1a69 A 2.1 BS01 FMB A 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 Ki=5uM -logKd/Ki=5.30, Ki=5uM P0ABP8 9653038 240 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1a69 B 2.1 BS01 FMB B 1 M64 S90 F159 V178 E179 M180 E181 M64 S90 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 Ki=5uM P0ABP8 9653038 240 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1a69 C 2.1 BS01 FMB C 1 S90 C91 G92 F159 V178 M180 E181 D204 S90 C91 G92 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R213 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 Ki=5uM -logKd/Ki=5.30, Ki=5uM P0ABP8 9653038 240 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTTAAERQTTFNDMIKIALESVLLGDK 1a9o A 2.0 BS01 PO4 A 1 G32 R84 N115 S220 G32 R84 N115 S220 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 9585525 291 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 1a9p A 2.4 BS01 PO4 A 1 G32 S33 H64 R84 H86 N115 S220 G32 S33 H64 R84 H86 N115 S220 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 9585525 291 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 1a9p A 2.4 BS02 9DI A 1 H86 Y88 A116 G118 F200 E201 M219 N243 H257 E259 H86 Y88 A116 G118 F200 E201 M219 N243 H257 E259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 9585525 290 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 1a9q A 2.0 BS01 HPA A 1 A117 G118 F200 E201 M219 N243 A117 G118 F200 E201 M219 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 -logKd/Ki=6.17, Kd=0.68uM Kd=680nM P55859 9585525 290 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1a9r A 2.0 BS01 HPA A 1 A117 G118 F200 E201 V217 N243 A117 G118 F200 E201 V217 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=680nM P55859 9585525 290 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1a9s A 2.0 BS01 NOS A 1 Y88 A116 G118 F200 E201 M219 T242 N243 H257 V260 Y88 A116 G118 F200 E201 M219 T242 N243 H257 V260 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 9585525 290 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1a9t A 2.0 BS01 R1P A 1 S33 R84 H86 Y88 N115 A116 F200 M219 S220 V260 S33 R84 H86 Y88 N115 A116 F200 M219 S220 V260 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 9585525 291 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 1a9t A 2.0 BS02 HPA A 1 A116 A117 G118 F200 E201 V217 N243 A116 A117 G118 F200 E201 V217 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=680nM P55859 9585525 290 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 1b8n A 2.0 BS01 IMG A 1 H86 Y88 A116 G118 F200 E201 V217 G218 M219 N243 H257 V260 H85 Y87 A115 G117 F199 E200 V216 G217 M218 N242 H256 V259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S32 H63 H85 Y87 E88 A115 M218 S219 N242 V244 H256 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Ki=30pM -logKd/Ki=10.52, Ki=30pM Ki=0.030000nM P55859 12463747 600 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLM 1b8o A 1.5 BS01 PO4 A 1 G32 S33 R84 H86 N115 S220 G30 S31 R82 H84 N113 S218 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 11170405 599 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1b8o A 1.5 BS02 IMH A 1 H86 Y88 A116 G118 F200 E201 M219 N243 H257 V260 H84 Y86 A114 G116 F198 E199 M217 N241 H255 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Ki=23pM -logKd/Ki=10.64, Ki=23pM P55859 11170405 600 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1c3x A 2.4 BS01 PO4 A 1 G45 S46 R103 H105 N134 S223 G37 S38 R87 H89 N118 S207 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 303 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x A 2.4 BS02 8IG A 1 G135 C136 G137 Y203 E204 G221 M222 T245 G119 C120 G121 Y187 E188 G205 M206 T229 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 -logKd/Ki=3.68, Ki=210uM P81989 10600382 306 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x B 2.4 BS01 PO4 B 1 G45 S46 R103 H105 N134 S223 G37 S38 R87 H89 N118 S207 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 302 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x B 2.4 BS02 CA B 1 G126 E128 G110 E112 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 300 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x B 2.4 BS03 8IG B 1 G135 C136 G137 Y203 E204 G221 M222 T245 G119 C120 G121 Y187 E188 G205 M206 T229 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 -logKd/Ki=3.68, Ki=210uM P81989 10600382 305 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x C 2.4 BS01 PO4 C 1 S46 R103 N134 S223 S38 R87 N118 S207 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 301 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1c3x C 2.4 BS02 8IG C 1 G135 C136 G137 Y203 E204 G221 M222 T245 G119 C120 G121 Y187 E188 G205 M206 T229 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 304 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1fxu A 2.2 BS01 PO4 A 1 G32 S33 R84 H86 N115 S220 G29 S30 R81 H83 N112 S217 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 H251 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 11134924 291 GYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTGKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 1fxu A 2.2 BS02 GU7 A 1 Y88 A116 A117 G118 F200 E201 M219 T242 N243 H257 V260 Y85 A113 A114 G115 F197 E198 M216 T239 N240 H251 V254 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 H251 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 11134924 290 GYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTGKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 1g2o A 1.75 BS01 PO4 A 1 G35 S36 R88 H90 N119 S208 G29 S30 R82 H84 N113 S202 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 11444966 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1g2o A 1.75 BS02 IMH A 1 Y92 A120 G122 Y188 E189 V205 G206 M207 N231 H243 Y86 A114 G116 Y182 E183 V199 G200 M201 N225 H237 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Ki=28pM -logKd/Ki=10.55, Ki=28pM P9WP01 11444966 351 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1g2o B 1.75 BS01 PO4 B 1 G35 S36 R88 H90 N119 S208 G29 S30 R82 H84 N113 S202 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 11444966 302 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1g2o B 1.75 BS02 IMH B 1 Y92 A120 G122 Y188 E189 G206 M207 N231 H243 Y86 A114 G116 Y182 E183 G200 M201 N225 H237 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Ki=28pM -logKd/Ki=10.55, Ki=28pM P9WP01 11444966 352 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1g2o C 1.75 BS01 PO4 C 1 G35 S36 R88 H90 N119 S208 G29 S30 R82 H84 N113 S202 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 11444966 303 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1g2o C 1.75 BS02 IMH C 1 H90 Y92 A120 G122 Y188 E189 G206 M207 N231 H243 H84 Y86 A114 G116 Y182 E183 G200 M201 N225 H237 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Ki=28pM P9WP01 11444966 353 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1i80 A 2.0 BS01 PO4 A 1 G35 S36 R88 H90 N119 A120 S208 G33 S34 R86 H88 N117 A118 S206 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S34 H66 H88 Y90 E91 A118 M205 S206 N229 A231 H241 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 11444966 401 DPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1i80 A 2.0 BS02 9HX A 1 A120 A121 G122 E189 V205 G206 M207 N231 A118 A119 G120 E187 V203 G204 M205 N229 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S34 H66 H88 Y90 E91 A118 M205 S206 N229 A231 H241 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Kd=0.39uM P9WP01 11444966 301 DPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1i80 A 2.0 BS03 IMR A 1 S36 Y92 Y188 M207 H243 S34 Y90 Y186 M205 H241 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S34 H66 H88 Y90 E91 A118 M205 S206 N229 A231 H241 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 11444966 351 DPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1i80 B 2.0 BS01 9HX B 1 A120 A121 G122 Y188 E189 V205 G206 T230 N231 A115 A116 G117 Y183 E184 V200 G201 T225 N226 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S31 H63 H85 Y87 E88 A115 M202 S203 N226 A228 H238 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Kd=0.39uM -logKd/Ki=6.41, Kd=0.39uM P9WP01 11444966 302 PDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1i80 C 2.0 BS01 9HX C 1 A120 A121 G122 Y188 E189 V205 G206 M207 T230 N231 A114 A115 G116 Y182 E183 V199 G200 M201 T224 N225 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Kd=0.39uM -logKd/Ki=6.41, Kd=0.39uM P9WP01 11444966 303 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 1jds A 1.8 BS01 PO4 A 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 1250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jds B 1.8 BS01 PO4 B 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jds C 1.8 BS01 PO4 C 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L217 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1jds D 1.8 BS01 PO4 D 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 4250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jds E 1.8 BS01 PO4 E 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 5250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jds F 1.8 BS01 PO4 F 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L213 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 6250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKITKEELEKSVMDGAKAVLDTLTS 1jdt A 2.0 BS01 SO4 A 1 G21 R25 R86 G88 T89 G20 R24 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L214 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 1250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKITKEELEKSVMDGAKAVLDTLTS 1jdt A 2.0 BS02 MTA A 1 T89 T90 G91 F160 E163 V179 E180 M181 E182 D205 T88 T89 G90 F159 E162 V178 E179 M180 E181 D204 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L214 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 1260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKITKEELEKSVMDGAKAVLDTLTS 1jdt B 2.0 BS01 SO4 B 1 G21 R25 R86 G88 T89 G20 R24 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L214 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKITKEELEKSVMDGAKAVLDTLTS 1jdt B 2.0 BS02 MTA B 1 T89 T90 F160 E163 V179 E180 M181 E182 D205 T88 T89 F159 E162 V178 E179 M180 E181 D204 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L214 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKITKEELEKSVMDGAKAVLDTLTS 1jdt B 2.0 BS03 MTA C 1 H5 R43 H4 R42 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L214 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKITKEELEKSVMDGAKAVLDTLTS 1jdt C 2.0 BS01 MTA B 1 H5 R43 H4 R42 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKLEKSVMDGAKAVLDTLTS 1jdt C 2.0 BS02 SO4 C 1 G21 R25 R86 G88 T89 G20 R24 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKLEKSVMDGAKAVLDTLTS 1jdt C 2.0 BS03 MTA C 1 T89 T90 F160 E163 V179 M181 E182 D205 T88 T89 F159 E162 V178 M180 E181 D204 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKLEKSVMDGAKAVLDTLTS 1jdv A 2.0 BS01 SO4 A 1 G21 R25 R86 G88 T89 G20 R24 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 1250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jdv A 2.0 BS02 ADN A 1 T89 T90 F160 E163 V179 E180 M181 E182 D205 T88 T89 F159 E162 V178 E179 M180 E181 D204 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 1260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jdv B 2.0 BS01 SO4 B 1 G21 R25 R86 G88 T89 G20 R24 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jdv B 2.0 BS02 ADN B 1 T89 T90 F160 E163 E180 M181 E182 D205 T88 T89 F159 E162 E179 M180 E181 D204 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jdv C 2.0 BS01 SO4 C 1 G21 R86 G88 T89 G20 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L218 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1jdv D 2.0 BS01 SO4 D 1 G21 R25 R86 G88 T89 G20 R24 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 4250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jdv D 2.0 BS02 ADN D 1 T89 T90 F160 E163 V179 E180 M181 E182 D205 T88 T89 F159 E162 V178 E179 M180 E181 D204 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jdv E 2.0 BS01 SO4 E 1 G21 R25 R86 G88 T89 G20 R24 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 5250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jdv E 2.0 BS02 ADN E 1 T89 T90 F160 E163 E180 M181 E182 D205 T88 T89 F159 E162 E179 M180 E181 D204 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 4260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKELEKSVMDGAKAVLDTLTS 1jdv F 2.0 BS01 SO4 F 1 G21 R86 G88 T89 G20 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L218 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 6250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1jdz A 2.0 BS01 SO4 A 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1jdz A 2.0 BS02 FMB A 1 I64 T89 T90 G91 V179 E180 M181 E182 I62 T87 T88 G89 V177 E178 M179 E180 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 270 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1jdz B 2.0 BS01 SO4 B 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 255 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1jdz B 2.0 BS02 FMB B 1 I64 T89 T90 G91 M181 E182 D205 I62 T87 T88 G89 M179 E180 D203 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 275 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1jdz B 2.0 BS03 FMB C 1 H5 R43 H3 R41 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 280 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1jdz C 2.0 BS01 SO4 C 1 G21 R86 G88 G19 R84 G86 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 260 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1jdz C 2.0 BS02 FMB C 1 I64 T89 T90 G91 V179 M181 E182 D205 I62 T87 T88 G89 V177 M179 E180 D203 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 280 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1je0 A 1.6 BS01 PO4 A 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1je0 B 1.6 BS01 PO4 B 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L209 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 255 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAEELEKSVMDGAKAVLDTLTS 1je0 C 1.6 BS01 PO4 C 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 260 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKEELEKSVMDGAKAVLDTLTS 1je1 A 1.8 BS01 SO4 A 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L215 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 1250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKIWITKEELEKSVMDGAKAVLDTLTS 1je1 A 1.8 BS02 GMP A 1 T89 T90 G91 F160 E163 E180 M181 E182 T87 T88 G89 F158 E161 E178 M179 E180 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L215 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 1260 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKIWITKEELEKSVMDGAKAVLDTLTS 1je1 B 1.8 BS01 SO4 B 1 G21 R25 R86 G88 T89 G20 R24 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L214 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKITKEELEKSVMDGAKAVLDTLTS 1je1 B 1.8 BS02 GMP B 1 T89 T90 F160 E163 V179 E180 M181 E182 T88 T89 F159 E162 V178 E179 M180 E181 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L214 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKITKEELEKSVMDGAKAVLDTLTS 1je1 C 1.8 BS01 SO4 C 1 G21 R86 G88 T89 G20 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L218 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1je1 C 1.8 BS02 GMP C 1 T89 T90 G91 F160 E163 E180 M181 E182 T88 T89 G90 F159 E162 E179 M180 E181 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L218 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1je1 D 1.8 BS01 SO4 D 1 G21 R25 R86 G88 T89 G19 R23 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L214 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 4250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKWITKEELEKSVMDGAKAVLDTLTS 1je1 D 1.8 BS02 GMP D 1 T89 T90 G91 F160 E163 V179 E180 M181 E182 T87 T88 G89 F158 E161 V177 E178 M179 E180 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L214 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 4260 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKWITKEELEKSVMDGAKAVLDTLTS 1je1 E 1.8 BS01 SO4 E 1 G21 R86 G88 T89 G20 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L213 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 5250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKTKEELEKSVMDGAKAVLDTLTS 1je1 E 1.8 BS02 GMP E 1 T89 T90 F160 E163 E180 M181 E182 T88 T89 F159 E162 E179 M180 E181 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L213 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 5260 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKTKEELEKSVMDGAKAVLDTLTS 1je1 F 1.8 BS01 SO4 F 1 G21 R86 G88 T89 G19 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L217 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 6250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1je1 F 1.8 BS02 GMP F 1 T89 T90 G91 F160 E163 E180 M181 E182 T87 T88 G89 F158 E161 E178 M179 E180 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L217 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 6260 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1jp7 A 1.8 BS01 SO4 A 1 G21 R86 G88 T89 G19 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L211 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 1250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKKEELEKSVMDGAKAVLDTLTS 1jp7 B 1.8 BS01 SO4 B 1 G21 R86 G88 T89 G19 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L210 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKEELEKSVMDGAKAVLDTLTS 1jp7 C 1.8 BS01 SO4 C 1 G21 R86 G88 T89 G19 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L211 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKKEELEKSVMDGAKAVLDTLTS 1jpv A 1.8 BS01 SO4 A 1 G21 R86 G88 T89 G20 R85 G87 T88 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H4 G20 R24 R42 E74 R85 T88 S203 D204 L206 L218 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 1250 NPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1jpv B 1.8 BS01 SO4 B 1 G21 R86 G88 T89 G19 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L217 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 2250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1jpv C 1.8 BS01 SO4 C 1 G21 R86 G88 T89 G19 R84 G86 T87 H5 G21 R25 R43 E75 R86 T89 S204 D205 L207 L219 H3 G19 R23 R41 E73 R84 T87 S202 D203 L205 L217 2.4.2.1,2.4.2.28 0003824,0005829,0009116,0009164,0016757,0016763,0017061 P50389 11489901 3250 PVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS 1k9s A 2.0 BS01 PO4 A 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9902 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s A 2.0 BS02 FM2 A 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 -logKd/Ki=6.52, Ki=0.30uM P0ABP8 11786017 9901 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s B 2.0 BS01 PO4 B 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9904 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s B 2.0 BS02 FM2 B 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9903 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s C 2.0 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9906 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s C 2.0 BS02 FM2 C 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9905 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s D 2.0 BS01 FM2 A 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 -logKd/Ki=6.52, Ki=0.30uM P0ABP8 11786017 9901 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s D 2.0 BS02 PO4 D 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9908 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s D 2.0 BS03 FM1 D 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 I206 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9907 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s E 2.0 BS01 FM2 B 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9903 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s E 2.0 BS02 PO4 E 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9910 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s E 2.0 BS03 FM1 E 1 M64 S90 F159 V178 E179 M180 E181 D204 M64 S90 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9909 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s F 2.0 BS01 FM2 C 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9905 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s F 2.0 BS02 PO4 F 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9912 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1k9s F 2.0 BS03 FM1 F 1 M64 S90 F159 V178 E179 M180 E181 D204 M64 S90 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 11786017 9911 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1lv8 A 2.3 BS01 CA A 1 S51 E58 S49 E56 S33 H64 Y88 A116 M219 S220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 7002 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 A 2.3 BS02 9PP A 1 G32 S33 H86 N115 A116 A117 G118 F200 E201 M219 S220 N243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S33 H64 Y88 A116 M219 S220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM -logKd/Ki=5.46, Kd=3.5uM P55859 15342253 3001 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 B 2.3 BS01 CA B 1 S1051 E1058 S49 E56 S1033 H1064 Y1088 A1116 M1219 S1220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 7005 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 B 2.3 BS02 9PP B 1 G1032 S1033 H1086 N1115 A1116 A1117 G1118 F1200 E1201 M1219 S1220 N1243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S1033 H1064 Y1088 A1116 M1219 S1220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM -logKd/Ki=5.46, Kd=3.5uM P55859 15342253 3002 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 C 2.3 BS01 CA C 1 S2051 E2058 S49 E56 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 7004 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDGKQAAQKLEQFVSLLMASIPV 1lv8 C 2.3 BS02 9PP C 1 G2032 S2033 H2086 N2115 A2116 A2117 G2118 F2200 E2201 M2219 S2220 N2243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM P55859 15342253 3003 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDGKQAAQKLEQFVSLLMASIPV 1lv8 D 2.3 BS01 CA D 1 S51 E58 S49 E56 S33 H64 Y88 A116 M219 S220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 7001 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 D 2.3 BS02 9PP D 1 G32 S33 H86 N115 A116 A117 G118 F200 E201 M219 S220 N243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S33 H64 Y88 A116 M219 S220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM P55859 15342253 3006 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 E 2.3 BS01 CA E 1 S1051 E1058 S49 E56 S1033 H1064 Y1088 A1116 M1219 S1220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 7003 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 E 2.3 BS02 9PP E 1 S1033 N1115 A1116 F1200 E1201 S1220 N1243 S31 N113 A114 F198 E199 S218 N241 S1033 H1064 Y1088 A1116 M1219 S1220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM P55859 15342253 3004 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 F 2.3 BS01 CA F 1 S2051 E2058 S49 E56 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 7006 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDKQAAQKLEQFVSLLMASIPV 1lv8 F 2.3 BS02 9PP F 1 G2032 S2033 H2086 N2115 A2116 A2117 G2118 F2200 E2201 M2219 S2220 N2243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM P55859 15342253 3005 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDKQAAQKLEQFVSLLMASIPV 1lvu A 2.05 BS01 CA A 1 S51 E58 S50 E57 S33 H64 Y88 A116 M219 S220 S32 H63 Y87 A115 M218 S219 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 8001 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEEAGKQAAQKLEQFVSLLMASIPV 1lvu A 2.05 BS02 9PP A 1 G32 S33 H86 N115 A116 G118 F200 E201 V217 M219 S220 N243 G31 S32 H85 N114 A115 G117 F199 E200 V216 M218 S219 N242 S33 H64 Y88 A116 M219 S220 S32 H63 Y87 A115 M218 S219 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM -logKd/Ki=5.32, Kd=4.8uM P55859 15342253 6100 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEEAGKQAAQKLEQFVSLLMASIPV 1lvu B 2.05 BS01 CA B 1 S1051 E1058 S50 E57 S1033 H1064 Y1088 A1116 M1219 S1220 H1257 S32 H63 Y87 A115 M218 S219 H250 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 8004 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEHEEVLEAGKQAAQKLEQFVSLLMASIPV 1lvu B 2.05 BS02 9PP B 1 G1032 S1033 R1084 H1086 N1115 A1116 A1117 G1118 F1200 E1201 V1217 M1219 S1220 N1243 G31 S32 R83 H85 N114 A115 A116 G117 F199 E200 V216 M218 S219 N242 S1033 H1064 Y1088 A1116 M1219 S1220 H1257 S32 H63 Y87 A115 M218 S219 H250 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM -logKd/Ki=5.32, Kd=4.8uM P55859 15342253 6200 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEHEEVLEAGKQAAQKLEQFVSLLMASIPV 1lvu C 2.05 BS01 CA C 1 S2051 E2058 S51 E58 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 8005 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKQAAQKLEQFVSLLMASIPV 1lvu C 2.05 BS02 9PP C 1 S2033 H2086 N2115 A2116 A2117 G2118 F2200 E2201 M2219 S2220 N2243 S33 H86 N115 A116 A117 G118 F200 E201 M219 S220 N243 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM P55859 15342253 6300 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKQAAQKLEQFVSLLMASIPV 1lvu D 2.05 BS01 CA D 1 S51 E58 S50 E57 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H252 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 8002 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQHEEVLEAGKQAAQKLEQFVSLLMASIPV 1lvu D 2.05 BS02 9PP D 1 G32 S33 H86 N115 A116 A117 G118 F200 E201 M219 S220 N243 G31 S32 H85 N114 A115 A116 G117 F199 E200 M218 S219 N242 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H252 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM P55859 15342253 6400 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQHEEVLEAGKQAAQKLEQFVSLLMASIPV 1lvu E 2.05 BS01 CA E 1 S1051 E1058 S50 E57 S1033 H1064 Y1088 A1116 M1219 S1220 S32 H63 Y87 A115 M218 S219 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 8006 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYKQAAQKLEQFVSLLMASIPV 1lvu E 2.05 BS02 9PP E 1 G1032 S1033 R1084 H1086 N1115 A1116 A1117 G1118 F1200 E1201 M1219 S1220 N1243 G31 S32 R83 H85 N114 A115 A116 G117 F199 E200 M218 S219 N242 S1033 H1064 Y1088 A1116 M1219 S1220 S32 H63 Y87 A115 M218 S219 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM P55859 15342253 6500 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYKQAAQKLEQFVSLLMASIPV 1lvu F 2.05 BS01 CA F 1 S2051 E2058 S51 E58 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 15342253 8003 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEQAAQKLEQFVSLLMASIPV 1lvu F 2.05 BS02 9PP F 1 G2032 S2033 H2086 N2115 A2116 A2117 G2118 F2200 E2201 V2217 M2219 S2220 N2243 G32 S33 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 N243 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM P55859 15342253 6600 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEQAAQKLEQFVSLLMASIPV 1nw4 A 2.2 BS01 IMH A 1 S91 C92 G93 Y160 E182 M183 E184 D206 W212 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM -logKd/Ki=9.07, Kd=860pM Q8I3X4 14982926 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 B 2.2 BS01 IMH B 1 S91 C92 G93 Y160 E182 M183 E184 D206 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM -logKd/Ki=9.07, Kd=860pM Q8I3X4 14982926 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 C 2.2 BS01 IMH C 1 S91 C92 Y160 E182 M183 E184 D206 W212 S89 C90 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 D 2.2 BS01 IMH D 1 S91 C92 G93 Y160 V181 E182 M183 E184 D206 W212 S89 C90 G91 Y158 V179 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 304 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 E 2.2 BS01 IMH E 1 S91 C92 G93 Y160 E182 M183 E184 D206 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 305 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1nw4 F 2.2 BS01 IMH F 1 S91 C92 G93 Y160 E182 M183 E184 D206 W212 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=0.86nM Q8I3X4 14982926 306 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1oty A 2.5 BS01 6MP A 1 G92 F159 V178 M180 G92 F159 V178 M180 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1oty B 2.5 BS01 6MP B 1 F159 V178 I206 F159 V178 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1oty C 2.5 BS01 6MP C 1 F159 V178 E179 M180 F159 V178 E179 M180 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1ou4 A 2.5 BS01 6MP A 1 F159 V178 E179 D204 F159 V178 E179 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 244 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1ou4 B 2.5 BS01 6MP B 1 F159 V178 I206 F159 V178 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1ou4 C 2.5 BS01 6MP C 1 F159 V178 M180 D204 F159 V178 M180 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1oum A 2.4 BS01 TAL A 1 D21 S90 C91 F159 V178 M180 E181 D21 S90 C91 F159 V178 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGVGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1oum B 2.4 BS01 TAL B 1 V64 S90 C91 G92 F159 V178 E179 M180 E181 V64 S90 C91 G92 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGVGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1oum C 2.4 BS01 TAL C 1 S90 F159 V178 E179 M180 E181 S90 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGVGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1ov6 A 2.4 BS01 DBM A 1 S90 C91 F159 V178 E179 M180 S203 S90 C91 F159 V178 E179 M180 S203 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGVGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1ov6 B 2.4 BS01 DBM B 1 S90 F159 V178 E179 M180 S90 F159 V178 E179 M180 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGVGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1ov6 C 2.4 BS01 DBM C 1 S90 F159 V178 E179 M180 I206 S90 F159 V178 E179 M180 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGVGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1ovg A 2.2 BS01 MDR A 1 S90 F159 V178 S90 F159 V178 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGVGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1ovg B 2.2 BS01 MDR B 1 F159 V178 M180 E181 D204 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGVGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1ovg C 2.2 BS01 MDR C 1 S90 C91 G92 F159 V178 E179 M180 E181 D204 I206 S90 C91 G92 F159 V178 E179 M180 E181 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 14700625 247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGVGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pf7 E 2.6 BS01 IMH E 1 Y88 A116 E201 M219 T242 N243 H257 Y87 A115 E200 M218 T241 N242 H256 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S32 H63 H85 Y87 E88 A115 M218 S219 N242 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=10.14, Ki=72pM P00491 13679061 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 1pk7 A 2.5 BS01 PO4 A 1 G20 R87 G20 R87 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1248 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk7 A 2.5 BS02 ADN A 1 M64 S90 C91 F159 M180 E181 D204 M64 S90 C91 F159 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk7 B 2.5 BS01 PO4 B 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1249 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk7 B 2.5 BS02 ADN B 1 C91 G92 F159 V178 E179 M180 C91 G92 F159 V178 E179 M180 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk7 C 2.5 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1250 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk7 C 2.5 BS02 ADN C 1 S90 C91 G92 F159 V178 E179 M180 E181 D204 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk9 A 1.9 BS01 PO4 A 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 309 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk9 A 1.9 BS02 2FA A 1 M64 S90 C91 F159 V178 E179 M180 E181 D204 M64 S90 C91 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 306 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk9 B 1.9 BS01 PO4 B 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 310 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk9 B 1.9 BS02 2FA B 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 307 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk9 C 1.9 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 311 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk9 C 1.9 BS02 2FA C 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 308 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pke A 2.3 BS01 PO4 A 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 449 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pke A 2.3 BS02 2FD A 1 S90 C91 F159 V178 E179 M180 E181 D204 S90 C91 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 446 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pke B 2.3 BS01 PO4 B 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 450 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pke B 2.3 BS02 2FD B 1 M64 S90 C91 G92 F159 V178 M180 E181 D204 M64 S90 C91 G92 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 447 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pke C 2.3 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 451 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTQTTFNDMIKIALESVLLGDK 1pke C 2.3 BS02 2FD C 1 M64 S90 C91 F159 V178 E179 M180 E181 D204 M64 S90 C91 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 448 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTQTTFNDMIKIALESVLLGDK 1pr0 A 2.2 BS01 PO4 A 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1248 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr0 A 2.2 BS02 NOS A 1 R87 S90 C91 F159 V178 E179 M180 E181 D204 R87 S90 C91 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr0 B 2.2 BS01 PO4 B 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1249 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr0 B 2.2 BS02 NOS B 1 M64 S90 C91 F159 V178 E179 M180 E181 S203 M64 S90 C91 F159 V178 E179 M180 E181 S203 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr0 C 2.2 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1250 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr0 C 2.2 BS02 NOS C 1 M64 S90 C91 F159 V178 E179 M180 E181 D204 M64 S90 C91 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr1 A 2.3 BS01 PO4 A 1 R87 G89 S90 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 R206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 248 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHRQTTFNDMIKIALESVLLGDK 1pr1 A 2.3 BS02 FMB A 1 M64 R87 S90 C91 G92 F159 V178 M180 E181 D204 M64 R87 S90 C91 G92 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 R206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Ki=5uM -logKd/Ki=5.30, Ki=5uM P0ABP9 12937174 245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHRQTTFNDMIKIALESVLLGDK 1pr1 B 2.3 BS01 PO4 B 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 249 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr1 B 2.3 BS02 FMB B 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 M64 S90 C91 G92 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Ki=5uM P0ABP9 12937174 246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr1 C 2.3 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 250 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr1 C 2.3 BS02 FMB C 1 S90 C91 G92 F159 V178 E179 M180 E181 D204 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Ki=5uM P0ABP9 12937174 247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr2 A 2.3 BS01 PO4 A 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1248 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr2 A 2.3 BS02 MDR A 1 M64 S90 F159 V178 E179 M180 E181 D204 M64 S90 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr2 B 2.3 BS01 PO4 B 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1249 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr2 B 2.3 BS02 MDR B 1 S90 C91 F159 V178 E179 M180 E181 S90 C91 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr2 C 2.3 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1250 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr2 C 2.3 BS02 MDR C 1 S90 F159 V178 E179 I206 S90 F159 V178 E179 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr4 A 2.4 BS01 PO4 A 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R212 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1248 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHITTAAERQTTFNDMIKIALESVLLGDK 1pr4 A 2.4 BS02 MTP A 1 M64 S90 C91 F159 V178 E179 M180 E181 M64 S90 C91 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R212 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHITTAAERQTTFNDMIKIALESVLLGDK 1pr4 B 2.4 BS01 PO4 B 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1249 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr4 B 2.4 BS02 MTP B 1 S90 C91 F159 V178 E179 M180 E181 S90 C91 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr4 C 2.4 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R214 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1250 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTRQTTFNDMIKIALESVLLGDK 1pr4 C 2.4 BS02 MTP C 1 M64 S90 C91 F159 V178 E179 M180 E181 I206 M64 S90 C91 F159 V178 E179 M180 E181 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R214 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTRQTTFNDMIKIALESVLLGDK 1pr5 A 2.5 BS01 PO4 A 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R211 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1248 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHITAAERQTTFNDMIKIALESVLLGDK 1pr5 A 2.5 BS02 TBN A 1 M64 R87 S90 C91 G92 F159 V178 M180 E181 D204 M64 R87 S90 C91 G92 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R211 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Ki=120uM -logKd/Ki=3.92, Ki=120uM P0ABP9 12937174 1245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHITAAERQTTFNDMIKIALESVLLGDK 1pr5 B 2.5 BS01 PO4 B 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R213 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1249 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTTAAERQTTFNDMIKIALESVLLGDK 1pr5 B 2.5 BS02 TBN B 1 S90 C91 G92 F159 V178 E179 M180 E181 D204 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R213 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Ki=120uM P0ABP9 12937174 1246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTTAAERQTTFNDMIKIALESVLLGDK 1pr5 C 2.5 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1250 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr5 C 2.5 BS02 TBN C 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Ki=120uM P0ABP9 12937174 1247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pr6 A 2.1 BS01 PO4 A 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1248 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRQTTAAERQTTFNDMIKIALESVLLGDK 1pr6 A 2.1 BS02 XYA A 1 M64 S90 C91 F159 V178 E179 M180 E181 M64 S90 C91 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1245 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRQTTAAERQTTFNDMIKIALESVLLGDK 1pr6 B 2.1 BS01 PO4 B 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1249 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIQTTAAERQTTFNDMIKIALESVLLGDK 1pr6 B 2.1 BS02 XYA B 1 S90 F159 V178 E179 M180 E181 S90 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1246 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIQTTAAERQTTFNDMIKIALESVLLGDK 1pr6 C 2.1 BS01 PO4 C 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1250 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTQTTFNDMIKIALESVLLGDK 1pr6 C 2.1 BS02 XYA C 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 1247 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTQTTFNDMIKIALESVLLGDK 1pw7 A 2.0 BS01 PO4 A 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 648 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pw7 A 2.0 BS02 RAB A 1 S90 C91 F159 E179 E181 S203 S90 C91 F159 E179 E181 S203 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 645 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pw7 B 2.0 BS01 PO4 B 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 649 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pw7 B 2.0 BS02 RAB B 1 S90 C91 F159 E179 M180 E181 S90 C91 F159 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 646 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pw7 C 2.0 BS01 PO4 C 1 G20 R24 R87 S90 G20 R24 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 650 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pw7 C 2.0 BS02 RAB C 1 S90 F159 E179 M180 E181 S90 F159 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 647 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pwy E 2.8 BS01 AC2 E 1 A116 A117 G118 F200 E201 V217 M219 T242 N243 H257 A115 A116 G117 F199 E200 V216 M218 T241 N242 H256 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=4.05, Ki=90uM Ki=180000nM P00491 12914786 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 1q1g A 2.02 BS01 MTI A 1 V66 S91 C92 G93 Y160 E182 M183 E184 D206 V64 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=2.7nM -logKd/Ki=8.57, Kd=2.7nM Q8I3X4 14982926 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1q1g B 2.02 BS01 MTI A 1 H7 V73 H5 V71 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=2.7nM -logKd/Ki=8.57, Kd=2.7nM Q8I3X4 14982926 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1q1g B 2.02 BS02 MTI B 1 V66 S91 C92 G93 Y160 E182 M183 E184 D206 W212 V64 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=2.7nM -logKd/Ki=8.57, Kd=2.7nM Q8I3X4 14982926 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1q1g C 2.02 BS01 MTI C 1 V66 S91 C92 G93 Y160 E182 M183 E184 D206 W212 V64 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=2.7nM Q8I3X4 14982926 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1q1g C 2.02 BS02 MTI D 1 H7 V73 H5 V71 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=2.7nM Q8I3X4 14982926 304 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1q1g D 2.02 BS01 MTI C 1 H7 V73 H5 V71 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=2.7nM Q8I3X4 14982926 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1q1g D 2.02 BS02 MTI D 1 S91 C92 G93 Y160 E182 M183 E184 D206 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=2.7nM Q8I3X4 14982926 304 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1q1g E 2.02 BS01 MTI E 1 S91 C92 G93 Y160 E182 M183 E184 D206 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=2.7nM Q8I3X4 14982926 305 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1q1g F 2.02 BS01 MTI F 1 S91 C92 G93 Y160 E182 M183 E184 D206 S89 C90 G91 Y158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Kd=2.7nM Q8I3X4 14982926 306 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 1qe5 A 2.2 BS01 PO4 A 1 S46 R103 H105 N134 S223 S38 R87 H89 N118 S207 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 303 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1qe5 B 2.2 BS01 PO4 B 1 G45 S46 R103 H105 N134 S223 G37 S38 R87 H89 N118 S207 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 302 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1qe5 B 2.2 BS02 CA B 1 G126 E128 G110 E112 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 300 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1qe5 C 2.2 BS01 PO4 C 1 S46 R103 H105 N134 S223 S38 R87 H89 N118 S207 S46 R83 H105 Y107 E108 G135 M222 S223 N246 H258 S38 R67 H89 Y91 E92 G119 M206 S207 N230 H242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 P81989 10600382 301 PPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVAEVPTHEIPGFSSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVRTAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLRELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLGVSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR 1rct E 2.8 BS01 NOS E 1 A116 G118 F200 E201 V217 M219 N243 H257 A115 G117 F199 E200 V216 M218 N242 H256 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 14706628 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 1rfg E 2.9 BS01 GMP E 1 A116 G118 F200 E201 V217 M219 T242 N243 H257 A115 G117 F199 E200 V216 M218 T241 N242 H256 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 15983407 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 1rr6 A 2.5 BS01 IMH A 1 A116 A117 G118 F200 E201 V217 M219 N243 H257 A114 A115 G116 F198 E199 V215 M217 N241 H255 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=10.25, Kd=56pM P00491 14982926 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 1rsz A 2.2 BS01 DIH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 V260 Y86 A114 A115 G116 F198 E199 V215 M217 N241 H255 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 1rt9 A 2.3 BS01 IMH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 Y86 A114 A115 G116 F198 E199 V215 M217 N241 H255 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=10.25, Ki=56pM P00491 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 1sq6 A 2.4 BS01 SO4 A 1 G31 R96 S99 G20 R85 S88 H15 G31 R35 R53 E85 R96 S99 D214 G215 H4 G20 R24 R42 E74 R85 S88 D203 G204 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 16131758 401 LLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGHQLENMIKIALGACAKLATKY 1t8h A 1.8 BS01 ZN A 1 C182 C183 C242 C245 C182 C183 C242 C245 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0004731,0005507,0016740,0016787,0017061,0046872,0046936 P84138 275 MPDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGDDRTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFATAVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAGGIAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPPESPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALFFSHRRDRGTTGRMLAFIGRREE 1tcu A 2.0 BS01 ACT A 1 A119 E203 V219 N245 A114 E198 V214 N240 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H61 H83 Y85 E86 A113 M216 S217 N240 S242 H254 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 700 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 1tcu A 2.0 BS02 PO4 A 1 G34 R86 H88 N117 A118 S222 G32 R81 H83 N112 A113 S217 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H61 H83 Y85 E86 A113 M216 S217 N240 S242 H254 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 706 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 1tcu B 2.0 BS01 ACT B 1 A119 G120 Y202 E203 V219 N245 A117 G118 Y200 E201 V217 N243 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 S33 H64 H86 Y88 E89 A116 M219 S220 N243 S245 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 701 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESAQRAELMQSWFEKIIEKLPKD 1tcu B 2.0 BS02 PO4 B 1 G34 R86 H88 N117 A118 S222 G32 R84 H86 N115 A116 S220 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 S33 H64 H86 Y88 E89 A116 M219 S220 N243 S245 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 707 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESAQRAELMQSWFEKIIEKLPKD 1tcu C 2.0 BS01 ACT C 1 A119 G120 E203 V219 N245 A117 G118 E201 V217 N243 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 702 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 1tcu C 2.0 BS02 PO4 C 1 G34 R86 H88 N117 S222 G32 R84 H86 N115 S220 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 708 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 1tcv A 1.75 BS01 ACT A 1 A119 G120 Y202 E203 V219 N245 A114 G115 Y197 E198 V214 N240 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 S33 H61 H83 Y85 E86 A113 M216 S217 N240 S242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 900 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDGAQRAELMQSWFEKIIEKLPKD 1tcv A 1.75 BS02 NDS A 1 S35 R86 H88 N117 S222 S33 R81 H83 N112 S217 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 S33 H61 H83 Y85 E86 A113 M216 S217 N240 S242 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 951 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDGAQRAELMQSWFEKIIEKLPKD 1tcv B 1.75 BS01 ACT B 1 A119 G120 Y202 E203 V219 N245 A112 G113 Y195 E196 V212 N238 S35 H88 Y90 E91 A118 M221 S222 N245 S247 S32 H81 Y83 E84 A111 M214 S215 N238 S240 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 901 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESEEVLATGAQRAELMQSWFEKIIEKLPKD 1tcv B 1.75 BS02 NDS B 1 R86 H88 Y90 N117 A118 M221 S222 R79 H81 Y83 N110 A111 M214 S215 S35 H88 Y90 E91 A118 M221 S222 N245 S247 S32 H81 Y83 E84 A111 M214 S215 N238 S240 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 952 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESEEVLATGAQRAELMQSWFEKIIEKLPKD 1tcv C 1.75 BS01 ACT C 1 A119 G120 Y202 E203 V219 N245 A112 G113 Y195 E196 V212 N238 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H59 H81 Y83 E84 A111 M214 S215 N238 S240 H252 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 902 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 1tcv C 1.75 BS02 NDS C 1 H88 Y90 A118 Y202 M221 S222 H81 Y83 A111 Y195 M214 S215 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H59 H81 Y83 E84 A111 M214 S215 N238 S240 H252 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 953 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 1td1 A 1.9 BS01 ACT A 1 A119 Y202 E203 V219 N245 A114 Y197 E198 V214 N240 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H61 H83 Y85 E86 A113 M216 S217 N240 S242 H254 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 700 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 1td1 B 1.9 BS01 ACT B 1 A119 G120 Y202 E203 V219 A117 G118 Y200 E201 V217 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 S33 H64 H86 Y88 E89 A116 M219 S220 N243 S245 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 701 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESAQRAELMQSWFEKIIEKLPKD 1td1 C 1.9 BS01 ACT C 1 A119 G120 Y202 E203 V219 A117 G118 Y200 E201 V217 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 16182308 702 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 1u05 A 2.5 BS01 ZN A 1 H71 C107 H124 H71 C107 H124 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016491,0016740,0016787,0017061,0046872,0046936 A0A384KG77 500 MSKLIVPQWPLPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADCLPVLFCNRAGTEVAAVHAGWRGLCAGVLEETVSCFADKPENILAWLGPAIGPRAFEVGAEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 1u05 B 2.5 BS01 ZN B 1 H71 C107 H124 H71 C107 H124 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016491,0016740,0016787,0017061,0046872,0046936 A0A384KG77 501 MSKLIVPQWPLPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADCLPVLFCNRAGTEVAAVHAGWRGLCAGVLEETVSCFADKPENILAWLGPAIGPRAFEVGAEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 1v2h E 2.7 BS01 GUN E 1 A117 G118 E201 M219 T242 N243 A116 G117 E200 M218 T241 N242 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=5.30, IC50=5uM P00491 14680831 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 1v3q E 2.8 BS01 2DI E 1 G118 F200 E201 V217 M219 N243 H257 G117 F199 E200 V216 M218 N242 H256 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 14706628 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 1v41 E 2.85 BS01 AZG E 1 A116 A117 G118 F200 E201 V217 M219 T242 N243 A115 A116 G117 F199 E200 V216 M218 T241 N242 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=4.70, Ki=20uM P00491 15983407 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 1v45 E 2.86 BS01 3DG E 1 A116 G118 F200 E201 V217 M219 N243 H257 A115 G117 F199 E200 V216 M218 N242 H256 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 15983407 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 1v48 A 2.2 BS01 HA1 A 1 S33 R84 H86 A116 G118 F200 E201 V217 M219 S220 N243 S32 R77 H79 A109 G111 F193 E194 V210 M212 S213 N236 S33 H86 Y88 E89 A116 M219 S220 N243 V245 S32 H79 Y81 E82 A109 M212 S213 N236 V238 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Ki=16nM -logKd/Ki=7.80, Ki=16nM Ki=2.7nM, IC50=18.7nM, Kd=0.46nM P55859 15272165 290 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEAAQKLEQFVSLLMASIPV 1vfn A 2.15 BS01 HPA A 1 A117 G118 F200 E201 V217 N243 A107 G108 F190 E191 V207 N233 S33 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S30 H76 Y78 E79 A106 M209 S210 N233 V235 H245 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Ki=2.5uM -logKd/Ki=5.60, Ki=2.5uM Kd=680nM P55859 9020983 300 GYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDSQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 1vhw A 1.54 BS01 ADN A 1 M65 R88 S91 C92 F160 V179 M181 E182 M64 R87 S90 C91 F159 V178 M180 E181 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw A 1.54 BS02 ADN D 1 H5 R44 H4 R43 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw B 1.54 BS01 ADN B 1 M65 R88 S91 C92 F160 V179 M181 E182 M64 R87 S90 C91 F159 V178 M180 E181 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw B 1.54 BS02 ADN F 1 H5 R44 H4 R43 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw C 1.54 BS01 ADN C 1 M65 R88 S91 C92 F160 V179 M181 E182 M64 R87 S90 C91 F159 V178 M180 E181 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw C 1.54 BS02 ADN E 1 H5 R44 H4 R43 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw D 1.54 BS01 ADN A 1 H5 R44 H4 R43 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw D 1.54 BS02 ADN D 1 M65 R88 S91 C92 F160 V179 M181 E182 M64 R87 S90 C91 F159 V178 M180 E181 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw E 1.54 BS01 ADN C 1 H5 R44 H3 R42 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H3 G19 R23 R42 E74 R86 S89 S202 D203 I205 R216 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 TPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw E 1.54 BS02 ADN E 1 M65 R88 S91 C92 F160 V179 M181 E182 M63 R86 S89 C90 F158 V177 M179 E180 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H3 G19 R23 R42 E74 R86 S89 S202 D203 I205 R216 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 TPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQ 1vhw F 1.54 BS01 ADN B 1 H5 R44 H4 R43 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R214 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTERQNTFNEMIEIALDSVLIGDQ 1vhw F 1.54 BS02 ADN F 1 M65 R88 S91 C92 F160 V179 M181 E182 M64 R87 S90 C91 F159 V178 M180 E181 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R214 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 16021622 252 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRRISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTERQNTFNEMIEIALDSVLIGDQ 1xaf A 2.01 BS01 ZN A 1 H71 C107 H124 H70 C106 H123 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016491,0016740,0016787,0017061,0046872,0046936 A0A384KG77 16498617 501 SKLIVPQWPLPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADCLPVLFCNRAGTEVAAVHAGWRGLCAGVLEETVSCFADKPENILAWLGPAIGPRAFEVGAEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 1xaf A 2.01 BS02 ZN A 2 C216 T219 C215 T218 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016491,0016740,0016787,0017061,0046872,0046936 A0A384KG77 16498617 503 SKLIVPQWPLPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADCLPVLFCNRAGTEVAAVHAGWRGLCAGVLEETVSCFADKPENILAWLGPAIGPRAFEVGAEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 1xaf B 2.01 BS01 ZN B 1 H71 C107 H124 H69 C105 H122 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016491,0016740,0016787,0017061,0046872,0046936 A0A384KG77 16498617 505 KLIVPQWPLPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADCLPVLFCNRAGTEVAAVHAGWRGLCAGVLEETVSCFADKPENILAWLGPAIGPRAFEVGAEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 1xaf B 2.01 BS02 ZN B 2 C216 T219 C214 T217 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016491,0016740,0016787,0017061,0046872,0046936 A0A384KG77 16498617 507 KLIVPQWPLPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADCLPVLFCNRAGTEVAAVHAGWRGLCAGVLEETVSCFADKPENILAWLGPAIGPRAFEVGAEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 1yqq A 2.6 BS01 PO4 A 1 H65 R85 H87 N116 S216 H61 R81 H83 N112 S212 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 500 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yqq A 2.6 BS02 GUN A 1 A118 G119 E197 G214 M215 T238 N239 T254 A114 G115 E193 G210 M211 T234 N235 T250 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 400 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yqq B 2.6 BS01 PO4 B 1 H65 R85 H87 N116 S216 H61 R81 H83 N112 S212 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 1500 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yqq B 2.6 BS02 GUN B 1 A118 G119 E197 G214 M215 T238 N239 T254 A114 G115 E193 G210 M211 T234 N235 T250 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 1400 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yqq C 2.6 BS01 PO4 C 1 H65 R85 H87 N116 S216 H61 R81 H83 N112 S212 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 2500 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yqq C 2.6 BS02 GUN C 1 A118 G119 E197 G214 M215 T238 N239 T254 A114 G115 E193 G210 M211 T234 N235 T250 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 2400 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yqu A 3.1 BS01 PO4 A 1 R85 H87 N116 S216 R74 H76 N105 S205 S34 H87 Y89 E90 A117 M215 S216 N239 S30 H76 Y78 E79 A106 M204 S205 N228 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 500 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNQNFINLICGFLRKIA 1yqu A 3.1 BS02 GUN A 1 A118 F196 E197 M215 T238 N239 A107 F185 E186 M204 T227 N228 S34 H87 Y89 E90 A117 M215 S216 N239 S30 H76 Y78 E79 A106 M204 S205 N228 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 400 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNQNFINLICGFLRKIA 1yqu B 3.1 BS01 PO4 B 1 R85 H87 N116 S216 R74 H76 N105 S205 S34 H87 Y89 E90 A117 M215 S216 N239 S30 H76 Y78 E79 A106 M204 S205 N228 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 501 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNQNFINLICGFLRKIA 1yqu B 3.1 BS02 GUN B 1 A118 F196 E197 M215 T238 N239 A107 F185 E186 M204 T227 N228 S34 H87 Y89 E90 A117 M215 S216 N239 S30 H76 Y78 E79 A106 M204 S205 N228 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 401 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNQNFINLICGFLRKIA 1yqu C 3.1 BS01 PO4 C 1 R85 H87 N116 S216 R74 H76 N105 S205 S34 H87 Y89 E90 A117 M215 S216 N239 S30 H76 Y78 E79 A106 M204 S205 N228 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 502 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNQNFINLICGFLRKIA 1yqu C 3.1 BS02 GUN C 1 A118 F196 E197 M215 T238 N239 A107 F185 E186 M204 T227 N228 S34 H87 Y89 E90 A117 M215 S216 N239 S30 H76 Y78 E79 A106 M204 S205 N228 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 402 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNQNFINLICGFLRKIA 1yr3 A 3.2 BS01 XAN A 1 A118 E197 G214 N239 A114 E193 G210 N235 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 400 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yr3 B 3.2 BS01 XAN B 1 A118 E197 G214 T238 N239 A114 E193 G210 T234 N235 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 401 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yr3 C 3.2 BS01 XAN C 1 A118 E197 G214 N239 A114 E193 G210 N235 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 402 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yr3 D 3.2 BS01 XAN D 1 A118 E197 G214 N239 A114 E193 G210 N235 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 403 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yr3 E 3.2 BS01 XAN E 1 A118 E197 G214 N239 A114 E193 G210 N235 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 404 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yr3 F 3.2 BS01 XAN F 1 A118 E197 G214 N239 A114 E193 G210 N235 S34 H65 H87 Y89 E90 A117 M215 S216 N239 A241 H251 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006148,0006149,0006152,0006161,0009116,0015949,0016757,0016763,0034214,0034355,0042802,0046115,0047724,0047975,0055086,1903228 P45563 15808857 405 QFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA 1yry E 2.8 BS01 MSG E 1 Y88 A116 A117 G118 E201 V217 G218 M219 T242 N243 H257 Y87 A115 A116 G117 E200 V216 G217 M218 T241 N242 H256 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S32 H63 H85 Y87 E88 A115 M218 S219 N242 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 16154528 290 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 2a0w A 2.28 BS01 DIH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 V260 Y86 A114 A115 G116 F198 E199 V215 M217 N241 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 G257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 G255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=270pM P00491 17407325 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANGEEVLAAGKQAAQKLEQFVSILMASIPL 2a0x A 2.28 BS01 DIH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 V260 Y86 A114 A115 G116 F198 E199 V215 M217 N241 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 F257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 F255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=950pM P00491 17407325 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANFEEVLAAGKQAAQKLEQFVSILMASIPL 2a0y A 2.28 BS01 DIH A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 D257 V260 Y86 A114 A115 G116 F198 E199 V215 M217 N241 D255 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 D257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 D255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=900pM P00491 17407325 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANDEEVLAAGKQAAQKLEQFVSILMASIPL 2ai1 A 2.0 BS01 P1G A 1 G32 S33 R84 H86 N115 A116 G118 F200 E201 V217 M219 S220 H257 V260 G30 S31 R76 H78 N107 A108 G110 F192 E193 V209 M211 S212 H249 V252 S33 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H78 Y80 E81 A108 M211 S212 N235 V237 H249 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 ic50=300nM P55859 16239721 293 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 2ai2 A 1.7 BS01 P1D A 1 S33 R84 H86 Y88 N115 A116 G118 F200 E201 M219 S220 N243 H257 S31 R76 H78 Y80 N107 A108 G110 F192 E193 M211 S212 N235 H249 S33 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H78 Y80 E81 A108 M211 S212 N235 V237 H249 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 ic50=30nM P55859 16239721 293 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASI 2ai3 A 1.7 BS01 P2G A 1 S33 H86 N115 A116 A117 G118 F200 E201 M219 S220 N243 S31 H78 N107 A108 A109 G110 F192 E193 M211 S212 N235 S33 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H78 Y80 E81 A108 M211 S212 N235 V237 H245 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 ic50=5000nM P55859 16239721 293 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 2bsx A 2.0 BS01 NOS A 1 S91 C92 Y160 M183 E184 S91 C92 Y160 M183 E184 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V216 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 16131758 1248 MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDELVPHQLENMIKIALGACAKLATKYALE 2i4t A 2.74 BS01 UA2 A 1 M64 T90 C91 G92 F159 E179 M180 E181 D204 M64 T90 C91 G92 F159 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 243 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHERQNSFQNMMKIALEAAIKLH 2i4t A 2.74 BS02 UA2 B 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 241 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHERQNSFQNMMKIALEAAIKLH 2i4t B 2.74 BS01 UA2 A 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 243 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHEETTAEERQNSFQNMMKIALEAAIKL 2i4t B 2.74 BS02 UA2 B 1 M64 T90 C91 F159 V178 E179 M180 E181 S203 D204 M64 T90 C91 F159 V178 E179 M180 E181 S203 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 241 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHEETTAEERQNSFQNMMKIALEAAIKL 2i4t C 2.74 BS01 UA2 C 1 M64 T90 C91 F159 E179 M180 E181 D204 M64 T90 C91 F158 E178 M179 E180 D203 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S202 D203 I205 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 242 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHNSFQNMMKIALEAAIKL 2isc A 2.7 BS01 223 A 1 M64 T90 C91 G92 F159 V178 M180 E181 D204 M64 T90 C91 G92 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 401 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHQNSFQNMMKIALEAAIKLH 2isc A 2.7 BS02 223 B 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 402 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHQNSFQNMMKIALEAAIKLH 2isc B 2.7 BS01 223 B 1 M64 T90 C91 G92 F159 V178 E179 M180 E181 D204 M64 T90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 402 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHEETTAEERQNSFQNMMKIALEAAIKLH 2isc C 2.7 BS01 223 C 1 M64 T90 C91 G92 F159 V178 E179 M180 E181 D204 M64 T90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R209 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 405 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHRQNSFQNMMKIALEAAIKLHHHH 2isc D 2.7 BS01 223 D 1 M64 T90 C91 G92 F159 V178 E179 M180 E181 S203 D204 M64 T90 C91 G92 F159 V178 E179 M180 E181 S203 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 403 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHEETTAEERQNSFQNMMKIALEAAIKLHHH 2isc D 2.7 BS02 223 F 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 404 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHEETTAEERQNSFQNMMKIALEAAIKLHHH 2isc E 2.7 BS01 223 E 1 M64 T90 C91 G92 F159 V178 M180 E181 D204 M64 T90 C91 G92 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R211 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 400 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHERQNSFQNMMKIALEAAIKL 2isc F 2.7 BS01 223 F 1 M64 T90 C91 G92 F159 V178 E179 M180 E181 D204 M64 T90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R213 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 A2E7Y6 17223688 404 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHAEERQNSFQNMMKIALEAAIKLHH 2oc4 A 2.592 BS01 IMH A 1 A116 A117 G118 F200 E201 V217 M219 N243 D257 A116 A117 G118 F200 E201 V217 M219 N243 D257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 D257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 D257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=7.07, Ki=86nM P00491 17407325 300 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANDEEVLAAGKQAAQKLEQFVSILMASIPLPD 2oc9 A 2.59 BS01 IMH A 1 A116 G118 F200 E201 V217 M219 N243 V260 A110 G112 F194 E195 V211 M213 N237 V254 S33 H86 Y88 E89 A116 M219 S220 N243 V245 G257 S33 H80 Y82 E83 A110 M213 S214 N237 V239 G251 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=7.96, Ki=11nM P00491 17407325 300 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANGEEVLAAGKQAAQKLEQFVSILMASIPL 2on6 A 2.503 BS01 IMH A 1 A116 A117 G118 F200 E201 V217 G218 M219 S220 N243 A112 A113 G114 F196 E197 V213 G214 M215 S216 N239 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 F257 S33 H60 H82 Y84 E85 A112 M215 S216 N239 V241 F253 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=172nM -logKd/Ki=6.76, Ki=172nM P00491 17407325 300 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANFEEVLAAGKQAAQKLEQFVSILMASIPLPD 2p4s A 2.2 BS01 PO4 A 1 G117 S118 R169 H171 N200 S305 G28 S29 R80 H82 N111 S216 S118 H149 H171 Y173 E174 A201 M304 S305 N328 C330 H342 S29 H60 H82 Y84 E85 A112 M215 S216 N239 C241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757 A4Q998 17918964 503 YTYDTLQEIATYLLERTELRPKVGIICGSGLGTLAEQLTDVDSFDYETIPHFPVSTVAGHVGRLVFGYLAGVPVMCMQGRFHHYEGYPLAKCAMPVRVMHLIGCTHLIATNAAGGANPKYRVGDIMLIKDHINLMGFAGNNPLQGPNDERFGPRFFGMANTYDPKLNQQAKVIARQIGIENELREGVYTCLGGPNFETVAEVKMLSMLGVDAIGMSTVHEIITARHCGMTCFAFSLITNMCTMSYEEEEEHCHDSIVGVGKNREKTLGEFVSRIVKHIHYEA 2p4s A 2.2 BS02 DIH A 1 Y173 A201 A202 G203 F285 E286 I302 G303 M304 N328 H342 Y84 A112 A113 G114 F196 E197 I213 G214 M215 N239 H253 S118 H149 H171 Y173 E174 A201 M304 S305 N328 C330 H342 S29 H60 H82 Y84 E85 A112 M215 S216 N239 C241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757 Ki=0.31nM -logKd/Ki=9.51, Ki=0.31nM A4Q998 17918964 401 YTYDTLQEIATYLLERTELRPKVGIICGSGLGTLAEQLTDVDSFDYETIPHFPVSTVAGHVGRLVFGYLAGVPVMCMQGRFHHYEGYPLAKCAMPVRVMHLIGCTHLIATNAAGGANPKYRVGDIMLIKDHINLMGFAGNNPLQGPNDERFGPRFFGMANTYDPKLNQQAKVIARQIGIENELREGVYTCLGGPNFETVAEVKMLSMLGVDAIGMSTVHEIITARHCGMTCFAFSLITNMCTMSYEEEEEHCHDSIVGVGKNREKTLGEFVSRIVKHIHYEA 2p4s B 2.2 BS01 PO4 B 1 G117 S118 R169 H171 N200 S305 G28 S29 R80 H82 N111 S216 S118 H149 H171 Y173 E174 A201 M304 S305 N328 C330 H342 S29 H60 H82 Y84 E85 A112 M215 S216 N239 C241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757 A4Q998 17918964 501 YTYDTLQEIATYLLERTELRPKVGIICGSGLGTLAEQLTDVDSFDYETIPHFPVSTVAGHVGRLVFGYLAGVPVMCMQGRFHHYEGYPLAKCAMPVRVMHLIGCTHLIATNAAGGANPKYRVGDIMLIKDHINLMGFAGNNPLQGPNDERFGPRFFGMANTYDPKLNQQAKVIARQIGIENELREGVYTCLGGPNFETVAEVKMLSMLGVDAIGMSTVHEIITARHCGMTCFAFSLITNMCTMSYEEEEEHCHDSIVGVGKNREKTLGEFVSRIVKHIHYEA 2p4s B 2.2 BS02 DIH B 1 H171 Y173 A201 A202 G203 F285 E286 I302 M304 N328 H342 H82 Y84 A112 A113 G114 F196 E197 I213 M215 N239 H253 S118 H149 H171 Y173 E174 A201 M304 S305 N328 C330 H342 S29 H60 H82 Y84 E85 A112 M215 S216 N239 C241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757 Ki=0.31nM A4Q998 17918964 403 YTYDTLQEIATYLLERTELRPKVGIICGSGLGTLAEQLTDVDSFDYETIPHFPVSTVAGHVGRLVFGYLAGVPVMCMQGRFHHYEGYPLAKCAMPVRVMHLIGCTHLIATNAAGGANPKYRVGDIMLIKDHINLMGFAGNNPLQGPNDERFGPRFFGMANTYDPKLNQQAKVIARQIGIENELREGVYTCLGGPNFETVAEVKMLSMLGVDAIGMSTVHEIITARHCGMTCFAFSLITNMCTMSYEEEEEHCHDSIVGVGKNREKTLGEFVSRIVKHIHYEA 2p4s C 2.2 BS01 PO4 C 1 G117 S118 R169 H171 N200 A201 S305 G28 S29 R80 H82 N111 A112 S216 S118 H149 H171 Y173 E174 A201 M304 S305 N328 C330 H342 S29 H60 H82 Y84 E85 A112 M215 S216 N239 C241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757 A4Q998 17918964 502 YTYDTLQEIATYLLERTELRPKVGIICGSGLGTLAEQLTDVDSFDYETIPHFPVSTVAGHVGRLVFGYLAGVPVMCMQGRFHHYEGYPLAKCAMPVRVMHLIGCTHLIATNAAGGANPKYRVGDIMLIKDHINLMGFAGNNPLQGPNDERFGPRFFGMANTYDPKLNQQAKVIARQIGIENELREGVYTCLGGPNFETVAEVKMLSMLGVDAIGMSTVHEIITARHCGMTCFAFSLITNMCTMSYEEEEEHCHDSIVGVGKNREKTLGEFVSRIVKHIHYEA 2p4s C 2.2 BS02 DIH C 1 Y173 A201 A202 G203 F285 E286 I302 M304 N328 H342 Y84 A112 A113 G114 F196 E197 I213 M215 N239 H253 S118 H149 H171 Y173 E174 A201 M304 S305 N328 C330 H342 S29 H60 H82 Y84 E85 A112 M215 S216 N239 C241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757 Ki=0.31nM -logKd/Ki=9.51, Ki=0.31nM A4Q998 17918964 402 YTYDTLQEIATYLLERTELRPKVGIICGSGLGTLAEQLTDVDSFDYETIPHFPVSTVAGHVGRLVFGYLAGVPVMCMQGRFHHYEGYPLAKCAMPVRVMHLIGCTHLIATNAAGGANPKYRVGDIMLIKDHINLMGFAGNNPLQGPNDERFGPRFFGMANTYDPKLNQQAKVIARQIGIENELREGVYTCLGGPNFETVAEVKMLSMLGVDAIGMSTVHEIITARHCGMTCFAFSLITNMCTMSYEEEEEHCHDSIVGVGKNREKTLGEFVSRIVKHIHYEA 2q7o E 2.9 BS01 IMH E 1 A116 A117 G118 F200 E201 V217 M219 T242 N243 A116 A117 G118 F200 E201 V217 M219 T242 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=7.92, Ki=12nM P00491 18154341 291 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 2qpl A 2.1 BS01 BTY A 1 A117 G118 F200 E201 V217 M219 T242 N243 A111 G112 F194 E195 V211 M213 T236 N237 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 S31 H58 H80 Y82 E83 A110 M213 S214 N237 V239 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 ic50=18.9uM P55859 17927987 292 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEAGKQAAQKLEQFVSLLMASIPV 3bgs A 2.099 BS01 DIH A 1 A116 A117 G118 F200 E201 V217 M219 N243 A116 A117 G118 F200 E201 V217 M219 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=380pM -logKd/Ki=9.42, Ki=380pM P00491 18154341 301 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 3d1v A 2.7 BS01 D1V A 1 A116 G118 F200 E201 V217 T242 N243 A115 G117 F199 E200 V216 T241 N242 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S32 H63 H85 Y87 E88 A115 M218 S219 N242 V244 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=3.49, Kd=0.324mM P00491 18790691 293 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 3djf A 2.302 BS01 BC3 A 1 A118 A119 G120 Y202 E203 V219 G220 M221 N245 H259 A111 A112 G113 Y195 E196 V212 G213 M214 N238 H252 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S31 H59 H81 Y83 E84 A111 M214 S215 N238 S240 H252 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 ic50=0.8uM -logKd/Ki=6.10, IC50=0.8uM Q9BMI9 20129792 290 VTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3djf B 2.302 BS01 BC3 B 1 A118 A119 G120 Y202 E203 V219 G220 M221 N245 A112 A113 G114 Y196 E197 V213 G214 M215 N239 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 S32 H60 H82 Y84 E85 A112 M215 S216 N239 S241 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 ic50=0.8uM -logKd/Ki=6.10, IC50=0.8uM Q9BMI9 20129792 289 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESAQRAELMQSWFEKIIEKLPKD 3djf C 2.302 BS01 BC3 C 1 A118 A119 G120 Y202 E203 M221 N245 H259 A115 A116 G117 Y199 E200 M218 N242 H256 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H63 H85 Y87 E88 A115 M218 S219 N242 S244 H256 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 ic50=0.8uM Q9BMI9 20129792 290 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3e0q A 1.9 BS01 JFD A 1 A119 G120 Y202 E203 V219 G220 M221 N245 A112 G113 Y195 E196 V212 G213 M214 N238 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S31 H59 H81 Y83 E84 A111 M214 S215 N238 S240 H252 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 -logKd/Ki=5.89, IC50=1.3uM Q9BMI9 20122887 400 VTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3e0q B 1.9 BS01 JFD B 1 G120 Y202 E203 G220 N245 G114 Y196 E197 G214 N239 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 S32 H60 H82 Y84 E85 A112 M215 S216 N239 S241 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 -logKd/Ki=5.89, IC50=1.3uM Q9BMI9 20122887 401 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVEQRAELMQSWFEKIIEKLPKD 3e0q C 1.9 BS01 JFD C 1 A118 G120 Y202 E203 G220 M221 N245 V262 A116 G118 Y200 E201 G218 M219 N243 V260 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20122887 402 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3e9r B 1.85 BS01 ADE B 1 A118 A119 G120 Y202 E203 G220 M221 N245 A111 A112 G113 Y195 E196 G213 M214 N238 S35 H88 Y90 E91 A118 M221 S222 N245 S247 S32 H81 Y83 E84 A111 M214 S215 N238 S240 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 288 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVEEEVLATGAQRAELMQSWFEKIIEKLPKD 3e9z A 2.31 BS01 6GU A 1 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 V262 A111 A112 G113 Y195 E196 V212 G213 M214 T237 N238 V255 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S31 H59 H81 Y83 E84 A111 M214 S215 N238 S240 H252 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 704 VTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3e9z C 2.31 BS01 6GU C 1 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 V262 A115 A116 G117 Y199 E200 V216 G217 M218 T241 N242 V259 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H63 H85 Y87 E88 A115 M218 S219 N242 S244 H256 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 704 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPK 3enz A 2.03 BS01 HPA A 1 S91 C92 G93 E182 D206 S89 C90 G91 E180 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYAL 3enz A 2.03 BS02 R1X A 1 S91 M183 E184 S89 M181 E182 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYAL 3enz A 2.03 BS03 ART A 1 G23 R27 R88 G90 S91 G21 R25 R86 G88 S89 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYAL 3enz B 2.03 BS01 HPA B 1 S91 C92 G93 Y160 D206 W212 S89 C90 G91 Y158 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYALE 3enz B 2.03 BS02 R1X B 1 S91 M183 E184 S89 M181 E182 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYALE 3enz B 2.03 BS03 ART B 1 G23 R27 R88 G90 S91 G21 R25 R86 G88 S89 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYALE 3enz C 2.03 BS01 HPA C 1 S91 C92 G93 Y160 D206 W212 S89 C90 G91 Y158 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYALEH 3enz C 2.03 BS02 R1X C 1 S91 M183 E184 S89 M181 E182 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYALEH 3enz C 2.03 BS03 ART C 1 G23 R27 R88 G90 S91 G21 R25 R86 G88 S89 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYALEH 3enz D 2.03 BS01 HPA D 1 S91 C92 G93 Y160 D206 S89 C90 G91 Y158 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYAL 3enz D 2.03 BS02 R1X D 1 S91 Y160 E182 M183 E184 S89 Y158 E180 M181 E182 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYAL 3enz D 2.03 BS03 ART D 1 G23 R27 R88 G90 S91 G21 R25 R86 G88 S89 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYAL 3enz D 2.03 BS04 R1X F 1 H7 R45 H5 R43 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYAL 3enz E 2.03 BS01 HPA E 1 S91 C92 G93 Y160 D206 S89 C90 G91 Y158 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3enz E 2.03 BS02 R1X E 1 S91 E182 M183 E184 S89 E180 M181 E182 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3enz E 2.03 BS03 ART E 1 G23 R27 R88 G90 S91 G21 R25 R86 G88 S89 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3enz F 2.03 BS01 HPA F 1 S91 C92 G93 Y160 D206 S89 C90 G91 Y158 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 301 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3enz F 2.03 BS02 R1X F 1 S91 M183 E184 S89 M181 E182 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3enz F 2.03 BS03 ART F 1 G23 R88 G90 S91 G21 R86 G88 S89 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 19575810 303 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3f8w A 2.3 BS01 ADN A 1 Y90 A118 G120 Y202 E203 G220 M221 T244 N245 H259 V262 Y84 A112 G114 Y196 E197 G214 M215 T238 N239 H253 V256 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H60 H82 Y84 E85 A112 M215 S216 N239 S241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 -logKd/Ki=4.08, IC50=82.3uM Q9BMI9 20057051 300 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPK 3f8w B 2.3 BS01 ADN B 1 Y90 A118 G120 Y202 E203 G220 M221 T244 N245 H259 V262 Y87 A115 G117 Y199 E200 G217 M218 T241 N242 H256 V259 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H63 H85 Y87 E88 A115 M218 S219 N242 S244 H256 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 -logKd/Ki=4.08, IC50=82.3uM Q9BMI9 20057051 301 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3f8w C 2.3 BS01 ADN C 1 Y90 A118 G120 Y202 E203 G220 M221 T244 N245 H259 V262 Y82 A110 G112 Y194 E195 G212 M213 T236 N237 H251 V254 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S31 H58 H80 Y82 E83 A110 M213 S214 N237 S239 H251 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 302 VTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3faz A 1.9 BS01 NOS A 1 Y90 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 H259 V262 Y85 A113 A114 G115 Y197 E198 V214 G215 M216 T239 N240 H254 V257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H61 H83 Y85 E86 A113 M216 S217 N240 S242 H254 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 301 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3faz B 1.9 BS01 NOS B 1 Y90 A118 A119 G120 Y202 E203 G220 M221 T244 N245 H259 V262 Y86 A114 A115 G116 Y198 E199 G216 M217 T240 N241 H255 V258 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H62 H84 Y86 E87 A114 M217 S218 N241 S243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 301 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3faz C 1.9 BS01 NOS C 1 A118 A119 G120 Y202 E203 G220 M221 T244 N245 H259 V262 A116 A117 G118 Y200 E201 G218 M219 T242 N243 H257 V260 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 301 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3fb1 A 2.002 BS01 R1P A 1 G34 S35 R86 H88 Y90 N117 A118 Y202 M221 S222 G31 S32 R80 H82 Y84 N111 A112 Y196 M215 S216 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H60 H82 Y84 E85 A112 M215 S216 N239 S241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 21169694 301 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3fb1 B 2.002 BS01 R1P B 1 G34 S35 R86 H88 Y90 N117 A118 Y202 M221 S222 G31 S32 R82 H84 Y86 N113 A114 Y198 M217 S218 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 S32 H62 H84 Y86 E87 A114 M217 S218 N241 S243 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 21169694 302 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESAQRAELMQSWFEKIIEKLPKD 3fb1 C 2.002 BS01 R1P C 1 G34 S35 R86 H88 Y90 N117 A118 Y202 M221 S222 H259 V262 G32 S33 R84 H86 Y88 N115 A116 Y200 M219 S220 H257 V260 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 21169694 300 ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3fnq A 1.85 BS01 HPA A 1 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 A112 A113 G114 Y196 E197 V213 G214 M215 T238 N239 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H60 H82 Y84 E85 A112 M215 S216 N239 S241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 981 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPK 3fnq B 1.85 BS01 HPA B 1 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 A105 A106 G107 Y189 E190 V206 G207 M208 T231 N232 S35 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H75 Y77 E78 A105 M208 S209 N232 S234 H243 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 991 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSLADGVKDKITIPYTKIPNFPQTGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLHEEVLATGAQRAELMQSWFEKIIEKLPKD 3fnq C 1.85 BS01 HPA C 1 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 A115 A116 G117 Y199 E200 V216 G217 M218 T241 N242 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H63 H85 Y87 E88 A115 M218 S219 N242 S244 H256 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20057051 975 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLP 3fow A 2.8 BS01 IMH A 1 S91 C92 G93 F160 E182 M183 E184 D206 S89 C90 G91 F158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V211 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 24416224 278 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGIGSAGCAICFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMFYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKLVPHQLENMIKIALGACAKLATKYA 3fow B 2.8 BS01 IMH B 1 I66 S91 C92 G93 F160 E182 M183 E184 D206 I64 S89 C90 G91 F158 E180 M181 E182 D204 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V210 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 24416224 276 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGIGSAGCAICFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMFYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFLVPHQLENMIKIALGACAKLATKYA 3fuc A 1.45 BS01 9D9 A 1 S33 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 T242 N243 S31 R74 H76 N105 A106 A107 G108 F190 E191 V207 M209 S210 T232 N233 S33 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H76 Y78 E79 A106 M209 S210 N233 V235 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=190pM -logKd/Ki=9.72, Kd=190pM IC50=10.2nM, Ki=1nM, Kd=0.1nM P55859 19944078 301 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 3fuc B 1.45 BS01 9D9 B 1 S33 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 T242 N243 S31 R74 H76 N105 A106 A107 G108 F190 E191 V207 M209 S210 T232 N233 S33 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H76 Y78 E79 A106 M209 S210 N233 V235 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=190pM -logKd/Ki=9.72, Kd=190pM IC50=10.2nM, Ki=1nM, Kd=0.1nM P55859 19944078 301 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 3fuc C 1.45 BS01 9D9 C 1 S33 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 T242 N243 S31 R74 H76 N105 A106 A107 G108 F190 E191 V207 M209 S210 T232 N233 S33 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H76 Y78 E79 A106 M209 S210 N233 V235 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=190pM IC50=10.2nM, Ki=1nM, Kd=0.1nM P55859 19944078 301 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 3fuc C 1.45 BS02 AZI C 1 P92 K95 P82 K85 S33 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H76 Y78 E79 A106 M209 S210 N233 V235 H247 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 P55859 19944078 304 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPV 3gb9 A 2.3 BS01 A2F A 1 G118 F200 Q201 G218 M219 D243 G116 F198 Q199 G216 M217 D241 S33 H64 H86 Y88 E89 A116 M219 S220 D243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 D241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 19388075 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFQTVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITDKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3gb9 B 2.3 BS01 A2F B 1 G118 F200 Q201 G218 M219 D243 G115 F197 Q198 G215 M216 D240 S33 H86 Y88 E89 A116 M219 S220 D243 V245 S35 H83 Y85 E86 A113 M216 S217 D240 V242 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 19388075 300 GHMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFQTVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITDKVIMDYEAGKQAAQKLEQFVSILMASIPLP 3gb9 C 2.3 BS01 A2F C 1 G118 F200 Q201 G218 M219 D243 G114 F196 Q197 G214 M215 D239 S33 H86 Y88 E89 A116 M219 S220 D243 V245 S33 H82 Y84 E85 A112 M215 S216 D239 V241 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 19388075 300 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFQTVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITDKVIMDYESVLAAGKQAAQKLEQFVSILMASIPLP 3ggs A 2.52 BS01 2FD A 1 Y88 A116 G118 F200 V217 M219 D243 Y86 A114 G116 F198 V215 M217 D241 S33 H64 H86 Y88 E89 A116 M219 S220 D243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 D241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 19388075 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFQTVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITDKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 3ggs B 2.52 BS01 2FD B 1 A116 G118 F200 Q201 V217 M219 D243 A116 G118 F200 Q201 V217 M219 D243 S33 H64 H86 Y88 E89 A116 M219 S220 D243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 D243 V245 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 19388075 300 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFQTVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITDKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3ggs C 2.52 BS01 2FD C 1 S33 A116 G118 F200 Q201 V217 M219 D243 S31 A110 G112 F194 Q195 V211 M213 D237 S33 H86 Y88 E89 A116 M219 S220 D243 V245 H257 S31 H80 Y82 E83 A110 M213 S214 D237 V239 H251 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 19388075 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFQTVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITDKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3iex A 2.05 BS01 GMP A 1 Y90 A118 A119 G120 Y202 E203 V219 G220 M221 N245 H259 V262 Y79 A107 A108 G109 Y191 E192 V208 G209 M210 N234 H248 V251 S35 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H77 Y79 E80 A107 M210 S211 N234 S236 H248 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20129792 300 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGGVKDKITIPYTKIPNFPQTSSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3iex C 2.05 BS01 GMP C 1 Y90 A118 A119 G120 Y202 E203 V219 G220 M221 T244 N245 H259 V262 Y87 A115 A116 G117 Y199 E200 V216 G217 M218 T241 N242 H256 V259 S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259 S32 H63 H85 Y87 E88 A115 M218 S219 N242 S244 H256 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 Q9BMI9 20129792 301 SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQTSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD 3iny A 2.75 BS01 7DG A 1 A116 A117 G118 F200 E201 V217 T242 N243 A115 A116 G117 F199 E200 V216 T241 N242 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S32 H63 H85 Y87 E88 A115 M218 S219 N242 V244 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=3.66, Kd=217uM P00491 19932753 293 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 3iom A 2.14 BS01 SO4 A 1 G35 S36 R88 H90 N119 S208 G29 S30 R82 H84 N113 S202 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 20570524 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3iom A 2.14 BS02 GNG A 1 S36 A120 G122 Y188 E189 G206 M207 T230 N231 H243 V246 S30 A114 G116 Y182 E183 G200 M201 T224 N225 H237 V240 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 20570524 800 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3iom B 2.14 BS01 SO4 B 1 G35 S36 R88 H90 S208 G29 S30 R82 H84 S202 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 20570524 302 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3iom B 2.14 BS02 GNG B 1 S36 A120 A121 G122 Y188 E189 V205 G206 M207 T230 N231 H243 V246 S30 A114 A115 G116 Y182 E183 V199 G200 M201 T224 N225 H237 V240 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 20570524 801 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3ix2 A 2.1 BS01 PO4 A 1 N119 A120 M207 S208 N113 A114 M201 S202 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 22033138 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3ix2 A 2.1 BS02 AC2 A 1 A120 A121 G122 Y188 E189 V205 G206 M207 T230 N231 L241 V246 A114 A115 G116 Y182 E183 V199 G200 M201 T224 N225 L235 V240 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Kd=12589nM P9WP01 22033138 302 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3ix2 B 2.1 BS01 PO4 B 1 G35 S36 R88 H90 N119 A120 S208 G29 S30 R82 H84 N113 A114 S202 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 22033138 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3ix2 B 2.1 BS02 AC2 B 1 S36 A120 A121 G122 Y188 E189 V205 G206 M207 T230 N231 S30 A114 A115 G116 Y182 E183 V199 G200 M201 T224 N225 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Kd=12589nM P9WP01 22033138 302 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3ix2 C 2.1 BS01 PO4 C 1 G35 S36 R88 H90 N119 A120 S208 G29 S30 R82 H84 N113 A114 S202 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 22033138 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3ix2 C 2.1 BS02 AC2 C 1 A120 A121 G122 Y180 Y188 E189 V205 G206 M207 T230 N231 A114 A115 G116 Y174 Y182 E183 V199 G200 M201 T224 N225 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 Kd=12589nM P9WP01 22033138 302 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3k8o E 2.4 BS01 229 E 1 A116 A117 G118 F200 E201 G218 M219 N243 H257 A114 A115 G116 F198 E199 G216 M217 N241 H255 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=11.07, Kd=8.6pM Ki=780nM, Kd=0.0086nM P00491 9006 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3k8o Q 2.4 BS01 229 Q 1 A116 A117 G118 F200 E201 V217 M219 N243 H257 A115 A116 G117 F199 E200 V216 M218 N242 H256 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S32 H63 H85 Y87 E88 A115 M218 S219 N242 H256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=780nM, Kd=0.0086nM P00491 9002 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3k8o S 2.4 BS01 229 S 1 A116 A117 G118 F200 E201 V217 M219 N243 H257 A113 A114 G115 F197 E198 V214 M216 N240 H254 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 H254 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=780nM, Kd=0.0086nM P00491 9005 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3k8o T 2.4 BS01 229 T 1 A116 A117 G118 F200 E201 M219 N243 H257 V260 A114 A115 G116 F198 E199 M217 N241 H255 V258 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=780nM, Kd=0.0086nM P00491 9004 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 3k8o U 2.4 BS01 229 U 1 Y88 A116 A117 G118 F200 E201 M219 N243 H257 Y86 A114 A115 G116 F198 E199 M217 N241 H255 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=780nM, Kd=0.0086nM P00491 9003 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDK 3k8o Y 2.4 BS01 229 Y 1 A116 A117 G118 F200 E201 M219 N243 H257 A114 A115 G116 F198 E199 M217 N241 H255 S33 H64 H86 Y88 E89 A116 M219 S220 N243 H257 S31 H62 H84 Y86 E87 A114 M217 S218 N241 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=11.07, Kd=8.6pM Ki=780nM, Kd=0.0086nM P00491 9001 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3k8q A 2.5 BS01 22A A 1 A116 A117 G118 F200 E201 V217 M219 N243 A116 A117 G118 F200 E201 V217 M219 N243 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=11.28, Kd=5.2pM Ki=0.11nM P00491 290 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 3khs A 2.38 BS01 PO4 A 1 S30 R81 H83 N112 S217 S30 R74 H76 N105 S210 S30 H83 Y85 E86 A113 M216 S217 N240 I242 S30 H76 Y78 E79 A106 M209 S210 N233 I235 2.4.2.1 0003824,0004731,0005737,0006139,0009116 Q5YBA4 20124695 290 MTDYDLAKETAAWLNKQLQIRPVLGIVCGSGLGKIGDSLETSITVAYSDIPNFPAGSLIFGSVNGVSCVCMKGRFHLYEGHTAARATFPMRVFKALGVKIVVLTNAAGGLNPSYRPGDFMVVRDHINLPGLAGANPLTGPNDDTEGERFPSMTSVYDKTLRKYAISAARELGMSYATHEGVYCCVNGPSFETPAECKILRLMGSDAVGMSTAPETIVAKHGGMRCLAVSLISNVIASNCEAGEEASARMTALVKLVIEKIRGEL 3khs B 2.38 BS01 PO4 B 1 G29 S30 R81 H83 N112 S217 G29 S30 R76 H78 N107 S212 S30 H83 Y85 E86 A113 M216 S217 N240 I242 S30 H78 Y80 E81 A108 M211 S212 N235 I237 2.4.2.1 0003824,0004731,0005737,0006139,0009116 Q5YBA4 20124695 291 MTDYDLAKETAAWLNKQLQIRPVLGIVCGSGLGKIGDSLETSITVAYSDIPNFPVGAGSLIFGSVNGVSCVCMKGRFHLYEGHTAARATFPMRVFKALGVKIVVLTNAAGGLNPSYRPGDFMVVRDHINLPGLAGANPLTGPNDDTEGERFPSMTSVYDKTLRKYAISAARELGMSYATHEGVYCCVNGPSFETPAECKILRLMGSDAVGMSTAPETIVAKHGGMRCLAVSLISNVIASNCEEVLRAGEEASARMTALVKLVIEKIRGEL 3khs C 2.38 BS01 PO4 C 1 S30 R81 H83 N112 S217 S30 R77 H79 N108 S213 S30 H83 Y85 E86 A113 M216 S217 N240 I242 S30 H79 Y81 E82 A109 M212 S213 N236 I238 2.4.2.1 0003824,0004731,0005737,0006139,0009116 Q5YBA4 20124695 292 MTDYDLAKETAAWLNKQLQIRPVLGIVCGSGLGKIGDSLETSITVAYSDIPNFPVGSAGSLIFGSVNGVSCVCMKGRFHLYEGHTAARATFPMRVFKALGVKIVVLTNAAGGLNPSYRPGDFMVVRDHINLPGLAGANPLTGPNDDTEGERFPSMTSVYDKTLRKYAISAARELGMSYATHEGVYCCVNGPSFETPAECKILRLMGSDAVGMSTAPETIVAKHGGMRCLAVSLISNVIASNCETAGEEASARMTALVKLVIEKIRGELPR 3khs D 2.38 BS01 PO4 D 1 G29 S30 R81 N112 S217 G29 S30 R74 N105 S210 S30 H83 Y85 E86 A113 M216 S217 N240 I242 S30 H76 Y78 E79 A106 M209 S210 N233 I235 2.4.2.1 0003824,0004731,0005737,0006139,0009116 Q5YBA4 20124695 293 MTDYDLAKETAAWLNKQLQIRPVLGIVCGSGLGKIGDSLETSITVAYSDIPNFPVGSLIFGSVNGVSCVCMKGRFHLYEGHTAARATFPMRVFKALGVKIVVLTNAAGGLNPSYRPGDFMVVRDHINLPGLAGANPLTGPNDDTEGERFPSMTSVYDKTLRKYAISAARELGMSYATHEGVYCCVNGPSFETPAECKILRLMGSDAVGMSTAPETIVAKHGGMRCLAVSLISNVIASNCEAGEEASARMTALVKLVIEKIRG 3lba A 2.24 BS01 HPA A 1 A113 A114 G115 Y190 E191 V207 G208 N233 A107 A108 G109 Y184 E185 V201 G202 N227 S30 H83 Y85 E86 A113 M209 S210 N233 A235 S30 H77 Y79 E80 A107 M203 S204 N227 A229 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q8DTU4 290 MSLLKKIYETRDFLTAKGVQKPEFGLILGSGLGELAEEIENALVLNYADIPNWGRSGKLIYGELAGRKVLALQGRFHYYEGNSMELVTFPIRIMKALGCQGLIVTNAAGGIGFGPGTLMAISDHINLTGANPLMGENLDDFGFRFPDMSNAYTADYREVAHQVADKIGIKLDEGVYIGVSGPSYETPAEIRAFKTLGADAVGMSTVPEVIVAVHSGLKVLGISAITNYAAGFQSELNVVAVTQQIKEDFKGLVKAILVEL 3mb8 A 1.9 BS01 IMH A 1 T96 C97 G98 F165 D186 M187 E188 D210 P213 T94 C95 G96 F163 D184 M185 E186 D208 P211 H12 G28 R32 R50 E82 R93 T96 D210 G211 P213 V226 H10 G26 R30 R48 E80 R91 T94 D208 G209 P211 V224 2.4.2.1 0003824,0004731,0004850,0005829,0006218,0009116,0016757 Q2HXR2 24585883 280 LMQGMEVQPHIRLRKEDVEPVVIIVGDPARTEEVANMCEKKQELAYNREYRSFRVVYDSQPITVISHGIGCPGTSIAIEELAYLGAKVIIRAGTCGSLKPKTLKQGDVCVTYAAVNETGLISNILPEGFPCVATPHVYQALMDAAKELGIEAASGIGVTQDYFYQNGILPSKLEMYSKCCDVIDMEMSGVLGLCQARGIATCGILAVDGSPLQWDEGDYDATGVKATTGKENMVKITLKACANLRRQY 3mb8 A 1.9 BS02 PO4 A 1 G28 R32 R93 T96 G26 R30 R91 T94 H12 G28 R32 R50 E82 R93 T96 D210 G211 P213 V226 H10 G26 R30 R48 E80 R91 T94 D208 G209 P211 V224 2.4.2.1 0003824,0004731,0004850,0005829,0006218,0009116,0016757 Q2HXR2 24585883 281 LMQGMEVQPHIRLRKEDVEPVVIIVGDPARTEEVANMCEKKQELAYNREYRSFRVVYDSQPITVISHGIGCPGTSIAIEELAYLGAKVIIRAGTCGSLKPKTLKQGDVCVTYAAVNETGLISNILPEGFPCVATPHVYQALMDAAKELGIEAASGIGVTQDYFYQNGILPSKLEMYSKCCDVIDMEMSGVLGLCQARGIATCGILAVDGSPLQWDEGDYDATGVKATTGKENMVKITLKACANLRRQY 3mb8 B 1.9 BS01 IMH B 1 T96 C97 G98 F165 D186 M187 E188 D210 T94 C95 G96 F163 D184 M185 E186 D208 H12 G28 R32 R50 E82 R93 T96 D210 G211 P213 V226 H10 G26 R30 R48 E80 R91 T94 D208 G209 P211 V224 2.4.2.1 0003824,0004731,0004850,0005829,0006218,0009116,0016757 Q2HXR2 24585883 280 LMQGMEVQPHIRLRKEDVEPVVIIVGDPARTEEVANMCEKKQELAYNREYRSFRVVYDSQPITVISHGIGCPGTSIAIEELAYLGAKVIIRAGTCGSLKPKTLKQGDVCVTYAAVNETGLISNILPEGFPCVATPHVYQALMDAAKELGIEAASGIGVTQDYFYQNGILPSKLEMYSKCCDVIDMEMSGVLGLCQARGIATCGILAVDGSPLQWDEGDYDATGVKATTGKENMVKITLKACANLRRQY 3mb8 B 1.9 BS02 PO4 B 1 G28 R32 R93 T96 G26 R30 R91 T94 H12 G28 R32 R50 E82 R93 T96 D210 G211 P213 V226 H10 G26 R30 R48 E80 R91 T94 D208 G209 P211 V224 2.4.2.1 0003824,0004731,0004850,0005829,0006218,0009116,0016757 Q2HXR2 24585883 281 LMQGMEVQPHIRLRKEDVEPVVIIVGDPARTEEVANMCEKKQELAYNREYRSFRVVYDSQPITVISHGIGCPGTSIAIEELAYLGAKVIIRAGTCGSLKPKTLKQGDVCVTYAAVNETGLISNILPEGFPCVATPHVYQALMDAAKELGIEAASGIGVTQDYFYQNGILPSKLEMYSKCCDVIDMEMSGVLGLCQARGIATCGILAVDGSPLQWDEGDYDATGVKATTGKENMVKITLKACANLRRQY 3occ A 1.7 BS01 DIH A 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 M63 S89 C90 G91 F158 V177 E178 M179 E180 D203 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H3 G19 R23 R42 E74 R86 S89 S202 D203 I205 R216 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 TPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ B 1.7 BS01 DIH B 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 M63 S89 C90 G91 F158 V177 E178 M179 E180 D203 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H3 G19 R23 R42 E74 R86 S89 S202 D203 I205 R216 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 TPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ C 1.7 BS01 DIH C 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 I207 M62 S88 C89 G90 F157 V176 E177 M178 E179 D202 I204 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H2 G18 R22 R41 E73 R85 S88 S201 D202 I204 R215 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 PHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ D 1.7 BS01 DIH D 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 ATPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ E 1.7 BS01 DIH E 1 M65 S91 C92 G93 F160 V179 E180 M181 E182 D205 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 ATPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ F 1.7 BS01 DIH A 1 H5 R44 H4 R43 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 ATPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3occ F 1.7 BS02 DIH F 1 M65 S91 C92 F160 V179 E180 M181 E182 D205 I207 M64 S90 C91 F159 V178 E179 M180 E181 D204 I206 H5 G21 R25 R44 E76 R88 S91 S204 D205 I207 R218 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 B1JL34 500 ATPHINAEMGDFADVVLMPGDPLRAKFIAETFLQDVREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYAKELITDFGVKKIIRVGSCGAVRTDVKLRDVVIGMGACTDSKVNRMRFKDHDYAAIADFEMTRNAVDAAKAKGVNVRVGNLFSADLFYTPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTGEQTTAAERQTTFNDMIEIALESVLLGDNA 3odg A 1.64 BS01 XAN A 1 A126 G127 F204 E205 G222 M223 T246 N247 A114 G115 F192 E193 G210 M211 T234 N235 S42 H73 H95 Y97 E98 A125 M223 S224 N247 A249 H259 S30 H61 H83 Y85 E86 A113 M211 S212 N235 A237 H247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0055086 Q66D48 288 DFNELPFQAVKYIQKIKPGFKPQIAFILGSGLGDLVDQITNDTTISYADIPGFPVSSVHGHAGELVLGDLCGVPVMCMKGRGHFYEGKGMSIMTNPVRTFKLMGCEFLFCTNAAGSLRPEVLPGSVVMLKDHINTMPGTPLVGPNDDRFGPRFFSLANAYDKDLRADMAKIAQQLDIPLTEGVFVSYPGPCFETPAEIRMMQIIGGDVVGMSVVPEVLSAAHCGLKVIALTAITNLAEGLSDVVLSHEQTLKFAKVASVNFTKLIEAFLKSKA 3of3 A 1.83 BS01 DIH A 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 B 1.83 BS01 DIH B 1 M78 S104 C105 G106 F173 V192 E193 M194 E195 D218 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 B 1.83 BS02 DIH E 1 H18 R57 H4 R43 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 C 1.83 BS01 DIH C 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 D 1.83 BS01 DIH D 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQA 3of3 E 1.83 BS01 DIH E 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 F 1.83 BS01 DIH F 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 I220 M64 S90 C91 F159 V178 E179 M180 E181 D204 I206 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 G 1.83 BS01 DIH G 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 H 1.83 BS01 DIH H 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 I 1.83 BS01 DIH I 1 M78 S104 C105 F173 V192 E193 M194 E195 D218 M64 S90 C91 F159 V178 E179 M180 E181 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 J 1.83 BS01 DIH J 1 M78 S104 C105 F173 V192 E193 M194 E195 M64 S90 C91 F159 V178 E179 M180 E181 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 K 1.83 BS01 DIH K 1 M78 S104 C105 F173 V192 E193 M194 E195 S217 D218 M64 S90 C91 F159 V178 E179 M180 E181 S203 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3of3 L 1.83 BS01 DIH L 1 M78 S104 C105 F173 V192 E193 M194 E195 S217 D218 M64 S90 C91 F159 V178 E179 M180 E181 S203 D204 H18 G34 R38 R57 E89 R101 S104 S217 D218 I220 R231 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q9KPM0 500 ATPHINAQMGDFADVVLMPGDPLRAKYIAENFLDNAVQVCDVRNMFGYTGTYKGRKISVMGHGMGIPSCSIYVTELIKDYGVKKIIRVGSCGAVNEGIKVRDVVIGMGACTDSKVNRIRFKDHDFAAIADYKMVKAAEEAAKARGIDVKVGNLFSAELFYTPDPSMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALAICTVSDHIKTGEQTTSEERQNTFNEMIEIALDSVLIGDQAGY 3ooe A 2.0 BS01 PO4 A 1 G20 R24 R87 S90 G20 R24 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3ooe B 2.0 BS01 PO4 B 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3ooe C 2.0 BS01 PO4 C 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 R205 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDRQTTFNDMIKIALESVLLGDK 3ooe D 2.0 BS01 PO4 D 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R210 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIAAERQTTFNDMIKIALESVLLGDK 3ooe E 2.0 BS01 PO4 E 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTTTFNDMIKIALESVLLGDK 3ooe E 2.0 BS02 PO4 E 2 T220 N222 T210 N212 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 239 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTTTFNDMIKIALESVLLGDK 3ooe F 2.0 BS01 PO4 F 1 G20 R24 R87 S90 G20 R24 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv A 2.4 BS01 PO4 A 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv B 2.4 BS01 PO4 B 1 G20 R87 S90 G20 R87 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv C 2.4 BS01 PO4 C 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv D 2.4 BS01 PO4 D 1 G20 R87 S90 G20 R87 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv E 2.4 BS01 PO4 E 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R212 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTAAERQTTFNDMIKIALESVLLGDK 3opv F 2.4 BS01 PO4 F 1 G20 R87 S90 G20 R87 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv G 2.4 BS01 PO4 G 1 G20 R87 S90 G20 R87 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv H 2.4 BS01 PO4 H 1 G20 R87 S90 G20 R87 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv I 2.4 BS01 PO4 I 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv J 2.4 BS01 PO4 J 1 G20 R87 S90 G20 R87 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R213 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTTAAERQTTFNDMIKIALESVLLGDK 3opv K 2.4 BS01 PO4 K 1 G20 R87 S90 G20 R87 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3opv L 2.4 BS01 PO4 L 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 A24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 21672603 238 ATPHINAEMGDFADVVLMPGDPLAAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3phb E 2.3 BS01 IM5 E 1 Y88 A116 A117 G118 F200 E201 V217 G218 M219 N243 H257 Y91 A119 A120 G121 F203 E204 V220 G221 M222 N246 H260 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S36 H67 H89 Y91 E92 A119 M222 S223 N246 V248 H260 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 290 PTLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3phb Q 2.3 BS01 IM5 Q 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 Y90 A118 A119 G120 F202 E203 V219 M221 N245 H259 S33 H64 Y88 A116 M219 S220 H257 S35 H66 Y90 A118 M221 S222 H259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 290 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3phb S 2.3 BS01 IM5 S 1 Y88 A116 G118 F200 E201 V217 M219 N243 H257 Y89 A117 G119 F201 E202 V218 M220 N244 H258 S33 H64 Y88 A116 M219 S220 H257 S34 H65 Y89 A117 M220 S221 H258 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 291 LMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3phb T 2.3 BS01 IM5 T 1 Y88 A116 A117 G118 F200 E201 V217 M219 T242 N243 H257 Y91 A119 A120 G121 F203 E204 V220 M222 T245 N246 H260 S33 H64 Y88 A116 M219 S220 H257 S36 H67 Y91 A119 M222 S223 H260 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 291 PTLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 3phb U 2.3 BS01 IM5 U 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 Y86 A114 A115 G116 F198 E199 V215 M217 N241 H255 S33 H64 Y88 A116 M219 S220 H257 S31 H62 Y86 A114 M217 S218 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 290 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDK 3phb Y 2.3 BS01 IM5 Y 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 S33 H64 Y88 A116 M219 S220 H257 S33 H64 Y88 A116 M219 S220 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 292 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3phc A 2.0 BS01 IM5 A 1 S91 C92 G93 Y160 E182 M183 E184 D206 W212 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 501 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3phc B 2.0 BS01 IM5 B 1 S91 C92 G93 Y160 E182 M183 E184 D206 W212 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 501 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3phc C 2.0 BS01 IM5 C 1 S91 C92 G93 Y160 E182 M183 E184 D206 W212 S89 C90 G91 Y158 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 501 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3phc D 2.0 BS01 IM5 D 1 S91 C92 G93 Y160 V181 E182 M183 E184 D206 W212 S89 C90 G91 Y158 V179 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 501 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3phc E 2.0 BS01 IM5 E 1 S91 C92 G93 Y160 V181 E182 M183 E184 D206 W212 S89 C90 G91 Y158 V179 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 501 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3phc F 2.0 BS01 IM5 F 1 S91 C92 G93 Y160 V181 E182 M183 E184 D206 W212 S89 C90 G91 Y158 V179 E180 M181 E182 D204 W210 H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222 H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 501 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 3scz A 1.95 BS01 HPA A 1 G122 Y188 E189 G206 M207 N231 G117 Y183 E184 G201 M202 N226 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S31 H63 H85 Y87 E88 A115 M202 S203 N226 A228 H238 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 269 PDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3scz B 1.95 BS01 HPA B 1 A120 A121 G122 Y188 E189 V205 G206 M207 T230 N231 A114 A115 G116 Y182 E183 V199 G200 M201 T224 N225 S36 H68 H90 Y92 E93 A120 M207 S208 N231 A233 H243 S30 H62 H84 Y86 E87 A114 M201 S202 N225 A227 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 269 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 3u40 A 2.05 BS01 ADN A 1 S95 F164 V182 M184 E185 S95 F164 V182 M184 E185 H9 G25 R29 R48 E80 R92 S95 D208 C210 R222 H9 G25 R29 R48 E80 R92 S95 D208 C210 R222 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 C4LXG4 21904041 251 MAEHCPTPHNGAKYGEIAETVLMAGDPLRVKLLADTYLTDVVQYNSVRGAVGYTGYYKGVKLSVQAHGMGMPSIGIYAYELFNFYGVKRIIRIGSAGAFDESLKLGDIVIGMGACYDSNFERQYDIPGKYSCIADFQLCREAVDAAEKLGYRYKVGNIYSANYFYDDGDHSGAWKKMGVLAVEMEAAALYMIAARARKQALCMLTISDLCYGSGEKMTAEERRTKFTQMMEVALSLAK 3u40 B 2.05 BS01 ADN B 1 S95 A96 F164 V182 M184 E185 S95 A96 F164 V182 M184 E185 H9 G25 R29 R48 E80 R92 S95 D208 C210 R222 H9 G25 R29 R48 E80 R92 S95 D208 C210 R222 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 C4LXG4 21904041 251 MAEHCPTPHNGAKYGEIAETVLMAGDPLRVKLLADTYLTDVVQYNSVRGAVGYTGYYKGVKLSVQAHGMGMPSIGIYAYELFNFYGVKRIIRIGSAGAFDESLKLGDIVIGMGACYDSNFERQYDIPGKYSCIADFQLCREAVDAAEKLGYRYKVGNIYSANYFYDDGDHSGAWKKMGVLAVEMEAAALYMIAARARKQALCMLTISDLCYGSGEKMTAEERRTKFTQMMEVALSLAK 3u40 C 2.05 BS01 ADN C 1 S95 A96 F164 V182 E183 M184 E185 D208 S95 A96 F164 V182 E183 M184 E185 D208 H9 G25 R29 R48 E80 R92 S95 D208 C210 R222 H9 G25 R29 R48 E80 R92 S95 D208 C210 R213 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 C4LXG4 21904041 251 MAEHCPTPHNGAKYGEIAETVLMAGDPLRVKLLADTYLTDVVQYNSVRGAVGYTGYYKGVKLSVQAHGMGMPSIGIYAYELFNFYGVKRIIRIGSAGAFDESLKLGDIVIGMGACYDSNFERQYDIPGKYSCIADFQLCREAVDAAEKLGYRYKVGNIYSANYFYDDGDHSGAWKKMGVLAVEMEAAALYMIAARARKQALCMLTISDLCYERRTKFTQMMEVALSLAK 3u40 D 2.05 BS01 ADN D 1 M69 S95 A96 F164 M184 E185 D208 M72 S98 A99 F167 M187 E188 D211 H9 G25 R29 R48 E80 R92 S95 D208 C210 R222 H12 G28 R32 R51 E83 R95 S98 D211 C213 R225 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 C4LXG4 21904041 251 PGSMAEHCPTPHNGAKYGEIAETVLMAGDPLRVKLLADTYLTDVVQYNSVRGAVGYTGYYKGVKLSVQAHGMGMPSIGIYAYELFNFYGVKRIIRIGSAGAFDESLKLGDIVIGMGACYDSNFERQYDIPGKYSCIADFQLCREAVDAAEKLGYRYKVGNIYSANYFYDDGDHSGAWKKMGVLAVEMEAAALYMIAARARKQALCMLTISDLCYGSGEKMTAEERRTKFTQMMEVALSLAK 3u40 E 2.05 BS01 ADN D 1 H9 R48 H9 R48 H9 G25 R29 R48 E80 R92 S95 D208 C210 H9 G25 R29 R48 E80 R92 S95 D208 C210 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 C4LXG4 21904041 251 MAEHCPTPHNGAKYGEIAETVLMAGDPLRVKLLADTYLTDVVQYNSVRGAVGYTGYYKGVKLSVQAHGMGMPSIGIYAYELFNFYGVKRIIRIGSAGAFDESLKLGDIVIGMGACYDSNFERQYDIPGKYSCIADFQLCREAVDAAEKLGYRYKVGNIYSANYFYDDGDHSGAWKKMGVLAVEMEAAALYMIAARARKQALCMLTISDLCYGSGEKMTKFTQMMEVALSLAK 3u40 E 2.05 BS02 ADN E 1 S95 A96 G97 F164 V182 E183 M184 E185 D208 S95 A96 G97 F164 V182 E183 M184 E185 D208 H9 G25 R29 R48 E80 R92 S95 D208 C210 H9 G25 R29 R48 E80 R92 S95 D208 C210 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 C4LXG4 21904041 251 MAEHCPTPHNGAKYGEIAETVLMAGDPLRVKLLADTYLTDVVQYNSVRGAVGYTGYYKGVKLSVQAHGMGMPSIGIYAYELFNFYGVKRIIRIGSAGAFDESLKLGDIVIGMGACYDSNFERQYDIPGKYSCIADFQLCREAVDAAEKLGYRYKVGNIYSANYFYDDGDHSGAWKKMGVLAVEMEAAALYMIAARARKQALCMLTISDLCYGSGEKMTKFTQMMEVALSLAK 3u40 F 2.05 BS01 ADN F 1 S95 F164 M184 E185 S95 F164 M184 E185 H9 G25 R29 R48 E80 R92 S95 D208 C210 R222 H9 G25 R29 R48 E80 R92 S95 D208 C210 R211 2.4.2.1 0003824,0004731,0004850,0005829,0006139,0006218,0009116 C4LXG4 21904041 251 MAEHCPTPHNGAKYGEIAETVLMAGDPLRVKLLADTYLTDVVQYNSVRGAVGYTGYYKGVKLSVQAHGMGMPSIGIYAYELFNFYGVKRIIRIGSAGAFDESLKLGDIVIGMGACYDSNFERQYDIPGKYSCIADFQLCREAVDAAEKLGYRYKVGNIYSANYFYDDGDHSGAWKKMGVLAVEMEAAALYMIAARARKQALCMLTISDLCRRTKFTQMMEVALSLAK 3uav A 1.4 BS01 SO4 A 1 G20 R87 T90 G19 R86 T89 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H3 G19 R23 R42 E74 R86 T89 S202 D203 I205 R210 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q5EEL8 22349225 236 SVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSDHIFSEERQTTFNEMIEIALDAAIQ 3uaw A 1.2 BS01 ADN A 1 M64 T90 C91 G92 F159 E179 M180 E181 D204 M63 T89 C90 G91 F158 E178 M179 E180 D203 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H3 G19 R23 R42 E74 R86 T89 S202 D203 I205 R216 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q5EEL8 22349225 236 SVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSDHIFTGEETTSEERQTTFNEMIEIALDAAIQ 3uaw A 1.2 BS02 SO4 A 1 G20 R87 G89 T90 G19 R86 G88 T89 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H3 G19 R23 R42 E74 R86 T89 S202 D203 I205 R216 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q5EEL8 22349225 237 SVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSDHIFTGEETTSEERQTTFNEMIEIALDAAIQ 3uax A 1.2 BS01 NOS A 1 M64 T90 C91 G92 F159 E179 M180 E181 M63 T89 C90 G91 F158 E178 M179 E180 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H3 G19 R23 R42 E74 R86 T89 S202 D203 I205 R210 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q5EEL8 22349225 236 SVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSDHIFSEERQTTFNEMIEIALDAAI 3uax A 1.2 BS02 SO4 A 1 G20 R87 G89 T90 G19 R86 G88 T89 H4 G20 R24 R43 E75 R87 T90 S203 D204 I206 R217 H3 G19 R23 R42 E74 R86 T89 S202 D203 I205 R210 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q5EEL8 22349225 237 SVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSDHIFSEERQTTFNEMIEIALDAAI 3uay A 1.4 BS01 ADN A 1 M64 T90 C91 F159 E179 M180 E181 N204 I206 M63 T89 C90 F158 E178 M179 E180 N203 I205 H4 G20 R24 R43 E75 R87 T90 S203 N204 I206 R217 H3 G19 R23 R42 E74 R86 T89 S202 N203 I205 R216 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q5EEL8 22349225 236 SVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSNHIFTGEETTSEERQTTFNEMIEIALDAAIQ 3uay A 1.4 BS02 SO4 A 1 G20 R87 G89 T90 G19 R86 G88 T89 H4 G20 R24 R43 E75 R87 T90 S203 N204 I206 R217 H3 G19 R23 R42 E74 R86 T89 S202 N203 I205 R216 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q5EEL8 22349225 237 SVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSNHIFTGEETTSEERQTTFNEMIEIALDAAIQ 3uaz A 1.4 BS01 NOS A 1 M64 T90 C91 G92 F159 E179 M180 E181 N204 M63 T89 C90 G91 F158 E178 M179 E180 N203 H4 G20 R24 R43 E75 R87 T90 S203 N204 I206 R217 H3 G19 R23 R42 E74 R86 T89 S202 N203 I205 R216 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q5EEL8 22349225 236 SVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSNHIFTGEETTSEERQTTFNEMIEIALDAAIQ 3uaz A 1.4 BS02 SO4 A 1 G20 R87 G89 T90 G19 R86 G88 T89 H4 G20 R24 R43 E75 R87 T90 S203 N204 I206 R217 H3 G19 R23 R42 E74 R86 T89 S202 N203 I205 R216 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 Q5EEL8 22349225 237 SVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSNHIFTGEETTSEERQTTFNEMIEIALDAAIQ 3ut6 A 1.895 BS01 FMC A 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 22569248 300 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3ut6 A 1.895 BS02 PO4 A 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 22569248 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3ut6 B 1.895 BS01 FMC B 1 M64 S90 F159 V178 E179 M180 E181 D204 M64 S90 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 22569248 300 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3ut6 B 1.895 BS02 PO4 B 1 G20 D21 V88 G89 S90 G20 D21 V88 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 22569248 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3ut6 B 1.895 BS03 PO4 B 2 D21 R24 R217 D21 R24 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 22569248 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3ut6 C 1.895 BS01 FMC C 1 S90 F159 V178 E179 M180 E181 D204 S90 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 22569248 300 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3ut6 C 1.895 BS02 PO4 C 1 D21 R24 D21 R24 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 22569248 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 3ut6 C 1.895 BS03 PO4 C 2 P19 G20 D21 R24 G89 P19 G20 D21 R24 G89 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 22569248 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4d8v A 2.35 BS01 ADE A 1 G92 F159 V177 E178 M179 G91 F158 V176 E177 M178 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 303 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4d8v B 2.35 BS01 ADE B 1 G92 F159 V177 G91 F158 V176 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 303 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4d9h A 1.91 BS01 ADN A 1 M64 S90 C91 G92 F159 V177 M179 E180 S202 M63 S89 C90 G91 F158 V176 M178 E179 S201 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4d9h B 1.91 BS01 ADN A 1 H4 R43 H3 R42 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S199 D200 V202 R213 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4da0 A 2.95 BS01 GNG A 1 S90 C91 G92 F159 V177 E178 M179 E180 S202 S89 C90 G91 F158 V176 E177 M178 E179 S201 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSV 4da6 A 1.7 BS01 GA2 A 1 S90 C91 G92 F159 V177 M179 E180 S202 S89 C90 G91 F158 V176 M178 E179 S201 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4da7 A 2.05 BS01 AC2 A 1 C91 G92 F159 V177 M179 E180 C90 G91 F158 V176 M178 E179 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4da7 A 2.05 BS02 PO4 A 1 G20 R87 S90 G19 R86 S89 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 302 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4da8 A 2.6 BS01 BG2 A 1 S90 G92 F159 V177 E178 M179 E180 S202 S89 G91 F158 V176 E177 M178 E179 S201 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4dab A 1.85 BS01 HPA A 1 G92 F159 V177 M179 G91 F158 V176 M178 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4dae A 2.35 BS01 6CR A 1 M64 S90 C91 G92 F159 E178 M179 E180 S202 M64 S90 C91 G92 F159 E178 M179 E180 S202 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4dan A 2.56 BS01 2FA A 1 S90 C91 G92 F159 V177 E178 M179 E180 S202 S89 C90 G91 F158 V176 E177 M178 E179 S201 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHS 4dan A 2.56 BS02 2FA B 1 H4 R43 H3 R42 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHS 4dan B 2.56 BS01 2FA A 1 H4 R43 H3 R42 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4dan B 2.56 BS02 2FA B 1 S90 F159 E178 M179 E180 S202 S89 F158 E177 M178 E179 S201 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4dao A 2.22 BS01 ADE A 1 C91 G92 F159 V177 C90 G91 F158 V176 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSV 4dao B 2.22 BS01 ADE B 1 C91 F159 V177 C90 F158 V176 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSV 4dar A 3.15 BS01 TBN A 1 S90 C91 G92 F159 E178 M179 E180 S202 S89 C90 G91 F158 E177 M178 E179 S201 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4ear A 1.7 BS01 IM5 A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 X257 Y85 A113 A114 G115 F197 E198 V214 M216 N240 X254 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 W254 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=9.82, Kd=151pM Ki=7nM P00491 23438750 301 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4ear A 1.7 BS02 PO4 A 1 G32 S33 R84 H86 N115 S220 G29 S30 R81 H83 N112 S217 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 W254 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 302 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4ear B 1.7 BS01 IM5 B 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 X257 V260 Y87 A115 A116 G117 F199 E200 V216 M218 N242 X256 V259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S32 H63 H85 Y87 E88 A115 M218 S219 N242 V244 W256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 23438750 301 ENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPDKA 4ear B 1.7 BS02 PO4 B 1 G32 S33 R84 H86 N115 S220 G31 S32 R83 H85 N114 S219 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S32 H63 H85 Y87 E88 A115 M218 S219 N242 V244 W256 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 302 ENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPDKA 4ear C 1.7 BS01 IM5 C 1 S33 Y88 A116 A117 G118 F200 E201 M219 N243 X257 S30 Y85 A113 A114 G115 F197 E198 M216 N240 X254 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 W254 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=9.82, Kd=151pM Ki=7nM P00491 23438750 301 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPDKA 4ear C 1.7 BS02 PO4 C 1 G32 S33 R84 H86 N115 S220 G29 S30 R81 H83 N112 S217 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 W254 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 302 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPDKA 4eb8 A 2.3 BS01 PO4 A 1 G32 S33 R84 H86 N115 S220 G34 S35 R86 H88 N117 S222 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 W259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 TLMENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 A 2.3 BS02 IM5 A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 W257 V260 Y90 A118 A119 G120 F202 E203 V219 M221 N245 W259 V262 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 W259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=9.82, Ki=151pM Ki=7nM P00491 23438750 302 TLMENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 B 2.3 BS01 PO4 B 1 G32 S33 H64 R84 H86 N115 S220 G34 S35 H66 R86 H88 N117 S222 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 W259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 TLMENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 B 2.3 BS02 IM5 B 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 Y90 A118 A119 G120 F202 E203 V219 M221 N245 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 W259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 23438750 302 TLMENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 C 2.3 BS01 PO4 C 1 G32 S33 R84 H86 N115 S220 G29 S30 R81 H83 N112 S217 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 W254 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 C 2.3 BS02 IM5 C 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 W257 Y85 A113 A114 G115 F197 E198 V214 M216 N240 W254 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 W254 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=9.82, Ki=151pM Ki=7nM P00491 23438750 302 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4gka A 2.2 BS01 PO4 A 1 G32 S33 R84 H86 N115 S220 G30 S31 R82 H84 N113 S218 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 NGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEQAAQKLEQFVSILMASIPLP 4gka B 2.2 BS01 PO4 B 1 S33 R84 H86 N115 S220 S32 R83 H85 N114 S219 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 S32 H63 H85 Y87 E88 A115 M218 S219 N242 V244 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 ENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEQAAQKLEQFVSILMASIPLP 4gka C 2.2 BS01 PO4 C 1 S33 R84 H86 N115 A116 S220 S30 R81 H83 N112 A113 S217 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYQAAQKLEQFVSILMASIPLP 4gka D 2.2 BS01 PO4 D 1 G32 S33 R84 H86 N115 S220 G29 S30 R81 H83 N112 S217 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEKQAAQKLEQFVSILMASIPLP 4gka E 2.2 BS01 PO4 E 1 S33 R84 N115 A116 S220 S31 R82 N113 A114 S218 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 NGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYQAAQKLEQFVSILMASIPLP 4gka F 2.2 BS01 PO4 F 1 S33 R84 N115 A116 S220 S30 R81 N112 A113 S217 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYKQAAQKLEQFVSILMASIPLP 4lna A 2.1 BS01 ADE A 1 A112 G113 E192 M210 D234 A110 G111 E190 M208 D232 T28 H81 Y83 E84 A111 M210 S211 D234 C236 L246 T29 H79 Y81 E82 A109 M208 S209 D232 C234 L244 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D2QIK7 502 SMFEQIQETTQFIQSKITLRPAIGIILGTGLGALTNELDIDTTIPYETIPHFPLSTVSGKLLIGTLGGKSVVVMQGRFHYYEGYTMQQVTYPVRVMHALGIQTLLVSNAAGGMNPTFQTSDLMVIDDHISLLLPQNPLICPNPPIFGDRFPDMSEPYRKSLIDLAFSVAAELDIPLKRGVYVSVTGPQLETRAEYRMLRQWGADAVGMSTVPEVIVANQLGMDVFGISVITDLCFPDTLEKAELVKILATAAQAEPKLTMLIREMIGRL 4m1e A 1.9 BS01 ADE A 1 A114 A115 G116 L193 E194 V210 M212 D236 A112 A113 G114 L191 E192 V208 M210 D234 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T29 H60 H82 Y84 E85 A112 M210 S211 D234 C236 L246 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 401 ELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e A 1.9 BS02 6PC A 1 R170 P181 K182 R168 P179 K180 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T29 H60 H82 Y84 E85 A112 M210 S211 D234 C236 L246 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 402 ELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e A 1.9 BS03 6PC F 1 N119 Q121 L122 H179 P181 N117 Q119 L120 H177 P179 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T29 H60 H82 Y84 E85 A112 M210 S211 D234 C236 L246 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 402 ELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e B 1.9 BS01 ADE B 1 A115 G116 E194 V210 D236 A114 G115 E193 V209 D235 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T30 H61 H83 Y85 E86 A113 M211 S212 D235 C237 L247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 401 SELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e B 1.9 BS02 6PC B 1 R170 P181 R169 P180 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T30 H61 H83 Y85 E86 A113 M211 S212 D235 C237 L247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 402 SELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e B 1.9 BS03 6PC E 1 N119 Q121 H179 P181 N118 Q120 H178 P180 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T30 H61 H83 Y85 E86 A113 M211 S212 D235 C237 L247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 402 SELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e C 1.9 BS01 ADE C 1 A115 G116 L193 E194 M212 D236 A114 G115 L192 E193 M211 D235 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T30 H61 H83 Y85 E86 A113 M211 S212 D235 C237 L247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 401 SELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e C 1.9 BS02 6PC C 1 N119 Q121 H179 P181 N118 Q120 H178 P180 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T30 H61 H83 Y85 E86 A113 M211 S212 D235 C237 L247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 402 SELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e D 1.9 BS01 6PC D 1 N119 Q121 L122 H179 P181 N118 Q120 L121 H178 P180 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T30 H61 H83 Y85 E86 A113 M211 S212 D235 C237 L247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 301 SELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e D 1.9 BS02 ADE D 1 A115 G116 E194 M212 D236 A114 G115 E193 M211 D235 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T30 H61 H83 Y85 E86 A113 M211 S212 D235 C237 L247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 303 SELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e E 1.9 BS01 6PC B 1 N119 Q121 L122 H179 P181 N119 Q121 L122 H179 P181 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 402 MSELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRI 4m1e E 1.9 BS02 ADE E 1 A115 G116 E194 V210 M212 D236 A115 G116 E194 V210 M212 D236 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 401 MSELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRI 4m1e E 1.9 BS03 6PC E 1 R170 P181 R170 P181 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 402 MSELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRI 4m1e F 1.9 BS01 6PC A 1 Q121 H179 P181 Q119 H177 P179 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T29 H60 H82 Y84 E85 A112 M210 S211 D234 C236 L246 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 402 ELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e F 1.9 BS02 ADE F 1 A114 A115 G116 L193 E194 V210 M212 D236 A112 A113 G114 L191 E192 V208 M210 D234 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T29 H60 H82 Y84 E85 A112 M210 S211 D234 C236 L246 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 401 ELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4m1e F 1.9 BS03 6PC F 1 R170 K182 R168 K180 T31 H62 H84 Y86 E87 A114 M212 S213 D236 C238 L248 T29 H60 H82 Y84 E85 A112 M210 S211 D234 C236 L246 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 D5SMY7 402 ELKSRIDQATAKISQLWQGEPAVGMILGTGLGGLAEQIEQDIAIPYSDIPHFPTSTVKSHAGRLVCGRLRGIPIVAMEGRFHYYEGYSLEQVTFPVRVMKAMGVKTLLVTNAAGGINPQLDLSDVLIIEDHINLMPENPLRGPNDEELGPRFPDMSHPYDCQHMEVARQVALELGIHCPKGVFVAVSGPNLETRAEYRMLKLMGADVVGMSTVPEVLVAVHAGLRVLGFSVVTDLCLPDALEPVELNKILEVAARGGAKLARLIPEILPRIA 4ns1 A 1.64 BS01 DA A 1 A129 G131 E208 Y213 I224 G225 M226 T249 N250 A109 G111 E188 Y193 I204 G205 M206 T229 N230 S46 H99 Y101 E102 A129 M226 S227 N250 E263 S31 H79 Y81 E82 A109 M206 S207 N230 E243 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 B2RKN6 301 MKLQEQHYHEAASFLSSRLPGDAKTAIILGSGLGELAEKIENKTVIPYNEIPHFAQAKGNIIGGILGGTPVVAMQGRFHYYEGYSMDQVTFPIRVMKLLGIENLFVSNAAGGINTSFKVGDLMIICDHINNLPNPLIGPNMDMFGVRFPDMTRAYDREFIAKAKGIAQELNIPVKEGVYVGLTGPSYETPAEYKFWGQVGGDAIGMSTVPEVIVARHTGIRVFGMSVITNEGYHFADDFVNDEQDVIRAANAASEKMGAIFARLIAAV 4ns1 B 1.64 BS01 DA B 1 A129 A130 G131 E208 Y213 I224 M226 T249 N250 A111 A112 G113 E190 Y195 I206 M208 T231 N232 S46 H99 Y101 E102 A129 M226 S227 N250 E263 S33 H81 Y83 E84 A111 M208 S209 N232 E245 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 B2RKN6 301 QSMKLQEQHYHEAASFLSSRLPGDAKTAIILGSGLGELAEKIENKTVIPYNEIPHFAQAKGNIIGGILGGTPVVAMQGRFHYYEGYSMDQVTFPIRVMKLLGIENLFVSNAAGGINTSFKVGDLMIICDHINNLPNPLIGPNMDMFGVRFPDMTRAYDREFIAKAKGIAQELNIPVKEGVYVGLTGPSYETPAEYKFWGQVGGDAIGMSTVPEVIVARHTGIRVFGMSVITNEGYHFADDFVNDEQDVIRAANAASEKMGAIFARLIAAV 4ns1 C 1.64 BS01 DA C 1 A129 G131 E208 Y213 I224 M226 T249 N250 A107 G109 E186 Y191 I202 M204 T227 N228 S46 H99 Y101 E102 A129 M226 S227 N250 E263 S31 H77 Y79 E80 A107 M204 S205 N228 E241 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 B2RKN6 301 MKLQEQHYHEAASFLSSRLPGDAKTAIILGSGLGELAEKIENKTVIPYNEIPHFAQGNIIGGILGGTPVVAMQGRFHYYEGYSMDQVTFPIRVMKLLGIENLFVSNAAGGINTSFKVGDLMIICDHINNLPNPLIGPNMDMFGVRFPDMTRAYDREFIAKAKGIAQELNIPVKEGVYVGLTGPSYETPAEYKFWGQVGGDAIGMSTVPEVIVARHTGIRVFGMSVITNEGYHFADDFVNDEQDVIRAANAASEKMGAIFARLIAAV 4ns1 D 1.64 BS01 DA D 1 A129 A130 G131 E208 Y213 I224 G225 M226 T249 N250 A111 A112 G113 E190 Y195 I206 G207 M208 T231 N232 S46 H99 Y101 E102 A129 M226 S227 N250 E263 S34 H81 Y83 E84 A111 M208 S209 N232 E245 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 B2RKN6 301 FQSMKLQEQHYHEAASFLSSRLPGDAKTAIILGSGLGELAEKIENKTVIPYNEIPHFAQKGNIIGGILGGTPVVAMQGRFHYYEGYSMDQVTFPIRVMKLLGIENLFVSNAAGGINTSFKVGDLMIICDHINNLPNPLIGPNMDMFGVRFPDMTRAYDREFIAKAKGIAQELNIPVKEGVYVGLTGPSYETPAEYKFWGQVGGDAIGMSTVPEVIVARHTGIRVFGMSVITNEGYHFADDFVNDEQDVIRAANAASEKMGAIFARLIAAV 4nsn A 1.6 BS01 ADE A 1 A129 A130 G131 Y207 E208 Y213 G225 M226 T249 N250 A114 A115 G116 Y192 E193 Y198 G210 M211 T234 N235 S46 H77 H99 Y101 E102 A129 M226 S227 N250 E263 S31 H62 H84 Y86 E87 A114 M211 S212 N235 E248 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 B2RKN6 301 MKLQEQHYHEAASFLSSRLPGDAKTAIILGSGLGELAEKIENKTVIPYNEIPHFAQATAVGHKGNIIGGILGGTPVVAMQGRFHYYEGYSMDQVTFPIRVMKLLGIENLFVSNAAGGINTSFKVGDLMIICDHINNLPNPLIGPNMDMFGVRFPDMTRAYDREFIAKAKGIAQELNIPVKEGVYVGLTGPSYETPAEYKFWGQVGGDAIGMSTVPEVIVARHTGIRVFGMSVITNEGYHFADDFVNDEQDVIRAANAASEKMGAIFARLIAAV 4nsn B 1.6 BS01 ADE B 1 A129 A130 G131 E208 Y213 I224 M226 N250 A114 A115 G116 E193 Y198 I209 M211 N235 S46 H77 H99 Y101 E102 A129 M226 S227 N250 E263 S31 H62 H84 Y86 E87 A114 M211 S212 N235 E248 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 B2RKN6 301 MKLQEQHYHEAASFLSSRLPGDAKTAIILGSGLGELAEKIENKTVIPYNEIPHFAQATAVGHKGNIIGGILGGTPVVAMQGRFHYYEGYSMDQVTFPIRVMKLLGIENLFVSNAAGGINTSFKVGDLMIICDHINNLPNPLIGPNMDMFGVRFPDMTRAYDREFIAKAKGIAQELNIPVKEGVYVGLTGPSYETPAEYKFWGQVGGDAIGMSTVPEVIVARHTGIRVFGMSVITNEGYHFADDFVNDEQDVIRAANAASEKMGAIFARLIAAV 4nsn C 1.6 BS01 ADE C 1 G131 Y207 E208 Y213 I224 G225 M226 N250 V266 G116 Y192 E193 Y198 I209 G210 M211 N235 V251 S46 H77 H99 Y101 E102 A129 M226 S227 N250 E263 S31 H62 H84 Y86 E87 A114 M211 S212 N235 E248 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 B2RKN6 301 MKLQEQHYHEAASFLSSRLPGDAKTAIILGSGLGELAEKIENKTVIPYNEIPHFAQATAVGHKGNIIGGILGGTPVVAMQGRFHYYEGYSMDQVTFPIRVMKLLGIENLFVSNAAGGINTSFKVGDLMIICDHINNLPNPLIGPNMDMFGVRFPDMTRAYDREFIAKAKGIAQELNIPVKEGVYVGLTGPSYETPAEYKFWGQVGGDAIGMSTVPEVIVARHTGIRVFGMSVITNEGYHFADDFVNDEQDVIRAANAASEKMGAIFARLIAAV 4ts3 A 2.3 BS01 FMC A 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 300 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts3 A 2.3 BS02 PO4 A 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts3 B 2.3 BS01 PO4 B 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts3 C 2.3 BS01 PO4 C 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts3 C 2.3 BS02 FMC F 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts3 D 2.3 BS01 FMC A 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 300 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts3 D 2.3 BS02 PO4 D 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts3 E 2.3 BS01 PO4 E 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts3 F 2.3 BS01 PO4 F 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts3 F 2.3 BS02 FMC F 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts9 A 1.77 BS01 FMC A 1 M64 S90 G92 F159 V178 E179 M180 E181 D204 M64 S90 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 300 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVASCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts9 A 1.77 BS02 PO4 A 1 G20 R24 R87 A89 S90 G20 R24 R87 A89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVASCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts9 B 1.77 BS01 PO4 B 1 G20 R87 A89 S90 G20 R87 A89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVASCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts9 B 1.77 BS02 FMC B 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVASCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts9 C 1.77 BS01 FMC A 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 300 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVASCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts9 C 1.77 BS02 PO4 C 1 G20 R87 A89 S90 G20 R87 A89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVASCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4ts9 C 1.77 BS03 FMC C 1 M64 S90 F159 V178 E179 M180 E181 M64 S90 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVASCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 4tta A 2.0 BS01 PO4 A 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tta A 2.0 BS02 FMC D 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tta B 2.0 BS01 PO4 B 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tta C 2.0 BS01 FMC C 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 M64 S90 C91 G92 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 A204 H4 G20 R24 R43 E75 R87 S90 S203 A204 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHTTFNDMIKIALESVLLGDK 4tta C 2.0 BS02 PO4 C 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 H4 G20 R24 R43 E75 R87 S90 S203 A204 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHTTFNDMIKIALESVLLGDK 4tta D 2.0 BS01 PO4 D 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tta D 2.0 BS02 FMC D 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 M64 S90 C91 G92 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tta E 2.0 BS01 PO4 E 1 G20 R87 G20 R87 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tta F 2.0 BS01 FMC C 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tta F 2.0 BS02 PO4 F 1 G20 R24 R87 S90 G20 R24 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti A 1.89 BS01 FMC A 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 300 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti A 1.89 BS02 PO4 A 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti A 1.89 BS03 FMC D 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti B 1.89 BS01 PO4 B 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti C 1.89 BS01 FMC C 1 S90 C91 G92 F159 V178 E179 M180 E181 S90 C91 G92 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 A204 H4 G20 R24 R43 E75 R87 S90 S203 A204 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHTTFNDMIKIALESVLLGDK 4tti C 1.89 BS02 PO4 C 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 H4 G20 R24 R43 E75 R87 S90 S203 A204 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHTTFNDMIKIALESVLLGDK 4tti C 1.89 BS03 FMC F 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 A204 H4 G20 R24 R43 E75 R87 S90 S203 A204 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHTTFNDMIKIALESVLLGDK 4tti D 1.89 BS01 PO4 D 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti D 1.89 BS02 FMC D 1 M64 S90 G92 F159 V178 E179 M180 E181 M64 S90 G92 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti E 1.89 BS01 PO4 E 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti F 1.89 BS01 FMC C 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti F 1.89 BS02 FMC F 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4tti F 1.89 BS03 PO4 F 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4ttj A 1.874 BS01 PO4 A 1 G20 R24 R87 G89 S90 G20 R24 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4ttj A 1.874 BS02 FMC A 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 M64 S90 C91 G92 F159 V178 E179 M180 E181 S203 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4ttj A 1.874 BS03 FMC D 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4ttj B 1.874 BS01 PO4 B 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4ttj B 1.874 BS02 FMC B 1 M64 R87 S90 C91 G92 F159 V178 E179 M180 E181 M64 R87 S90 C91 G92 F159 V178 E179 M180 E181 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 H4 G20 R24 R43 E75 R87 S90 S203 A204 I206 A217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4ttj D 1.874 BS01 FMC A 1 H4 R43 H4 R43 H4 R24 R43 R87 S203 H4 R24 R43 R87 S203 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4ttj D 1.874 BS02 PO4 D 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 R24 R43 R87 S203 H4 R24 R43 R87 S203 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4ttj D 1.874 BS03 FMC D 1 M64 R87 S90 C91 G92 F159 V178 E179 M180 E181 M64 R87 S90 C91 G92 F159 V178 E179 M180 E181 H4 R24 R43 R87 S203 H4 R24 R43 R87 S203 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 30337572 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK 4uc0 A 2.4 BS01 HPA A 1 A109 G110 F184 E185 G202 M203 T226 N227 A99 G100 F174 E175 G192 M193 T216 N217 S25 H78 Y80 E81 A108 M203 S204 N227 G229 S23 H68 Y70 E71 A98 M193 S194 N217 G219 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 B9JYS2 301 PAVDLLIDRLNGLLPRIAIVLGSGLGGLVDEVENAVRIPFADIPGFPKELVAGLFAGQPIIMLAGRVHYYEEGDAAAMRLPIETLASLGVTTLILTNAAGSLRADMPPGSVMQLIDHINFSGHNPLIGETGDGRFVGMTQAYDGELAEAMRRAADAEDISLSSGVYMWFSGPSFETPAEIRMARTLGADAVGMSTVPEVILARFFGLKVAAASVITNYGAGMTDMAPIGGRRLVAILKRMIVDGGAD 5etj A 2.3 BS01 IM5 A 1 Y88 A116 G118 F200 E201 M219 N243 H257 Y90 A118 G120 F202 E203 M221 N245 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 H259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Kd=66pM -logKd/Ki=10.18, Ki=66pM Ki=7nM P00491 26927977 301 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5etj B 2.3 BS01 IM5 B 1 Y88 A116 A117 G118 F200 E201 M219 N243 H257 V260 Y89 A117 A118 G119 F201 E202 M220 N244 H258 V261 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S34 H65 H87 Y89 E90 A117 M220 S221 N244 V246 H258 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Kd=66pM -logKd/Ki=10.18, Ki=66pM Ki=7nM P00491 26927977 301 LMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5etj C 2.3 BS01 IM5 C 1 Y88 A116 G118 F200 E201 V217 M219 N243 H257 V260 Y90 A118 G120 F202 E203 V219 M221 N245 H259 V262 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 H259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Kd=66pM Ki=7nM P00491 26927977 301 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5etj D 2.3 BS01 IM5 D 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 Y90 A118 A119 G120 F202 E203 V219 M221 N245 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 H259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Kd=66pM Ki=7nM P00491 26927977 301 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5etj E 2.3 BS01 IM5 E 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 Y90 A118 A119 G120 F202 E203 V219 M221 N245 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 H259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Kd=66pM Ki=7nM P00491 26927977 301 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5etj F 2.3 BS01 IM5 F 1 Y88 A116 G118 F200 E201 M219 N243 H257 Y90 A118 G120 F202 E203 M221 N245 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 H259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Kd=66pM Ki=7nM P00491 26927977 302 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHDEVAAAGKQAAQKLEQFVSILMASIPLPD 5i3c A 2.32 BS01 AC2 A 1 S90 C91 G92 F159 V178 E179 I206 S90 C91 G92 F159 V178 E179 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 A7ZVS7 29969103 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5i3c A 2.32 BS02 SO4 A 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 A7ZVS7 29969103 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5i3c B 2.32 BS01 AC2 B 1 S90 C91 G92 F159 V178 E179 M180 I206 S90 C91 G92 F159 V178 E179 M180 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 A7ZVS7 29969103 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5i3c B 2.32 BS02 SO4 B 1 G20 R87 G89 S90 G20 R87 G89 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 A7ZVS7 29969103 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5i3c C 2.32 BS01 AC2 C 1 M64 S90 C91 G92 F159 V178 E179 M180 M64 S90 C91 G92 F159 V178 E179 M180 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 A7ZVS7 29969103 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5i3c C 2.32 BS02 SO4 C 1 G20 R87 S90 G20 R87 S90 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 A7ZVS7 29969103 302 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5i3c C 2.32 BS03 SO4 C 2 T219 N222 T219 N222 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 A7ZVS7 29969103 303 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5ifk A 1.967 BS01 HPA A 1 A130 G131 E214 M232 T255 N256 A119 G120 E203 M221 T244 N245 S42 H98 Y100 E101 A129 M232 S233 N256 C258 H281 S38 H87 Y89 E90 A118 M221 S222 N245 C247 H270 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 27768715 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 5ifk B 1.967 BS01 HPA B 1 A130 G131 F213 E214 M232 N256 A117 G118 F200 E201 M219 N243 S42 H98 Y100 E101 A129 M232 S233 N256 C258 H281 S38 H85 Y87 E88 A116 M219 S220 N243 C245 H268 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 27768715 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 5ifk C 1.967 BS01 HPA C 1 A130 G131 F213 E214 V230 M232 T255 N256 A116 G117 F199 E200 V216 M218 T241 N242 S42 H98 Y100 E101 A129 M232 S233 N256 C258 H281 S37 H84 Y86 E87 A115 M218 S219 N242 C244 H267 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 27768715 401 INEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 5iu6 A 2.51 BS01 7HX A 1 C91 G92 F159 V178 E179 C91 G92 F159 V178 E179 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 -logKd/Ki=3.89, Ki=0.13mM P0ABP8 29870020 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5iu6 B 2.51 BS01 7HX B 1 G92 F159 V178 I206 G92 F159 V178 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 -logKd/Ki=3.89, Ki=0.13mM P0ABP8 29870020 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5iu6 C 2.51 BS01 7HX C 1 S90 C91 G92 F159 V178 E179 D204 S90 C91 G92 F159 V178 E179 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 29870020 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 5ko5 A 1.36 BS01 CYT A 1 L118 A119 G120 Y202 E203 M221 L114 A115 G116 Y198 E199 M217 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 S243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 -logKd/Ki=4.57, Kd=27uM A0A0U3AGT1 30192840 301 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPLD 5ko6 A 1.42 BS01 CYT A 1 L118 A119 G120 Y202 E203 M221 N245 L116 A117 G118 Y200 E201 M219 N243 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 L116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 30192840 301 TPVVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPLD 5ko6 A 1.42 BS02 R1P A 1 G34 S35 R86 H88 Y90 N117 L118 Y202 M221 S222 H259 G32 S33 R84 H86 Y88 N115 L116 Y200 M219 S220 H257 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 L116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 30192840 302 TPVVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPLD 5lu0 A 1.73 BS01 PO4 A 1 G20 R24 R87 G89 T90 G20 R24 R87 G89 T90 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 5lu0 B 1.73 BS01 PO4 B 1 G20 R24 R87 G89 T90 G20 R24 R87 G89 T90 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 5lu0 C 1.73 BS01 PO4 C 1 G20 R24 R87 G89 T90 G20 R24 R87 G89 T90 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 5lu0 E 1.73 BS01 PO4 E 1 G20 R24 R87 G89 T90 G20 R24 R87 G89 T90 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 5mx6 A 2.41 BS01 HPA A 1 T90 C91 F159 I178 D204 T90 C91 F159 I178 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx6 B 2.41 BS01 HPA B 1 G92 F159 G92 F159 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx6 C 2.41 BS01 HPA C 1 T90 C91 G92 F159 I178 D204 T90 C91 G92 F159 I178 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx6 D 2.41 BS01 HPA D 1 T90 G92 F159 T90 G92 F159 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx6 F 2.41 BS01 HPA F 1 T90 C91 F159 T90 C91 F159 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5mx8 A 2.4 BS01 HPA A 1 T90 C91 G92 F159 M180 S203 D204 T90 C91 G92 F159 M180 S203 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 28336275 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFDLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMIILALEMMS 5tbs A 1.9 BS01 ADE A 1 A119 G120 Y202 E203 A244 N245 A117 G118 Y200 E201 A242 N243 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S33 H64 H86 Y88 E89 L116 M219 S220 N243 S245 H257 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 30192840 301 TPVVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPL 5tbt A 2.101 BS01 CTN A 1 L118 Y202 E203 G220 M221 H259 V262 L114 Y198 E199 G216 M217 H255 V258 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 S243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 30192840 301 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPLD 5tbu A 2.1 BS01 HPA A 1 A119 G120 Y202 E203 N245 A115 G116 Y198 E199 N241 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 S243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 30192840 301 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPLD 5tbv A 1.95 BS01 TBN A 1 H88 Y90 L118 G120 Y202 E203 G220 M221 H259 V262 H84 Y86 L114 G116 Y198 E199 G216 M217 H255 V258 S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 S243 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 301 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPLD 5ugf A 2.2 BS01 IM5 A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 28584087 308 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRYPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 5ugf B 2.2 BS01 IM5 B 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 V260 Y89 A117 A118 G119 F201 E202 V218 M220 N244 H258 V261 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S34 H65 H87 Y89 E90 A117 M220 S221 N244 V246 H258 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 28584087 306 LMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRYPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 5ugf C 2.2 BS01 IM5 C 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 Y90 A118 A119 G120 F202 E203 V219 M221 N245 H259 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 H259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 28584087 305 TLMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRYPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 5ugf D 2.2 BS01 IM5 D 1 Y88 A116 A117 G118 F200 E201 M219 N243 H257 V260 Y88 A116 A117 G118 F200 E201 M219 N243 H257 V260 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 28584087 307 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRYPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 5ugf E 2.2 BS01 IM5 E 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 V260 Y89 A117 A118 G119 F201 E202 V218 M220 N244 H258 V261 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S34 H65 H87 Y89 E90 A117 M220 S221 N244 V246 H258 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 28584087 306 LMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRYPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 5ugf F 2.2 BS01 IM5 F 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 H257 V260 Y89 A117 A118 G119 F201 E202 V218 M220 N244 H258 V261 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257 S34 H65 H87 Y89 E90 A117 M220 S221 N244 V246 H258 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 28584087 303 LMENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRYPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 5znc A 1.66 BS01 QI9 A 1 V66 S91 C92 G93 Y160 V181 E182 M183 D218 V63 S88 C89 G90 Y157 V178 E179 M180 D215 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006166,0006218,0009116,0016757,0047975 Kd=65nM -logKd/Ki=7.52, Kd=29.9nM Q8T9Z7 30602534 301 LLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA 5zni A 2.3 BS01 YMZ A 1 C92 G93 Y160 V181 M183 D206 G207 C208 C90 G91 Y158 V179 M181 D204 G205 C206 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006166,0006218,0009116,0016757,0047975 Kd=11uM -logKd/Ki=4.39, Kd=40.3uM Q8T9Z7 30602534 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKHQLENMIKIALGACAKLATKYA 6aqs A 1.57 BS01 IM5 A 1 S91 C92 Y160 D181 E182 M183 E184 S89 C90 Y158 D179 E180 M181 E182 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Ki=28nM -logKd/Ki=7.55, Ki=28nM Q8I3X4 29440412 302 NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVDEMELATLMVIGTLRKVKTGGILIVDGCVPHQLENMIKIALGACAKLATKYA 6awe A 1.65 BS01 C0J A 1 L118 A119 G120 Y202 E203 V219 N245 S247 D250 I257 L114 A115 G116 Y198 E199 V215 N241 S243 D246 I253 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 309 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6axa A 1.59 BS01 D4Y A 1 L118 A119 G120 Y202 E203 V219 G220 M221 V262 L114 A115 G116 Y198 E199 V215 G216 M217 V258 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 309 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6b2l A 1.56 BS01 2IM A 1 A119 G120 E203 N245 A115 G116 E199 N241 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 308 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6b37 A 1.5 BS01 CGD A 1 A119 G120 E203 G220 M221 A115 G116 E199 G216 M217 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 307 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6b3l A 1.52 BS01 XM0 A 1 N183 F185 M275 W276 N179 F181 M271 W272 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 307 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6b4q A 1.6 BS01 CQG A 1 A119 G120 Y202 E203 N245 A115 G116 Y198 E199 N241 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 307 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6b4t A 1.51 BS01 CQJ A 1 A119 G120 Y202 E203 N245 V262 A115 G116 Y198 E199 N241 V258 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 308 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6b56 A 1.42 BS01 CQV A 1 I53 K60 T61 T62 I49 K56 T57 T58 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 304 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6b6k A 1.46 BS01 CVG A 1 A119 G120 Y202 E203 M221 A116 G117 Y199 E200 M218 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S32 H63 H85 Y87 E88 L115 M218 S219 N242 H256 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 308 PVVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPL 6b71 A 1.52 BS01 A5H A 1 N183 F185 M275 W276 N179 F181 M271 W272 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 306 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6b7i A 1.54 BS01 CXJ A 1 Q174 L175 K178 R283 P285 Q170 L171 K174 R279 P281 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 308 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPL 6bb7 A 1.44 BS01 D4V A 1 L118 A119 G120 Y202 E203 A244 N245 L114 A115 G116 Y198 E199 A240 N241 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 305 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6bfv A 1.921 BS01 DJP A 1 A119 G120 Y202 E203 A115 G116 Y198 E199 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 306 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6bhb A 2.0 BS01 DS1 A 1 G120 Y202 E203 M221 G116 Y198 E199 M217 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 309 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6bi1 A 1.42 BS01 SEM A 1 N183 F185 M275 W276 N179 F181 M271 W272 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 308 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6bi9 A 1.59 BS01 DS7 A 1 L118 A119 G120 N197 Y202 E203 G220 M221 L114 A115 G116 N193 Y198 E199 G216 M217 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 306 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6bif A 1.6 BS01 DSJ A 1 L118 A119 G120 Y202 E203 M221 L114 A115 G116 Y198 E199 M217 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 309 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6bj6 A 1.73 BS01 DTS A 1 S35 N117 L118 G120 Y202 S31 N113 L114 G116 Y198 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 305 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLP 6bj7 A 1.56 BS01 DU7 A 1 L118 A119 G120 Y202 E203 G220 M221 N245 V262 L114 A115 G116 Y198 E199 G216 M217 N241 V258 S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259 S31 H62 H84 Y86 E87 L114 M217 S218 N241 H255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0047975 A0A0U3AGT1 306 VVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYINIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIRVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPNQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAENDVSINHEKVLAVAEKRADLLQMWFKEIITRLPL 6dzd A 2.66 BS01 ZN A 1 C189 C249 C252 C181 C241 C244 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016740,0016787,0017061,0046872,0046936 A5A677 301 NTYNPFRLDAPSMLLIEEWNQVTAGFTTKNGGESEPPFHSLNTGLHVQDHEQHVINNRKKVADILKTDLHDWVFADQTHEDRIHKVTDGDRASGAFRYDTALKATDGLYTDRPNLFLALCFADCVPVYFYDPVRSLVGIAHAGWKGTALGIAASMVDMWIRREGSNPADIRAVIGPAIGSCCYTVDDHVIDKIRNLPLQQEDKAFLTIKEGEYRLELKEVNRQLLVHAGIPNGQIEVSSLCTSCERSLFFSHRRDRGKTGRMMSFIGLK 6dzd B 2.66 BS01 ZN B 1 C189 C190 C249 C252 C179 C180 C239 C242 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016740,0016787,0017061,0046872,0046936 A5A677 301 YNPFRLDAPSMLLIEEWNQVTAGFTTKNGGESEPPFHSLNTGLHVQDHEQHVINNRKKVADILKTDLHDWVFADQTHEDRIHKVTDGDRASGAFRYDTALKATDGLYTDRPNLFLALCFADCVPVYFYDPVRSLVGIAHAGWKGTALGIAASMVDMWIRREGSNPADIRAVIGPAIGSCCYTVDDHVIDKIRNLPLQQEDKAFLTIKEGEYRLELKEVNRQLLVHAGIPNGQIEVSSLCTSCERSLFFSHRRDRGKTGRMMSFIGLK 6f4w A 2.293 BS01 FMC A 1 M64 C91 G92 F159 E179 E181 D204 M64 C91 G92 F159 E179 E181 D204 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM -logKd/Ki=5.53, Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w A 2.293 BS02 FMC D 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM -logKd/Ki=5.53, Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w B 2.293 BS01 FMC B 1 T90 C91 G92 F159 E179 E181 L206 T90 C91 G92 F159 E179 E181 L206 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w B 2.293 BS02 FMC E 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w C 2.293 BS01 FMC C 1 M64 T90 C91 G92 F159 E181 M64 T90 C91 G92 F159 E181 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w C 2.293 BS02 FMC F 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w D 2.293 BS01 FMC A 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM -logKd/Ki=5.53, Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w D 2.293 BS02 FMC D 1 T90 C91 G92 F159 E181 L206 T90 C91 G92 F159 E181 L206 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM -logKd/Ki=5.53, Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w E 2.293 BS01 FMC B 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w E 2.293 BS02 FMC E 1 T90 C91 G92 F159 M180 E181 T90 C91 G92 F159 M180 E181 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4w F 2.293 BS01 FMC F 1 M64 T90 C91 G92 F159 E181 M64 T90 C91 G92 F159 E181 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=2.95uM P56463 29430816 300 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x A 1.694 BS01 FMC A 1 M64 T90 C91 F159 E179 M180 E181 M64 T90 C91 F159 E179 M180 E181 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=10.7uM -logKd/Ki=4.97, Kd=10.7uM P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x A 1.694 BS02 PO4 A 1 G20 T90 G20 T90 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 29430816 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x B 1.694 BS01 FMC B 1 T90 C91 G92 F159 M180 E181 T90 C91 G92 F159 M180 E181 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=10.7uM P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x B 1.694 BS02 FMC E 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=10.7uM P56463 29430816 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x C 1.694 BS01 PO4 C 1 G20 R24 R87 G89 T90 G20 R24 R87 G89 T90 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x C 1.694 BS02 FMC C 1 M64 T90 C91 G92 F159 E179 M180 E181 M64 T90 C91 G92 F159 E179 M180 E181 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=10.7uM P56463 29430816 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x C 1.694 BS03 FMC F 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=10.7uM P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x D 1.694 BS01 FMC A 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=10.7uM -logKd/Ki=4.97, Kd=10.7uM P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x D 1.694 BS02 FMC D 1 M64 T90 C91 G92 F159 E181 M64 T90 C91 G92 F159 E181 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=10.7uM -logKd/Ki=4.97, Kd=10.7uM P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x E 1.694 BS01 FMC B 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x E 1.694 BS02 PO4 E 1 G20 R24 R87 G89 T90 G20 R24 R87 G89 T90 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x E 1.694 BS03 FMC E 1 M64 T90 C91 G92 F159 I178 E179 M180 E181 M64 T90 C91 G92 F159 I178 E179 M180 E181 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 R217 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 29430816 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 6f4x F 1.694 BS01 FMC C 1 H4 R43 H4 R43 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=10.7uM P56463 29430816 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKESFDNMIILALEMMS 6f4x F 1.694 BS02 FMC F 1 M64 T90 C91 G92 F159 E179 M180 E181 D204 L206 M64 T90 C91 G92 F159 E179 M180 E181 D204 L206 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 H4 G20 R24 R43 E75 R87 T90 S203 D204 L206 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 Kd=10.7uM P56463 29430816 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKESFDNMIILALEMMS 6t0y A 1.2 BS01 ZN A 1 C182 C183 C242 C245 C181 C182 C241 C244 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0004731,0005507,0016740,0016787,0017061,0046872,0046936 P84138 31978345 301 PDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGDDRTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFATAVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAGGIAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPPESPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALFFSHRRDRGTTGRMLAFIGRRE 6t0y A 1.2 BS02 ZN A 2 H80 C125 H142 H79 C124 H141 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0004731,0005507,0016740,0016787,0017061,0046872,0046936 P84138 31978345 302 PDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGDDRTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFATAVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAGGIAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPPESPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALFFSHRRDRGTTGRMLAFIGRRE 6t1b A 1.2 BS01 NOS A 1 G45 L46 H47 Q78 H80 F99 C121 H142 G44 L45 H46 Q77 H79 F98 C120 H141 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0004731,0005507,0016740,0016787,0017061,0046872,0046936 P84138 31978345 301 PDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGDDRTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFATAVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAGGIAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPPESPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALFFSHRRDRGTTGRMLAFIGRREE 6t1b A 1.2 BS02 ZN A 1 C182 C183 C242 C245 C181 C182 C241 C244 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0004731,0005507,0016740,0016787,0017061,0046872,0046936 P84138 31978345 302 PDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGDDRTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFATAVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAGGIAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPPESPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALFFSHRRDRGTTGRMLAFIGRREE 6t1b A 1.2 BS03 ZN A 2 H80 C125 H142 H79 C124 H141 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0004731,0005507,0016740,0016787,0017061,0046872,0046936 P84138 31978345 303 PDIFQQEARGWLRCGAPPFAGAVAGLTTKHGGESKGPFASLNMGLHVGDDRTDVVNNRRRLAEWLAFPLERWVCCEQVHGADIQKVTKSDRGNGAQDFATAVPGVDGLYTDEAGVLLALCFADCVPIYFVAPSAGLVGLAHAGWRGTAGGIAGHMVWLWQTREHIAPSDIYVAIGPAIGPCCYTVDDRVVDSLRPTLPPESPLPWRETSPGQYALDLKEANRLQLLAAGVPNSHIYVSERCTSCEEALFFSHRRDRGTTGRMLAFIGRREE 6xz2 B 1.65 BS01 FMC B 1 M64 S90 F159 V178 E179 M180 E181 D204 M64 S90 F159 V178 E179 M180 E181 D204 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 34045551 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFWSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 6xz2 C 1.65 BS01 FMC B 1 H4 R43 H4 R43 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0006974,0009116,0009164,0016020,0016757,0016763,0019686,0042278,0042802,0047975 P0ABP8 34045551 301 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFWSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 7f3v A 1.47 BS01 EPZ A 1 H71 T104 A105 A107 H124 G126 W127 R128 F162 E163 V164 G165 V168 K189 Y227 R228 H70 T103 A104 A106 H123 G125 W126 R127 F161 E162 V163 G164 V167 K188 Y226 R227 1.10.3.-,2.4.2.1,2.4.2.28,3.5.4.4 0000270,0004000,0004731,0005507,0005829,0016491,0016682,0016740,0016787,0017061,0030288,0042803,0046872,0046936 P33644 35164571 301 SKLIVPQWPQPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADALPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILAWLGPAIGPRAFEVGGEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 7f3v B 1.47 BS01 EPZ B 1 H71 T104 A105 A107 H124 G126 W127 R128 E163 V164 G165 K189 Y227 R228 H69 T102 A103 A105 H122 G124 W125 R126 E161 V162 G163 K187 Y225 R226 1.10.3.-,2.4.2.1,2.4.2.28,3.5.4.4 0000270,0004000,0004731,0005507,0005829,0016491,0016682,0016740,0016787,0017061,0030288,0042803,0046872,0046936 P33644 35164571 301 KLIVPQWPQPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADALPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILAWLGPAIGPRAFEVGGEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 7f3v C 1.47 BS01 EPZ C 1 H71 T104 A105 A107 H124 G126 W127 R128 E163 V164 G165 E167 V168 K189 Y227 R228 H70 T99 A100 A102 H119 G121 W122 R123 E158 V159 G160 E162 V163 K184 Y222 R223 1.10.3.-,2.4.2.1,2.4.2.28,3.5.4.4 0000270,0004000,0004731,0005507,0005829,0016491,0016682,0016740,0016787,0017061,0030288,0042803,0046872,0046936 P33644 35164571 301 SKLIVPQWPQPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGSKRADASYSNTPGTVCAVMTADALPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILAWLGPAIGPRAFEVGGEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 7f3v D 1.47 BS01 EPZ D 1 H71 T104 A105 A107 H124 G126 W127 E163 V164 G165 V168 K189 Y227 R228 H69 T95 A96 A98 H115 G117 W118 E154 V155 G156 V159 K180 Y218 R219 1.10.3.-,2.4.2.1,2.4.2.28,3.5.4.4 0000270,0004000,0004731,0005507,0005829,0016491,0016682,0016740,0016787,0017061,0030288,0042803,0046872,0046936 P33644 35164571 301 KLIVPQWPQPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLKRADASYSNTPGTVCAVMTADALPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILAWLGPAIGPRAFEVGGEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 7fbg A 1.6 BS01 ZN A 1 H80 C125 H142 H81 C126 H143 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016740,0016787,0017061,0046872,0046936 Q812W6 302 AMREPFKYVDGILYLQAWKELGNITAGFTTKDGGISTGSFHAMNLGLHVNDIVENVHENRRILANKLQKPLENWICSEQVHAHHVEKVGQQEKGSGVYSYEDGISKTDGIYTSNEDVLLTSCYADCVPLYFYAPSHGMIGLAHAGWKGTVQEIAKEMIQKWNAEGISSDEIHVAIGPSIGSCCYVVDDRVLTAAQEVVSGAVPHQKISDGQYAINLKEINRILCVQAGIKEEHIVMSSLCTSCEEQLFFSHRRDQGKTGRMLSFIGFK 7fbg A 1.6 BS02 ZN A 2 C181 C239 C242 C182 C240 C243 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016740,0016787,0017061,0046872,0046936 Q812W6 303 AMREPFKYVDGILYLQAWKELGNITAGFTTKDGGISTGSFHAMNLGLHVNDIVENVHENRRILANKLQKPLENWICSEQVHAHHVEKVGQQEKGSGVYSYEDGISKTDGIYTSNEDVLLTSCYADCVPLYFYAPSHGMIGLAHAGWKGTVQEIAKEMIQKWNAEGISSDEIHVAIGPSIGSCCYVVDDRVLTAAQEVVSGAVPHQKISDGQYAINLKEINRILCVQAGIKEEHIVMSSLCTSCEEQLFFSHRRDQGKTGRMLSFIGFK 7fbg A 1.6 BS03 CA A 1 Q194 V197 Q195 V198 2.4.2.1,2.4.2.28,3.5.4.4 0004000,0005507,0016740,0016787,0017061,0046872,0046936 Q812W6 304 AMREPFKYVDGILYLQAWKELGNITAGFTTKDGGISTGSFHAMNLGLHVNDIVENVHENRRILANKLQKPLENWICSEQVHAHHVEKVGQQEKGSGVYSYEDGISKTDGIYTSNEDVLLTSCYADCVPLYFYAPSHGMIGLAHAGWKGTVQEIAKEMIQKWNAEGISSDEIHVAIGPSIGSCCYVVDDRVLTAAQEVVSGAVPHQKISDGQYAINLKEINRILCVQAGIKEEHIVMSSLCTSCEEQLFFSHRRDQGKTGRMLSFIGFK 7ooy B 1.9 BS01 05Z B 1 T90 C91 G92 F159 Y160 I178 M180 S203 D204 T90 C91 G92 F159 Y160 I178 M180 S203 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 303 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7ooz B 1.7 BS01 05Q B 1 T90 C91 G92 F159 F167 I178 M180 S203 D204 T90 C91 G92 F159 F167 I178 M180 S203 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 A 1.5 BS01 06K A 1 T90 C91 G92 F159 I178 E179 M180 D204 T90 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 B 1.5 BS01 06K B 1 C91 G92 F159 I178 E179 M180 D204 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 C 1.5 BS01 06K C 1 T90 F159 I178 E179 M180 D204 T90 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 D 1.5 BS01 06K D 1 T90 C91 G92 F159 I178 E179 M180 D204 T90 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 E 1.5 BS01 06K E 1 C91 G92 F159 I178 E179 M180 D204 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 F 1.5 BS01 06K F 1 T90 G92 F159 I178 E179 M180 D204 T90 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 G 1.5 BS01 06K G 1 T90 C91 G92 F159 I178 E179 M180 D204 T90 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 H 1.5 BS01 06K H 1 T90 C91 G92 F159 I178 E179 M180 D204 T90 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 I 1.5 BS01 06K I 1 T90 C91 G92 F159 I178 E179 M180 D204 T90 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 J 1.5 BS01 06K J 1 C91 G92 F159 I178 E179 M180 D204 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 K 1.5 BS01 06K K 1 T90 C91 G92 F159 I178 E179 M180 D204 T90 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7op9 L 1.5 BS01 06K L 1 T90 G92 F159 I178 E179 M180 D204 T90 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 301 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7opa C 2.0 BS01 05Z C 1 C91 G92 F159 I178 E179 M180 D204 L206 C91 G92 F159 I178 E179 M180 D204 L206 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7opa H 2.0 BS01 05Z H 1 C91 G92 F159 I178 E179 M180 D204 C91 G92 F159 I178 E179 M180 D204 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763 P56463 35437103 302 MTPHINAKIGDFYPQCLLCGDPLRVSYIAKKFLQDAKEITNVRNMLGFSGKYKGRGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIIMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKVGNVFSSDFFYSFETHAFDLMAKYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERVESFDNMIILALEMMS 7w1g A 1.86 BS01 EPZ A 1 H71 T104 A105 A107 G126 W127 R128 E163 V164 G165 E167 K189 Y227 R228 H70 T103 A104 A106 G125 W126 R127 E162 V163 G164 E166 K188 Y226 R227 1.10.3.-,2.4.2.1,2.4.2.28,3.5.4.4 0000270,0004000,0004731,0005507,0005829,0016491,0016682,0016740,0016787,0017061,0030288,0042803,0046872,0046936 P33644 35164571 301 SKLIVPQWPQPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADALPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILAWLGPAIGPRAFEVGGEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 7w1g B 1.86 BS01 EPZ B 1 H71 T104 A105 D106 A107 G126 W127 R128 E163 V164 G165 E167 V168 K189 Y227 R228 H70 T103 A104 D105 A106 G125 W126 R127 E162 V163 G164 E166 V167 K188 Y226 R227 1.10.3.-,2.4.2.1,2.4.2.28,3.5.4.4 0000270,0004000,0004731,0005507,0005829,0016491,0016682,0016740,0016787,0017061,0030288,0042803,0046872,0046936 P33644 35164571 301 SKLIVPQWPQPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADALPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILAWLGPAIGPRAFEVGGEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLI 7w1g C 1.86 BS01 87E C 1 Q69 H71 M103 T104 A105 A107 H124 G126 W127 R128 E163 V164 G165 E167 V168 K189 Y227 R228 R235 Q68 H70 M102 T103 A104 A106 H123 G125 W126 R127 E162 V163 G164 E166 V167 K188 Y226 R227 R234 1.10.3.-,2.4.2.1,2.4.2.28,3.5.4.4 0000270,0004000,0004731,0005507,0005829,0016491,0016682,0016740,0016787,0017061,0030288,0042803,0046872,0046936 P33644 35164571 301 SKLIVPQWPQPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADALPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILAWLGPAIGPRAFEVGGEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLIL 7w1g D 1.86 BS01 87E D 1 Q69 H71 A105 A107 H124 G126 W127 R128 E163 V164 G165 V168 K189 Y227 R228 R235 Q68 H70 A104 A106 H123 G125 W126 R127 E162 V163 G164 V167 K188 Y226 R227 R234 1.10.3.-,2.4.2.1,2.4.2.28,3.5.4.4 0000270,0004000,0004731,0005507,0005829,0016491,0016682,0016740,0016787,0017061,0030288,0042803,0046872,0046936 P33644 35164571 301 SKLIVPQWPQPKGVAACSSTRIGGVSLPPYDSLNLGAHCGDNPDHVEENRKRLFAAGNLPSKPVWLEQVHGKDVLKLTGEPYASKRADASYSNTPGTVCAVMTADALPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVSCFADNPENILAWLGPAIGPRAFEVGGEVREAFMAVDAKASAAFIQHGDKYLADIYQLARQRLANVGVEQIFGGDRCTYTENETFFSYRRDKTTGRMASFIWLIL 7zsl A 1.8 BS01 JTO A 1 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 T242 N243 H257 R75 H77 N106 A107 A108 G109 F191 E192 V208 M210 S211 T233 N234 H248 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 7zsl B 1.8 BS01 JTO B 1 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 T242 N243 H257 R74 H76 N105 A106 A107 G108 F190 E191 V207 M209 S210 T232 N233 H247 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 7zsl C 1.8 BS01 JTO C 1 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 T242 N243 H257 R73 H75 N104 A105 A106 G107 F187 E188 V204 M206 S207 T229 N230 H244 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 7zsl D 1.8 BS01 JTO D 1 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 T242 N243 H257 R71 H73 N102 A103 A104 G105 F187 E188 V204 M206 S207 T229 N230 H244 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 GYTYEDYKNTAEWLLSHTKHRPQVAIICLGGLTDKLTQAQIFDYGEIPNFPRGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 7zsl E 1.8 BS01 JTO E 1 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 N243 R73 H75 N104 A105 A106 G107 F189 E190 V206 M208 S209 N232 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 7zsl F 1.8 BS01 JTO F 1 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 T242 N243 H257 R74 H76 N105 A106 A107 G108 F186 E187 V203 M205 S206 T228 N229 H243 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 7zsm A 2.65 BS01 JU9 A 1 R84 H86 N115 A116 A117 G118 F200 E201 V217 G218 S220 T242 N243 R82 H84 N113 A114 A115 G116 F198 E199 V215 G216 S218 T240 N241 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 7zsn A 2.36 BS01 JSI A 1 G32 S33 R84 H86 N115 A116 G118 F200 E201 V217 M219 S220 N243 V260 G29 S30 R81 H83 N112 A113 G115 F197 E198 V214 M216 S217 N240 V257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 7zsn A 2.36 BS02 TEW A 1 R207 D248 Y249 E250 R204 D245 Y246 E247 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 303 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 7zsn A 2.36 BS03 TEW A 2 N55 F56 R58 K95 N52 F53 R55 K92 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 304 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 7zso A 1.95 BS01 JTC A 1 S33 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 T242 N243 V260 L261 S31 R82 H84 N113 A114 A115 G116 F198 E199 V215 M217 S218 T240 N241 V258 L259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDK 7zso B 1.95 BS01 JTC B 1 G32 S33 G34 R84 H86 N115 A116 A117 G118 F200 E201 V217 G218 M219 S220 N243 H257 V260 L261 G29 S30 G31 R81 H83 N112 A113 A114 G115 F197 E198 V214 G215 M216 S217 N240 H254 V257 L258 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 7zso C 1.95 BS01 JTC C 1 S33 R84 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 N243 H257 V260 L261 S30 R81 H83 N112 A113 A114 G115 F197 E198 V214 M216 S217 N240 H254 V257 L258 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 7zsp A 2.29 BS01 JT3 A 1 S33 N115 A116 A117 G118 F200 E201 V217 M219 S220 N243 L261 S30 N112 A113 A114 G115 F197 E198 V214 M216 S217 N240 L258 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 301 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 7zsp A 2.29 BS02 TEW A 1 N55 F56 P57 R58 K95 N52 F53 P54 R55 K92 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 302 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 7zsp A 2.29 BS03 TEW A 2 R207 D248 Y249 E250 R204 D245 Y246 E247 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 303 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 7zsp A 2.29 BS04 TEW A 3 W94 R148 W91 R145 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 37134237 304 GYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPL 7zsq A 1.77 BS01 JTO A 1 G35 S36 R88 H90 N119 A120 A121 G122 Y188 E189 V205 M207 S208 N231 H243 G29 S30 R82 H84 N113 A114 A115 G116 Y182 E183 V199 M201 S202 N225 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 7zsq A 1.77 BS02 TEW A 1 S36 H68 R88 H90 Y92 H243 S30 H62 R82 H84 Y86 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 302 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 7zsq B 1.77 BS01 TEW A 1 G151 F153 G145 F147 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 302 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIAR 7zsq B 1.77 BS02 JTO B 1 S36 R88 H90 Y92 N119 A120 A121 G122 Y188 E189 V205 M207 S208 N231 S30 R82 H84 Y86 N113 A114 A115 G116 Y182 E183 V199 M201 S202 N225 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIAR 7zsq B 1.77 BS03 P4K B 1 L142 M196 L136 M190 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 302 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIAR 7zsq C 1.77 BS01 JTO C 1 G35 S36 R88 H90 Y92 N119 A120 A121 G122 Y188 E189 V205 M207 S208 N231 G35 S36 R88 H90 Y92 N119 A120 A121 G122 Y188 E189 V205 M207 S208 N231 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 301 VADPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 7zsr A 1.97 BS01 JSI A 1 G35 S36 R88 H90 N119 A120 A121 G122 Y188 E189 V205 M207 S208 T230 N231 G29 S30 R82 H84 N113 A114 A115 G116 Y182 E183 V199 M201 S202 T224 N225 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 7zsr B 1.97 BS01 JSI B 1 S36 R88 H90 Y92 N119 A120 A121 G122 Y188 E189 V205 M207 S208 T230 N231 S30 R82 H84 Y86 N113 A114 A115 G116 Y182 E183 V199 M201 S202 T224 N225 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 7zsr C 1.97 BS01 JSI C 1 G35 S36 R88 H90 N119 A120 A121 G122 Y188 E189 V205 M207 S208 N231 H243 V246 G29 S30 R82 H84 N113 A114 A115 G116 Y182 E183 V199 M201 S202 N225 H237 V240 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 8c25 A 1.56 BS01 JU9 A 1 G35 S36 R88 H90 Y92 N119 A120 A121 G122 Y188 E189 V205 M207 S208 T230 N231 H243 G29 S30 R82 H84 Y86 N113 A114 A115 G116 Y182 E183 V199 M201 S202 T224 N225 H237 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 301 DPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 8c25 B 1.56 BS01 JU9 B 1 G35 S36 R88 H90 N119 A120 A121 G122 Y188 E189 V205 M207 S208 T230 N231 H243 G30 S31 R83 H85 N114 A115 A116 G117 Y183 E184 V200 M202 S203 T225 N226 H238 2.4.2.1 0003824,0004731,0005737,0006139,0006154,0006161,0009116,0016757,0016763 P9WP01 37134237 301 PDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF 8swp A 2.1 BS01 HPA A 1 A129 A130 G131 F213 E214 V230 T255 N256 A118 A119 G120 F202 E203 V219 T244 N245 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 400 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swp B 2.1 BS01 HPA B 1 A129 A130 G131 E214 M232 N256 A119 A120 G121 E184 M202 N226 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 400 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swp D 2.1 BS01 HPA D 1 A129 A130 G131 F213 E214 V230 M232 T255 N256 A120 A121 G122 F204 E205 V221 M223 T246 N247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVSSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swp E 2.1 BS01 HPA E 1 A130 G131 F213 E214 M232 N256 A123 G124 F188 E189 M207 N231 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 400 EQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVSTVPGHSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swq A 1.979 BS01 DIH A 1 A129 A130 G131 F213 E214 M232 N256 H281 V284 A125 A126 G127 F209 E210 M228 N252 H277 V280 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKVSTVPGHSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swq B 1.979 BS01 DIH B 1 Y100 A129 A130 G131 F213 E214 M232 N256 H281 V284 Y88 A117 A118 G119 F185 E186 M204 N228 H253 V256 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swq D 1.979 BS01 DIH D 1 Y100 A129 A130 G131 F213 E214 M232 N256 H281 V284 Y88 A117 A118 G119 F201 E202 M220 N244 H269 V272 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swq E 1.979 BS01 DIH E 1 Y100 A129 A130 G131 F213 E214 M232 N256 H281 V284 Y85 A114 A115 G116 F182 E183 M201 N225 H250 V253 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 401 EQRALIKSAHRYISEKLEDHFSSEFLPKALVICGSGLSGISTKIADEPKPLILSYSTIPGFKGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swr A 2.3 BS01 IM5 A 1 A129 A130 G131 F213 E214 V230 M232 T255 N256 H281 V284 A118 A119 G120 F202 E203 V219 M221 T244 N245 H270 V273 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 400 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGEGLSGISTKIADEPKPLILSYSTIPGFKSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swr B 2.3 BS01 IM5 B 1 A129 A130 G131 F213 E214 V230 M232 N256 H281 V284 A117 A118 G119 F181 E182 V198 M200 N224 H249 V252 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 400 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGEGLSGISTKIADEPKPLILSYSTIPGFKGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swr D 2.3 BS01 IM5 D 1 A129 A130 G131 F213 E214 V230 G231 M232 T255 N256 H281 V284 A118 A119 G120 F202 E203 V219 G220 M221 T244 N245 H270 V273 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757,0016763 Q6CSZ6 37812583 400 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGEGLSGISTKIADEPKPLILSYSTIPGFKSGELIFGYMNGAPVVLMNGRLHSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8sws A 1.99 BS01 IM5 A 1 A129 A130 G131 F213 E214 V230 M232 T255 N256 H281 V284 A125 A126 G127 F209 E210 V226 M228 T251 N252 H277 V280 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGEGLSGISTKIADEPKPLILSYSTIPGFKVSTVPGHSGELIFGYMNGAPVVLMNGRLRSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8sws B 1.99 BS01 IM5 B 1 Y100 A129 A130 G131 F213 E214 V230 G231 M232 N256 V284 Y86 A115 A116 G117 F184 E185 V201 G202 M203 N227 V255 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q6CSZ6 37812583 401 EQRALIKSAHRYISEKLEDHFSSEFLPKALVICGEGLSGISTKIADEPKPLILSYSTIPGFKSGELIFGYMNGAPVVLMNGRLRSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8sws D 1.99 BS01 IM5 D 1 Y100 A129 A130 G131 F213 E214 V230 M232 N256 H281 V284 Y97 A126 A127 G128 F195 E196 V212 M214 N238 H263 V266 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q6CSZ6 37812583 401 LDINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGEGLSGISTKIADEPKPLILSYSTIPGFKVSTVPGHSGELIFGYMNGAPVVLMNGRLRSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8sws E 1.99 BS01 IM5 E 1 Y100 A129 A130 G131 F213 E214 V230 G231 M232 N256 H281 V284 Y89 A118 A119 G120 F202 E203 V219 G220 M221 N245 H270 V273 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q6CSZ6 37812583 401 DINEQRALIKSAHRYISEKLEDHFSSEFLPKALVICGEGLSGISTKIADEPKPLILSYSTIPGFKVGELIFGYMNGAPVVLMNGRLRSYEGHSLAETVHPIRALHLLGSINVLIVTNAAGGINASFKAGDLMCVYDHINFPGLCGFHPLRGANFDEFGPRFLATSDAYDLELRKLLFSKKKELNIERKIHEGTYSYVHGPTFESRAESRFLRLAGTDAVGMSTVPEVVTARHCGWRVLALSLITNECVVDPPASAHDENPVPIQEGKATHEEVLENSAKASKDVQELIFSVVAEI 8swt A 1.66 BS01 IMH A 1 H84 Y86 A114 S115 G116 F192 E193 Y198 G210 M211 D235 H247 H90 Y92 A120 S121 G122 F198 E199 Y204 G216 M217 D241 H253 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q5LAA3 37812583 300 NLYFQSMMAMLEKIQETAAFLKGKMHTSPETAIILGTGLGSLANEITEKYEIKYEDIPNFPVSTVEGHSGKLIFGKLGNKEIMAMQGRFHYYEGYSMKEVTFPVRVMRELGIKTLFVSNASGGTNPEFEIGDLMIITDHINYFPEHPLRGKNIPYGPRFPDMSEAYDKELIRKADAIAAEKGIKVQHGIYIGTQGPTFETPAEYKLFHILGADAVGMSTVPEVIVANHCGIKVFGISVVTDLGVEGKIVEVSHEEVQKAADAAQPKMTTIMRELINRA 8swt B 1.66 BS01 IMH B 1 H84 Y86 A114 S115 G116 F192 E193 G210 M211 D235 H247 H85 Y87 A115 S116 G117 F193 E194 G211 M212 D236 H248 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 Q5LAA3 37812583 300 SMMAMLEKIQETAAFLKGKMHTSPETAIILGTGLGSLANEITEKYEIKYEDIPNFPVSTVEGHSGKLIFGKLGNKEIMAMQGRFHYYEGYSMKEVTFPVRVMRELGIKTLFVSNASGGTNPEFEIGDLMIITDHINYFPEHPLRGKNIPYGPRFPDMSEAYDKELIRKADAIAAEKGIKVQHGIYIGTQGPTFETPAEYKLFHILGADAVGMSTVPEVIVANHCGIKVFGISVVTDLGVEGKIVEVSHEEVQKAADAAQPKMTTIMRELINRA 8swu A 2.34 BS01 IMH A 1 Y85 A113 A114 G115 Y192 E193 M211 N235 H247 V250 Y82 A110 A111 G112 Y189 E190 M208 N232 H244 V247 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 A0A0H2YR30 37812583 301 SMDLSNKIKAAAEYIKGKSKYNPTIGLILGSGLGAIADQIEDAEYFPYNEIPNFPVSTAGRLVIGKFQGKEVVAMQGRFHYYEGYSMQEVTCPVRVMRLLGVETLVVTNAAGAVNKDYTPGDLMIISDHLNLSGSNPLIGKNLNEFGTRFPDMSNAYDKDLRAQVKDIAKNLGIEVREGVYAMFSGPTYETPAEVRMARILGADAVGMSTVPEVIIANHSGMKVIGVSCMTNMAAGILEQPLNHEEVMETSAKVRKTFIELMTNIIKEI 8swu B 2.34 BS01 IMH B 1 A113 G115 Y192 E193 G210 M211 N235 H247 V250 A108 G110 Y187 E188 G205 M206 N230 H242 V245 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 A0A0H2YR30 37812583 301 MDLSNKIKAAAEYIKGKSKYNPTIGLILGSGLGAIADQIEDAEYFPYNEIPNFPVSAGRLVIGKFQGKEVVAMQGRFHYYEGYSMQEVTCPVRVMRLLGVETLVVTNAAGAVNKDYTPGDLMIISDHLNLSGSNPLIGKNLNEFGTRFPDMSNAYDKDLRAQVKDIAKNLGIEVREGVYAMFSGPTYETPAEVRMARILGADAVGMSTVPEVIIANHSGMKVIGVSCMTNMAAGILEQPLNHEEVMETSAKVRKTFIELMTNIIKEI 8swu C 2.34 BS01 IMH C 1 A113 G115 Y192 E193 M211 N235 H247 V250 A109 G111 Y188 E189 M207 N231 H243 V246 2.4.2.1 0003824,0004731,0005737,0006139,0009116,0016757 A0A0H2YR30 37812583 301 SMDLSNKIKAAAEYIKGKSKYNPTIGLILGSGLGAIADQIEDAEYFPYNEIPNFPVSTGRLVIGKFQGKEVVAMQGRFHYYEGYSMQEVTCPVRVMRLLGVETLVVTNAAGAVNKDYTPGDLMIISDHLNLSGSNPLIGKNLNEFGTRFPDMSNAYDKDLRAQVKDIAKNLGIEVREGVYAMFSGPTYETPAEVRMARILGADAVGMSTVPEVIIANHSGMKVIGVSCMTNMAAGILEQPLNHEEVMETSAKVRKTFIELMTNIIKEI 8w7h A 1.85 BS01 XUH A 1 C92 G93 Y160 V181 M183 D206 G207 C208 P209 C89 G90 Y157 V178 M180 D203 G204 C205 P206 2.4.2.1,2.4.2.44 0003824,0004731,0004850,0005829,0006148,0006166,0006195,0006218,0009116,0016757,0017061,0047975 Q8I3X4 38141766 301 LLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKVPHQLENMIKIALGACAKLATKYA