3fnu A 3.0 BS01 006 A 1 W39 F109A F111 Y112 V120 W40 F110 F113 Y114 V122 H32 S35 N37 W39 S75 D215 T218 H33 S36 N38 W40 S76 D213 T216 3.4.23.39 0004190,0006508 -logKd/Ki=6.16, IC50=0.69uM Q8IM15 19285084 329 EFDNVELKDLANVLSFGEAKLGDNGQKFNFLFHTASSNVWVPSIKCTSESCESKNHYDSSKSKTYEKDDTPVKLTSKAGTISGIFSKDLVTIGKLSVPYKFIEMTEIVGFEPFYSESDVDGVFGLGWKDLSIGSIDPYIVELKTQNKIEQAVYSIYLPPENKNKGYLTIGGIEERFFDGPLNYEKLNHDLMWQVDLDVHFGNVSSKKANVILDSATSVITVPTEFFNQFVESASVFKVPFLSLYVTTCGNTKLPTLEYRSPNKVYTLEPKQYLEPLENIFSALCMLNIVPIDLEKNTFVLGDPFMRKYFTVYDYDNHTVGFALAKN 3fnu B 3.0 BS01 006 B 1 V12 S35 W39 M104 F109A F111 V120 V13 S36 W40 M104 F110 F113 V122 H32 S35 N37 W39 S75 D215 T218 H33 S36 N38 W40 S76 D213 T216 3.4.23.39 0004190,0006508 -logKd/Ki=6.16, IC50=0.69uM Q8IM15 19285084 329 EFDNVELKDLANVLSFGEAKLGDNGQKFNFLFHTASSNVWVPSIKCTSESCESKNHYDSSKSKTYEKDDTPVKLTSKAGTISGIFSKDLVTIGKLSVPYKFIEMTEIVGFEPFYSESDVDGVFGLGWKDLSIGSIDPYIVELKTQNKIEQAVYSIYLPPENKNKGYLTIGGIEERFFDGPLNYEKLNHDLMWQVDLDVHFGNVSSKKANVILDSATSVITVPTEFFNQFVESASVFKVPFLSLYVTTCGNTKLPTLEYRSPNKVYTLEPKQYLEPLENIFSALCMLNIVPIDLEKNTFVLGDPFMRKYFTVYDYDNHTVGFALAKN 3fnu C 3.0 BS01 006 C 1 V12 S35 W39 F109A F111 V120 A217 V13 S36 W40 F110 F113 V122 A215 H32 S35 N37 W39 S75 D215 T218 H33 S36 N38 W40 S76 D213 T216 3.4.23.39 0004190,0006508 Q8IM15 19285084 329 EFDNVELKDLANVLSFGEAKLGDNGQKFNFLFHTASSNVWVPSIKCTSESCESKNHYDSSKSKTYEKDDTPVKLTSKAGTISGIFSKDLVTIGKLSVPYKFIEMTEIVGFEPFYSESDVDGVFGLGWKDLSIGSIDPYIVELKTQNKIEQAVYSIYLPPENKNKGYLTIGGIEERFFDGPLNYEKLNHDLMWQVDLDVHFGNVSSKKANVILDSATSVITVPTEFFNQFVESASVFKVPFLSLYVTTCGNTKLPTLEYRSPNKVYTLEPKQYLEPLENIFSALCMLNIVPIDLEKNTFVLGDPFMRKYFTVYDYDNHTVGFALAKN 3fnu D 3.0 BS01 006 D 1 V12 S35 W39 M104 F109A F111 Y112 V13 S36 W40 M104 F110 F113 Y114 H32 S35 N37 W39 S75 D215 T218 H33 S36 N38 W40 S76 D213 T216 3.4.23.39 0004190,0006508 Q8IM15 19285084 329 EFDNVELKDLANVLSFGEAKLGDNGQKFNFLFHTASSNVWVPSIKCTSESCESKNHYDSSKSKTYEKDDTPVKLTSKAGTISGIFSKDLVTIGKLSVPYKFIEMTEIVGFEPFYSESDVDGVFGLGWKDLSIGSIDPYIVELKTQNKIEQAVYSIYLPPENKNKGYLTIGGIEERFFDGPLNYEKLNHDLMWQVDLDVHFGNVSSKKANVILDSATSVITVPTEFFNQFVESASVFKVPFLSLYVTTCGNTKLPTLEYRSPNKVYTLEPKQYLEPLENIFSALCMLNIVPIDLEKNTFVLGDPFMRKYFTVYDYDNHTVGFALAKN 3kdb A 1.66 BS01 006 B 1 D25 G27 A28 D29 V32 I47 G48 I50 P81 V82 D25 G27 A28 D29 V32 I47 G48 I50 P81 V82 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 -logKd/Ki=9.85, Kd=0.14nM P03367 20028396 100 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF 3kdb B 1.66 BS01 006 B 1 D25 G27 A28 D29 D30 I47 G49 I50 I84 D25 G27 A28 D29 D30 I47 G49 I50 I84 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 Kd=0.14nM -logKd/Ki=9.85, Kd=0.14nM P03367 20028396 100 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF 3qs1 A 3.1 BS01 006 A 1 D32 G34 Y75 V76 S77 D215 G217 T218 S219 D33 G35 Y76 V77 S78 D213 G215 T216 S217 D32 S35 N37 W39 Y75 D215 T218 D33 S36 N38 W40 Y76 D213 T216 3.4.23.38 0004190,0006508 -logKd/Ki=7.96, Ki=11.0nM IC50=280nM P39898 21521654 330 AGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILGDPFMRKYFTVFDYDNHTVGFALAKKK 3qs1 B 3.1 BS01 006 B 1 D32 G34 N74 Y75 V76 S77 L128 D215 G217 T218 S219 I300 D33 G35 N75 Y76 V77 S78 L130 D213 G215 T216 S217 I299 D32 S35 N37 W39 Y75 D215 T218 D33 S36 N38 W40 Y76 D213 T216 3.4.23.38 0004190,0006508 -logKd/Ki=7.96, Ki=11.0nM IC50=280nM P39898 21521654 330 AGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILGDPFMRKYFTVFDYDNHTVGFALAKKK 3qs1 C 3.1 BS01 006 C 1 D32 G34 S35 Y75 V76 S77 I130 D215 G217 T218 S219 I287 D32 G34 S35 Y75 V76 S77 I131 D212 G214 T215 S216 I288 D32 S35 N37 W39 Y75 D215 T218 D32 S35 N37 W39 Y75 D212 T215 3.4.23.38 0004190,0006508 IC50=280nM P39898 21521654 330 GDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILGDPFMRKYFTVFDYDNHTVGFALAKKK 3qs1 D 3.1 BS01 006 D 1 D32 G34 Y75 V76 S77 I130 Y189 D215 T218 S219 I287 L291 I300 D32 G34 Y75 V76 S77 I131 Y190 D212 T215 S216 I288 L292 I298 D32 S35 N37 W39 Y75 D215 T218 D32 S35 N37 W39 Y75 D212 T215 3.4.23.38 0004190,0006508 IC50=280nM P39898 21521654 330 GDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILGDPFMRKYFTVFDYDNHTVGFALAKKK