3qqu A 2.9 BS01 01P A 1 Q1004 V1010 A1028 E1077 M1079 M1139 D1150 M1153 Q17 V23 A41 E90 M92 M142 D153 M156 D1132 R1136 N1137 D1150 E1159 D135 R139 N140 D153 E162 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 -logKd/Ki=8.62, IC50=2.4nM IC50=2.4nM P08069 21414779 1 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN 3qqu B 2.9 BS01 01P B 1 Q1004 V1010 A1028 E1077 M1079 G1082 D1083 M1139 D1150 M1153 D1156 Q20 V26 A44 E93 M95 G98 D99 M144 D155 M158 D161 D1132 R1136 N1137 D1150 E1159 D137 R141 N142 D155 E164 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 IC50=2.4nM P08069 21414779 1 VPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3qqu C 2.9 BS01 01P C 1 L1002 G1003 Q1004 A1028 E1077 L1078 M1079 G1082 M1139 D1150 M1153 L17 G18 Q19 A43 E92 L93 M94 G97 M150 D161 M164 D1132 R1136 N1137 D1150 E1159 D143 R147 N148 D161 E170 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 IC50=2.4nM P08069 21414779 1 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN 3qqu D 2.9 BS01 01P D 1 L1002 G1003 Q1004 V1010 A1028 E1077 M1079 G1082 M1139 D1150 M1153 L17 G18 Q19 V25 A43 E92 M94 G97 M149 D160 M163 D1132 R1136 N1137 D1150 E1159 D142 R146 N147 D160 E169 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 IC50=2.4nM P08069 21414779 1 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN