1x7b A 2.3 BS02 041 A 1 M295 E305 L339 M340 L343 I373 I376 H475 L476 M33 E43 L77 M78 L81 I111 I114 H203 L204 ? 0003677,0004879,0006355 ic50=4.1nM -logKd/Ki=8.39, IC50=4.1nM IC50=5nM Q92731 15548008 201 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL 1x7b B 2.3 BS02 041 B 1 M295 E305 L339 M340 L343 I376 F377 H475 L476 M33 E43 L77 M78 L81 I114 F115 H203 L204 ? 0003677,0004879,0006355 ic50=4.1nM IC50=5nM Q92731 15548008 202 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNA 6qy7 A 2.1 BS01 041 A 1 K68 F113 V116 M163 I174 D175 K67 F112 V115 M162 I173 D174 D156 K158 N161 D175 S194 D155 K157 N160 D174 S193 2.7.11.1 0004672,0004674,0005524,0006468 P68400 500 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMG 6qy7 B 2.1 BS01 041 B 1 K68 F113 V116 M163 I174 D175 K67 F109 V112 M159 I170 D171 D156 K158 N161 D175 S194 D152 K154 N157 D171 S190 2.7.11.1 0004672,0004674,0005524,0006468 P68400 401 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM 6qy8 A 1.7 BS01 041 A 1 L46 K69 F114 I117 N119 M164 I175 D176 L39 K62 F105 I108 N110 M155 I166 D167 D157 K159 N162 D176 S195 D148 K150 N153 D167 S186 2.7.11.1 0000785,0001669,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005829,0005956,0006302,0006338,0006468,0006915,0007283,0016055,0016310,0021987,0031519,0032435,0044024,0051726,0097421,0106310,1901524,1903955,1905818,2001234 P19784 500 SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVK 6qy8 B 1.7 BS01 041 B 1 L46 V54 K69 F114 I117 N119 M164 I175 D176 L39 V47 K62 F105 I108 N110 M155 I166 D167 D157 K159 N162 D176 S195 D148 K150 N153 D167 S186 2.7.11.1 0000785,0001669,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005829,0005956,0006302,0006338,0006468,0006915,0007283,0016055,0016310,0021987,0031519,0032435,0044024,0051726,0097421,0106310,1901524,1903955,1905818,2001234 P19784 500 SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ 6qy8 C 1.7 BS01 041 C 1 L46 V54 K69 F114 I117 N119 M164 I175 D176 L39 V47 K62 F107 I110 N112 M157 I168 D169 D157 K159 N162 D176 S195 D150 K152 N155 D169 S188 2.7.11.1 0000785,0001669,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005829,0005956,0006302,0006338,0006468,0006915,0007283,0016055,0016310,0021987,0031519,0032435,0044024,0051726,0097421,0106310,1901524,1903955,1905818,2001234 P19784 500 SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ 6qy8 D 1.7 BS01 041 D 1 L46 V54 K69 F114 I117 M164 I175 D176 L39 V47 K62 F105 I108 M155 I166 D167 D157 K159 N162 D176 S195 D148 K150 N153 D167 S186 2.7.11.1 0000785,0001669,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005829,0005956,0006302,0006338,0006468,0006915,0007283,0016055,0016310,0021987,0031519,0032435,0044024,0051726,0097421,0106310,1901524,1903955,1905818,2001234 P19784 500 SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ