3r1n A 2.09 BS01 05B A 1 L50 G51 L52 G53 V58 A71 K73 C120 M121 E122 G124 E170 L173 T186 D187 L18 G19 L20 G21 V26 A39 K41 C88 M89 E90 G92 E136 L139 T152 D153 D166 K168 N171 D187 D132 K134 N137 D153 2.7.11.1 0004672,0005524,0006468 Q16644 21565500 1 EPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTPEKYDKSCDMWSLGVIMYILLCGFPPFYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQ 3r2b A 2.9 BS01 05B A 1 L70 G71 L72 V78 A91 K93 E139 C140 L141 E190 N191 L193 D207 L24 G25 L26 V32 A45 K47 E93 C94 L95 E140 N141 L143 D157 D186 K188 E190 N191 D207 D136 K138 E140 N141 D157 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.40, IC50=4nM EC50=620nM P49137 21565500 1000 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLYDKSCDMWSLGVIMYILLCGYPPFYSGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED 3r2b B 2.9 BS01 05B B 1 L72 V78 A91 K93 L141 D142 N191 L193 T206 D207 L26 V32 A45 K47 L95 D96 N141 L143 T156 D157 D186 K188 E190 N191 D207 D136 K138 E140 N141 D157 2.7.11.1 0004672,0005524,0006468 EC50=620nM P49137 21565500 1000 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLYDKSCDMWSLGVIMYILLCGYPPFYSGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED