3og7 A 2.45 BS01 032 A 1 I463 A481 L505 L514 T529 W531 C532 F583 D594 F595 G596 I15 A33 L57 L66 T81 W83 C84 F132 D143 F144 G145 D576 K578 N580 N581 D594 S616 D125 K127 N129 N130 D143 S147 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.51, IC50=31nM IC50=31nM, Kd=51nM, EC50=2290nM P15056 20823850 1 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTAPQLAIVTQWCEGSSLYHHLHASFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGGSILWMAPEVIRNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARE 4rzv A 2.994 BS01 032 A 1 I463 V471 A481 K483 L514 T529 W531 C532 S535 H539 F583 D594 F595 G596 I15 V23 A33 K35 L66 T81 W83 C84 S87 H91 F135 D146 F147 G148 D576 K578 N580 N581 D594 S616 D128 K130 N132 N133 D146 S156 2.7.11.1 0004672,0005524,0006468 IC50=31nM, Kd=51nM, EC50=2290nM P15056 801 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTHHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 4rzv B 2.994 BS01 032 B 1 I463 V471 A481 V482 K483 L514 T529 Q530 W531 C532 S535 H539 F583 D594 F595 G596 I15 V23 A33 V34 K35 L66 T81 Q82 W83 C84 S87 H91 F135 D146 F147 G148 D576 K578 N580 N581 D594 S616 D128 K130 N132 N133 D146 S168 2.7.11.1 0004672,0005524,0006468 IC50=31nM, Kd=51nM, EC50=2290nM P15056 801 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTHHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELS 5hes A 2.14 BS01 032 A 1 G23 F27 V30 A43 I66 I80 T82 E83 Y84 A85 C150 D151 F152 G153 G18 F22 V25 A38 I61 I75 T77 E78 Y79 A80 C145 D146 F147 G148 D133 K135 R137 N138 D151 T169 D128 K130 R132 N133 D146 T158 2.7.11.25 0004672,0005524,0006468 Kd=29nM -logKd/Ki=7.54, Kd=29nM IC50=23nM Q9NYL2 26999302 401 ASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLER 5hes B 2.14 BS01 032 B 1 G23 F27 V30 A43 K45 I66 T82 E83 Y84 A85 C150 D151 F152 G153 G17 F21 V24 A37 K39 I60 T76 E77 Y78 A79 C144 D145 F146 G147 D133 K135 R137 N138 D151 T169 D127 K129 R131 N132 D145 T149 2.7.11.25 0004672,0005524,0006468 Kd=29nM IC50=23nM Q9NYL2 26999302 401 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLE