3tmz A 2.248 BS03 06X A 1 I101 F206 F297 A298 T302 V477 I73 F177 F268 A269 T273 V448 T302 F429 C436 T273 F400 C407 1.14.14.1 0004497,0005506,0005737,0005783,0005789,0006805,0008392,0016020,0016705,0016712,0019373,0020037,0043231,0046872,0070330 ic50=2uM P00178 22909231 503 GKLPPGPSPLPVLGNLLQMDKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLARH 3tmz A 2.248 BS04 06X A 2 L51 L70 I101 I209 Q215 E218 F365 E387 V477 L23 L42 I73 I180 Q186 E189 F336 E358 V448 T302 F429 C436 T273 F400 C407 1.14.14.1 0004497,0005506,0005737,0005783,0005789,0006805,0008392,0016020,0016705,0016712,0019373,0020037,0043231,0046872,0070330 ic50=2uM P00178 22909231 504 GKLPPGPSPLPVLGNLLQMDKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLARH 3ua5 A 2.8 BS02 06X A 1 I101 F206 F297 A298 V477 I74 F179 F270 A271 V450 T302 F429 C436 T275 F402 C409 1.14.13.- 0004497,0005506,0005737,0005783,0005789,0006629,0006805,0008202,0008390,0008392,0016020,0016705,0016712,0019373,0020037,0042178,0042180,0043231,0046872,0062184,0062187,0062188,0062189,0101021 P20813 22909231 501 GKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPRH 3ua5 A 2.8 BS03 06X A 2 L51 Q215 E218 M365 F389 V477 L24 Q188 E191 M338 F362 V450 T302 F429 C436 T275 F402 C409 1.14.13.- 0004497,0005506,0005737,0005783,0005789,0006629,0006805,0008202,0008390,0008392,0016020,0016705,0016712,0019373,0020037,0042178,0042180,0043231,0046872,0062184,0062187,0062188,0062189,0101021 P20813 22909231 502 GKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPRH 3ua5 B 2.8 BS02 06X B 1 I101 F206 S210 F297 A298 V477 I73 F178 S182 F267 A268 V447 T302 F429 C436 T272 F399 C406 1.14.13.- 0004497,0005506,0005737,0005783,0005789,0006629,0006805,0008202,0008390,0008392,0016020,0016705,0016712,0019373,0020037,0042178,0042180,0043231,0046872,0062184,0062187,0062188,0062189,0101021 P20813 22909231 501 KLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPRH 3ua5 B 2.8 BS03 06X B 2 L51 Q215 E218 F389 G476 V477 L23 Q187 E190 F359 G446 V447 T302 F429 C436 T272 F399 C406 1.14.13.- 0004497,0005506,0005737,0005783,0005789,0006629,0006805,0008202,0008390,0008392,0016020,0016705,0016712,0019373,0020037,0042178,0042180,0043231,0046872,0062184,0062187,0062188,0062189,0101021 P20813 22909231 502 KLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPRH