3u8m A 2.7 BS01 09R A 1 Y89 W143 T144 Y185 Y192 Y89 W143 T144 Y181 Y188 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 -logKd/Ki=8.89, Ki=1.3nM Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR 3u8m A 2.7 BS02 09R E 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 -logKd/Ki=8.89, Ki=1.3nM Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR 3u8m B 2.7 BS01 09R A 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 -logKd/Ki=8.89, Ki=1.3nM Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m B 2.7 BS02 09R B 1 Y89 W143 T144 Y185 C187 Y192 Y89 W143 T144 Y179 C181 Y186 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 -logKd/Ki=8.89, Ki=1.3nM Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m C 2.7 BS01 09R B 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR 3u8m C 2.7 BS02 09R C 1 Y89 W143 T144 Y192 Y89 W143 T144 Y187 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR 3u8m D 2.7 BS01 09R C 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m D 2.7 BS02 09R D 1 Y89 W143 T144 Y192 Y89 W143 T144 Y189 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m E 2.7 BS01 09R D 1 W53 A103 R104 L112 M114 W51 A99 R100 L108 M110 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m E 2.7 BS02 09R E 1 Y89 W143 T144 Y185 Y192 Y85 W139 T140 Y176 Y183 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m F 2.7 BS01 09R F 1 Y89 W143 T144 Y185 Y192 Y89 W143 T144 Y183 Y190 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTEDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRS 3u8m F 2.7 BS02 09R J 1 W53 R104 L112 M114 W53 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTEDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRS 3u8m G 2.7 BS01 09R F 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m G 2.7 BS02 09R G 1 Y89 W143 T144 Y192 Y89 W143 T144 Y186 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m H 2.7 BS01 09R G 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m H 2.7 BS02 09R H 1 Y89 W143 T144 Y192 Y89 W143 T144 Y185 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m I 2.7 BS01 09R H 1 W53 R104 L112 M114 W53 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRS 3u8m I 2.7 BS02 09R I 1 Y89 W143 T144 Y185 C187 Y89 W143 T144 Y182 C184 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRS 3u8m J 2.7 BS01 09R I 1 A103 R104 L112 M114 A103 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 3u8m J 2.7 BS02 09R J 1 Y89 W143 T144 Y192 Y89 W143 T144 Y189 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 3u8m K 2.7 BS01 09R K 1 Y89 W143 T144 Y185 C187 Y192 Y89 W143 T144 Y181 C183 Y188 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSE 3u8m K 2.7 BS02 09R O 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSE 3u8m L 2.7 BS01 09R K 1 A103 R104 L112 M114 A103 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRS 3u8m L 2.7 BS02 09R L 1 Y89 W143 T144 Y192 Y89 W143 T144 Y188 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRS 3u8m M 2.7 BS01 09R L 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m M 2.7 BS02 09R M 1 Y89 W143 T144 Y185 Y192 Y89 W143 T144 Y180 Y187 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m N 2.7 BS01 09R M 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 3u8m N 2.7 BS02 09R N 1 Y89 W143 T144 Y192 Y89 W143 T144 Y189 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 3u8m O 2.7 BS01 09R N 1 W53 R104 L112 M114 W53 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 3u8m O 2.7 BS02 09R O 1 Y89 W143 Y185 Y192 Y89 W143 Y178 Y185 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 3u8m P 2.7 BS01 09R P 1 Y89 W143 T144 Y185 Y192 Y89 W143 T144 Y180 Y187 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m P 2.7 BS02 09R T 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m Q 2.7 BS01 09R P 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m Q 2.7 BS02 09R Q 1 Y89 W143 T144 Y185 Y192 Y89 W143 T144 Y179 Y186 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m R 2.7 BS01 09R Q 1 W53 R104 L112 M114 W53 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m R 2.7 BS02 09R R 1 Y89 W143 T144 Y192 Y89 W143 T144 Y186 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m S 2.7 BS01 09R R 1 W53 R104 L112 M114 W53 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m S 2.7 BS02 09R S 1 Y89 W143 T144 Y185 Y192 Y89 W143 T144 Y180 Y187 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m T 2.7 BS01 09R S 1 R104 L112 M114 R104 L112 M114 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 3u8m T 2.7 BS02 09R T 1 Y89 W143 T144 Y192 Y89 W143 T144 Y187 ? 0004888,0005216,0005230,0005231,0005576,0006811,0007165,0007268,0016020,0034220,0042391,0043005,0043083,0045202,0050877,0060078,0060079,0098794,1904315 Ki=1.3nM P58154 22170047 211 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 A 2.703 BS01 09R A 1 Y89 W143 Y185 C187 Y192 Y88 W142 Y179 C181 Y186 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRS 4um3 a 2.703 BS01 09R Z 1 W53 H104 Q112 T114 W51 H102 Q110 T112 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 a 2.703 BS02 09R a 1 Y89 W143 Y185 C187 Y192 Y87 W141 Y177 C179 Y184 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 A 2.703 BS02 09R E 1 H104 Q112 T114 H103 Q111 T113 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRS 4um3 b 2.703 BS01 09R a 1 A103 H104 Q112 T114 A103 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 B 2.703 BS01 09R A 1 H104 Q112 T114 H103 Q111 T113 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 B 2.703 BS02 09R B 1 Y89 W143 Y185 C187 C188 Y192 Y88 W142 Y178 C180 C181 Y185 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 b 2.703 BS02 09R b 1 Y89 W143 Y185 C187 Y192 Y89 W143 Y178 C180 Y185 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 c 2.703 BS01 09R b 1 W53 H104 Q112 T114 W51 H102 Q110 T112 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 C 2.703 BS01 09R B 1 W53 H104 Q112 T114 W53 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR 4um3 c 2.703 BS02 09R c 1 Y89 W143 C187 Y192 Y87 W141 C182 Y187 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 C 2.703 BS02 09R C 1 Y89 W143 C187 Y192 Y89 W143 C182 Y187 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR 4um3 D 2.703 BS01 09R C 1 A103 H104 Q112 T114 A103 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 d 2.703 BS01 09R c 1 W53 H104 Q112 T114 W51 H102 Q110 T112 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 d 2.703 BS02 09R d 1 Y89 W143 Y185 C187 Y192 Y87 W141 Y178 C180 Y185 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 D 2.703 BS02 09R D 1 Y89 W143 Y185 C187 Y192 Y89 W143 Y181 C183 Y188 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 E 2.703 BS01 09R D 1 W53 A103 H104 Q112 T114 W50 A100 H101 Q109 T111 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 e 2.703 BS01 09R f 1 Y89 W143 Y192 Y89 W143 Y185 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 E 2.703 BS02 09R E 1 Y89 W143 Y185 C187 Y192 Y86 W140 Y175 C177 Y182 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 e 2.703 BS02 09R i 1 W53 H104 Q112 T114 W53 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 f 2.703 BS01 09R f 1 W53 H104 Q112 T114 W51 H102 Q110 T112 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 F 2.703 BS01 09R F 1 Y89 W143 C187 Y192 Y87 W141 C178 Y183 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 f 2.703 BS02 09R f 2 Y89 W143 C187 Y192 Y87 W141 C178 Y183 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 302 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 F 2.703 BS02 09R J 1 H104 Q112 T114 H102 Q110 T112 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 G 2.703 BS01 09R F 1 W53 H104 Q112 T114 W53 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 g 2.703 BS01 09R f 2 W53 A103 H104 Q112 W53 A103 H104 Q112 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 302 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 g 2.703 BS02 09R g 1 Y89 W143 Y185 C187 Y192 Y89 W143 Y179 C181 Y186 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 G 2.703 BS02 09R G 1 Y89 W143 Y185 C187 Y192 Y89 W143 Y180 C182 Y187 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 H 2.703 BS01 09R G 1 W53 H104 Q112 T114 W50 H101 Q109 T111 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 h 2.703 BS01 09R g 1 W53 H104 Q112 W51 H102 Q110 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 h 2.703 BS02 09R h 1 Y89 W143 C187 Y192 Y87 W141 C182 Y187 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 H 2.703 BS02 09R H 1 Y89 W143 Y185 C187 Y192 Y86 W140 Y177 C179 Y184 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 i 2.703 BS01 09R h 1 W53 H104 Q112 T114 W50 H101 Q109 T111 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 I 2.703 BS01 09R H 1 W53 H104 Q112 T114 W53 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 i 2.703 BS02 09R i 1 Y89 W143 C187 Y192 Y86 W140 C179 Y184 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 I 2.703 BS02 09R I 1 Y89 W143 Y185 C187 Y192 Y89 W143 Y180 C182 Y187 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 J 2.703 BS01 09R I 1 A103 H104 Q112 T114 A103 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 j 2.703 BS01 09R j 1 Y89 W143 Y185 C187 Y192 Y89 W143 Y179 C181 Y186 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 J 2.703 BS02 09R J 1 Y89 W143 Y185 C187 Y192 Y89 W143 Y180 C182 Y187 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 j 2.703 BS02 09R n 1 W53 A103 H104 Q112 T114 W53 A103 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 k 2.703 BS01 09R j 1 H104 Q112 H103 Q111 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 K 2.703 BS01 09R K 1 Y89 W143 C187 Y192 Y86 W140 C179 Y184 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 k 2.703 BS02 09R k 1 Y89 W143 Y185 C187 Y192 Y88 W142 Y178 C180 Y185 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 K 2.703 BS02 09R O 1 W53 A103 H104 Q112 W50 A100 H101 Q109 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 L 2.703 BS01 09R K 1 W53 H104 Q112 T114 W50 H101 Q109 T111 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 l 2.703 BS01 09R k 1 W53 H104 Q112 W53 H104 Q112 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 l 2.703 BS02 09R l 1 Y89 W143 C187 Y192 Y89 W143 C182 Y187 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 L 2.703 BS02 09R L 1 Y89 W143 Y185 C187 Y192 Y86 W140 Y176 C178 Y183 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 M 2.703 BS01 09R L 1 A103 H104 Q112 T114 A102 H103 Q111 T113 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 m 2.703 BS01 09R l 1 H104 Q112 T114 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 M 2.703 BS02 09R M 1 Y89 W143 Y185 C187 Y192 Y88 W142 Y179 C181 Y186 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 m 2.703 BS02 09R m 1 Y89 W143 Y185 C187 Y89 W143 Y181 C183 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 N 2.703 BS01 09R M 1 H104 Q112 H101 Q109 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 n 2.703 BS01 09R m 1 W53 H104 Q112 T114 W50 H101 Q109 T111 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 n 2.703 BS02 09R n 1 Y89 W143 Y185 C187 Y192 Y86 W140 Y176 C178 Y183 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 N 2.703 BS02 09R N 1 Y89 W143 Y185 C187 Y192 Y86 W140 Y176 C178 Y183 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 O 2.703 BS01 09R N 1 W53 H104 Q112 T114 W50 H101 Q109 T111 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 O 2.703 BS02 09R O 1 Y89 W143 Y185 C187 Y192 Y86 W140 Y177 C179 Y184 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 P 2.703 BS01 09R P 1 Y89 W143 Y185 C187 Y192 Y88 W142 Y180 C182 Y187 ? 0004888,0005216,0005230,0006811,0016020,0034220 -logKd/Ki=7.54, Ki=29nM Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR 4um3 P 2.703 BS02 09R T 1 W53 H104 Q112 T114 W52 H103 Q111 T113 ? 0004888,0005216,0005230,0006811,0016020,0034220 -logKd/Ki=7.54, Ki=29nM Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGR 4um3 Q 2.703 BS01 09R P 1 W53 H104 Q112 T114 W50 H101 Q109 T111 ? 0004888,0005216,0005230,0006811,0016020,0034220 -logKd/Ki=7.54, Ki=29nM Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 Q 2.703 BS02 09R Q 1 Y89 W143 Y185 C187 C188 Y192 Y86 W140 Y176 C178 C179 Y183 ? 0004888,0005216,0005230,0006811,0016020,0034220 -logKd/Ki=7.54, Ki=29nM Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 R 2.703 BS01 09R Q 1 H104 Q112 T114 H103 Q111 T113 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 R 2.703 BS02 09R R 1 Y89 W143 Y185 C187 Y192 Y88 W142 Y179 C181 Y186 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKK 4um3 S 2.703 BS01 09R R 1 A103 H104 Q112 T114 A103 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTQSGATCRIKIGSWTHHSREISVDPTSDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 S 2.703 BS02 09R S 1 Y89 W143 Y185 C187 Y192 Y89 W143 Y181 C183 Y188 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTQSGATCRIKIGSWTHHSREISVDPTSDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 T 2.703 BS01 09R S 1 W53 A103 H104 Q112 T114 W51 A99 H100 Q108 T110 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 T 2.703 BS02 09R T 1 Y89 W143 Y185 C187 Y192 Y85 W139 Y174 C176 Y181 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 U 2.703 BS01 09R U 1 Y89 W143 Y185 C187 Y192 Y88 W142 Y177 C179 Y184 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 U 2.703 BS02 09R Y 1 W53 H104 Q112 T114 W52 H103 Q111 T113 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 V 2.703 BS01 09R U 1 W53 A103 H104 Q112 T114 W53 A103 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 V 2.703 BS02 09R V 1 Y89 W143 Y185 C187 Y192 Y89 W143 Y179 C181 Y186 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 302 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 W 2.703 BS01 09R V 1 A103 H104 Q112 T114 A101 H102 Q110 T112 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 302 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 W 2.703 BS02 09R W 1 Y89 W143 Y185 C187 Y192 Y87 W141 Y177 C179 Y184 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 X 2.703 BS01 09R W 1 H104 Q112 T114 H104 Q112 T114 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 X 2.703 BS02 09R X 1 Y89 W143 Y185 C187 C188 Y192 Y89 W143 Y182 C184 C185 Y189 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 Y 2.703 BS01 09R X 1 W53 H104 Q112 T114 W50 H101 Q109 T111 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 Y 2.703 BS02 09R Y 1 Y89 W143 Y185 C187 Y192 Y86 W140 Y177 C179 Y184 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 Z 2.703 BS01 09R Z 1 Y89 W143 C187 Y192 Y87 W141 C178 Y183 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG 4um3 Z 2.703 BS02 09R d 1 A103 H104 Q112 T114 A101 H102 Q110 T112 ? 0004888,0005216,0005230,0006811,0016020,0034220 Ki=1.3nM P58154 26180047 301 LDRADILYNIRQTSRPDVIPTQRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLAHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG