5xii C 2.17 BS01 ANP C 1 R470 E472 R481 T482 F485 Q555 T558 T592 R594 R132 E134 R143 T144 F147 Q217 T220 T254 R256 6.1.1.15 0000166,0004812,0004827,0005524,0005737,0006418,0006433 S8G8I1 28867614 1001 MVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRFFDDEIKKMGVENSYFPMFVSRHKLEKGFSPEVAWVTHYGDSPLPEKIAIRPTSETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQEGHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKKTTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTSWGCTTRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEILGKCRELKTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAKGTARVVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEKISTFDEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIGAMKTLCIPFDQPPMPEGTKCFYTGKPAKRWTLWGRSY 5xii C 2.17 BS02 86X C 1 F415 V419 P438 T439 E441 R470 W487 F534 H560 F77 V81 P100 T101 E103 R132 W149 F196 H222 6.1.1.15 0000166,0004812,0004827,0005524,0005737,0006418,0006433 ic50=72nM -logKd/Ki=7.12, IC50=75nM S8G8I1 28867614 1004 MVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRFFDDEIKKMGVENSYFPMFVSRHKLEKGFSPEVAWVTHYGDSPLPEKIAIRPTSETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQEGHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKKTTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTSWGCTTRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEILGKCRELKTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAKGTARVVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEKISTFDEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIGAMKTLCIPFDQPPMPEGTKCFYTGKPAKRWTLWGRSY