3poz A 1.5 BS01 03P A 1 V726 A743 K745 M766 C775 R776 L788 T790 M793 L844 T854 D855 F856 V26 A39 K41 M55 C64 R65 L77 T79 M82 L133 T143 D144 F145 D837 A839 R841 N842 D855 D126 A128 R130 N131 D144 2.7.10.1 0004672,0004713,0005524,0006468 ic50=23nM -logKd/Ki=7.64, IC50=23nM IC50=4.0nM P00533 21454582 1023 QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPVKIPVAIKELANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDVVDADEYL 3rcd A 3.21 BS01 03P A 1 G727 V734 A751 K753 S783 L785 T798 L800 M801 G804 L852 T862 D863 G18 V25 A42 K44 S70 L72 T85 L87 M88 G91 L139 T149 D150 D845 A847 R849 N850 D863 D132 A134 R136 N137 D150 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=7.77, IC50=17nM IC50=17nM P04626 22003817 9001 ALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNLDSTFYRSLLEDDDLVDAEE 3rcd C 3.21 BS01 03P C 1 A751 K753 S783 L785 T798 L800 M801 G804 L852 T862 D863 A42 K44 S70 L72 T85 L87 M88 G91 L139 T149 D150 D845 A847 R849 N850 D863 D132 A134 R136 N137 D150 2.7.10.1 0004672,0004713,0005524,0006468 IC50=17nM P04626 22003817 9001 ALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNLDSTFYRSLLEDDDLVDAEE 3w2o A 2.35 BS01 03P A 1 S720 G721 V726 A743 K745 E762 M766 L788 M790 M793 S24 G25 V30 A47 K49 E66 M70 L92 M94 M97 D837 A839 R841 N842 D855 G874 D141 A143 R145 N146 D159 G178 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=5.08, IC50=8400nM IC50=4.0nM P00533 24900643 1101 HAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPMDDVVDADEYL