3pp0 A 2.25 BS01 03Q A 1 L726 V734 A751 K753 E770 M774 L785 L796 T798 L800 M801 R849 L852 T862 D863 F864 L21 V29 A46 K48 E65 M69 L80 L91 T93 L95 M96 R144 L147 T157 D158 F159 D845 A847 R849 N850 D863 D140 A142 R144 N145 D158 2.7.10.1 0004672,0004713,0005524,0006468 ic50=11nM -logKd/Ki=7.96, IC50=11nM IC50=11nM P04626 21454582 1 APNQALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNED 3pp0 B 2.25 BS01 03Q B 1 L726 V734 A751 K753 E770 M774 S783 L785 L796 T798 L800 M801 R849 L852 T862 D863 F1004 L21 V29 A46 K48 E65 M69 S78 L80 L91 T93 L95 M96 R144 L147 T157 D158 F291 D845 A847 R849 N850 D863 D140 A142 R144 N145 D158 2.7.10.1 0004672,0004713,0005524,0006468 ic50=11nM IC50=11nM P04626 21454582 2 APNQALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEPLDSTFYRSLL