3un4 b 3.4 BS01 04C b 1 T1 R19 T20 T21 T22 K33 R45 G47 S48 A49 T52 T94 T1 R19 T20 T21 T22 K33 R45 G47 S48 A49 T52 T94 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 22341445 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 3un4 H 3.4 BS01 04C H 1 T1 S20 T21 G47 T48 A49 T52 G168 T1 S20 T21 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 22341445 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 3un4 I 3.4 BS01 04C H 1 D124 I126 D124 I126 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 22341445 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 3un4 K 3.4 BS01 04C K 1 T1 R19 A20 T21 V31 K33 M45 G47 G48 A49 Y170 T1 R19 A20 T21 V31 K33 M45 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 22341445 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 3un4 L 3.4 BS01 04C K 1 D126 V128 D126 V128 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603 P23724 22341445 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 3un4 N 3.4 BS01 04C N 1 T1 R19 T20 T21 T22 K33 R45 G47 A49 T94 S168 T1 R19 T20 T21 T22 K33 R45 G47 A49 T94 S168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 22341445 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 3un4 V 3.4 BS01 04C V 1 T1 S20 T21 A46 G47 A49 T52 G168 T1 S20 T21 A46 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 22341445 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 3un4 W 3.4 BS01 04C V 1 D124 I126 D124 I126 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 22341445 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 3un4 Y 3.4 BS01 04C Y 1 T1 R19 A20 T21 V31 K33 M45 G47 G48 A49 Y170 T1 R19 A20 T21 V31 K33 M45 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 22341445 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 3un4 Z 3.4 BS01 04C Y 1 D126 V128 D126 V128 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603 P23724 22341445 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 3unb 1 2.9 BS01 04C 1 1 T1 A20 T21 V31 M45 G47 G48 A49 Y169 T1 A20 T21 V31 M45 G47 G48 A49 Y169 3.4.25.1 0004298,0005839,0051603 O55234 22341445 301 TTTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYSS 3unb 4 2.9 BS01 04C 4 1 T1 T20 T21 T22 K33 R45 S46 G47 S48 A49 M95 S169 T1 T20 T21 T22 K33 R45 S46 G47 S48 A49 M95 S169 3.4.25.1 0004298,0005839,0051603 Q60692 22341445 301 TTIMAVQFNGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVERQVLLGDQIPKFTIATL 3unb b 2.9 BS01 04C b 1 T1 T20 T21 K33 R45 S46 G47 S48 A49 M95 S169 T1 T20 T21 K33 R45 S46 G47 S48 A49 M95 S169 3.4.25.1 0004298,0005839,0051603 Q60692 22341445 301 TTIMAVQFNGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVERQVLLGDQIPKFTIATL 3unb H 2.9 BS01 04C H 1 T1 A20 T21 C31 G47 T48 A49 T52 G168 T1 A20 T21 C31 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P70195 22341445 301 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPFSVPNKKGTRLGRYRCEKGTTAVLTEKVTPLE 3unb I 2.9 BS01 04C H 1 D124 I126 D124 I126 D24 R26 K40 G54 T140 D177 S180 D24 R26 K40 G54 T140 D177 S180 3.4.25.1 0000502,0004175,0005634,0005654,0005737,0005829,0005839,0019774,0030163,0043161,0051603 Q9R1P1 22341445 301 SIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHVIEKDKITTRTLKARMD 3unb j 2.9 BS01 04C j 1 T1 T21 C31 G47 T48 A49 T52 G168 T1 T21 C31 G47 T48 A49 T52 G168 3.4.25.1 0004298,0005839,0051603 P70195 22341445 301 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPFSVPNKKGTRLGRYRCEKGTTAVLTEKVTPLE 3unb k 2.9 BS01 04C j 1 D124 I126 D124 I126 3.4.25.1 0000502,0004175,0005634,0005654,0005737,0005829,0005839,0019774,0030163,0043161,0051603 Q9R1P1 22341445 301 SIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHVIEKDKITTRTLKARMD 3unb K 2.9 BS01 04C K 1 T1 R19 A20 T21 K33 G47 G48 A49 Y169 T1 R19 A20 T21 K33 G47 G48 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 O55234 22341445 301 TTTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYSS 3unb m 2.9 BS01 04C m 1 T1 R19 A20 T21 K33 M45 G47 G48 A49 Y169 T1 R19 A20 T21 K33 M45 G47 G48 A49 Y169 3.4.25.1 0004298,0005839,0051603 O55234 22341445 301 TTTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYSS 3unb N 2.9 BS01 04C N 1 T1 T20 T21 K33 R45 G47 S48 A49 M95 T1 T20 T21 K33 R45 G47 S48 A49 M95 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 Q60692 22341445 301 TTIMAVQFNGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVERQVLLGDQIPKFTIATL 3unb p 2.9 BS01 04C p 1 T1 R19 T20 T21 K33 R45 G47 S48 A49 M95 T1 R19 T20 T21 K33 R45 G47 S48 A49 M95 3.4.25.1 0004298,0005839,0051603 Q60692 22341445 301 TTIMAVQFNGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVERQVLLGDQIPKFTIATL 3unb V 2.9 BS01 04C V 1 T1 A20 T21 C31 K33 A46 G47 T48 A49 G168 T1 A20 T21 C31 K33 A46 G47 T48 A49 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P70195 22341445 301 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPFSVPNKKGTRLGRYRCEKGTTAVLTEKVTPLE 3unb x 2.9 BS01 04C x 1 T1 A20 T21 A46 G47 A49 G168 T1 A20 T21 A46 G47 A49 G168 3.4.25.1 0004298,0005839,0051603 P70195 22341445 301 TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPFSVPNKKGTRLGRYRCEKGTTAVLTEKVTPLE 3unb y 2.9 BS01 04C x 1 D124 I126 D124 I126 3.4.25.1 0000502,0004175,0005634,0005654,0005737,0005829,0005839,0019774,0030163,0043161,0051603 Q9R1P1 22341445 301 SIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHVIEKDKITTRTLKARMD 3unb Y 2.9 BS01 04C Y 1 T1 A20 T21 V31 M45 G47 G48 A49 Y169 T1 A20 T21 V31 M45 G47 G48 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 O55234 22341445 301 TTTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYSS 3unf b 2.9 BS01 04C b 1 T1 R19 V20 S21 F31 L45 G47 S48 A49 S168 T1 R19 V20 S21 F31 L45 G47 S48 A49 S168 3.4.25.1 0000502,0002376,0004298,0005634,0005654,0005737,0005829,0005839,0006508,0009617,0019774,0019882,0051603,1990111 P28076 22341445 201 TTIMAVEFDGGVVVGSDSRVSAGTAVVNRVFDKLSPLHQRIFCALSGSAADAQAIADMAAYQLELHGLELEEPPLVLAAANVVKNISYKYREDLLAHLIVAGWDQREGGQVYGTMGGMLIRQPFTIGGSGSSYIYGYVDAAYKPGMTPEECRRFTTNAITLAMNRDGSSGGVIYLVTITAAGVDHRVILGDELPKFYDE 3unf H 2.9 BS01 04C H 1 T1 A20 T21 N22 K33 G47 V48 A49 T52 G168 T1 A20 T21 N22 K33 G47 V48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 O35955 22341445 301 TTIAGLVFRDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADTEMTTRMAASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLVVGGVDLNGPQLYEVHPHGSYSRLPFTALGSGQGAAVALLEDRFQPNMTLEAAQELLVEAITAGILSDLGSGGNVDACVITAGGAKLQRALSTPTEPVQRAGRYRFAPGTTPVLTREVRPL 3unf I 2.9 BS01 04C H 1 D124 I126 D124 I126 D24 R26 K40 G54 T140 D177 S180 D24 R26 K40 G54 T140 D177 S180 ? 0000502,0004175,0005634,0005654,0005737,0005829,0005839,0019774,0030163,0043161,0051603 Q9R1P1 22341445 301 SIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHVIEKDKITTRTLKARMD 3unf K 2.9 BS01 04C K 1 T1 R19 A20 T21 M31 K33 M45 G47 C48 A49 Y169 T1 R19 A20 T21 M31 K33 M45 G47 C48 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28063 22341445 301 TTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQDLSPEEAYDLGRRAIAYATHRDNYSGGVVNMYHMKEDGWVKVESSDVSDLLYKYGE 3unf N 2.9 BS01 04C N 1 T1 R19 V20 S21 F31 L45 G47 S48 A49 S168 T1 R19 V20 S21 F31 L45 G47 S48 A49 S168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0002376,0004298,0005634,0005654,0005737,0005829,0005839,0006508,0009617,0019774,0019882,0051603,1990111 P28076 22341445 201 TTIMAVEFDGGVVVGSDSRVSAGTAVVNRVFDKLSPLHQRIFCALSGSAADAQAIADMAAYQLELHGLELEEPPLVLAAANVVKNISYKYREDLLAHLIVAGWDQREGGQVYGTMGGMLIRQPFTIGGSGSSYIYGYVDAAYKPGMTPEECRRFTTNAITLAMNRDGSSGGVIYLVTITAAGVDHRVILGDELPKFYDE 3unf V 2.9 BS01 04C V 1 T1 A20 T21 N22 G47 V48 A49 T52 G168 T1 A20 T21 N22 G47 V48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 O35955 22341445 301 TTIAGLVFRDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADTEMTTRMAASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLVVGGVDLNGPQLYEVHPHGSYSRLPFTALGSGQGAAVALLEDRFQPNMTLEAAQELLVEAITAGILSDLGSGGNVDACVITAGGAKLQRALSTPTEPVQRAGRYRFAPGTTPVLTREVRPL 3unf W 2.9 BS01 04C V 1 D124 I126 D124 I126 D24 R26 K40 G54 T140 D177 S180 D24 R26 K40 G54 T140 D177 S180 ? 0000502,0004175,0005634,0005654,0005737,0005829,0005839,0019774,0030163,0043161,0051603 Q9R1P1 22341445 301 SIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHVIEKDKITTRTLKARMD 3unf Y 2.9 BS01 04C Y 1 T1 R19 A20 T21 M31 M45 G47 C48 A49 Y169 T1 R19 A20 T21 M31 M45 G47 C48 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28063 22341445 301 TTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQDLSPEEAYDLGRRAIAYATHRDNYSGGVVNMYHMKEDGWVKVESSDVSDLLYKYGE 4qwx b 2.9 BS01 04C b 1 T1 T20 T21 T31 R45 S46 G47 A49 T1 T20 T21 T31 R45 S46 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qwx H 2.9 BS01 04C H 1 T1 S20 T21 Q22 G47 A49 T52 G168 T1 S20 T21 Q22 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=6.27, IC50=0.540uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qwx K 2.9 BS01 04C K 1 T1 A20 T21 V31 K33 M45 G47 G48 A49 Y170 T1 A20 T21 V31 K33 M45 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qwx N 2.9 BS01 04C N 1 T1 T20 T21 T31 R45 S46 G47 A49 T1 T20 T21 T31 R45 S46 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qwx V 2.9 BS01 04C V 1 T1 S20 T21 Q22 G47 A49 T52 G168 T1 S20 T21 Q22 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qwx Y 2.9 BS01 04C Y 1 T1 A20 T21 V31 K33 M45 G47 G48 A49 Y170 T1 A20 T21 V31 K33 M45 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qxj b 2.8 BS01 04C b 1 T1 T20 T21 T31 R45 G47 S48 A49 T1 T20 T21 T31 R45 G47 S48 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qxj H 2.8 BS01 04C H 1 T1 S20 T21 G47 A49 T52 G168 T1 S20 T21 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.90, IC50=1.265uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qxj K 2.8 BS01 04C K 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTAAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qxj N 2.8 BS01 04C N 1 T1 T20 T21 T31 R45 G47 S48 A49 T1 T20 T21 T31 R45 G47 S48 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qxj V 2.8 BS01 04C V 1 T1 S20 T21 G47 A49 T52 G168 T1 S20 T21 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qxj Y 2.8 BS01 04C Y 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTAAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz0 b 3.0 BS01 04C b 1 T1 T20 T21 T22 T31 R45 S46 G47 A49 T1 T20 T21 T22 T31 R45 S46 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz0 H 3.0 BS01 04C H 1 T1 S20 T21 Q22 G47 T48 A49 T52 G168 T1 S20 T21 Q22 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.46, IC50=3.502uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz0 K 3.0 BS01 04C K 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTVAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz0 N 3.0 BS01 04C N 1 T1 T20 T21 T22 T31 R45 S46 G47 A49 T1 T20 T21 T22 T31 R45 S46 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz0 V 3.0 BS01 04C V 1 T1 S20 T21 Q22 G47 T48 A49 T52 G168 T1 S20 T21 Q22 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz0 Y 3.0 BS01 04C Y 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTVAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz1 b 3.0 BS01 04C b 1 T1 T20 T21 T31 R45 S46 G47 A49 T94 T1 T20 T21 T31 R45 S46 G47 A49 T94 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz1 H 3.0 BS01 04C H 1 T1 S20 T21 Q22 G47 A49 G168 T1 S20 T21 Q22 G47 A49 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.44, IC50=3.658uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz1 K 3.0 BS01 04C K 1 T1 R19 A20 T21 V31 K33 T45 G47 G48 A49 Y170 T1 R19 A20 T21 V31 K33 T45 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTTAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz1 N 3.0 BS01 04C N 1 T1 T20 T21 T22 T31 R45 S46 G47 A49 T94 T1 T20 T21 T22 T31 R45 S46 G47 A49 T94 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz1 V 3.0 BS01 04C V 1 T1 S20 T21 Q22 G47 A49 G168 T1 S20 T21 Q22 G47 A49 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz1 Y 3.0 BS01 04C Y 1 T1 R19 A20 T21 V31 K33 T45 G47 G48 A49 Y170 T1 R19 A20 T21 V31 K33 T45 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTTAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz2 b 2.7 BS01 04C b 1 T1 T20 T21 T22 T31 R45 G47 S48 A49 T1 T20 T21 T22 T31 R45 G47 S48 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz2 H 2.7 BS01 04C H 1 T1 S20 T21 Q22 G47 A49 T52 G168 T1 S20 T21 Q22 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.21, IC50=6.167uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz2 K 2.7 BS01 04C K 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTIAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz2 N 2.7 BS01 04C N 1 T1 T20 T21 T22 T31 R45 G47 S48 A49 T1 T20 T21 T22 T31 R45 G47 S48 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz2 V 2.7 BS01 04C V 1 T1 S20 T21 Q22 G47 A49 T52 G168 T1 S20 T21 Q22 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz2 Y 2.7 BS01 04C Y 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTIAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz3 b 2.8 BS01 04C b 1 T1 T20 T21 T31 R45 G47 A49 T1 T20 T21 T31 R45 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz3 H 2.8 BS01 04C H 1 T1 S20 T21 C31 G47 T48 A49 G168 T1 S20 T21 C31 G47 T48 A49 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.51, IC50=3.085uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz3 K 2.8 BS01 04C K 1 T1 R19 A20 T21 V31 K33 M45 G47 G48 V49 Y170 T1 R19 A20 T21 V31 K33 M45 G47 G48 V49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGVADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz3 N 2.8 BS01 04C N 1 T1 T20 T21 T31 R45 G47 A49 T1 T20 T21 T31 R45 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz3 V 2.8 BS01 04C V 1 T1 S20 T21 C31 G47 T48 A49 T1 S20 T21 C31 G47 T48 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz3 Y 2.8 BS01 04C Y 1 T1 R19 A20 T21 V31 K33 M45 G47 G48 V49 Y170 T1 R19 A20 T21 V31 K33 M45 G47 G48 V49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGVADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz4 b 3.0 BS01 04C b 1 T1 T20 T21 T22 T31 R45 S46 G47 A49 T1 T20 T21 T22 T31 R45 S46 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz4 H 3.0 BS01 04C H 1 T1 S20 T21 Q22 G47 T48 A49 T52 G168 T1 S20 T21 Q22 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.01, IC50=9.830uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz4 K 3.0 BS01 04C K 1 T1 A20 T21 V31 K33 G47 G48 S49 Y170 T1 A20 T21 V31 K33 G47 G48 S49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGSADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz4 N 3.0 BS01 04C N 1 T1 T20 T21 T22 T31 R45 S46 G47 A49 T1 T20 T21 T22 T31 R45 S46 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz4 V 3.0 BS01 04C V 1 T1 S20 T21 Q22 G47 T48 A49 T52 G168 T1 S20 T21 Q22 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz4 Y 3.0 BS01 04C Y 1 T1 A20 T21 V31 K33 M45 G47 G48 S49 Y170 T1 A20 T21 V31 K33 M45 G47 G48 S49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGSADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz5 b 2.8 BS01 04C b 1 T1 T20 T21 T31 R45 G47 S48 A49 S168 T1 T20 T21 T31 R45 G47 S48 A49 S168 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz5 H 2.8 BS01 04C H 1 T1 S20 T21 C31 G47 A49 T52 G168 T1 S20 T21 C31 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.26, IC50=5.452uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz5 K 2.8 BS01 04C K 1 T1 A20 T21 V31 K33 M45 G47 G48 T49 Y170 T1 A20 T21 V31 K33 M45 G47 G48 T49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGTADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz5 N 2.8 BS01 04C N 1 T1 T20 T21 T31 R45 G47 S48 A49 S168 T1 T20 T21 T31 R45 G47 S48 A49 S168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz5 V 2.8 BS01 04C V 1 T1 S20 T21 C31 G47 A49 T52 G168 T1 S20 T21 C31 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz5 W 2.8 BS01 04C V 1 D124 L125 D124 L125 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 25599643 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4qz5 Y 2.8 BS01 04C Y 1 T1 A20 T21 V31 K33 M45 G47 G48 T49 Y170 T1 A20 T21 V31 K33 M45 G47 G48 T49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGTADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz6 b 2.9 BS01 04C b 1 T1 T20 T21 T31 R45 G47 A49 T1 T20 T21 T31 R45 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz6 H 2.9 BS01 04C H 1 T1 S20 T21 G47 T48 A49 G168 T1 S20 T21 G47 T48 A49 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.53, IC50=2.979uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz6 K 2.9 BS01 04C K 1 T1 T21 V31 K33 M45 G47 G48 T49 Y170 T1 T21 V31 K33 M45 G47 G48 T49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGTVDCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz6 N 2.9 BS01 04C N 1 T1 T20 T21 T31 R45 G47 A49 T1 T20 T21 T31 R45 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz6 V 2.9 BS01 04C V 1 T1 S20 T21 G47 T48 A49 G168 T1 S20 T21 G47 T48 A49 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz6 Y 2.9 BS01 04C Y 1 T1 T21 V31 K33 M45 G47 G48 T49 Y170 T1 T21 V31 K33 M45 G47 G48 T49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGTVDCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz7 b 2.8 BS01 04C b 1 T1 T20 T21 T22 T31 R45 S46 G47 A49 S129 T1 T20 T21 T22 T31 R45 S46 G47 A49 S129 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz7 H 2.8 BS01 04C H 1 T1 T21 A46 G47 T48 A49 T52 G168 T1 T21 A46 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.65, IC50=2.262uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz7 K 2.8 BS01 04C K 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAVDCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qz7 N 2.8 BS01 04C N 1 T1 T20 T21 T22 T31 R45 S46 G47 A49 S129 T1 T20 T21 T22 T31 R45 S46 G47 A49 S129 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qz7 V 2.8 BS01 04C V 1 T1 T21 A46 G47 T48 A49 T52 G168 T1 T21 A46 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qz7 Y 2.8 BS01 04C Y 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAVDCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qzw b 3.0 BS01 04C b 1 T1 T20 T21 R45 S46 G47 A49 T94 T1 T20 T21 R45 S46 G47 A49 T94 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qzw H 3.0 BS01 04C H 1 T1 S20 T21 Q22 G47 A49 T52 G168 T1 S20 T21 Q22 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=5.15, IC50=7.155uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qzw N 3.0 BS01 04C N 1 T1 T20 T21 R45 G47 A49 T94 T1 T20 T21 R45 G47 A49 T94 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qzw V 3.0 BS01 04C V 1 T1 S20 T21 Q22 G47 A49 T52 G168 T1 S20 T21 Q22 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qzx b 2.6 BS01 04C b 1 T1 T20 T21 T22 T31 R45 G47 S48 A49 T1 T20 T21 T22 T31 R45 G47 S48 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qzx H 2.6 BS01 04C H 1 T1 S20 T21 Q22 G47 A49 T52 G168 T1 S20 T21 Q22 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=6.26, IC50=0.553uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qzx K 2.6 BS01 04C K 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQFRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qzx N 2.6 BS01 04C N 1 T1 T20 T21 T22 T31 R45 G47 S48 A49 T1 T20 T21 T22 T31 R45 G47 S48 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qzx V 2.6 BS01 04C V 1 T1 S20 T21 Q22 G47 A49 T52 G168 T1 S20 T21 Q22 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qzx Y 2.6 BS01 04C Y 1 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 A20 T21 V31 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQFRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5cgi b 2.8 BS01 04C b 1 T1 T20 T21 T31 R45 G47 A49 T1 T20 T21 T31 R45 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 26563572 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 5cgi H 2.8 BS01 04C H 1 T1 S20 T21 Q22 K33 G47 A49 G168 T1 S20 T21 Q22 K33 G47 A49 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 26563572 302 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 5cgi K 2.8 BS02 04C K 1 T1 A20 T21 V31 K33 G47 C48 A49 Y170 T1 A20 T21 V31 K33 G47 C48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 26563572 304 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGCAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5cgi N 2.8 BS02 04C N 1 T1 T20 T21 T31 R45 G47 A49 T1 T20 T21 T31 R45 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 26563572 202 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 5cgi V 2.8 BS02 04C V 1 T1 S20 T21 Q22 K33 G47 A49 T52 G168 T1 S20 T21 Q22 K33 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 26563572 302 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 5cgi W 2.8 BS01 04C V 1 D124 I126 D124 I126 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 26563572 302 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 5cgi Y 2.8 BS02 04C Y 1 T1 R19 A20 T21 V31 K33 M45 G47 C48 A49 Y170 T1 R19 A20 T21 V31 K33 M45 G47 C48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 26563572 303 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGCAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5d b 2.8 BS01 04C b 1 T1 T20 T21 T31 K33 R45 G47 A49 T1 T20 T21 T31 K33 R45 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 27789522 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 5l5d H 2.8 BS01 04C H 1 T1 S20 T21 Q22 C31 A46 G47 T48 A49 T52 G168 T1 S20 T21 Q22 C31 A46 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l5d I 2.8 BS01 04C H 1 D124 I126 D124 I126 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 27789522 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 5l5d K 2.8 BS01 04C K 1 T1 S21 K33 M45 G47 A49 Y169 T1 S21 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 301 TTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5d N 2.8 BS01 04C N 1 T1 T20 T21 T31 R45 G47 A49 T1 T20 T21 T31 R45 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 27789522 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 5l5d V 2.8 BS02 04C V 1 T1 S20 T21 Q22 C31 A46 G47 T48 A49 T52 G168 T1 S20 T21 Q22 C31 A46 G47 T48 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l5d Y 2.8 BS02 04C Y 1 T1 S21 K33 M45 G47 A49 Y169 T1 S21 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 301 TTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5u H 2.6 BS01 04C H 1 T1 S20 T21 C31 G45 A46 G47 A49 T1 S20 T21 C31 G45 A46 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l5u K 2.6 BS01 04C K 1 T1 R19 A20 S21 S27 M31 K33 M45 G47 A49 Y169 T1 R19 A20 S21 S27 M31 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 301 TTTLAFKFQHGVIAAVDSRASAGSYISALRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5u L 2.6 BS01 04C K 1 S124 S130 R137 S124 S130 R137 3.4.25.1 0005839,0051603 P20618,P23724 27789522 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5l5u V 2.6 BS02 04C V 1 T1 S20 T21 C31 G45 A46 G47 A49 T1 S20 T21 C31 G45 A46 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l5u Y 2.6 BS03 04C Y 1 T1 R19 A20 S21 S27 M31 K33 M45 G47 A49 Y169 T1 R19 A20 S21 S27 M31 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 302 TTTLAFKFQHGVIAAVDSRASAGSYISALRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5u Z 2.6 BS01 04C Y 1 S124 S130 R137 S124 S130 R137 3.4.25.1 0005839,0051603 P20618,P23724 27789522 302 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5l5x b 2.9 BS01 04C b 1 T1 T20 T21 R45 S46 G47 A49 T1 T20 T21 R45 S46 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 27789522 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 5l5x H 2.9 BS01 04C H 1 T1 S20 T21 Q22 C31 A46 G47 T48 A49 G168 T1 S20 T21 Q22 C31 A46 G47 T48 A49 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l5x K 2.9 BS01 04C K 1 T1 T21 K33 M45 G47 A49 Y169 T1 T21 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28074,P30656 27789522 301 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5x N 2.9 BS01 04C N 1 T1 T20 T21 R45 G47 A49 T1 T20 T21 R45 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 27789522 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 5l5x V 2.9 BS02 04C V 1 T1 S20 T21 Q22 C31 A46 G47 T48 A49 G168 T1 S20 T21 Q22 C31 A46 G47 T48 A49 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l5x Y 2.9 BS02 04C Y 1 T1 T21 K33 M45 G47 A49 Y169 T1 T21 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28074,P30656 27789522 301 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l63 H 2.7 BS01 04C H 1 T1 S20 T21 C31 A46 G47 A49 T1 S20 T21 C31 A46 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l63 I 2.7 BS01 04C H 1 D124 I126 D124 I126 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 27789522 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 5l63 K 2.7 BS01 04C K 1 T1 R19 A20 T21 K33 M45 G47 A49 Y169 T1 R19 A20 T21 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28074,P30656 27789522 301 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l63 L 2.7 BS01 04C K 1 S124 S130 S124 S130 3.4.25.1 0005839,0051603 P20618,P23724 27789522 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5l63 V 2.7 BS02 04C V 1 T1 S20 T21 C31 A46 G47 A49 T1 S20 T21 C31 A46 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l63 W 2.7 BS01 04C V 1 D124 I126 D124 I126 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 27789522 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 5l63 Y 2.7 BS02 04C Y 1 T1 R19 A20 T21 K33 M45 G47 A49 Y169 T1 R19 A20 T21 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28074,P30656 27789522 301 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l63 Z 2.7 BS01 04C Y 1 S124 S130 S124 S130 3.4.25.1 0005839,0051603 P20618,P23724 27789522 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5l6b b 2.6 BS01 04C b 1 T1 T20 T21 T31 K33 R45 G47 A49 T1 T20 T21 T31 K33 R45 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 27789522 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 5l6b H 2.6 BS01 04C H 1 T1 S20 T21 Q22 A46 G47 A49 T52 G168 T1 S20 T21 Q22 A46 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l6b I 2.6 BS01 04C H 1 D124 I126 D124 I126 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 27789522 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 5l6b K 2.6 BS01 04C K 1 T1 R19 A20 T21 M31 K33 M45 G47 A49 Y169 T1 R19 A20 T21 M31 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28063,P30656 27789522 301 TTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l6b N 2.6 BS01 04C N 1 T1 T20 T21 T31 K33 R45 G47 A49 T1 T20 T21 T31 K33 R45 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 27789522 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 5l6b V 2.6 BS02 04C V 1 T1 S20 T21 Q22 G47 A49 T52 G168 T1 S20 T21 Q22 G47 A49 T52 G168 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 27789522 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 5l6b W 2.6 BS01 04C V 1 D124 I126 D124 I126 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 27789522 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 5l6b Y 2.6 BS02 04C Y 1 T1 R19 A20 T21 M31 K33 M45 G47 A49 Y169 T1 R19 A20 T21 M31 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28063,P30656 27789522 301 TTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG