50 N54 P55 A56 D116 T144 Y155 M158 K162 T193 1.3.1.9 0000166,0004318,0006633,0016491 Ki=360nM Q5NGQ3 22642319 262 GFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL