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BioLiP
Download all results in tab-seperated text for 594392 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
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  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    34401 1uh4:A (1.8) BS16 CA 3.2.1.135 GO:0004553 ... Q60053 14687576
    34402 1uhl:A (2.9) BS01 peptide ? GO:0003677 ... P28702 12970175
    34403 1uhl:A (2.9) BS02 MEI ? GO:0003677 ... P28702 12970175
    34404 1uib:A (1.76) BS01 NAG 3.2.1.17 GO:0003796 ... P00698 11983077
    34405 1uib:A (1.76) BS02 NAG 3.2.1.17 GO:0003796 ... P00698 11983077
    34406 1uib:A (1.76) BS03 NAG 3.2.1.17 GO:0003796 ... P00698 11983077
    34407 1uih:A (1.75) BS01 NAG 3.2.1.17 GO:0003796 ... P00698 11983077
    34408 1uih:A (1.75) BS02 NAG 3.2.1.17 GO:0003796 ... P00698 11983077
    34409 1uim:A (2.15) BS01 PLP 4.2.3.1 GO:0004795 ... P83823 12952961
    34410 1uim:B (2.15) BS01 PLP 4.2.3.1 GO:0004795 ... P83823 12952961
    34411 1uin:A (2.25) BS01 PLP 4.2.3.1 GO:0004795 ... P83823 12952961
    34412 1uin:B (2.25) BS01 PLP 4.2.3.1 GO:0004795 ... P83823 12952961
    34413 1uio:A (2.4) BS01 ZN 3.5.4.4 GO:0000255 ... P03958 8942668
    34414 1uio:A (2.4) BS02 HPR 3.5.4.4 GO:0000255 ... P03958 8942668 MOAD: Ki=45uM
    34415 1uip:A (2.4) BS01 ZN 3.5.4.4 GO:0000255 ... P03958 8942668
    34416 1uip:A (2.4) BS02 PUR 3.5.4.4 GO:0000255 ... P03958 8942668
    34417 1uiw:A (1.5) BS01 HEM ? GO:0004601 ... P69905 15236579
    34418 1uiw:B (1.5) BS01 HEM ? GO:0004601 ... P68871 15236579
    34419 1uiw:C (1.5) BS01 HEM ? GO:0004601 ... P69905 15236579
    34420 1uiw:D (1.5) BS01 HEM ? GO:0004601 ... P68871 15236579
    34421 1uiw:E (1.5) BS01 HEM ? GO:0004601 ... P69905 15236579
    34422 1uiw:F (1.5) BS01 HEM ? GO:0004601 ... P68871 15236579
    34423 1uiw:G (1.5) BS01 HEM ? GO:0004601 ... P69905 15236579
    34424 1uiw:H (1.5) BS01 HEM ? GO:0004601 ... P68871 15236579
    34425 1uj2:A (1.8) BS01 C5P 2.7.1.48 GO:0004849 ... Q9BZX2 15130468
    34426 1uj2:A (1.8) BS02 ADP 2.7.1.48 GO:0004849 ... Q9BZX2 15130468
    34427 1uj2:B (1.8) BS01 C5P 2.7.1.48 GO:0004849 ... Q9BZX2 15130468
    34428 1uj2:B (1.8) BS02 ADP 2.7.1.48 GO:0004849 ... Q9BZX2 15130468
    34429 1ujc:A (1.9) BS01 WO4 3.1.3.- GO:0004721 ... P76502 15670209
    34430 1ujj:A (2.6) BS01 peptide ? GO:0005802 ... Q9UJY5 15117318
    34431 1ujk:A (1.9) BS01 peptide ? GO:0005802 ... Q9UJY5 15117318
    34432 1ujk:B (1.9) BS01 peptide ? GO:0005802 ... Q9UJY5 15117318
    34433 1ujw:A (2.75) BS01 GP1 ? GO:0005509 ... P06129 14528295
    34434 1ujw:A (2.75) BS02 GP1 ? GO:0005509 ... P06129 14528295
    34435 1ujw:A (2.75) BS03 LIM ? GO:0005509 ... P06129 14528295
    34436 1ujw:A (2.75) BS04 LIM ? GO:0005509 ... P06129 14528295
    34437 1uke:A (2.2) BS01 UP5 2.7.4.14 GO:0000287 ... P20425 8703943
    34438 1ukm:B (1.9) BS01 NAG ? GO:0005576 ... Q7T2Q0 14580195
    34439 1ukq:A (2.0) BS01 BGC 2.4.1.19 GO:0003824 ... P05618 14769878
    34440 1ukq:A (2.0) BS02 G6D 2.4.1.19 GO:0003824 ... P05618 14769878
    34441 1ukq:A (2.0) BS03 GLC 2.4.1.19 GO:0003824 ... P05618 14769878
    34442 1ukq:A (2.0) BS04 ACI 2.4.1.19 GO:0003824 ... P05618 14769878
    34443 1ukq:A (2.0) BS05 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34444 1ukq:A (2.0) BS06 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34445 1ukq:B (2.0) BS01 GLC 2.4.1.19 GO:0003824 ... P05618 14769878
    34446 1ukq:B (2.0) BS02 G6D 2.4.1.19 GO:0003824 ... P05618 14769878
    34447 1ukq:B (2.0) BS03 GLC 2.4.1.19 GO:0003824 ... P05618 14769878
    34448 1ukq:B (2.0) BS04 ACI 2.4.1.19 GO:0003824 ... P05618 14769878
    34449 1ukq:B (2.0) BS05 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34450 1ukq:B (2.0) BS06 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34451 1uks:A (1.9) BS01 GAL 2.4.1.19 GO:0003824 ... P05618 14769878
    34452 1uks:A (1.9) BS02 GLD 2.4.1.19 GO:0003824 ... P05618 14769878
    34453 1uks:A (1.9) BS03 GLC 2.4.1.19 GO:0003824 ... P05618 14769878
    34454 1uks:A (1.9) BS04 ACI 2.4.1.19 GO:0003824 ... P05618 14769878
    34455 1uks:A (1.9) BS05 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34456 1uks:A (1.9) BS06 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34457 1uks:B (1.9) BS01 GAL 2.4.1.19 GO:0003824 ... P05618 14769878
    34458 1uks:B (1.9) BS02 GLD 2.4.1.19 GO:0003824 ... P05618 14769878
    34459 1uks:B (1.9) BS03 ACI 2.4.1.19 GO:0003824 ... P05618 14769878
    34460 1uks:B (1.9) BS04 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34461 1uks:B (1.9) BS05 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34462 1ukt:A (2.2) BS01 GLC 2.4.1.19 GO:0003824 ... P05618 14769878 PDBbind: -logKd/Ki=2.25, IC50>5600uM
    34463 1ukt:A (2.2) BS02 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34464 1ukt:A (2.2) BS03 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34465 1ukt:B (2.2) BS01 GLC 2.4.1.19 GO:0003824 ... P05618 14769878
    34466 1ukt:B (2.2) BS02 GLD 2.4.1.19 GO:0003824 ... P05618 14769878
    34467 1ukt:B (2.2) BS03 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34468 1ukt:B (2.2) BS04 CA 2.4.1.19 GO:0003824 ... P05618 14769878
    34469 1ukv:G (1.5) BS01 GER ? GO:0005092 ... P39958 14576435
    34470 1ukv:Y (1.5) BS01 GDP ? GO:0000045 ... P01123 14576435
    34471 1uky:A (2.13) BS01 ADP 2.7.4.14 GO:0004017 ... P15700 7877173
    34472 1uky:A (2.13) BS02 ADP 2.7.4.14 GO:0004017 ... P15700 7877173
    34473 1ukz:A (1.9) BS01 ADP 2.7.4.14 GO:0004017 ... P15700 7877173
    34474 1ukz:A (1.9) BS02 AMP 2.7.4.14 GO:0004017 ... P15700 7877173
    34475 1ul1:X (2.9) BS01 MG 3.1.-.- GO:0000287 ... P39748 15616578
    34476 1ul1:X (2.9) BS02 MG 3.1.-.- GO:0000287 ... P39748 15616578
    34477 1ul3:B (2.0) BS01 CA ? GO:0000166 ... Q55247 14646076
    34478 1ul3:C (2.0) BS01 CA ? GO:0000166 ... Q55247 14646076
    34479 1ul4:A (-1.00) BS01 ZN ? GO:0003677 ... Q9S7A9 15001351
    34480 1ul4:A (-1.00) BS02 ZN ? GO:0003677 ... Q9S7A9 15001351
    34481 1ul5:A (-1.00) BS01 ZN ? GO:0003677 ... Q8S9G8 15001351
    34482 1ul5:A (-1.00) BS02 ZN ? GO:0003677 ... Q8S9G8 15001351
    34483 1ulc:A (2.6) BS01 BGC ? GO:0005576 ... Q9P4R8 15062091
    34484 1ulc:A (2.6) BS02 GAL ? GO:0005576 ... Q9P4R8 15062091
    34485 1ulc:B (2.6) BS01 BGC ? GO:0005576 ... Q9P4R8 15062091
    34486 1ulc:B (2.6) BS02 GAL ? GO:0005576 ... Q9P4R8 15062091
    34487 1uld:A (2.1) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34488 1uld:B (2.1) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34489 1uld:C (2.1) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34490 1uld:D (2.1) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34491 1ule:A (2.15) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34492 1ule:B (2.15) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34493 1ulf:A (2.36) BS01 BGC ? GO:0005576 ... Q9P4R8 15062091
    34494 1ulf:A (2.36) BS02 GAL ? GO:0005576 ... Q9P4R8 15062091
    34495 1ulf:B (2.36) BS01 BGC ? GO:0005576 ... Q9P4R8 15062091
    34496 1ulf:B (2.36) BS02 GAL ? GO:0005576 ... Q9P4R8 15062091
    34497 1ulg:A (2.2) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34498 1ulg:B (2.2) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34499 1ulg:C (2.2) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34500 1ulg:D (2.2) BS01 GAL ? GO:0005576 ... Q9P4R8 15062091
    34501 1ulx:A (2.0) BS01 HEM 1.14.14.18 GO:0001525 ... P06762 15312758
    34502 1um0:A (1.95) BS01 FMN 4.2.3.5 GO:0004107 ... P56122 15095868
    34503 1um0:A (1.95) BS02 FMN 4.2.3.5 GO:0004107 ... P56122 15095868
    34504 1um0:B (1.95) BS01 FMN 4.2.3.5 GO:0004107 ... P56122 15095868
    34505 1um0:B (1.95) BS02 FMN 4.2.3.5 GO:0004107 ... P56122 15095868
    34506 1um0:C (1.95) BS01 FMN 4.2.3.5 GO:0004107 ... P56122 15095868
    34507 1um0:C (1.95) BS02 FMN 4.2.3.5 GO:0004107 ... P56122 15095868
    34508 1um0:D (1.95) BS01 FMN 4.2.3.5 GO:0004107 ... P56122 15095868
    34509 1um0:D (1.95) BS02 FMN 4.2.3.5 GO:0004107 ... P56122 15095868
    34510 1umk:A (1.75) BS01 FAD 1.6.2.2 GO:0004128 ... P00387 15502298
    34511 1uml:A (2.5) BS01 ZN 3.5.4.4 GO:0004000 ... P56658 15239652
    34512 1uml:A (2.5) BS02 FR4 3.5.4.4 GO:0004000 ... P56658 15239652 MOAD: Ki=30nM
    PDBbind: -logKd/Ki=7.52, Ki=30nM
    34513 1umn:K (1.95) BS01 CA 1.16.-.- GO:0005737 ... P0CB53 15081812
    34514 1umo:A (2.59) BS01 HEM 1.11.1.-
    1.14.12.-
    1.15.1.1
    1.7.-.-    		 GO:0001666 ... Q8WWM9 15095869
    34515 1umo:B (2.59) BS01 HEM 1.11.1.-
    1.14.12.-
    1.15.1.1
    1.7.-.-    		 GO:0001666 ... Q8WWM9 15095869
    34516 1ump:A (2.13) BS01 C8E 4.2.1.129
    5.4.99.17    		 GO:0005811 ... P33247 15113001
    34517 1ump:A (2.13) BS02 SQA 4.2.1.129
    5.4.99.17    		 GO:0005811 ... P33247 15113001
    34518 1ump:B (2.13) BS01 C8E 4.2.1.129
    5.4.99.17    		 GO:0005811 ... P33247 15113001
    34519 1ump:B (2.13) BS02 C8E 4.2.1.129
    5.4.99.17    		 GO:0005811 ... P33247 15113001
    34520 1ump:B (2.13) BS03 SQA 4.2.1.129
    5.4.99.17    		 GO:0005811 ... P33247 15113001
    34521 1ump:C (2.13) BS01 C8E 4.2.1.129
    5.4.99.17    		 GO:0005811 ... P33247 15113001
    34522 1ump:C (2.13) BS02 C8E 4.2.1.129
    5.4.99.17    		 GO:0005811 ... P33247 15113001
    34523 1ump:C (2.13) BS03 SQA 4.2.1.129
    5.4.99.17    		 GO:0005811 ... P33247 15113001
    34524 1ums:A (-1.00) BS01 ZN 3.4.24.17 GO:0004222 ... P08254 8580839
    34525 1ums:A (-1.00) BS02 ZN 3.4.24.17 GO:0004222 ... P08254 8580839
    34526 1ums:A (-1.00) BS03 CA 3.4.24.17 GO:0004222 ... P08254 8580839
    34527 1ums:A (-1.00) BS04 0DS 3.4.24.17 GO:0004222 ... P08254 8580839 BindingDB: Ki=127nM
    34528 1umt:A (-1.00) BS01 ZN 3.4.24.17 GO:0004222 ... P08254 8580839
    34529 1umt:A (-1.00) BS02 ZN 3.4.24.17 GO:0004222 ... P08254 8580839
    34530 1umt:A (-1.00) BS03 CA 3.4.24.17 GO:0004222 ... P08254 8580839
    34531 1umt:A (-1.00) BS04 0DS 3.4.24.17 GO:0004222 ... P08254 8580839 BindingDB: Ki=127nM
    34532 1umv:X (1.79) BS01 CA 3.1.1.4 GO:0004623 ... Q8AXY1 15351695
    34533 1umx:L (2.8) BS01 BCL ? GO:0009772 ... P0C0Y8 14741581
    34534 1umx:L (2.8) BS02 BCL ? GO:0009772 ... P0C0Y8 14741581
    34535 1umx:L (2.8) BS03 BPB ? GO:0009772 ... P0C0Y8 14741581
    34536 1umx:L (2.8) BS04 BCL ? GO:0009772 ... P0C0Y8 14741581
    34537 1umx:L (2.8) BS05 FE ? GO:0009772 ... P0C0Y8 14741581
    34538 1umx:L (2.8) BS06 BPB ? GO:0009772 ... P0C0Y8 14741581
    34539 1umx:M (2.8) BS01 BCL ? GO:0009772 ... P0C0Y9 14741581
    34540 1umx:M (2.8) BS02 BPB ? GO:0009772 ... P0C0Y9 14741581
    34541 1umx:M (2.8) BS03 BCL ? GO:0009772 ... P0C0Y9 14741581
    34542 1umx:M (2.8) BS04 BCL ? GO:0009772 ... P0C0Y9 14741581
    34543 1umx:M (2.8) BS05 FE ? GO:0009772 ... P0C0Y9 14741581
    34544 1umx:M (2.8) BS06 BPB ? GO:0009772 ... P0C0Y9 14741581
    34545 1umx:M (2.8) BS07 SPN ? GO:0009772 ... P0C0Y9 14741581
    34546 1umx:M (2.8) BS08 U10 ? GO:0009772 ... P0C0Y9 14741581
    34547 1umy:A (2.5) BS01 ZN 2.1.1.5 GO:0005634 ... O09171 15099744
    34548 1umy:B (2.5) BS01 ZN 2.1.1.5 GO:0005634 ... O09171 15099744
    34549 1umy:C (2.5) BS01 ZN 2.1.1.5 GO:0005634 ... O09171 15099744
    34550 1umy:D (2.5) BS01 ZN 2.1.1.5 GO:0005634 ... O09171 15099744
    34551 1umz:A (1.8) BS01 BGC 2.4.1.207 GO:0004553 ... Q8GZD5 15020748
    34552 1umz:A (1.8) BS02 GAL 2.4.1.207 GO:0004553 ... Q8GZD5 15020748
    34553 1umz:B (1.8) BS01 BGC 2.4.1.207 GO:0004553 ... Q8GZD5 15020748
    34554 1umz:B (1.8) BS02 BGC 2.4.1.207 GO:0004553 ... Q8GZD5 15020748
    34555 1umz:B (1.8) BS03 XYS 2.4.1.207 GO:0004553 ... Q8GZD5 15020748
    34556 1umz:B (1.8) BS04 XYS 2.4.1.207 GO:0004553 ... Q8GZD5 15020748
    34557 1umz:B (1.8) BS05 GAL 2.4.1.207 GO:0004553 ... Q8GZD5 15020748
    34558 1un0:A (2.6) BS01 peptide ? GO:0005737 ... Q02821 14532109
    34559 1un0:B (2.6) BS01 peptide ? GO:0005737 ... Q02821 14532109
    34560 1un9:A (3.1) BS01 ANP 2.7.1.29 GO:0004371 ... P45510 12966101
    34561 1un9:A (3.1) BS02 MG 2.7.1.29 GO:0004371 ... P45510 12966101
    34562 1un9:A (3.1) BS03 MG 2.7.1.29 GO:0004371 ... P45510 12966101
    34563 1un9:A (3.1) BS04 2HA 2.7.1.29 GO:0004371 ... P45510 12966101
    34564 1un9:B (3.1) BS01 ANP 2.7.1.29 GO:0004371 ... P45510 12966101
    34565 1un9:B (3.1) BS02 MG 2.7.1.29 GO:0004371 ... P45510 12966101
    34566 1un9:B (3.1) BS03 MG 2.7.1.29 GO:0004371 ... P45510 12966101
    34567 1un9:B (3.1) BS04 2HA 2.7.1.29 GO:0004371 ... P45510 12966101
    34568 1une:A (1.5) BS01 CA 3.1.1.4 GO:0002227 ... P00593 10089393
    34569 1unf:X (1.97) BS01 FE 1.15.1.1 GO:0004784 ... Q9M7R2 15659371
    34570 1ung:A (2.3) BS01 ALH 2.7.11.1 GO:0000226 ... Q00535 15689152 MOAD: ic50=0.18uM
    PDBbind: -logKd/Ki=6.80, IC50=0.16uM
    BindingDB: IC50=200nM
    34571 1ung:B (2.3) BS01 ALH 2.7.11.1 GO:0000226 ... Q00535 15689152 MOAD: ic50=0.18uM
    BindingDB: IC50=200nM
    34572 1unh:A (2.35) BS01 IXM 2.7.11.1 GO:0000226 ... Q00535 15689152 MOAD: ic50=0.1uM
    PDBbind: -logKd/Ki=7.00, IC50=0.10uM
    34573 1unh:B (2.35) BS01 IXM 2.7.11.1 GO:0000226 ... Q00535 15689152 MOAD: ic50=0.1uM
    34574 1unl:A (2.2) BS01 RRC 2.7.11.1 GO:0000226 ... Q00535 15689152 PDBbind: -logKd/Ki=6.70, IC50=0.20uM
    BindingDB: IC50=160nM, Kd=1900nM
    34575 1uns:A (2.0) BS01 ZN ? GO:0005576 ... P34071 14559915
    34576 1uns:A (2.0) BS02 ZN ? GO:0005576 ... P34071 14559915
    34577 1uo6:A (1.65) BS01 XE 3.4.21.36 GO:0004252 ... P00772 14684889
    34578 1uoc:A (2.3) BS01 CA 3.1.13.4 GO:0003676 ... P39008 14618157
    34579 1uoc:B (2.3) BS01 CA 3.1.13.4 GO:0003676 ... P39008 14618157
    34580 1uod:A (1.9) BS01 G3H 2.7.1.121 GO:0004371 ... P76015 15476397 PDBbind: -logKd/Ki=3.11, Kd=0.78mM
    34581 1uod:B (1.9) BS01 G3H 2.7.1.121 GO:0004371 ... P76015 15476397
    34582 1uoe:A (2.0) BS01 GOL 2.7.1.121 GO:0004371 ... P76015 15476397
    34583 1uoe:B (2.0) BS01 GOL 2.7.1.121 GO:0004371 ... P76015 15476397
    34584 1uol:A (1.9) BS01 ZN ? GO:0000976 ... P04637 14534297
    34585 1uol:B (1.9) BS01 ZN ? GO:0000976 ... P04637 14534297
    34586 1uon:A (7.6) BS01 rna 2.7.7.48 GO:0001172 ... Q8V1A3 14608373
    34587 1uon:A (7.6) BS02 rna 2.7.7.48 GO:0001172 ... Q8V1A3 14608373
    34588 1uon:A (7.6) BS03 CH1 2.7.7.48 GO:0001172 ... Q8V1A3 14608373
    34589 1uon:A (7.6) BS04 CH1 2.7.7.48 GO:0001172 ... Q8V1A3 14608373
    34590 1uon:A (7.6) BS05 CH1 2.7.7.48 GO:0001172 ... Q8V1A3 14608373
    34591 1uon:A (7.6) BS06 MN 2.7.7.48 GO:0001172 ... Q8V1A3 14608373
    34592 1uon:A (7.6) BS07 MN 2.7.7.48 GO:0001172 ... Q8V1A3 14608373
    34593 1uoo:A (2.35) BS01 peptide 3.4.21.26 GO:0004252 ... P23687 14514675
    34594 1uop:A (1.85) BS01 peptide 3.4.21.26 GO:0004252 ... P23687 14514675
    34595 1uoq:A (2.1) BS01 peptide 3.4.21.26 GO:0004252 ... P23687 14514675
    34596 1uou:A (2.11) BS01 CMU 2.4.2.4 GO:0000002 ... P19971 14725767 MOAD: Ki=20nM
    PDBbind: -logKd/Ki=7.70, Ki=20nM
    BindingDB: IC50=35nM, Ki=20nM
    34597 1uov:A (1.65) BS01 CA ? GO:0016020 ... P21707 15340165
    34598 1uov:A (1.65) BS02 CA ? GO:0016020 ... P21707 15340165
    34599 1uov:A (1.65) BS03 CA ? GO:0016020 ... P21707 15340165
    34600 1uow:A (1.04) BS01 CA ? GO:0016020 ... P21707 15340165
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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