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●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

BioLiP
Download all results in tab-seperated text for 713946 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    39601 1s5l:D (3.5) BS07 CLA 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39602 1s5l:D (3.5) BS08 PHO 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39603 1s5l:D (3.5) BS09 CLA 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39604 1s5l:E (3.5) BS01 HEC ? GO:0005506 ... Q8DIP0 14764885
    39605 1s5l:F (3.5) BS01 HEC ? GO:0005506 ... Q8DIN9 14764885
    39606 1s5l:H (3.5) BS01 CLA ? GO:0009523 ... Q8DJ43 14764885
    39607 1s5l:H (3.5) BS02 CLA ? GO:0009523 ... Q8DJ43 14764885
    39608 1s5l:H (3.5) BS03 CLA ? GO:0009523 ... Q8DJ43 14764885
    39609 1s5l:H (3.5) BS04 CLA ? GO:0009523 ... Q8DJ43 14764885
    39610 1s5l:K (3.5) BS01 CLA ? GO:0009523 ... Q9F1K9 14764885
    39611 1s5l:K (3.5) BS02 CLA ? GO:0009523 ... Q9F1K9 14764885
    39612 1s5l:M (3.5) BS01 CLA ? GO:0005737 ... Q8DHA7 14764885
    39613 1s5l:V (3.5) BS01 HEC ? GO:0005506 ... P0A386 14764885
    39614 1s5l:a (3.5) BS01 FE 1.10.3.9 GO:0005506 ... P0A444 14764885
    39615 1s5l:a (3.5) BS02 OEC 1.10.3.9 GO:0005506 ... P0A444 14764885
    39616 1s5l:a (3.5) BS03 CLA 1.10.3.9 GO:0005506 ... P0A444 14764885
    39617 1s5l:a (3.5) BS04 CLA 1.10.3.9 GO:0005506 ... P0A444 14764885
    39618 1s5l:a (3.5) BS05 PHO 1.10.3.9 GO:0005506 ... P0A444 14764885
    39619 1s5l:a (3.5) BS06 CLA 1.10.3.9 GO:0005506 ... P0A444 14764885
    39620 1s5l:a (3.5) BS07 CLA 1.10.3.9 GO:0005506 ... P0A444 14764885
    39621 1s5l:a (3.5) BS08 BCT 1.10.3.9 GO:0005506 ... P0A444 14764885
    39622 1s5l:a (3.5) BS09 CLA 1.10.3.9 GO:0005506 ... P0A444 14764885
    39623 1s5l:a (3.5) BS10 CLA 1.10.3.9 GO:0005506 ... P0A444 14764885
    39624 1s5l:a (3.5) BS11 PHO 1.10.3.9 GO:0005506 ... P0A444 14764885
    39625 1s5l:b (3.5) BS01 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39626 1s5l:b (3.5) BS02 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39627 1s5l:b (3.5) BS03 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39628 1s5l:b (3.5) BS04 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39629 1s5l:b (3.5) BS05 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39630 1s5l:b (3.5) BS06 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39631 1s5l:b (3.5) BS07 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39632 1s5l:b (3.5) BS08 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39633 1s5l:b (3.5) BS09 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39634 1s5l:b (3.5) BS10 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39635 1s5l:b (3.5) BS11 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39636 1s5l:b (3.5) BS12 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39637 1s5l:b (3.5) BS13 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39638 1s5l:b (3.5) BS14 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39639 1s5l:b (3.5) BS15 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39640 1s5l:b (3.5) BS16 CLA ? GO:0009521 ... Q8DIQ1 14764885
    39641 1s5l:c (3.5) BS01 CLA ? GO:0005737 ... Q8DIF8 14764885
    39642 1s5l:c (3.5) BS02 CLA ? GO:0005737 ... Q8DIF8 14764885
    39643 1s5l:c (3.5) BS03 CLA ? GO:0005737 ... Q8DIF8 14764885
    39644 1s5l:c (3.5) BS04 CLA ? GO:0005737 ... Q8DIF8 14764885
    39645 1s5l:c (3.5) BS05 CLA ? GO:0005737 ... Q8DIF8 14764885
    39646 1s5l:c (3.5) BS06 CLA ? GO:0005737 ... Q8DIF8 14764885
    39647 1s5l:c (3.5) BS07 CLA ? GO:0005737 ... Q8DIF8 14764885
    39648 1s5l:c (3.5) BS08 CLA ? GO:0005737 ... Q8DIF8 14764885
    39649 1s5l:c (3.5) BS09 CLA ? GO:0005737 ... Q8DIF8 14764885
    39650 1s5l:c (3.5) BS10 CLA ? GO:0005737 ... Q8DIF8 14764885
    39651 1s5l:c (3.5) BS11 CLA ? GO:0005737 ... Q8DIF8 14764885
    39652 1s5l:c (3.5) BS12 CLA ? GO:0005737 ... Q8DIF8 14764885
    39653 1s5l:c (3.5) BS13 CLA ? GO:0005737 ... Q8DIF8 14764885
    39654 1s5l:c (3.5) BS14 CLA ? GO:0005737 ... Q8DIF8 14764885
    39655 1s5l:d (3.5) BS01 FE 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39656 1s5l:d (3.5) BS02 CLA 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39657 1s5l:d (3.5) BS03 PHO 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39658 1s5l:d (3.5) BS04 CLA 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39659 1s5l:d (3.5) BS05 BCT 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39660 1s5l:d (3.5) BS06 CLA 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39661 1s5l:d (3.5) BS07 CLA 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39662 1s5l:d (3.5) BS08 PHO 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39663 1s5l:d (3.5) BS09 CLA 1.10.3.9 GO:0005506 ... Q8CM25 14764885
    39664 1s5l:e (3.5) BS01 HEC ? GO:0005506 ... Q8DIP0 14764885
    39665 1s5l:f (3.5) BS01 HEC ? GO:0005506 ... Q8DIN9 14764885
    39666 1s5l:h (3.5) BS01 CLA ? GO:0009523 ... Q8DJ43 14764885
    39667 1s5l:h (3.5) BS02 CLA ? GO:0009523 ... Q8DJ43 14764885
    39668 1s5l:h (3.5) BS03 CLA ? GO:0009523 ... Q8DJ43 14764885
    39669 1s5l:h (3.5) BS04 CLA ? GO:0009523 ... Q8DJ43 14764885
    39670 1s5l:i (3.5) BS01 CLA ? GO:0005737 ... Q8DJZ6 14764885
    39671 1s5l:k (3.5) BS01 CLA ? GO:0009523 ... Q9F1K9 14764885
    39672 1s5l:k (3.5) BS02 CLA ? GO:0009523 ... Q9F1K9 14764885
    39673 1s5l:m (3.5) BS01 CLA ? GO:0005737 ... Q8DHA7 14764885
    39674 1s5l:v (3.5) BS01 HEC ? GO:0005506 ... P0A386 14764885
    39675 1s5m:A (0.98) BS01 GLC 5.3.1.5 GO:0000287 ... P15587 15157080
    39676 1s5m:A (0.98) BS02 MN 5.3.1.5 GO:0000287 ... P15587 15157080
    39677 1s5m:A (0.98) BS03 MN 5.3.1.5 GO:0000287 ... P15587 15157080
    39678 1s5n:A (0.95) BS01 XYL 5.3.1.5 GO:0000287 ... P15587 15157080
    39679 1s5n:A (0.95) BS02 MN 5.3.1.5 GO:0000287 ... P15587 15157080
    39680 1s5n:A (0.95) BS03 MN 5.3.1.5 GO:0000287 ... P15587 15157080
    39681 1s5o:A (1.8) BS01 152 2.3.1.137
    2.3.1.7    		 GO:0003997 ... P43155 15099582
    39682 1s5q:B (-1.00) BS01 peptide ? GO:0003714 ... Q60520 15235594
    39683 1s5r:B (-1.00) BS01 peptide ? GO:0003714 ... Q60520 15235594
    39684 1s5s:A (1.4) BS01 CA 3.4.21.4 GO:0004252 ... P00761 15005618
    39685 1s5s:A (1.4) BS02 PG3 3.4.21.4 GO:0004252 ... P00761 15005618
    39686 1s5x:A (2.4) BS01 HEM ? GO:0004601 ... P80043 15096204
    39687 1s5x:B (2.4) BS01 HEM ? GO:0004601 ... P80044 15096204
    39688 1s5y:A (2.5) BS01 HEM ? GO:0004601 ... P80043 15096204
    39689 1s5y:B (2.5) BS01 HEM ? GO:0004601 ... P80044 15096204
    39690 1s5y:C (2.5) BS01 HEM ? GO:0004601 ... P80043 15096204
    39691 1s5y:D (2.5) BS01 HEM ? GO:0004601 ... P80044 15096204
    39692 1s5z:A (2.0) BS01 SON 2.7.4.6 GO:0004550 ... P22887 16787337 PDBbind: -logKd/Ki=3.21, Kd=0.62mM
    39693 1s60:A (3.0) BS01 COA 2.3.1.82 GO:0006084 ... Q9R381 15123251
    39694 1s61:A (2.1) BS01 HEM ? GO:0005344 ... P9WN25 15016811
    39695 1s61:B (2.1) BS01 HEM ? GO:0005344 ... P9WN25 15016811
    39696 1s63:A (1.9) BS01 GLC 2.5.1.58
    2.5.1.59    		 GO:0004659 ... P49354 15248757
    39697 1s63:A (1.9) BS02 FPP 2.5.1.58
    2.5.1.59    		 GO:0004659 ... P49354 15248757 BindingDB: Kd=2.0nM
    39698 1s63:B (1.9) BS01 GLC 2.5.1.58 GO:0003824 ... P49356 15248757
    39699 1s63:B (1.9) BS02 FRU 2.5.1.58 GO:0003824 ... P49356 15248757
    39700 1s63:B (1.9) BS03 ZN 2.5.1.58 GO:0003824 ... P49356 15248757
    39701 1s63:B (1.9) BS04 FPP 2.5.1.58 GO:0003824 ... P49356 15248757
    39702 1s63:B (1.9) BS05 778 2.5.1.58 GO:0003824 ... P49356 15248757 MOAD: Ki=0.9nM
    PDBbind: -logKd/Ki=9.05, Ki=0.9nM
    BindingDB: IC50=2nM
    39703 1s64:B (2.55) BS01 ZN 2.5.1.59 GO:0003824 ... P53610 15248757
    39704 1s64:B (2.55) BS02 778 2.5.1.59 GO:0003824 ... P53610 15248757 PDBbind: -logKd/Ki=8.40, Ki=4nM
    39705 1s64:D (2.55) BS01 ZN 2.5.1.59 GO:0003824 ... P53610 15248757
    39706 1s64:D (2.55) BS02 778 2.5.1.59 GO:0003824 ... P53610 15248757
    39707 1s64:F (2.55) BS01 ZN 2.5.1.59 GO:0003824 ... P53610 15248757
    39708 1s64:F (2.55) BS02 778 2.5.1.59 GO:0003824 ... P53610 15248757
    39709 1s64:H (2.55) BS01 ZN 2.5.1.59 GO:0003824 ... P53610 15248757
    39710 1s64:H (2.55) BS02 778 2.5.1.59 GO:0003824 ... P53610 15248757
    39711 1s64:J (2.55) BS01 ZN 2.5.1.59 GO:0003824 ... P53610 15248757
    39712 1s64:J (2.55) BS02 778 2.5.1.59 GO:0003824 ... P53610 15248757
    39713 1s64:L (2.55) BS01 ZN 2.5.1.59 GO:0003824 ... P53610 15248757
    39714 1s64:L (2.55) BS02 778 2.5.1.59 GO:0003824 ... P53610 15248757
    39715 1s69:A (1.68) BS01 CYN ? GO:0005344 ... P73925 15289104
    39716 1s69:A (1.68) BS02 HEM ? GO:0005344 ... P73925 15289104
    39717 1s6a:A (1.69) BS01 AZI ? GO:0005344 ... P73925 15289104
    39718 1s6a:A (1.69) BS02 HEM ? GO:0005344 ... P73925 15289104
    39719 1s6b:A (1.6) BS01 CA 3.1.1.4 GO:0004623 ... P60043 15828003
    39720 1s6b:B (1.6) BS01 CA 3.1.1.4 GO:0004623 ... P60044 15828003
    39721 1s6b:B (1.6) BS02 CA 3.1.1.4 GO:0004623 ... P60044 15828003
    39722 1s6f:A (1.8) BS01 CA 3.4.21.4 GO:0004252 ... P00761 15005618
    39723 1s6f:A (1.8) BS02 SBP 3.4.21.4 GO:0004252 ... P00761 15005618
    39724 1s6f:A (1.8) BS03 EDO 3.4.21.4 GO:0004252 ... P00761 15005618
    39725 1s6f:A (1.8) BS04 EDO 3.4.21.4 GO:0004252 ... P00761 15005618
    39726 1s6f:A (1.8) BS05 EDO 3.4.21.4 GO:0004252 ... P00761 15005618
    39727 1s6h:A (1.45) BS01 CA 3.4.21.4 GO:0004252 ... P00761 15005618
    39728 1s6h:A (1.45) BS02 4BZ 3.4.21.4 GO:0004252 ... P00761 15005618
    39729 1s6p:A (2.9) BS01 MG 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0003676 ... P03366 15115397
    39730 1s6p:A (2.9) BS02 IET 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0003676 ... P03366 15115397
    39731 1s6q:A (3.0) BS01 TPB 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0003676 ... P03366 15115397
    39732 1s6r:A (2.24) BS01 IAP 3.5.2.6 GO:0008800 ... Q93CA2 14521155
    39733 1s6v:A (1.88) BS01 HEC 1.11.1.5 GO:0004601 ... P00431 15071191
    39734 1s6v:B (1.88) BS01 HEC ? GO:0005515 ... P00044 15071191
    39735 1s6v:C (1.88) BS01 HEC 1.11.1.5 GO:0004601 ... P00431 15071191
    39736 1s6v:D (1.88) BS01 HEC ? GO:0005515 ... P00044 15071191
    39737 1s70:A (2.7) BS01 MN 3.1.3.16
    3.1.3.53    		 GO:0004721 ... P62207 15164081
    39738 1s70:A (2.7) BS02 MN 3.1.3.16
    3.1.3.53    		 GO:0004721 ... P62207 15164081
    39739 1s72:1 (2.4) BS01 rna ? GO:0003723 ... P32410 15184028
    39740 1s72:2 (2.4) BS01 rna ? GO:0003735 ... P22452 15184028
    39741 1s72:3 (2.4) BS01 rna ? GO:0000049 ... P32411 15184028
    39742 1s72:3 (2.4) BS02 MG ? GO:0000049 ... P32411 15184028
    39743 1s72:A (2.4) BS01 rna ? GO:0002181 ... P20276 15184028
    39744 1s72:A (2.4) BS02 MG ? GO:0002181 ... P20276 15184028
    39745 1s72:B (2.4) BS01 rna ? GO:0003723 ... P20279 15184028
    39746 1s72:C (2.4) BS01 rna ? GO:0003723 ... P12735 15184028
    39747 1s72:D (2.4) BS01 rna ? GO:0000049 ... P14124 15184028
    39748 1s72:D (2.4) BS02 rna ? GO:0000049 ... P14124 15184028
    39749 1s72:E (2.4) BS01 rna ? GO:0002181 ... P14135 15184028
    39750 1s72:F (2.4) BS01 rna ? GO:0001682 ... P12743 15184028
    39751 1s72:H (2.4) BS01 rna ? GO:0000027 ... P60617 15184028
    39752 1s72:I (2.4) BS01 rna ? GO:0003735 ... P14122 15184028
    39753 1s72:J (2.4) BS01 rna ? GO:0003729 ... P29198 15184028
    39754 1s72:K (2.4) BS01 rna ? GO:0003735 ... P22450 15184028
    39755 1s72:L (2.4) BS01 rna ? GO:0003735 ... P12737 15184028
    39756 1s72:M (2.4) BS01 rna ? GO:0002181 ... P60618 15184028
    39757 1s72:N (2.4) BS01 rna ? GO:0000027 ... P14123 15184028
    39758 1s72:N (2.4) BS02 rna ? GO:0000027 ... P14123 15184028
    39759 1s72:O (2.4) BS01 rna ? GO:0003723 ... P12733 15184028
    39760 1s72:P (2.4) BS01 rna ? GO:0003723 ... P14119 15184028
    39761 1s72:Q (2.4) BS01 rna ? GO:0003735 ... P12734 15184028
    39762 1s72:Q (2.4) BS02 rna ? GO:0003735 ... P12734 15184028
    39763 1s72:R (2.4) BS01 rna ? GO:0002181 ... P10970 15184028
    39764 1s72:S (2.4) BS01 rna ? GO:0000027 ... P12732 15184028
    39765 1s72:T (2.4) BS01 rna ? GO:0002181 ... P10972 15184028
    39766 1s72:T (2.4) BS02 MG ? GO:0002181 ... P10972 15184028
    39767 1s72:U (2.4) BS01 rna ? GO:0003735 ... P14116 15184028
    39768 1s72:V (2.4) BS01 rna ? GO:0003735 ... P10971 15184028
    39769 1s72:W (2.4) BS01 rna ? GO:0000463 ... P14121 15184028
    39770 1s72:W (2.4) BS02 rna ? GO:0000463 ... P14121 15184028
    39771 1s72:X (2.4) BS01 rna ? GO:0002181 ... P18138 15184028
    39772 1s72:Y (2.4) BS01 rna ? GO:0000166 ... P12736 15184028
    39773 1s72:Y (2.4) BS02 MG ? GO:0000166 ... P12736 15184028
    39774 1s72:Z (2.4) BS01 rna ? GO:0003735 ... P60619 15184028
    39775 1s73:A (1.53) BS01 FMI 1.11.1.5 GO:0004601 ... P00431 N/A
    39776 1s76:D (2.88) BS01 dna 2.7.7.6 GO:0000428 ... P00573 15016374
    39777 1s76:D (2.88) BS02 dna 2.7.7.6 GO:0000428 ... P00573 15016374
    39778 1s76:D (2.88) BS03 rna 2.7.7.6 GO:0000428 ... P00573 15016374
    39779 1s76:D (2.88) BS04 APC 2.7.7.6 GO:0000428 ... P00573 15016374
    39780 1s76:D (2.88) BS05 MG 2.7.7.6 GO:0000428 ... P00573 15016374
    39781 1s76:D (2.88) BS06 MG 2.7.7.6 GO:0000428 ... P00573 15016374
    39782 1s77:D (2.69) BS01 dna 2.7.7.6 GO:0000428 ... P00573 15016374
    39783 1s77:D (2.69) BS02 dna 2.7.7.6 GO:0000428 ... P00573 15016374
    39784 1s77:D (2.69) BS03 rna 2.7.7.6 GO:0000428 ... P00573 15016374
    39785 1s77:D (2.69) BS04 MG 2.7.7.6 GO:0000428 ... P00573 15016374
    39786 1s77:D (2.69) BS05 POP 2.7.7.6 GO:0000428 ... P00573 15016374
    39787 1s7g:A (2.3) BS01 ZN 2.3.1.286 GO:0005737 ... O30124 15023335
    39788 1s7g:A (2.3) BS02 ZN 2.3.1.286 GO:0005737 ... O30124 15023335
    39789 1s7g:A (2.3) BS03 NAD 2.3.1.286 GO:0005737 ... O30124 15023335
    39790 1s7g:B (2.3) BS01 ZN 2.3.1.286 GO:0005737 ... O30124 15023335
    39791 1s7g:B (2.3) BS02 ZN 2.3.1.286 GO:0005737 ... O30124 15023335
    39792 1s7g:B (2.3) BS03 NAD 2.3.1.286 GO:0005737 ... O30124 15023335
    39793 1s7g:C (2.3) BS01 ZN 2.3.1.286 GO:0005737 ... O30124 15023335
    39794 1s7g:C (2.3) BS02 ZN 2.3.1.286 GO:0005737 ... O30124 15023335
    39795 1s7g:C (2.3) BS03 NAD 2.3.1.286 GO:0005737 ... O30124 15023335
    39796 1s7g:D (2.3) BS01 ZN 2.3.1.286 GO:0005737 ... O30124 15023335
    39797 1s7g:D (2.3) BS02 ZN 2.3.1.286 GO:0005737 ... O30124 15023335
    39798 1s7g:E (2.3) BS01 ZN 2.3.1.286 GO:0005737 ... O30124 15023335
    39799 1s7g:E (2.3) BS02 APR 2.3.1.286 GO:0005737 ... O30124 15023335
    39800 1s7q:A (1.99) BS01 peptide ? GO:0001913 ... P01901 15100292
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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