2fjm A 2.1 BS01 073 A 1 Y546 R547 D548 V549 F682 C715 S716 A717 I719 G720 R721 M758 Q762 Y50 R51 D52 V53 F182 C215 S216 A217 I219 G220 R221 M258 Q262 D681 C715 R721 S722 Q762 D181 C215 R221 S222 Q262 3.1.3.48 0004725,0006470,0016311 ic50=142nM -logKd/Ki=6.85, IC50=142nM IC50=39nM P18031 16407290 800 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 2fjm A 2.1 BS02 073 B 1 A518 H525 E526 A22 H29 E30 D681 C715 R721 S722 Q762 D181 C215 R221 S222 Q262 3.1.3.48 0004725,0006470,0016311 ic50=142nM -logKd/Ki=6.85, IC50=142nM IC50=39nM P18031 16407290 801 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 2fjm B 2.1 BS01 073 A 1 A518 D522 H525 A22 D26 H29 D681 C715 R721 S722 Q762 D181 C215 R221 S222 Q262 3.1.3.48 0004725,0006470,0016311 ic50=142nM IC50=39nM P18031 16407290 800 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 2fjm B 2.1 BS02 073 B 1 Y546 R547 D548 V549 F682 C715 S716 A717 I719 G720 R721 M758 Q762 Y50 R51 D52 V53 F182 C215 S216 A217 I219 G220 R221 M258 Q262 D681 C715 R721 S722 Q762 D181 C215 R221 S222 Q262 3.1.3.48 0004725,0006470,0016311 ic50=142nM IC50=39nM P18031 16407290 801 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 2fjn A 2.2 BS01 073 A 1 Y546 R547 D548 V549 L619 F682 C715 S716 A717 I719 G720 R721 Q762 Y50 R51 D52 V53 L123 F186 C219 S220 A221 I223 G224 R225 Q266 D681 C715 R721 S722 Q762 D185 C219 R225 S226 Q266 3.1.3.48 0004725,0006470,0016311 ic50=39nM -logKd/Ki=7.41, IC50=39nM IC50=39nM P18031 16407290 401 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 2fjn A 2.2 BS02 073 B 1 A518 D522 H525 E526 A22 D26 H29 E30 D681 C715 R721 S722 Q762 D185 C219 R225 S226 Q266 3.1.3.48 0004725,0006470,0016311 ic50=39nM -logKd/Ki=7.41, IC50=39nM IC50=39nM P18031 16407290 402 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 2fjn B 2.2 BS01 073 A 1 G514 A518 Q521 G18 A22 Q25 D681 C715 R721 S722 Q762 D185 C219 R225 S226 Q266 3.1.3.48 0004725,0006470,0016311 ic50=39nM IC50=39nM P18031 16407290 401 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS 2fjn B 2.2 BS02 073 B 1 Y546 R547 D548 V549 L619 F682 C715 S716 A717 I719 G720 R721 M758 Q762 Y50 R51 D52 V53 L123 F186 C219 S220 A221 I223 G224 R225 M262 Q266 D681 C715 R721 S722 Q762 D185 C219 R225 S226 Q266 3.1.3.48 0004725,0006470,0016311 ic50=39nM IC50=39nM P18031 16407290 402 KLEFMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDS