3u9y A 2.3 BS02 09L A 1 H1031 G1032 F1035 I1039 D1045 H1048 A1049 Y1050 I1059 Y1060 S1068 Y1071 I1075 E1138 H80 G81 F84 I88 D94 H97 A98 Y99 I108 Y109 S117 Y120 I124 E185 2.4.2.-,2.4.2.30 0003950 IC50=2340nM Q9H2K2 22233320 1165 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4tkg A 1.95 BS02 09L A 1 H1031 G1032 I1039 H1048 Y1050 I1059 Y1060 F1061 S1068 Y1071 I1075 E1138 H70 G71 I78 H87 Y89 I98 Y99 F100 S107 Y110 I114 E177 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=6.85, IC50=0.140uM IC50=2340nM Q9H2K2 25286857 1202 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4tkg B 1.95 BS02 09L B 1 H1031 G1032 I1039 D1045 H1048 Y1050 I1059 Y1060 S1068 Y1071 I1075 H75 G76 I83 D89 H92 Y94 I103 Y104 S112 Y115 I119 2.4.2.-,2.4.2.30 0003950 IC50=2340nM Q9H2K2 25286857 1202 QGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4tkg C 1.95 BS02 09L C 1 H1031 G1032 H1048 I1059 Y1060 F1061 S1068 Y1071 E1138 H80 G81 H97 I106 Y107 F108 S115 Y118 E185 2.4.2.-,2.4.2.30 0003950 IC50=2340nM Q9H2K2 25286857 1202 ENLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4tkg D 1.95 BS02 09L D 1 H1031 G1032 H1048 A1049 G1058 I1059 Y1060 F1061 S1068 Y1071 E1138 H67 G68 H84 A85 G93 I94 Y95 F96 S103 Y106 E173 2.4.2.-,2.4.2.30 0003950 IC50=2340nM Q9H2K2 25286857 1202 FQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4tvj A 2.1 BS01 09L A 1 E335 H428 G429 R444 Y455 Y462 F463 S470 Y473 E113 H206 G207 R222 Y233 Y240 F241 S248 Y251 K264 A265 I289 F305 T307 S470 Y473 E558 K42 A43 I67 F83 T85 S248 Y251 E336 2.4.2.-,2.4.2.30 0003950 ic50=251nM -logKd/Ki=7.91, IC50=12.3nM IC50=2.8nM, Kd=0.280000nM Q9UGN5 28001384 601 DLGTENLYFQSMDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAHPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNF 4tvj B 2.1 BS01 09L B 1 E335 H428 G429 R444 Y455 Y462 F463 S470 Y473 E110 H200 G201 R216 Y227 Y234 F235 S242 Y245 K264 A265 I289 F305 T307 S470 Y473 E558 K39 A40 I64 F80 T82 S242 Y245 E330 2.4.2.-,2.4.2.30 0003950 ic50=251nM IC50=2.8nM, Kd=0.280000nM Q9UGN5 28001384 601 TENLYFQSMDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAHPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNF 5ds3 A 2.6 BS01 09L A 1 H862 G863 R878 Y889 G894 I895 Y896 F897 K903 S904 Y907 E988 H95 G96 R111 Y122 G127 I128 Y129 F130 K136 S137 Y140 E221 S904 Y907 E988 S137 Y140 E221 2.4.2.-,2.4.2.30 0003950 IC50=6.0nM, EC50=3.6nM, Kd=0.240000nM P09874 26626480 1102 SKLPKPVQDLIKMIFGSGSGSGGDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 7aad A 2.21 BS01 09L A 1 D766 L769 H862 G863 R878 G894 I895 Y896 F897 S904 Y907 E988 D105 L108 H201 G202 R217 G233 I234 Y235 F236 S243 Y246 E327 S904 Y907 E988 S243 Y246 E327 2.4.2.-,2.4.2.30 0003950 IC50=5.0nM, EC50=3.6nM, Kd=0.240000nM P09874 33511412 1101 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 7aad B 2.21 BS01 09L B 1 D766 L769 H862 G863 R878 G894 I895 Y896 F897 S904 Y907 E988 D105 L108 H201 G202 R217 G233 I234 Y235 F236 S243 Y246 E327 S904 Y907 E988 S243 Y246 E327 2.4.2.-,2.4.2.30 0003950 IC50=5.0nM, EC50=3.6nM, Kd=0.240000nM P09874 33511412 1101 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 7kk4 A 1.96 BS01 09L A 1 D766 L769 H862 G863 R878 Y889 Y896 F897 S904 Y907 E988 D101 L104 H192 G193 R208 Y219 Y226 F227 S234 Y237 E318 S904 Y907 E988 S234 Y237 E318 2.4.2.-,2.4.2.30 0003950 IC50=5.0nM, EC50=3.6nM, Kd=0.240000nM P09874 33361107 9001 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 7kk4 B 1.96 BS01 09L B 1 D766 L769 H862 G863 R878 Y889 Y896 F897 K903 S904 Y907 E988 D102 L105 H193 G194 R209 Y220 Y227 F228 K234 S235 Y238 E319 S904 Y907 E988 S235 Y238 E319 2.4.2.-,2.4.2.30 0003950 IC50=5.0nM, EC50=3.6nM, Kd=0.240000nM P09874 33361107 9001 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 7kko A 1.56 BS02 09L A 1 H1184 G1185 I1192 F1197 D1198 H1201 Y1203 I1212 Y1213 F1214 A1215 S1221 Y1224 I1228 H80 G81 I88 F93 D94 H97 Y99 I108 Y109 F110 A111 S117 Y120 I124 2.4.2.-,2.4.2.30 0003950 IC50=1230nM O95271 33361107 1402 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE 7kko B 1.56 BS02 09L B 1 H1184 G1185 F1188 I1192 H1201 Y1203 I1212 Y1213 F1214 S1221 Y1224 E1291 H82 G83 F86 I90 H99 Y101 I110 Y111 F112 S119 Y122 E189 2.4.2.-,2.4.2.30 0003950 IC50=1230nM O95271 33361107 1402 SQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE 7kko C 1.56 BS02 09L C 1 H1184 G1185 I1192 F1197 D1198 H1201 Y1203 I1212 Y1213 S1221 Y1224 I1228 H80 G81 I88 F93 D94 H97 Y99 I108 Y109 S117 Y120 I124 2.4.2.-,2.4.2.30 0003950 IC50=1230nM O95271 33361107 1402 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE 8hlj A 2.24 BS01 09L A 1 E335 H428 G429 R444 I445 G460 I461 Y462 F463 S470 Y473 E106 H199 G200 R215 I216 G231 I232 Y233 F234 S241 Y244 2.4.2.-,2.4.2.30 0003950 Q9UGN5 601 PESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKSERQGLEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNF 8hlj B 2.24 BS01 09L B 1 E335 H428 G429 R444 G460 I461 Y462 F463 S470 Y473 E558 E107 H200 G201 R216 G232 I233 Y234 F235 S242 Y245 E330 2.4.2.-,2.4.2.30 0003950 Q9UGN5 601 GPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKSERQGLEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFL