3tt0 A 2.8 BS01 07J A 1 V492 A512 K514 E531 M535 I545 V561 Y563 A564 G567 L630 A640 D641 V32 A52 K54 E71 M75 I85 V101 Y103 A104 G107 L170 A180 D181 T521 L525 L528 G567 R576 S588 Q606 D623 A625 R627 N628 V629 D641 G697 T61 L65 L68 G107 R116 S128 Q146 D163 A165 R167 N168 V169 D181 G237 2.7.10.1 0004672,0004713,0005007,0005524,0006468 -logKd/Ki=9.05, IC50=0.9nM IC50=1.0nM P11362 21936542 1 SEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 3tt0 B 2.8 BS01 07J B 1 V492 A512 K514 E531 V561 A564 G567 E571 L630 A640 D641 V34 A54 K56 E73 V103 A106 G109 E113 L156 A166 D167 T521 L525 L528 G567 R576 Q606 D623 A625 R627 N628 V629 D641 G697 T63 L67 L70 G109 R118 Q132 D149 A151 R153 N154 V155 D167 G206 2.7.10.1 0004672,0004713,0005007,0005524,0006468 IC50=1.0nM P11362 21936542 1 GVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN