4kn1 A 2.301 BS01 04J A 1 Y76 Y101 W118 H151 R152 G153 W154 W156 W187 S190 Y53 Y78 W95 H128 R129 G130 W131 W133 W164 S167 ? Kd=144nM -logKd/Ki=6.84, Kd=144nM P14207 23934049 301 RTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMH 4ky4 A 2.79 BS02 04J A 1 V8 V9 A10 D31 F32 F35 F91 L94 V6 V7 A8 D29 F30 F33 F57 L60 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E260 W282 Y308 C368 R389 D392 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 24470841 702 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKVCASLPAALSLLEEEYKDSVDQIFVVGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKEATYRPIFISKTFSDNGVPYDFVVLEKRSSAAAIAPVLAWMDEKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 4ky4 B 2.79 BS03 04J B 1 V9 D31 F32 F35 S36 F91 R97 V7 D29 F30 F33 S34 F57 R63 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E262 W284 Y310 C370 R391 D394 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 24470841 702 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKVCASLPAALSLLEEEYKDSVDQIFVVGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKEATYRPIFISKTFSDNGVPYDFVVLEKRSSAAAIAPVLAWMDEEDKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 4ky4 C 2.79 BS02 04J C 1 V8 V9 D31 F32 F35 S36 F91 L94 R97 V6 V7 D29 F30 F33 S34 F57 L60 R63 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E260 W282 Y308 C368 R389 D392 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 24470841 702 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKVCASLPAALSLLEEEYKDSVDQIFVVGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKEATYRPIFISKTFSDNGVPYDFVVLEKRSSAAAIAPVLAWMDEKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 4ky4 D 2.79 BS03 04J D 1 V9 D31 F32 F35 S36 F91 R97 V7 D29 F30 F33 S34 F57 R63 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E262 W284 Y310 C370 R391 D394 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 24470841 702 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKVCASLPAALSLLEEEYKDSVDQIFVVGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKEATYRPIFISKTFSDNGVPYDFVVLEKRSSAAAIAPVLAWMDEEDKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 4ky4 E 2.79 BS02 04J E 1 V8 V9 D31 F32 F35 S36 F91 L94 R97 V6 V7 D29 F30 F33 S34 F57 L60 R63 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E260 W282 Y308 C368 R389 D392 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 24470841 702 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKVCASLPAALSLLEEEYKDSVDQIFVVGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKEATYRPIFISKTFSDNGVPYDFVVLEKRSSAAAIAPVLAWMDEKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 4ky4 F 2.79 BS03 04J F 1 V9 D31 F32 F35 S36 F91 R97 V7 D29 F30 F33 S34 F57 R63 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E262 W284 Y310 C370 R391 D394 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 24470841 702 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKVCASLPAALSLLEEEYKDSVDQIFVVGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKEATYRPIFISKTFSDNGVPYDFVVLEKRSSAAAIAPVLAWMDEEDKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 4ky4 G 2.79 BS02 04J G 1 V9 D31 F32 F35 S36 F91 L94 R97 V7 D29 F30 F33 S34 F57 L60 R63 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E260 W282 Y308 C368 R389 D392 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 24470841 702 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKVCASLPAALSLLEEEYKDSVDQIFVVGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKEATYRPIFISKTFSDNGVPYDFVVLEKRSSAAAIAPVLAWMDEKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 4ky4 H 2.79 BS02 04J H 1 V8 V9 A10 D31 F32 F35 S36 F91 L94 R97 V6 V7 A8 D29 F30 F33 S34 F57 L60 R63 L23 D31 E381 W403 Y429 C489 R510 D513 L21 D29 E262 W284 Y310 C370 R391 D394 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q07422 24470841 702 KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKVCASLPAALSLLEEEYKDSVDQIFVVGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKEATYRPIFISKTFSDNGVPYDFVVLEKRSSAAAIAPVLAWMDEEDKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV